Drug Metabolism and Disposition: 41 (12)

December 01, 2013; Volume 41,Issue 12

Special Section on Prediction of Human Pharmacokinetic Parameters from In Vitro Systems

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Prediction of Human Pharmacokinetics in 2013 and Beyond
J. Brian Houston

Drug Metabolism and Disposition December 2013, 41 (12) 1973-1974; DOI: https://doi.org/10.1124/dmd.113.055376
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A Perspective on the Prediction of Drug Pharmacokinetics and Disposition in Drug Research and Development
Li Di, Bo Feng, Theunis C. Goosen, Yurong Lai, Stefanus J. Steyn, Manthena V. Varma and R. Scott Obach

Drug Metabolism and Disposition December 2013, 41 (12) 1975-1993; DOI: https://doi.org/10.1124/dmd.113.054031
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Impact of Physiologically Based Pharmacokinetic Modeling and Simulation in Drug Development
Carole E. Shardlow, Grant T. Generaux, Aarti H. Patel, Guoying Tai, Thuy Tran and Jackie C. Bloomer

Drug Metabolism and Disposition December 2013, 41 (12) 1994-2003; DOI: https://doi.org/10.1124/dmd.113.052803
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CYP2B6 Pharmacogenetics–Based In Vitro–In Vivo Extrapolation of Efavirenz Clearance by Physiologically Based Pharmacokinetic Modeling
Cong Xu, Sara K. Quinney, Yingying Guo, Stephen D. Hall, Lang Li and Zeruesenay Desta

Drug Metabolism and Disposition December 2013, 41 (12) 2004-2011; DOI: https://doi.org/10.1124/dmd.113.051755
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In Vitro P-glycoprotein Efflux Ratio Can Predict the In Vivo Brain Penetration Regardless of Biopharmaceutics Drug Disposition Classification System Class
Ryota Kikuchi, Sonia M. de Morais and J. Cory Kalvass

Drug Metabolism and Disposition December 2013, 41 (12) 2012-2017; DOI: https://doi.org/10.1124/dmd.113.053868
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In Vitro–In Vivo Correlation for Low-Clearance Compounds Using Hepatocyte Relay Method
Li Di, Karen Atkinson, Christine C. Orozco, Carrie Funk, Hui Zhang, Thomas S. McDonald, Beijing Tan, Jian Lin, Cheng Chang and R. Scott Obach

Drug Metabolism and Disposition December 2013, 41 (12) 2018-2023; DOI: https://doi.org/10.1124/dmd.113.053322
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Meeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPac
Tom S. Chan, Hongbin Yu, Amanda Moore, Salman R. Khetani and Donald Tweedie

Drug Metabolism and Disposition December 2013, 41 (12) 2024-2032; DOI: https://doi.org/10.1124/dmd.113.053397
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Utility of In Vitro Systems and Preclinical Data for the Prediction of Human Intestinal First-Pass Metabolism during Drug Discovery and Preclinical Development
Fredrik H. Karlsson, Salim Bouchene, Constanze Hilgendorf, Hugues Dolgos and Sheila Annie Peters

Drug Metabolism and Disposition December 2013, 41 (12) 2033-2046; DOI: https://doi.org/10.1124/dmd.113.051664
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Drug Metabolites as Cytochrome P450 Inhibitors: A Retrospective Analysis and Proposed Algorithm for Evaluation of the Pharmacokinetic Interaction Potential of Metabolites in Drug Discovery and Development
Ernesto Callegari, Amit S. Kalgutkar, Louis Leung, R. Scott Obach, David R. Plowchalk and Susanna Tse

Drug Metabolism and Disposition December 2013, 41 (12) 2047-2055; DOI: https://doi.org/10.1124/dmd.113.052241
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Stereoselective Inhibition of CYP2C19 and CYP3A4 by Fluoxetine and Its Metabolite: Implications for Risk Assessment of Multiple Time-Dependent Inhibitor Systems
Justin D. Lutz, Brooke M. VandenBrink, Katipudi N. Babu, Wendel L. Nelson, Kent L. Kunze and Nina Isoherranen

Drug Metabolism and Disposition December 2013, 41 (12) 2056-2065; DOI: https://doi.org/10.1124/dmd.113.052639
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Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu₅: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions
Anna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott Daniels

Drug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662

Short Communication

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Targeted Precise Quantification of 12 Human Recombinant Uridine-Diphosphate Glucuronosyl Transferase 1A and 2B Isoforms Using Nano-Ultra-High-Performance Liquid Chromatography/Tandem Mass Spectrometry with Selected Reaction Monitoring
John K. Fallon, Hendrik Neubert, Theunis C. Goosen and Philip C. Smith

Drug Metabolism and Disposition December 2013, 41 (12) 2076-2080; DOI: https://doi.org/10.1124/dmd.113.053801

Articles

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N-Acetylation of Etamicastat, a Reversible Dopamine-β-Hydroxylase Inhibitor
Ana I. Loureiro, Carlos Fernandes-Lopes, Maria João Bonifácio, Lyndon C. Wright and Patrício Soares-da-Silva

Drug Metabolism and Disposition December 2013, 41 (12) 2081-2086; DOI: https://doi.org/10.1124/dmd.113.053736
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Activity, Inhibition, and Induction of Cytochrome P450 2J2 in Adult Human Primary Cardiomyocytes
Eric A. Evangelista, Rüdiger Kaspera, Nahush A. Mokadam, J. P. Jones and Rheem A. Totah

