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Determination of Intracellular Unbound Concentrations and Subcellular Localization of Drugs in Rat Sandwich-Cultured Hepatocytes Compared with Liver Tissue

Nathan D. Pfeifer, Kevin B. Harris, Grace Zhixia Yan and Kim L. R. Brouwer
Drug Metabolism and Disposition November 2013, 41 (11) 1949-1956; DOI: https://doi.org/10.1124/dmd.113.052134

Article Information

vol. 41 no. 11 1949-1956
DOI 
https://doi.org/10.1124/dmd.113.052134
PubMed 
23990525
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received March 29, 2013
  • Accepted August 29, 2013
  • Published online October 16, 2013.

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Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Nathan D. Pfeifer,
  2. Kevin B. Harris,
  3. Grace Zhixia Yan, and
  4. Kim L. R. Brouwer
  1. Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
  1. Address correspondence to:
    Kim L. R. Brouwer, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, CB #7569, Chapel Hill, NC 27599-7569. E-mail: kbrouwer{at}email.unc.edu
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Cunbound and Localization in Sandwich-Cultured Hepatocytes

Nathan D. Pfeifer, Kevin B. Harris, Grace Zhixia Yan and Kim L. R. Brouwer
Drug Metabolism and Disposition November 1, 2013, 41 (11) 1949-1956; DOI: https://doi.org/10.1124/dmd.113.052134
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