Department of Pharmacology and Toxicology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada (D.S.R.); Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany, Albany, New York (X.D., Q.-Y.Z., J.G.); Molecular Pharmacology Group, Division of Cancer Research, University of Dundee, and Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, Dundee, United Kingdom (C.R.W., R.D.F., S.R., L.A.M., C.J.H.); Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky (T.D.P., L.Z.); Department of Pediatrics, Division of Pediatric Endocrinology and Diabetology, and Department of Clinical Research, University of Bern, Bern, Switzerland (A.V.P., C.E.F.)

Department of Pharmacology and Toxicology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada (D.S.R.); Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany, Albany, New York (X.D., Q.-Y.Z., J.G.); Molecular Pharmacology Group, Division of Cancer Research, University of Dundee, and Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, Dundee, United Kingdom (C.R.W., R.D.F., S.R., L.A.M., C.J.H.); Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky (T.D.P., L.Z.); Department of Pediatrics, Division of Pediatric Endocrinology and Diabetology, and Department of Clinical Research, University of Bern, Bern, Switzerland (A.V.P., C.E.F.)

Department of Pharmacology and Toxicology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada (D.S.R.); Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany, Albany, New York (X.D., Q.-Y.Z., J.G.); Molecular Pharmacology Group, Division of Cancer Research, University of Dundee, and Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, Dundee, United Kingdom (C.R.W., R.D.F., S.R., L.A.M., C.J.H.); Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky (T.D.P., L.Z.); Department of Pediatrics, Division of Pediatric Endocrinology and Diabetology, and Department of Clinical Research, University of Bern, Bern, Switzerland (A.V.P., C.E.F.)

Department of Pharmacology and Toxicology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada (D.S.R.); Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany, Albany, New York (X.D., Q.-Y.Z., J.G.); Molecular Pharmacology Group, Division of Cancer Research, University of Dundee, and Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, Dundee, United Kingdom (C.R.W., R.D.F., S.R., L.A.M., C.J.H.); Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky (T.D.P., L.Z.); Department of Pediatrics, Division of Pediatric Endocrinology and Diabetology, and Department of Clinical Research, University of Bern, Bern, Switzerland (A.V.P., C.E.F.)

Department of Pharmacology and Toxicology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada (D.S.R.); Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany, Albany, New York (X.D., Q.-Y.Z., J.G.); Molecular Pharmacology Group, Division of Cancer Research, University of Dundee, and Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, Dundee, United Kingdom (C.R.W., R.D.F., S.R., L.A.M., C.J.H.); Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky (T.D.P., L.Z.); Department of Pediatrics, Division of Pediatric Endocrinology and Diabetology, and Department of Clinical Research, University of Bern, Bern, Switzerland (A.V.P., C.E.F.)

Department of Pharmacology and Toxicology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada (D.S.R.); Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany, Albany, New York (X.D., Q.-Y.Z., J.G.); Molecular Pharmacology Group, Division of Cancer Research, University of Dundee, and Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, Dundee, United Kingdom (C.R.W., R.D.F., S.R., L.A.M., C.J.H.); Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky (T.D.P., L.Z.); Department of Pediatrics, Division of Pediatric Endocrinology and Diabetology, and Department of Clinical Research, University of Bern, Bern, Switzerland (A.V.P., C.E.F.)

Department of Pharmacology and Toxicology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada (D.S.R.); Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany, Albany, New York (X.D., Q.-Y.Z., J.G.); Molecular Pharmacology Group, Division of Cancer Research, University of Dundee, and Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, Dundee, United Kingdom (C.R.W., R.D.F., S.R., L.A.M., C.J.H.); Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky (T.D.P., L.Z.); Department of Pediatrics, Division of Pediatric Endocrinology and Diabetology, and Department of Clinical Research, University of Bern, Bern, Switzerland (A.V.P., C.E.F.)

Department of Pharmacology and Toxicology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada (D.S.R.); Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany, Albany, New York (X.D., Q.-Y.Z., J.G.); Molecular Pharmacology Group, Division of Cancer Research, University of Dundee, and Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, Dundee, United Kingdom (C.R.W., R.D.F., S.R., L.A.M., C.J.H.); Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky (T.D.P., L.Z.); Department of Pediatrics, Division of Pediatric Endocrinology and Diabetology, and Department of Clinical Research, University of Bern, Bern, Switzerland (A.V.P., C.E.F.)

Department of Pharmacology and Toxicology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada (D.S.R.); Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany, Albany, New York (X.D., Q.-Y.Z., J.G.); Molecular Pharmacology Group, Division of Cancer Research, University of Dundee, and Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, Dundee, United Kingdom (C.R.W., R.D.F., S.R., L.A.M., C.J.H.); Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky (T.D.P., L.Z.); Department of Pediatrics, Division of Pediatric Endocrinology and Diabetology, and Department of Clinical Research, University of Bern, Bern, Switzerland (A.V.P., C.E.F.)

Department of Pharmacology and Toxicology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada (D.S.R.); Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany, Albany, New York (X.D., Q.-Y.Z., J.G.); Molecular Pharmacology Group, Division of Cancer Research, University of Dundee, and Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, Dundee, United Kingdom (C.R.W., R.D.F., S.R., L.A.M., C.J.H.); Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky (T.D.P., L.Z.); Department of Pediatrics, Division of Pediatric Endocrinology and Diabetology, and Department of Clinical Research, University of Bern, Bern, Switzerland (A.V.P., C.E.F.)

Department of Pharmacology and Toxicology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada (D.S.R.); Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany, Albany, New York (X.D., Q.-Y.Z., J.G.); Molecular Pharmacology Group, Division of Cancer Research, University of Dundee, and Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, Dundee, United Kingdom (C.R.W., R.D.F., S.R., L.A.M., C.J.H.); Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky (T.D.P., L.Z.); Department of Pediatrics, Division of Pediatric Endocrinology and Diabetology, and Department of Clinical Research, University of Bern, Bern, Switzerland (A.V.P., C.E.F.)

Department of Pharmacology and Toxicology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada (D.S.R.); Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany, Albany, New York (X.D., Q.-Y.Z., J.G.); Molecular Pharmacology Group, Division of Cancer Research, University of Dundee, and Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, Dundee, United Kingdom (C.R.W., R.D.F., S.R., L.A.M., C.J.H.); Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky (T.D.P., L.Z.); Department of Pediatrics, Division of Pediatric Endocrinology and Diabetology, and Department of Clinical Research, University of Bern, Bern, Switzerland (A.V.P., C.E.F.)

Department of Pharmacology and Toxicology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada (D.S.R.); Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany, Albany, New York (X.D., Q.-Y.Z., J.G.); Molecular Pharmacology Group, Division of Cancer Research, University of Dundee, and Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, Dundee, United Kingdom (C.R.W., R.D.F., S.R., L.A.M., C.J.H.); Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky (T.D.P., L.Z.); Department of Pediatrics, Division of Pediatric Endocrinology and Diabetology, and Department of Clinical Research, University of Bern, Bern, Switzerland (A.V.P., C.E.F.)