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Research ArticleArticle

Impact of Hydrolysis-Mediated Clearance on the Pharmacokinetics of Novel Anaplastic Lymphoma Kinase Inhibitors

Yohannes Teffera, Loren M. Berry, Rachael L. Brake, Richard T. Lewis, Douglas C. Saffran, Earl Moore, Jingzhou Liu and Zhiyang Zhao
Drug Metabolism and Disposition January 2013, 41 (1) 238-247; DOI: https://doi.org/10.1124/dmd.112.047993
Yohannes Teffera
Departments of Pharmacokinetics and Drug Metabolism (Y.T., L.M.B., E.M, J.L., Z.Z.) and Discovery Research (R.L.B., R.T.L., D.C.S.), Amgen, Inc., Cambridge, Massachusetts
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Loren M. Berry
Departments of Pharmacokinetics and Drug Metabolism (Y.T., L.M.B., E.M, J.L., Z.Z.) and Discovery Research (R.L.B., R.T.L., D.C.S.), Amgen, Inc., Cambridge, Massachusetts
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Rachael L. Brake
Departments of Pharmacokinetics and Drug Metabolism (Y.T., L.M.B., E.M, J.L., Z.Z.) and Discovery Research (R.L.B., R.T.L., D.C.S.), Amgen, Inc., Cambridge, Massachusetts
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Richard T. Lewis
Departments of Pharmacokinetics and Drug Metabolism (Y.T., L.M.B., E.M, J.L., Z.Z.) and Discovery Research (R.L.B., R.T.L., D.C.S.), Amgen, Inc., Cambridge, Massachusetts
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Douglas C. Saffran
Departments of Pharmacokinetics and Drug Metabolism (Y.T., L.M.B., E.M, J.L., Z.Z.) and Discovery Research (R.L.B., R.T.L., D.C.S.), Amgen, Inc., Cambridge, Massachusetts
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Earl Moore
Departments of Pharmacokinetics and Drug Metabolism (Y.T., L.M.B., E.M, J.L., Z.Z.) and Discovery Research (R.L.B., R.T.L., D.C.S.), Amgen, Inc., Cambridge, Massachusetts
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Jingzhou Liu
Departments of Pharmacokinetics and Drug Metabolism (Y.T., L.M.B., E.M, J.L., Z.Z.) and Discovery Research (R.L.B., R.T.L., D.C.S.), Amgen, Inc., Cambridge, Massachusetts
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Zhiyang Zhao
Departments of Pharmacokinetics and Drug Metabolism (Y.T., L.M.B., E.M, J.L., Z.Z.) and Discovery Research (R.L.B., R.T.L., D.C.S.), Amgen, Inc., Cambridge, Massachusetts
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Article Information

vol. 41 no. 1 238-247
DOI 
https://doi.org/10.1124/dmd.112.047993
PubMed 
23118327

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received July 16, 2012
  • Accepted November 1, 2012
  • Published online December 20, 2012.

Article Versions

  • Earlier version (November 1, 2012 - 11:32).
  • Earlier version (November 6, 2012 - 07:05).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Yohannes Teffera,
  2. Loren M. Berry,
  3. Rachael L. Brake,
  4. Richard T. Lewis,
  5. Douglas C. Saffran,
  6. Earl Moore,
  7. Jingzhou Liu, and
  8. Zhiyang Zhao
  1. Departments of Pharmacokinetics and Drug Metabolism (Y.T., L.M.B., E.M, J.L., Z.Z.) and Discovery Research (R.L.B., R.T.L., D.C.S.), Amgen, Inc., Cambridge, Massachusetts
  1. Address correspondence to:
    Dr. Yohannes Teffera, Department of Pharmacokinetics and Drug Metabolism, Amgen, Inc., 360 Binney St., Cambridge, MA 02142. E-mail: yteffera{at}amgen.com
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Drug Metabolism and Disposition: 41 (1)
Drug Metabolism and Disposition
Vol. 41, Issue 1
1 Jan 2013
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Research ArticleArticle

Impact of Hydrolysis on the PK of ALK Inhibitors

Yohannes Teffera, Loren M. Berry, Rachael L. Brake, Richard T. Lewis, Douglas C. Saffran, Earl Moore, Jingzhou Liu and Zhiyang Zhao
Drug Metabolism and Disposition January 1, 2013, 41 (1) 238-247; DOI: https://doi.org/10.1124/dmd.112.047993

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Research ArticleArticle

Impact of Hydrolysis on the PK of ALK Inhibitors

Yohannes Teffera, Loren M. Berry, Rachael L. Brake, Richard T. Lewis, Douglas C. Saffran, Earl Moore, Jingzhou Liu and Zhiyang Zhao
Drug Metabolism and Disposition January 1, 2013, 41 (1) 238-247; DOI: https://doi.org/10.1124/dmd.112.047993
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