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Drug Metabolism & Disposition

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Table of Contents

January 01, 2013; Volume 41,Issue 1

Symposium Reports

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    Role of Nuclear Receptors in Lipid Dysfunction and Obesity-Related Diseases
    Hollie I. Swanson, Taira Wada, Wen Xie, Barbara Renga, Angela Zampella, Eleonora Distrutti, Stefano Fiorucci, Bo Kong, Ann M. Thomas, Grace L. Guo, Ramesh Narayanan, Muralimohan Yepuru, James T. Dalton and John Y. L. Chiang
    Drug Metabolism and Disposition January 2013, 41 (1) 1-11; DOI: https://doi.org/10.1124/dmd.112.048694
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    NADPH–Cytochrome P450 Oxidoreductase: Roles in Physiology, Pharmacology, and Toxicology
    David S. Riddick, Xinxin Ding, C. Roland Wolf, Todd D. Porter, Amit V. Pandey, Qing-Yu Zhang, Jun Gu, Robert D. Finn, Sebastien Ronseaux, Lesley A. McLaughlin, Colin J. Henderson, Ling Zou and Christa E. Flück
    Drug Metabolism and Disposition January 2013, 41 (1) 12-23; DOI: https://doi.org/10.1124/dmd.112.048991

Short Communications

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    Evidence for Substrate-Dependent Inhibition Profiles for Human Liver Aldehyde Oxidase
    John T. Barr and Jeffrey P. Jones
    Drug Metabolism and Disposition January 2013, 41 (1) 24-29; DOI: https://doi.org/10.1124/dmd.112.048546
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    Metabolism of Triethylenetetramine and 1,12-Diamino-3,6,9-Triazadodecane by the Spermidine/Spermine-N1-Acetyltransferase and Thialysine Acetyltransferase
    Mervi T. Hyvönen, Janne Weisell, Alex R. Khomutov, Leena Alhonen, Jouko Vepsäläinen and Tuomo A. Keinänen
    Drug Metabolism and Disposition January 2013, 41 (1) 30-32; DOI: https://doi.org/10.1124/dmd.112.047274

