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Research ArticleSpecial Section on Epigenetic Regulation of Drug Metabolizing Enzymes and Transporters

Epigenetic Regulation of ADME-Related Genes: Focus on Drug Metabolism and Transport

Xiao-bo Zhong and J. Steven Leeder
Drug Metabolism and Disposition October 2013, 41 (10) 1721-1724; DOI: https://doi.org/10.1124/dmd.113.053942
Xiao-bo Zhong
Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut (X.B.Z.); and Division of Clinical Pharmacology and Therapeutic Innovation, Department of Pediatrics, Children's Mercy Hospitals and Clinics and University of Missouri-Kansas City, Kansas City, Missouri (J.S.L.)
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J. Steven Leeder
Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut (X.B.Z.); and Division of Clinical Pharmacology and Therapeutic Innovation, Department of Pediatrics, Children's Mercy Hospitals and Clinics and University of Missouri-Kansas City, Kansas City, Missouri (J.S.L.)
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Abstract

Epigenetic regulation of gene expression refers to heritable factors that are functionally relevant genomic modifications but that do not involve changes in DNA sequence. Examples of such modifications include DNA methylation, histone modifications, noncoding RNAs, and chromatin architecture. Epigenetic modifications are crucial for packaging and interpreting the genome, and they have fundamental functions in regulating gene expression and activity under the influence of physiologic and environmental factors. Recently, epigenetics has become one of the fastest-growing areas of science and has now become a central issue in biologic studies of development and disease pathogenesis. The interest in epigenetics is also true for studies of drug metabolism and transport. In this issue of Drug Metabolism and Disposition, a series of articles is presented to demonstrate the role of epigenetic factors in regulating the expression of genes involved in drug absorption, distribution, metabolism, and excretion in organ development, tissue-specific gene expression, sexual dimorphism, and in the adaptive response to xenobiotic exposure, both therapeutic and toxic. The articles also demonstrate that, in addition to genetic polymorphisms, epigenetics may also contribute to wide interindividual variations in drug metabolism and transport. Identification of functionally relevant epigenetic biomarkers in human specimens has the potential to improve prediction of drug responses based on patient’s epigenetic profiles.

Footnotes

    • Received May 14, 2013.
    • Accepted August 1, 2013.
  • dx.doi.org/10.1124/dmd.113.053942.

  • Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics
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Drug Metabolism and Disposition: 41 (10)
Drug Metabolism and Disposition
Vol. 41, Issue 10
1 Oct 2013
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Research ArticleSpecial Section on Epigenetic Regulation of Drug Metabolizing Enzymes and Transporters

Epigenetics in Regulation of Drug Metabolism and Transport

Xiao-bo Zhong and J. Steven Leeder
Drug Metabolism and Disposition October 1, 2013, 41 (10) 1721-1724; DOI: https://doi.org/10.1124/dmd.113.053942

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Research ArticleSpecial Section on Epigenetic Regulation of Drug Metabolizing Enzymes and Transporters

Epigenetics in Regulation of Drug Metabolism and Transport

Xiao-bo Zhong and J. Steven Leeder
Drug Metabolism and Disposition October 1, 2013, 41 (10) 1721-1724; DOI: https://doi.org/10.1124/dmd.113.053942
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  • Article
    • Abstract
    • Introduction
    • Epigenetic Regulation of ADME Genes during Development
    • Epigenetic Regulation of Tissue-Specific Expression of ADME Genes
    • Epigenetic Regulation of Sexual Dimorphism
    • Contribution of Epigenetics to Interindividual Variability in Drug Disposition and Response
    • Epigenetic Regulation of ADME Genes in the Adaptive Response to Xenobiotic Exposure
    • Conclusion
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