Drug Metabolism and Disposition: 41 (1)

January 01, 2013; Volume 41,Issue 1

Symposium Reports

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Role of Nuclear Receptors in Lipid Dysfunction and Obesity-Related Diseases
Hollie I. Swanson, Taira Wada, Wen Xie, Barbara Renga, Angela Zampella, Eleonora Distrutti, Stefano Fiorucci, Bo Kong, Ann M. Thomas, Grace L. Guo, Ramesh Narayanan, Muralimohan Yepuru, James T. Dalton and John Y. L. Chiang

Drug Metabolism and Disposition January 2013, 41 (1) 1-11; DOI: https://doi.org/10.1124/dmd.112.048694
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NADPH–Cytochrome P450 Oxidoreductase: Roles in Physiology, Pharmacology, and Toxicology
David S. Riddick, Xinxin Ding, C. Roland Wolf, Todd D. Porter, Amit V. Pandey, Qing-Yu Zhang, Jun Gu, Robert D. Finn, Sebastien Ronseaux, Lesley A. McLaughlin, Colin J. Henderson, Ling Zou and Christa E. Flück

Drug Metabolism and Disposition January 2013, 41 (1) 12-23; DOI: https://doi.org/10.1124/dmd.112.048991

Short Communications

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Evidence for Substrate-Dependent Inhibition Profiles for Human Liver Aldehyde Oxidase
John T. Barr and Jeffrey P. Jones

Drug Metabolism and Disposition January 2013, 41 (1) 24-29; DOI: https://doi.org/10.1124/dmd.112.048546
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Metabolism of Triethylenetetramine and 1,12-Diamino-3,6,9-Triazadodecane by the Spermidine/Spermine-N¹-Acetyltransferase and Thialysine Acetyltransferase
Mervi T. Hyvönen, Janne Weisell, Alex R. Khomutov, Leena Alhonen, Jouko Vepsäläinen and Tuomo A. Keinänen

Drug Metabolism and Disposition January 2013, 41 (1) 30-32; DOI: https://doi.org/10.1124/dmd.112.047274

Articles

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Function of the Blood-Brain Barrier and Restriction of Drug Delivery to Invasive Glioma Cells: Findings in an Orthotopic Rat Xenograft Model of Glioma
Sagar Agarwal, Pooja Manchanda, Michael A. Vogelbaum, John R. Ohlfest and William F. Elmquist

Drug Metabolism and Disposition January 2013, 41 (1) 33-39; DOI: https://doi.org/10.1124/dmd.112.048322
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Carboxylesterases Are Uniquely Expressed among Tissues and Regulated by Nuclear Hormone Receptors in the Mouse
Ryan D. Jones, Anna M. Taylor, Ernest Y. Tong and Joyce J. Repa

Drug Metabolism and Disposition January 2013, 41 (1) 40-49; DOI: https://doi.org/10.1124/dmd.112.048397
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Autoinhibition of CYP3A4 Leads to Important Role of CYP2C8 in Imatinib Metabolism: Variability in CYP2C8 Activity May Alter Plasma Concentrations and Response
Anne M. Filppula, Mikko Neuvonen, Jouko Laitila, Pertti J. Neuvonen and Janne T. Backman

Drug Metabolism and Disposition January 2013, 41 (1) 50-59; DOI: https://doi.org/10.1124/dmd.112.048017
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Discovery and Characterization of Novel, Potent, and Selective Cytochrome P450 2J2 Inhibitors
Shuang Ren, Juan Zeng, Ye Mei, John Z. H. Zhang, S. Frank Yan, Jian Fei and Li Chen

Drug Metabolism and Disposition January 2013, 41 (1) 60-71; DOI: https://doi.org/10.1124/dmd.112.048264
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DNA Methylation and Histone Modification Profiles of Mouse Organic Anion Transporting Polypeptides
Satoki Imai, Ryota Kikuchi, Hiroyuki Kusuhara and Yuichi Sugiyama

Drug Metabolism and Disposition January 2013, 41 (1) 72-78; DOI: https://doi.org/10.1124/dmd.112.047969
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Characterization of Differential Cocaine Metabolism in Mouse and Rat through Metabolomics-Guided Metabolite Profiling
Dan Yao, Xiaolei Shi, Lei Wang, Blake A. Gosnell and Chi Chen

