Drug Metabolism and Disposition: 41 (10)

October 01, 2013; Volume 41,Issue 10

Special Section on Epigenetic Regulation of Drug Metabolizing Enzymes and Transporters

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Epigenetic Regulation of ADME-Related Genes: Focus on Drug Metabolism and Transport
Xiao-bo Zhong and J. Steven Leeder

Drug Metabolism and Disposition October 2013, 41 (10) 1721-1724; DOI: https://doi.org/10.1124/dmd.113.053942
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Potential Role of Epigenetic Mechanisms in the Regulation of Drug Metabolism and Transport
Magnus Ingelman-Sundberg, Xiao-Bo Zhong, Oliver Hankinson, Sudheer Beedanagari, Ai-Ming Yu, Lai Peng and Yoichi Osawa

Drug Metabolism and Disposition October 2013, 41 (10) 1725-1731; DOI: https://doi.org/10.1124/dmd.113.053157
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Role of Multiple MicroRNAs in the Sexually Dimorphic Expression of Cyp2b9 in Mouse Liver
Xiaofeng Xie, Lingling Miao, Jun Yao, Chenchen Feng, Chenggang Li, Man Gao, Mingxia Liu, Likun Gong, Yizheng Wang, Xinming Qi and Jin Ren

Drug Metabolism and Disposition October 2013, 41 (10) 1732-1737; DOI: https://doi.org/10.1124/dmd.113.052217
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Epigenetic Regulation Is a Crucial Factor in the Repression of UGT1A1 Expression in the Human Kidney
Shingo Oda, Tatsuki Fukami, Tsuyoshi Yokoi and Miki Nakajima

Drug Metabolism and Disposition October 2013, 41 (10) 1738-1743; DOI: https://doi.org/10.1124/dmd.113.051201
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Small Nucleolar RNA-Derived MicroRNA hsa-miR-1291 Modulates Cellular Drug Disposition through Direct Targeting of ABC Transporter ABCC1
Yu-Zhuo Pan, Amy Zhou, Zihua Hu and Ai-Ming Yu

Drug Metabolism and Disposition October 2013, 41 (10) 1744-1751; DOI: https://doi.org/10.1124/dmd.113.052092
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Expression Variability of Absorption, Distribution, Metabolism, Excretion–Related MicroRNAs in Human Liver: Influence of Nongenetic Factors and Association with Gene Expression
Jessica K. Rieger, Kathrin Klein, Stefan Winter and Ulrich M. Zanger

Drug Metabolism and Disposition October 2013, 41 (10) 1752-1762; DOI: https://doi.org/10.1124/dmd.113.052126
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Regulation of MicroRNA Expression by Rifampin in Human Hepatocytes
Anuradha Ramamoorthy, Yunlong Liu, Santosh Philips, Zeruesenay Desta, Hai Lin, Chirayu Goswami, Andrea Gaedigk, Lang Li, David A. Flockhart and Todd C. Skaar

Drug Metabolism and Disposition October 2013, 41 (10) 1763-1768; DOI: https://doi.org/10.1124/dmd.113.052886
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Insights into Insulin-Mediated Regulation of CYP2E1: miR-132/-212 Targeting of CYP2E1 and Role of Phosphatidylinositol 3-Kinase, Akt (Protein Kinase B), Mammalian Target of Rapamycin Signaling in Regulating miR-132/-212 and miR-122/-181a Expression in Primary Cultured Rat Hepatocytes
Upasana Shukla, Nithin Tumma, Theresa Gratsch, Alan Dombkowski and Raymond F. Novak

Drug Metabolism and Disposition October 2013, 41 (10) 1769-1777; DOI: https://doi.org/10.1124/dmd.113.052860
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Incubation of Whole Blood at Room Temperature Does Not Alter the Plasma Concentrations of MicroRNA-16 and -223
Eric A. Benson and Todd C. Skaar

Drug Metabolism and Disposition October 2013, 41 (10) 1778-1781; DOI: https://doi.org/10.1124/dmd.113.052357

Short Communication

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Downregulation of Mouse Hepatic CYP3A Protein by 3-Methylcholanthrene Does Not Require Cytochrome P450-Dependent Metabolism
Chunja Lee, Xinxin Ding and David S. Riddick

Drug Metabolism and Disposition October 2013, 41 (10) 1782-1786; DOI: https://doi.org/10.1124/dmd.113.052993

Articles

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In Vitro Investigation of Amyloid-β Hepatobiliary Disposition in Sandwich-Cultured Primary Rat Hepatocytes
Loqman A. Mohamed and Amal Kaddoumi