Articles

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    Function of the Blood-Brain Barrier and Restriction of Drug Delivery to Invasive Glioma Cells: Findings in an Orthotopic Rat Xenograft Model of Glioma
    Sagar Agarwal, Pooja Manchanda, Michael A. Vogelbaum, John R. Ohlfest and William F. Elmquist
    Drug Metabolism and Disposition January 2013, 41 (1) 33-39; DOI: https://doi.org/10.1124/dmd.112.048322
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    Carboxylesterases Are Uniquely Expressed among Tissues and Regulated by Nuclear Hormone Receptors in the Mouse
    Ryan D. Jones, Anna M. Taylor, Ernest Y. Tong and Joyce J. Repa
    Drug Metabolism and Disposition January 2013, 41 (1) 40-49; DOI: https://doi.org/10.1124/dmd.112.048397
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    Autoinhibition of CYP3A4 Leads to Important Role of CYP2C8 in Imatinib Metabolism: Variability in CYP2C8 Activity May Alter Plasma Concentrations and Response
    Anne M. Filppula, Mikko Neuvonen, Jouko Laitila, Pertti J. Neuvonen and Janne T. Backman
    Drug Metabolism and Disposition January 2013, 41 (1) 50-59; DOI: https://doi.org/10.1124/dmd.112.048017
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    Discovery and Characterization of Novel, Potent, and Selective Cytochrome P450 2J2 Inhibitors
    Shuang Ren, Juan Zeng, Ye Mei, John Z. H. Zhang, S. Frank Yan, Jian Fei and Li Chen
    Drug Metabolism and Disposition January 2013, 41 (1) 60-71; DOI: https://doi.org/10.1124/dmd.112.048264
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    DNA Methylation and Histone Modification Profiles of Mouse Organic Anion Transporting Polypeptides
    Satoki Imai, Ryota Kikuchi, Hiroyuki Kusuhara and Yuichi Sugiyama
    Drug Metabolism and Disposition January 2013, 41 (1) 72-78; DOI: https://doi.org/10.1124/dmd.112.047969
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    Characterization of Differential Cocaine Metabolism in Mouse and Rat through Metabolomics-Guided Metabolite Profiling
    Dan Yao, Xiaolei Shi, Lei Wang, Blake A. Gosnell and Chi Chen
    Drug Metabolism and Disposition January 2013, 41 (1) 79-88; DOI: https://doi.org/10.1124/dmd.112.048678
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    Metabolism and Disposition of Vilanterol, a Long-Acting β2-Adrenoceptor Agonist for Inhalation Use in Humans
    Andrew W. Harrell, Sarah K. Siederer, Jo Bal, Nainesh H. Patel, Graeme C. Young, Clive C. Felgate, Sebastian J. Pearce, Andy D. Roberts, Claire Beaumont, Amanda J. Emmons, Adrian I. Pereira and Rodger D. Kempsford
    Drug Metabolism and Disposition January 2013, 41 (1) 89-100; DOI: https://doi.org/10.1124/dmd.112.048603
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    Interactions between CYP2E1 and CYP2B4: Effects on Affinity for NADPH-Cytochrome P450 Reductase and Substrate Metabolism
    Cesar Kenaan, Erin V. Shea, Hsia-lien Lin, Haoming Zhang, Matthew J. Pratt-Hyatt and Paul F. Hollenberg
    Drug Metabolism and Disposition January 2013, 41 (1) 101-110; DOI: https://doi.org/10.1124/dmd.112.046094
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    Interaction of γ-Glutamyltranspeptidase with Ibuprofen-S-Acyl-Glutathione In Vitro and In Vivo in Human
    Mark P. Grillo, Michelle Tadano Lohr and Smriti Khera
    Drug Metabolism and Disposition January 2013, 41 (1) 111-121; DOI: https://doi.org/10.1124/dmd.112.048645
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    Metabolism and Quantification of [18F]DPA-714, a New TSPO Positron Emission Tomography Radioligand
    Marie-Anne Peyronneau, Wadad Saba, Sébastien Goutal, Annelaure Damont, Frédéric Dollé, Michael Kassiou, Michel Bottlaender and Héric Valette
    Drug Metabolism and Disposition January 2013, 41 (1) 122-131; DOI: https://doi.org/10.1124/dmd.112.046342
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    Generation and Characterization of a Novel Cyp2a(4/5)bgs-Null Mouse Model
    Yuan Wei, Lei Li, Xin Zhou, Qing-Yu Zhang, Anwar Dunbar, Fang Liu, Kerri Kluetzman, Weizhu Yang and Xinxin Ding
    Drug Metabolism and Disposition January 2013, 41 (1) 132-140; DOI: https://doi.org/10.1124/dmd.112.048736
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    Carbon Monoxide–Bound Red Blood Cells Protect Red Blood Cell Transfusion-Induced Hepatic Cytochrome P450 Impairment in Hemorrhagic-Shock Rats
    Shigeru Ogaki, Kazuaki Taguchi, Hiroshi Watanabe, Masaki Otagiri and Toru Maruyama
    Drug Metabolism and Disposition January 2013, 41 (1) 141-148; DOI: https://doi.org/10.1124/dmd.112.048744
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    Evaluation and Prediction of Potential Drug-Drug Interactions of Linagliptin Using In Vitro Cell Culture Methods
    Naoki Ishiguro, Hidetada Shimizu, Wataru Kishimoto, Thomas Ebner and Olaf Schaefer
