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Research ArticleArticle

Different Hydrolases Involved in Bioactivation of Prodrug-Type Angiotensin Receptor Blockers: Carboxymethylenebutenolidase and Carboxylesterase 1

Tomoko Ishizuka, Yasushi Yoshigae, Nobuyuki Murayama and Takashi Izumi
Drug Metabolism and Disposition November 2013, 41 (11) 1888-1895; DOI: https://doi.org/10.1124/dmd.113.053595

Article Information

vol. 41 no. 11 1888-1895
DOI 
https://doi.org/10.1124/dmd.113.053595
PubMed 
23946449
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received July 1, 2013
  • Accepted August 13, 2013
  • Published online October 16, 2013.

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Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Tomoko Ishizuka,
  2. Yasushi Yoshigae,
  3. Nobuyuki Murayama, and
  4. Takashi Izumi
  1. Drug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, Japan
  1. Address correspondence to:
    Dr. Tomoko Ishizuka, Drug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan. E-mail: ishizuka.tomoko.xx{at}daiichisankyo.co.jp
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Bioactivation of ARB Prodrugs by CMBL and CES1

Tomoko Ishizuka, Yasushi Yoshigae, Nobuyuki Murayama and Takashi Izumi
Drug Metabolism and Disposition November 1, 2013, 41 (11) 1888-1895; DOI: https://doi.org/10.1124/dmd.113.053595
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