Research ArticleArticle
Impact of Hydrolysis-Mediated Clearance on the Pharmacokinetics of Novel Anaplastic Lymphoma Kinase Inhibitors
Yohannes Teffera, Loren M. Berry, Rachael L. Brake, Richard T. Lewis, Douglas C. Saffran, Earl Moore, Jingzhou Liu and Zhiyang Zhao
Drug Metabolism and Disposition January 2013, 41 (1) 238-247; DOI: https://doi.org/10.1124/dmd.112.047993
Yohannes Teffera
Departments of Pharmacokinetics and Drug Metabolism (Y.T., L.M.B., E.M, J.L., Z.Z.) and Discovery Research (R.L.B., R.T.L., D.C.S.), Amgen, Inc., Cambridge, Massachusetts
Loren M. Berry
Departments of Pharmacokinetics and Drug Metabolism (Y.T., L.M.B., E.M, J.L., Z.Z.) and Discovery Research (R.L.B., R.T.L., D.C.S.), Amgen, Inc., Cambridge, Massachusetts
Rachael L. Brake
Departments of Pharmacokinetics and Drug Metabolism (Y.T., L.M.B., E.M, J.L., Z.Z.) and Discovery Research (R.L.B., R.T.L., D.C.S.), Amgen, Inc., Cambridge, Massachusetts
Richard T. Lewis
Departments of Pharmacokinetics and Drug Metabolism (Y.T., L.M.B., E.M, J.L., Z.Z.) and Discovery Research (R.L.B., R.T.L., D.C.S.), Amgen, Inc., Cambridge, Massachusetts
Douglas C. Saffran
Departments of Pharmacokinetics and Drug Metabolism (Y.T., L.M.B., E.M, J.L., Z.Z.) and Discovery Research (R.L.B., R.T.L., D.C.S.), Amgen, Inc., Cambridge, Massachusetts
Earl Moore
Departments of Pharmacokinetics and Drug Metabolism (Y.T., L.M.B., E.M, J.L., Z.Z.) and Discovery Research (R.L.B., R.T.L., D.C.S.), Amgen, Inc., Cambridge, Massachusetts
Jingzhou Liu
Departments of Pharmacokinetics and Drug Metabolism (Y.T., L.M.B., E.M, J.L., Z.Z.) and Discovery Research (R.L.B., R.T.L., D.C.S.), Amgen, Inc., Cambridge, Massachusetts
Zhiyang Zhao
Departments of Pharmacokinetics and Drug Metabolism (Y.T., L.M.B., E.M, J.L., Z.Z.) and Discovery Research (R.L.B., R.T.L., D.C.S.), Amgen, Inc., Cambridge, Massachusetts

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Research ArticleArticle
Impact of Hydrolysis on the PK of ALK Inhibitors
Yohannes Teffera, Loren M. Berry, Rachael L. Brake, Richard T. Lewis, Douglas C. Saffran, Earl Moore, Jingzhou Liu and Zhiyang Zhao
Drug Metabolism and Disposition January 1, 2013, 41 (1) 238-247; DOI: https://doi.org/10.1124/dmd.112.047993
Research ArticleArticle
Impact of Hydrolysis on the PK of ALK Inhibitors
Yohannes Teffera, Loren M. Berry, Rachael L. Brake, Richard T. Lewis, Douglas C. Saffran, Earl Moore, Jingzhou Liu and Zhiyang Zhao
Drug Metabolism and Disposition January 1, 2013, 41 (1) 238-247; DOI: https://doi.org/10.1124/dmd.112.047993