    Drug Metabolism and Disposition January 2013, 41 (1) 149-158; DOI: https://doi.org/10.1124/dmd.112.048470
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    Effect of Solvents on the Time-Dependent Inhibition of CYP3A4 and the Biotransformation of AZD3839 in Human Liver Microsomes and Hepatocytes
    Jenny Aasa, Yin Hu, Göran Eklund, Anders Lindgren, Pawel Baranczewski, Jonas Malmquist, Dominika Turek and Tjerk Bueters
    Drug Metabolism and Disposition January 2013, 41 (1) 159-169; DOI: https://doi.org/10.1124/dmd.112.047597
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    Importance of UDP-Glucuronosyltransferases 2A2 and 2A3 in Tobacco Carcinogen Metabolism
    Ryan T. Bushey, Douglas F. Dluzen and Philip Lazarus
    Drug Metabolism and Disposition January 2013, 41 (1) 170-179; DOI: https://doi.org/10.1124/dmd.112.049171
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    Pharmacokinetic Mechanism Involved in the Prolonged High Retention of Laninamivir in Mouse Respiratory Tissues after Intranasal Administration of its Prodrug Laninamivir Octanoate
    Kumiko Koyama, Daisuke Nakai, Makoto Takahashi, Naoko Nakai, Nobuhiro Kobayashi, Teruko Imai and Takashi Izumi
    Drug Metabolism and Disposition January 2013, 41 (1) 180-187; DOI: https://doi.org/10.1124/dmd.112.048280
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    Combination Lopinavir and Ritonavir Alter Exogenous and Endogenous Bile Acid Disposition in Sandwich-Cultured Rat Hepatocytes
    LaToya M. Griffin, Paul B. Watkins, Cassandra H. Perry, Robert L. St. Claire and Kim L. R. Brouwer
    Drug Metabolism and Disposition January 2013, 41 (1) 188-196; DOI: https://doi.org/10.1124/dmd.112.047225
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    Differential Influences of Ethanol on Early Exposure to Racemic Methylphenidate Compared with Dexmethylphenidate in Humans
    Kennerly S. Patrick, Arthur B. Straughn, Owen T. Reeves, Hilary Bernstein, Guinevere H. Bell, Erica R. Anderson and Robert J. Malcolm
    Drug Metabolism and Disposition January 2013, 41 (1) 197-205; DOI: https://doi.org/10.1124/dmd.112.048595
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    Effect of Coadministration of Single and Multiple Doses of Rifampicin on the Pharmacokinetics of Fexofenadine Enantiomers in Healthy Subjects
    Hiroyuki Kusuhara, Masatomo Miura, Norio Yasui-Furukori, Kenta Yoshida, Yumiko Akamine, Miyu Yokochi, Shinya Fukizawa, Kazuaki Ikejiri, Kayoko Kanamitsu, Tsukasa Uno and Yuichi Sugiyama
    Drug Metabolism and Disposition January 2013, 41 (1) 206-213; DOI: https://doi.org/10.1124/dmd.112.048330
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    Effects of Hypothermia on the Disposition of Morphine, Midazolam, Fentanyl, and Propofol in Intensive Care Unit Patients
    Thor Wilhelm Bjelland, Pål Klepstad, Bjørn Olav Haugen, Turid Nilsen and Ola Dale
    Drug Metabolism and Disposition January 2013, 41 (1) 214-223; DOI: https://doi.org/10.1124/dmd.112.045567
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    Evaluation of the Relationship between Sex, Polymorphisms in CYP2C8 and CYP2C9, and Pharmacokinetics of Angiotensin Receptor Blockers
    Teresa Cabaleiro, Manuel Román, Dolores Ochoa, María Talegón, Rocío Prieto-Pérez, Aneta Wojnicz, Rosario López-Rodríguez, Jesús Novalbos and Francisco Abad-Santos
    Drug Metabolism and Disposition January 2013, 41 (1) 224-229; DOI: https://doi.org/10.1124/dmd.112.046292
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    Clinical Pharmacokinetics, Metabolism, and Drug-Drug Interaction of Carfilzomib
    Zhengping Wang, Jinfu Yang, Christopher Kirk, Ying Fang, Melissa Alsina, Ashraf Badros, Kyriakos Papadopoulos, Alvin Wong, Tina Woo, Darrin Bomba, Jin Li and Jeffrey R. Infante
    Drug Metabolism and Disposition January 2013, 41 (1) 230-237; DOI: https://doi.org/10.1124/dmd.112.047662
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    Impact of Hydrolysis-Mediated Clearance on the Pharmacokinetics of Novel Anaplastic Lymphoma Kinase Inhibitors
    Yohannes Teffera, Loren M. Berry, Rachael L. Brake, Richard T. Lewis, Douglas C. Saffran, Earl Moore, Jingzhou Liu and Zhiyang Zhao
    Drug Metabolism and Disposition January 2013, 41 (1) 238-247; DOI: https://doi.org/10.1124/dmd.112.047993
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    Mechanisms of Subcutaneous Absorption of Rituximab in Rats
    Leonid Kagan and Donald E. Mager
    Drug Metabolism and Disposition January 2013, 41 (1) 248-255; DOI: https://doi.org/10.1124/dmd.112.048496
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Drug Metabolism and Disposition: 41 (1)
Drug Metabolism and Disposition
Vol. 41, Issue 1
1 Jan 2013
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