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Research ArticleArticle

Clinical Pharmacokinetics, Metabolism, and Drug-Drug Interaction of Carfilzomib

Zhengping Wang, Jinfu Yang, Christopher Kirk, Ying Fang, Melissa Alsina, Ashraf Badros, Kyriakos Papadopoulos, Alvin Wong, Tina Woo, Darrin Bomba, Jin Li and Jeffrey R. Infante
Drug Metabolism and Disposition January 2013, 41 (1) 230-237; DOI: https://doi.org/10.1124/dmd.112.047662
Zhengping Wang
Onyx Pharmaceuticals, South San Francisco, California (Z.W., J.Y., C.K., Y.F., A.W., T.W., D.B., J.L.); H. Lee Moffitt Cancer and Research Center, Tampa, Florida (M.A.); Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland (A.B.); The START (South Texas Accelerated Research Therapeutics) Center for Cancer Care, San Antonio, Texas (K.P.); and Sarah Cannon Research Institute, Nashville, Tennessee (J.R.I.)
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Jinfu Yang
Onyx Pharmaceuticals, South San Francisco, California (Z.W., J.Y., C.K., Y.F., A.W., T.W., D.B., J.L.); H. Lee Moffitt Cancer and Research Center, Tampa, Florida (M.A.); Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland (A.B.); The START (South Texas Accelerated Research Therapeutics) Center for Cancer Care, San Antonio, Texas (K.P.); and Sarah Cannon Research Institute, Nashville, Tennessee (J.R.I.)
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Christopher Kirk
Onyx Pharmaceuticals, South San Francisco, California (Z.W., J.Y., C.K., Y.F., A.W., T.W., D.B., J.L.); H. Lee Moffitt Cancer and Research Center, Tampa, Florida (M.A.); Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland (A.B.); The START (South Texas Accelerated Research Therapeutics) Center for Cancer Care, San Antonio, Texas (K.P.); and Sarah Cannon Research Institute, Nashville, Tennessee (J.R.I.)
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Ying Fang
Onyx Pharmaceuticals, South San Francisco, California (Z.W., J.Y., C.K., Y.F., A.W., T.W., D.B., J.L.); H. Lee Moffitt Cancer and Research Center, Tampa, Florida (M.A.); Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland (A.B.); The START (South Texas Accelerated Research Therapeutics) Center for Cancer Care, San Antonio, Texas (K.P.); and Sarah Cannon Research Institute, Nashville, Tennessee (J.R.I.)
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Melissa Alsina
Onyx Pharmaceuticals, South San Francisco, California (Z.W., J.Y., C.K., Y.F., A.W., T.W., D.B., J.L.); H. Lee Moffitt Cancer and Research Center, Tampa, Florida (M.A.); Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland (A.B.); The START (South Texas Accelerated Research Therapeutics) Center for Cancer Care, San Antonio, Texas (K.P.); and Sarah Cannon Research Institute, Nashville, Tennessee (J.R.I.)
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Ashraf Badros
Onyx Pharmaceuticals, South San Francisco, California (Z.W., J.Y., C.K., Y.F., A.W., T.W., D.B., J.L.); H. Lee Moffitt Cancer and Research Center, Tampa, Florida (M.A.); Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland (A.B.); The START (South Texas Accelerated Research Therapeutics) Center for Cancer Care, San Antonio, Texas (K.P.); and Sarah Cannon Research Institute, Nashville, Tennessee (J.R.I.)
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Kyriakos Papadopoulos
Onyx Pharmaceuticals, South San Francisco, California (Z.W., J.Y., C.K., Y.F., A.W., T.W., D.B., J.L.); H. Lee Moffitt Cancer and Research Center, Tampa, Florida (M.A.); Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland (A.B.); The START (South Texas Accelerated Research Therapeutics) Center for Cancer Care, San Antonio, Texas (K.P.); and Sarah Cannon Research Institute, Nashville, Tennessee (J.R.I.)
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Alvin Wong
Onyx Pharmaceuticals, South San Francisco, California (Z.W., J.Y., C.K., Y.F., A.W., T.W., D.B., J.L.); H. Lee Moffitt Cancer and Research Center, Tampa, Florida (M.A.); Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland (A.B.); The START (South Texas Accelerated Research Therapeutics) Center for Cancer Care, San Antonio, Texas (K.P.); and Sarah Cannon Research Institute, Nashville, Tennessee (J.R.I.)
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Tina Woo
Onyx Pharmaceuticals, South San Francisco, California (Z.W., J.Y., C.K., Y.F., A.W., T.W., D.B., J.L.); H. Lee Moffitt Cancer and Research Center, Tampa, Florida (M.A.); Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland (A.B.); The START (South Texas Accelerated Research Therapeutics) Center for Cancer Care, San Antonio, Texas (K.P.); and Sarah Cannon Research Institute, Nashville, Tennessee (J.R.I.)
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Darrin Bomba
Onyx Pharmaceuticals, South San Francisco, California (Z.W., J.Y., C.K., Y.F., A.W., T.W., D.B., J.L.); H. Lee Moffitt Cancer and Research Center, Tampa, Florida (M.A.); Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland (A.B.); The START (South Texas Accelerated Research Therapeutics) Center for Cancer Care, San Antonio, Texas (K.P.); and Sarah Cannon Research Institute, Nashville, Tennessee (J.R.I.)
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Jin Li
Onyx Pharmaceuticals, South San Francisco, California (Z.W., J.Y., C.K., Y.F., A.W., T.W., D.B., J.L.); H. Lee Moffitt Cancer and Research Center, Tampa, Florida (M.A.); Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland (A.B.); The START (South Texas Accelerated Research Therapeutics) Center for Cancer Care, San Antonio, Texas (K.P.); and Sarah Cannon Research Institute, Nashville, Tennessee (J.R.I.)
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Jeffrey R. Infante
Onyx Pharmaceuticals, South San Francisco, California (Z.W., J.Y., C.K., Y.F., A.W., T.W., D.B., J.L.); H. Lee Moffitt Cancer and Research Center, Tampa, Florida (M.A.); Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland (A.B.); The START (South Texas Accelerated Research Therapeutics) Center for Cancer Care, San Antonio, Texas (K.P.); and Sarah Cannon Research Institute, Nashville, Tennessee (J.R.I.)
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Article Information