Drug Metabolism and Disposition January 2013, 41 (1) 79-88; DOI: https://doi.org/10.1124/dmd.112.048678
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Metabolism and Disposition of Vilanterol, a Long-Acting β₂-Adrenoceptor Agonist for Inhalation Use in Humans
Andrew W. Harrell, Sarah K. Siederer, Jo Bal, Nainesh H. Patel, Graeme C. Young, Clive C. Felgate, Sebastian J. Pearce, Andy D. Roberts, Claire Beaumont, Amanda J. Emmons, Adrian I. Pereira and Rodger D. Kempsford

Drug Metabolism and Disposition January 2013, 41 (1) 89-100; DOI: https://doi.org/10.1124/dmd.112.048603
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Interactions between CYP2E1 and CYP2B4: Effects on Affinity for NADPH-Cytochrome P450 Reductase and Substrate Metabolism
Cesar Kenaan, Erin V. Shea, Hsia-lien Lin, Haoming Zhang, Matthew J. Pratt-Hyatt and Paul F. Hollenberg

Drug Metabolism and Disposition January 2013, 41 (1) 101-110; DOI: https://doi.org/10.1124/dmd.112.046094
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Interaction of γ-Glutamyltranspeptidase with Ibuprofen-S-Acyl-Glutathione In Vitro and In Vivo in Human
Mark P. Grillo, Michelle Tadano Lohr and Smriti Khera

Drug Metabolism and Disposition January 2013, 41 (1) 111-121; DOI: https://doi.org/10.1124/dmd.112.048645
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Metabolism and Quantification of [¹⁸F]DPA-714, a New TSPO Positron Emission Tomography Radioligand
Marie-Anne Peyronneau, Wadad Saba, Sébastien Goutal, Annelaure Damont, Frédéric Dollé, Michael Kassiou, Michel Bottlaender and Héric Valette

Drug Metabolism and Disposition January 2013, 41 (1) 122-131; DOI: https://doi.org/10.1124/dmd.112.046342
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Generation and Characterization of a Novel Cyp2a(4/5)bgs-Null Mouse Model
Yuan Wei, Lei Li, Xin Zhou, Qing-Yu Zhang, Anwar Dunbar, Fang Liu, Kerri Kluetzman, Weizhu Yang and Xinxin Ding

Drug Metabolism and Disposition January 2013, 41 (1) 132-140; DOI: https://doi.org/10.1124/dmd.112.048736
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Carbon Monoxide–Bound Red Blood Cells Protect Red Blood Cell Transfusion-Induced Hepatic Cytochrome P450 Impairment in Hemorrhagic-Shock Rats
Shigeru Ogaki, Kazuaki Taguchi, Hiroshi Watanabe, Masaki Otagiri and Toru Maruyama

Drug Metabolism and Disposition January 2013, 41 (1) 141-148; DOI: https://doi.org/10.1124/dmd.112.048744
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Evaluation and Prediction of Potential Drug-Drug Interactions of Linagliptin Using In Vitro Cell Culture Methods
Naoki Ishiguro, Hidetada Shimizu, Wataru Kishimoto, Thomas Ebner and Olaf Schaefer

Drug Metabolism and Disposition January 2013, 41 (1) 149-158; DOI: https://doi.org/10.1124/dmd.112.048470
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Effect of Solvents on the Time-Dependent Inhibition of CYP3A4 and the Biotransformation of AZD3839 in Human Liver Microsomes and Hepatocytes
Jenny Aasa, Yin Hu, Göran Eklund, Anders Lindgren, Pawel Baranczewski, Jonas Malmquist, Dominika Turek and Tjerk Bueters

Drug Metabolism and Disposition January 2013, 41 (1) 159-169; DOI: https://doi.org/10.1124/dmd.112.047597
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Importance of UDP-Glucuronosyltransferases 2A2 and 2A3 in Tobacco Carcinogen Metabolism
Ryan T. Bushey, Douglas F. Dluzen and Philip Lazarus