Drug Metabolism and Disposition October 2013, 41 (10) 1787-1796; DOI: https://doi.org/10.1124/dmd.113.052514
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Aldehyde Oxidase 1 (AOX1) in Human Liver Cytosols: Quantitative Characterization of AOX1 Expression Level and Activity Relationship
Cexiong Fu, Li Di, Xiaogang Han, Cathy Soderstrom, Mark Snyder, Matthew D. Troutman, R. Scott Obach and Hui Zhang

Drug Metabolism and Disposition October 2013, 41 (10) 1797-1804; DOI: https://doi.org/10.1124/dmd.113.053082
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Overlapping Substrate and Inhibitor Specificity of Human and Murine ABCG2
Joshua Bakhsheshian, Matthew D. Hall, Robert W. Robey, Michelle A. Herrmann, Jin-Qiu Chen, Susan E. Bates and Michael M. Gottesman

Drug Metabolism and Disposition October 2013, 41 (10) 1805-1812; DOI: https://doi.org/10.1124/dmd.113.053140
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The Effect of Ritonavir on Human CYP2B6 Catalytic Activity: Heme Modification Contributes to the Mechanism-Based Inactivation of CYP2B6 and CYP3A4 by Ritonavir
Hsia-lien Lin, Jaime D’Agostino, Cesar Kenaan, Diane Calinski and Paul F. Hollenberg

Drug Metabolism and Disposition October 2013, 41 (10) 1813-1824; DOI: https://doi.org/10.1124/dmd.113.053108
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Multispecific Drug Transporter Slc22a8 (Oat3) Regulates Multiple Metabolic and Signaling Pathways
Wei Wu, Neema Jamshidi, Satish A. Eraly, Henry C. Liu, Kevin T. Bush, Bernhard O. Palsson and Sanjay K. Nigam

Drug Metabolism and Disposition October 2013, 41 (10) 1825-1834; DOI: https://doi.org/10.1124/dmd.113.052647
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Transcriptomic Hepatotoxicity Signature of Chlorpromazine after Short- and Long-Term Exposure in Primary Human Sandwich Cultures
Céline Parmentier, Germaine L. Truisi, Konrad Moenks, Sven Stanzel, Arno Lukas, Annette Kopp-Schneider, Eliane Alexandre, Philip G. Hewitt, Stefan O. Mueller and Lysiane Richert

Drug Metabolism and Disposition October 2013, 41 (10) 1835-1842; DOI: https://doi.org/10.1124/dmd.113.052415
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Ritonavir and Efavirenz Significantly Alter the Metabolism of Erlotinib—an Observation in Primary Cultures of Human Hepatocytes That Is Relevant to HIV Patients with Cancer
Venkateswaran C. Pillai, Raman Venkataramanan, Robert A. Parise, Susan M. Christner, Roberto Gramignoli, Stephen C. Strom, Michelle A. Rudek and Jan H. Beumer

Drug Metabolism and Disposition October 2013, 41 (10) 1843-1851; DOI: https://doi.org/10.1124/dmd.113.052100
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Evaluation of Rhesus Monkey and Guinea Pig Hepatic Cytosol Fractions as Models for Human Aldehyde Oxidase
Kanika V. Choughule, John T. Barr and Jeffrey P. Jones

Drug Metabolism and Disposition October 2013, 41 (10) 1852-1858; DOI: https://doi.org/10.1124/dmd.113.052985
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Substrate-Dependent Inhibition of Organic Anion Transporting Polypeptide 1B1: Comparative Analysis with Prototypical Probe Substrates Estradiol-17β-Glucuronide, Estrone-3-Sulfate, and Sulfobromophthalein
Saki Izumi, Yoshitane Nozaki, Takafumi Komori, Kazuya Maeda, Osamu Takenaka, Kazutomi Kusano, Tsutomu Yoshimura, Hiroyuki Kusuhara and Yuichi Sugiyama

Drug Metabolism and Disposition October 2013, 41 (10) 1859-1866; DOI: https://doi.org/10.1124/dmd.113.052290
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Impact of Peptide Transporter 1 on the Intestinal Absorption and Pharmacokinetics of Valacyclovir after Oral Dose Escalation in Wild-Type and PepT1 Knockout Mice
Bei Yang, Yongjun Hu and David E. Smith

Drug Metabolism and Disposition October 2013, 41 (10) 1867-1874; DOI: https://doi.org/10.1124/dmd.113.052597
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Pitavastatin as an In Vivo Probe for Studying Hepatic Organic Anion Transporting Polypeptide-Mediated Drug–Drug Interactions in Cynomolgus Monkeys
Tsuyoshi Takahashi, Tatsuyuki Ohtsuka, Takahiro Yoshikawa, Ichiro Tatekawa, Yasuhiro Uno, Masahiro Utoh, Hiroshi Yamazaki and Toshiyuki Kume

Drug Metabolism and Disposition October 2013, 41 (10) 1875-1882; DOI: https://doi.org/10.1124/dmd.113.052753

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