vol. 41 no. 1 230-237
DOI 
https://doi.org/10.1124/dmd.112.047662
PubMed 
23118326

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received July 24, 2012
  • Accepted November 1, 2012
  • Published online December 20, 2012.

Article Versions

  • Earlier version (November 1, 2012 - 11:04).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Zhengping Wang,
  2. Jinfu Yang,
  3. Christopher Kirk,
  4. Ying Fang,
  5. Melissa Alsina,
  6. Ashraf Badros,
  7. Kyriakos Papadopoulos,
  8. Alvin Wong,
  9. Tina Woo,
  10. Darrin Bomba,
  11. Jin Li, and
  12. Jeffrey R. Infante
  1. Onyx Pharmaceuticals, South San Francisco, California (Z.W., J.Y., C.K., Y.F., A.W., T.W., D.B., J.L.); H. Lee Moffitt Cancer and Research Center, Tampa, Florida (M.A.); Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland (A.B.); The START (South Texas Accelerated Research Therapeutics) Center for Cancer Care, San Antonio, Texas (K.P.); and Sarah Cannon Research Institute, Nashville, Tennessee (J.R.I.)
  1. Address correspondence to:
    Dr. Jinfu Yang, Onyx Pharmaceuticals, 249 E. Grand Ave., South San Francisco, CA 94080. E-mail: yangjinfu{at}yahoo.com
  1. J.Y. and Z.W. contributed equally to this work.

  1. This work was partially presented in abstract form as follows: Zhengping Wang, Jinfu Yang, Ying Fang, Frances Zhao, Marcy Valone, Darrin Bomba, Alvin Wong and Christopher Kirk. (2011) In vitro and In vivo Drug-drug Interaction Studies of Carfilzomib. American Association of Pharmaceutical Scientists, Annual Meeting and Exposition (2011) (Abstract #: T2419) Oct 23–27; Washington, DC.

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Drug Metabolism and Disposition: 41 (1)
Drug Metabolism and Disposition
Vol. 41, Issue 1
1 Jan 2013
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Research ArticleArticle

PK, Metabolism, and Drug-Drug Interaction of Carfilzomib

Zhengping Wang, Jinfu Yang, Christopher Kirk, Ying Fang, Melissa Alsina, Ashraf Badros, Kyriakos Papadopoulos, Alvin Wong, Tina Woo, Darrin Bomba, Jin Li and Jeffrey R. Infante
Drug Metabolism and Disposition January 1, 2013, 41 (1) 230-237; DOI: https://doi.org/10.1124/dmd.112.047662

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Research ArticleArticle

PK, Metabolism, and Drug-Drug Interaction of Carfilzomib

Zhengping Wang, Jinfu Yang, Christopher Kirk, Ying Fang, Melissa Alsina, Ashraf Badros, Kyriakos Papadopoulos, Alvin Wong, Tina Woo, Darrin Bomba, Jin Li and Jeffrey R. Infante
Drug Metabolism and Disposition January 1, 2013, 41 (1) 230-237; DOI: https://doi.org/10.1124/dmd.112.047662
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