Drug Metabolism and Disposition January 2013, 41 (1) 170-179; DOI: https://doi.org/10.1124/dmd.112.049171
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Pharmacokinetic Mechanism Involved in the Prolonged High Retention of Laninamivir in Mouse Respiratory Tissues after Intranasal Administration of its Prodrug Laninamivir Octanoate
Kumiko Koyama, Daisuke Nakai, Makoto Takahashi, Naoko Nakai, Nobuhiro Kobayashi, Teruko Imai and Takashi Izumi

Drug Metabolism and Disposition January 2013, 41 (1) 180-187; DOI: https://doi.org/10.1124/dmd.112.048280
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Combination Lopinavir and Ritonavir Alter Exogenous and Endogenous Bile Acid Disposition in Sandwich-Cultured Rat Hepatocytes
LaToya M. Griffin, Paul B. Watkins, Cassandra H. Perry, Robert L. St. Claire and Kim L. R. Brouwer

Drug Metabolism and Disposition January 2013, 41 (1) 188-196; DOI: https://doi.org/10.1124/dmd.112.047225
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Differential Influences of Ethanol on Early Exposure to Racemic Methylphenidate Compared with Dexmethylphenidate in Humans
Kennerly S. Patrick, Arthur B. Straughn, Owen T. Reeves, Hilary Bernstein, Guinevere H. Bell, Erica R. Anderson and Robert J. Malcolm

Drug Metabolism and Disposition January 2013, 41 (1) 197-205; DOI: https://doi.org/10.1124/dmd.112.048595
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Effect of Coadministration of Single and Multiple Doses of Rifampicin on the Pharmacokinetics of Fexofenadine Enantiomers in Healthy Subjects
Hiroyuki Kusuhara, Masatomo Miura, Norio Yasui-Furukori, Kenta Yoshida, Yumiko Akamine, Miyu Yokochi, Shinya Fukizawa, Kazuaki Ikejiri, Kayoko Kanamitsu, Tsukasa Uno and Yuichi Sugiyama

Drug Metabolism and Disposition January 2013, 41 (1) 206-213; DOI: https://doi.org/10.1124/dmd.112.048330
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Effects of Hypothermia on the Disposition of Morphine, Midazolam, Fentanyl, and Propofol in Intensive Care Unit Patients
Thor Wilhelm Bjelland, Pål Klepstad, Bjørn Olav Haugen, Turid Nilsen and Ola Dale

Drug Metabolism and Disposition January 2013, 41 (1) 214-223; DOI: https://doi.org/10.1124/dmd.112.045567
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Evaluation of the Relationship between Sex, Polymorphisms in CYP2C8 and CYP2C9, and Pharmacokinetics of Angiotensin Receptor Blockers
Teresa Cabaleiro, Manuel Román, Dolores Ochoa, María Talegón, Rocío Prieto-Pérez, Aneta Wojnicz, Rosario López-Rodríguez, Jesús Novalbos and Francisco Abad-Santos

Drug Metabolism and Disposition January 2013, 41 (1) 224-229; DOI: https://doi.org/10.1124/dmd.112.046292
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Clinical Pharmacokinetics, Metabolism, and Drug-Drug Interaction of Carfilzomib
Zhengping Wang, Jinfu Yang, Christopher Kirk, Ying Fang, Melissa Alsina, Ashraf Badros, Kyriakos Papadopoulos, Alvin Wong, Tina Woo, Darrin Bomba, Jin Li and Jeffrey R. Infante

Drug Metabolism and Disposition January 2013, 41 (1) 230-237; DOI: https://doi.org/10.1124/dmd.112.047662
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Impact of Hydrolysis-Mediated Clearance on the Pharmacokinetics of Novel Anaplastic Lymphoma Kinase Inhibitors
Yohannes Teffera, Loren M. Berry, Rachael L. Brake, Richard T. Lewis, Douglas C. Saffran, Earl Moore, Jingzhou Liu and Zhiyang Zhao

Drug Metabolism and Disposition January 2013, 41 (1) 238-247; DOI: https://doi.org/10.1124/dmd.112.047993
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Mechanisms of Subcutaneous Absorption of Rituximab in Rats
Leonid Kagan and Donald E. Mager

Drug Metabolism and Disposition January 2013, 41 (1) 248-255; DOI: https://doi.org/10.1124/dmd.112.048496

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