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Research ArticleSpecial Section on Epigenetic Regulation of Drug Metabolizing Enzymes and Transporters

Regulation of MicroRNA Expression by Rifampin in Human Hepatocytes

Anuradha Ramamoorthy, Yunlong Liu, Santosh Philips, Zeruesenay Desta, Hai Lin, Chirayu Goswami, Andrea Gaedigk, Lang Li, David A. Flockhart and Todd C. Skaar
Drug Metabolism and Disposition October 2013, 41 (10) 1763-1768; DOI: https://doi.org/10.1124/dmd.113.052886
Anuradha Ramamoorthy
Department of Medicine, Division of Clinical Pharmacology (A.R., S.P., Z.D., D.A.F., T.C.S.), and Department of Medical and Molecular Genetics (A.R., Y.L., H.L., C.G., L.L.), Indiana University School of Medicine, Indianapolis, Indiana; and Division of Clinical Pharmacology and Innovative Therapeutics, the Children’s Mercy Hospital and Clinics, Kansas City, Missouri (A.G.)
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Yunlong Liu
Department of Medicine, Division of Clinical Pharmacology (A.R., S.P., Z.D., D.A.F., T.C.S.), and Department of Medical and Molecular Genetics (A.R., Y.L., H.L., C.G., L.L.), Indiana University School of Medicine, Indianapolis, Indiana; and Division of Clinical Pharmacology and Innovative Therapeutics, the Children’s Mercy Hospital and Clinics, Kansas City, Missouri (A.G.)
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Santosh Philips
Department of Medicine, Division of Clinical Pharmacology (A.R., S.P., Z.D., D.A.F., T.C.S.), and Department of Medical and Molecular Genetics (A.R., Y.L., H.L., C.G., L.L.), Indiana University School of Medicine, Indianapolis, Indiana; and Division of Clinical Pharmacology and Innovative Therapeutics, the Children’s Mercy Hospital and Clinics, Kansas City, Missouri (A.G.)
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Zeruesenay Desta
Department of Medicine, Division of Clinical Pharmacology (A.R., S.P., Z.D., D.A.F., T.C.S.), and Department of Medical and Molecular Genetics (A.R., Y.L., H.L., C.G., L.L.), Indiana University School of Medicine, Indianapolis, Indiana; and Division of Clinical Pharmacology and Innovative Therapeutics, the Children’s Mercy Hospital and Clinics, Kansas City, Missouri (A.G.)
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Hai Lin
Department of Medicine, Division of Clinical Pharmacology (A.R., S.P., Z.D., D.A.F., T.C.S.), and Department of Medical and Molecular Genetics (A.R., Y.L., H.L., C.G., L.L.), Indiana University School of Medicine, Indianapolis, Indiana; and Division of Clinical Pharmacology and Innovative Therapeutics, the Children’s Mercy Hospital and Clinics, Kansas City, Missouri (A.G.)
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Chirayu Goswami
Department of Medicine, Division of Clinical Pharmacology (A.R., S.P., Z.D., D.A.F., T.C.S.), and Department of Medical and Molecular Genetics (A.R., Y.L., H.L., C.G., L.L.), Indiana University School of Medicine, Indianapolis, Indiana; and Division of Clinical Pharmacology and Innovative Therapeutics, the Children’s Mercy Hospital and Clinics, Kansas City, Missouri (A.G.)
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Andrea Gaedigk
Department of Medicine, Division of Clinical Pharmacology (A.R., S.P., Z.D., D.A.F., T.C.S.), and Department of Medical and Molecular Genetics (A.R., Y.L., H.L., C.G., L.L.), Indiana University School of Medicine, Indianapolis, Indiana; and Division of Clinical Pharmacology and Innovative Therapeutics, the Children’s Mercy Hospital and Clinics, Kansas City, Missouri (A.G.)
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Lang Li
Department of Medicine, Division of Clinical Pharmacology (A.R., S.P., Z.D., D.A.F., T.C.S.), and Department of Medical and Molecular Genetics (A.R., Y.L., H.L., C.G., L.L.), Indiana University School of Medicine, Indianapolis, Indiana; and Division of Clinical Pharmacology and Innovative Therapeutics, the Children’s Mercy Hospital and Clinics, Kansas City, Missouri (A.G.)
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David A. Flockhart
Department of Medicine, Division of Clinical Pharmacology (A.R., S.P., Z.D., D.A.F., T.C.S.), and Department of Medical and Molecular Genetics (A.R., Y.L., H.L., C.G., L.L.), Indiana University School of Medicine, Indianapolis, Indiana; and Division of Clinical Pharmacology and Innovative Therapeutics, the Children’s Mercy Hospital and Clinics, Kansas City, Missouri (A.G.)
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Todd C. Skaar
Department of Medicine, Division of Clinical Pharmacology (A.R., S.P., Z.D., D.A.F., T.C.S.), and Department of Medical and Molecular Genetics (A.R., Y.L., H.L., C.G., L.L.), Indiana University School of Medicine, Indianapolis, Indiana; and Division of Clinical Pharmacology and Innovative Therapeutics, the Children’s Mercy Hospital and Clinics, Kansas City, Missouri (A.G.)
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Article Information

vol. 41 no. 10 1763-1768
DOI 
https://doi.org/10.1124/dmd.113.052886
PubMed 
23935064

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received May 10, 2013
  • Accepted August 9, 2013
  • Published online September 16, 2013.

Article Versions

  • Earlier version (August 9, 2013 - 06:43).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Anuradha Ramamoorthy,
  2. Yunlong Liu,
  3. Santosh Philips,
  4. Zeruesenay Desta,
  5. Hai Lin,
  6. Chirayu Goswami,
  7. Andrea Gaedigk,
  8. Lang Li,
  9. David A. Flockhart, and
  10. Todd C. Skaar
  1. Department of Medicine, Division of Clinical Pharmacology (A.R., S.P., Z.D., D.A.F., T.C.S.), and Department of Medical and Molecular Genetics (A.R., Y.L., H.L., C.G., L.L.), Indiana University School of Medicine, Indianapolis, Indiana; and Division of Clinical Pharmacology and Innovative Therapeutics, the Children’s Mercy Hospital and Clinics, Kansas City, Missouri (A.G.)
  1. Address correspondence to:
    Todd C. Skaar, 1001 W. 10th Street, WD Myers Building W7123, Indianapolis, IN 46202. E-mail: tskaar{at}iu.edu
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Drug Metabolism and Disposition: 41 (10)
Drug Metabolism and Disposition
Vol. 41, Issue 10
1 Oct 2013
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Research ArticleSpecial Section on Epigenetic Regulation of Drug Metabolizing Enzymes and Transporters

Rifampin Regulation of miRNAs

Anuradha Ramamoorthy, Yunlong Liu, Santosh Philips, Zeruesenay Desta, Hai Lin, Chirayu Goswami, Andrea Gaedigk, Lang Li, David A. Flockhart and Todd C. Skaar
Drug Metabolism and Disposition October 1, 2013, 41 (10) 1763-1768; DOI: https://doi.org/10.1124/dmd.113.052886

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Research ArticleSpecial Section on Epigenetic Regulation of Drug Metabolizing Enzymes and Transporters

Rifampin Regulation of miRNAs

Anuradha Ramamoorthy, Yunlong Liu, Santosh Philips, Zeruesenay Desta, Hai Lin, Chirayu Goswami, Andrea Gaedigk, Lang Li, David A. Flockhart and Todd C. Skaar
Drug Metabolism and Disposition October 1, 2013, 41 (10) 1763-1768; DOI: https://doi.org/10.1124/dmd.113.052886
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