Drug Metabolism and Disposition December 2013, 41 (12) 2087-2094; DOI: https://doi.org/10.1124/dmd.113.053389
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Assessment of Vandetanib as an Inhibitor of Various Human Renal Transporters: Inhibition of Multidrug and Toxin Extrusion as a Possible Mechanism Leading to Decreased Cisplatin and Creatinine Clearance
Hong Shen, Zheng Yang, Weiping Zhao, Yueping Zhang and A. David Rodrigues

Drug Metabolism and Disposition December 2013, 41 (12) 2095-2103; DOI: https://doi.org/10.1124/dmd.113.053215
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Learning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins Antagonist
Harvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. Fairbrother

Drug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926
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Characterization of Inhibition Kinetics of (S)-Warfarin Hydroxylation by Noscapine: Implications in Warfarin Therapy
Nan Zhang, Ryan P. Seguin, Kent L. Kunze, Yan-Yan Zhang and Hyunyoung Jeong

Drug Metabolism and Disposition December 2013, 41 (12) 2114-2123; DOI: https://doi.org/10.1124/dmd.113.053330
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Characterization of Transplacental Transfer of Paroxetine in Perfused Human Placenta: Development of a Pharmacokinetic Model to Evaluate Tapered Dosing
Marie Nagai, Hisakazu Ohtani, Hiroki Satoh, Sayo Matsuoka, Satoko Hori, Tomoyuki Fujii, Yuji Taketani and Yasufumi Sawada

Drug Metabolism and Disposition December 2013, 41 (12) 2124-2132; DOI: https://doi.org/10.1124/dmd.113.052332
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Metabolism and Excretion of 6-Chloro-9-(4-methoxy-3,5-dimethylpyridin-2-ylmethyl)-9H-purin-2-ylamine, an HSP90 Inhibitor, in Rats and Dogs and Assessment of Its Metabolic Profile in Plasma of Humans
Lin Xu, Caroline Woodward, Jing Dai and Chandra Prakash

Drug Metabolism and Disposition December 2013, 41 (12) 2133-2147; DOI: https://doi.org/10.1124/dmd.113.054023
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In Vitro Metabolism of the Glucagon-Like Peptide-1 (GLP-1)–Derived Metabolites GLP-1(9-36)amide and GLP-1(28-36)amide in Mouse and Human Hepatocytes
Raman Sharma, Thomas S. McDonald, Heather Eng, Chris Limberakis, Benjamin D. Stevens, Sheena Patel and Amit S. Kalgutkar

Drug Metabolism and Disposition December 2013, 41 (12) 2148-2157; DOI: https://doi.org/10.1124/dmd.113.054254
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Assessment of the Roles of P-glycoprotein and Cytochrome P450 in Triptolide-induced Liver Toxicity in Sandwich-Cultured Rat Hepatocyte Model
Xiao-Mei Zhuang, Guo-Lin Shen, Wei-Bin Xiao, Yan Tan, Chuang Lu and Hua Li

Drug Metabolism and Disposition December 2013, 41 (12) 2158-2165; DOI: https://doi.org/10.1124/dmd.113.054056
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Cytochrome P4503A Does Not Mediate the Interaction between Methadone and Ritonavir-Lopinavir
Evan D. Kharasch and Kristi Stubbert

Drug Metabolism and Disposition December 2013, 41 (12) 2166-2174; DOI: https://doi.org/10.1124/dmd.113.053991
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RNA-Sequencing Quantification of Hepatic Ontogeny of Phase-I Enzymes in Mice
Lai Peng, Julia Y. Cui, Byunggil Yoo, Sumedha S. Gunewardena, Hong Lu, Curtis D. Klaassen and Xiao-bo Zhong

Drug Metabolism and Disposition December 2013, 41 (12) 2175-2186; DOI: https://doi.org/10.1124/dmd.113.054635
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Two Polymorphic Variants of ABCC1 Selectively Alter Drug Resistance and Inhibitor Sensitivity of the Multidrug and Organic Anion Transporter Multidrug Resistance Protein 1
Gwenaëlle Conseil and Susan P.C. Cole

Drug Metabolism and Disposition December 2013, 41 (12) 2187-2196; DOI: https://doi.org/10.1124/dmd.113.054213
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Modulation of the UGT2B7 Enzyme Activity by C-Terminally Truncated Proteins Derived from Alternative Splicing
Vincent Ménard, Pierre Collin, Guillaume Margaillan and Chantal Guillemette

Drug Metabolism and Disposition December 2013, 41 (12) 2197-2205; DOI: https://doi.org/10.1124/dmd.113.053876
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Lymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and Rats
Yan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. Reddy

Drug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524
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Metabolism and Disposition of Oral Dabrafenib in Cancer Patients: Proposed Participation of Aryl Nitrogen in Carbon-Carbon Bond Cleavage via Decarboxylation following Enzymatic Oxidation
David A. Bershas, Daniele Ouellet, Donna B. Mamaril-Fishman, Noelia Nebot, Stanley W. Carson, Samuel C. Blackman, Royce A. Morrison, Jerry L. Adams, Kristen E. Jurusik, Dana M. Knecht, Peter D. Gorycki and Lauren E. Richards-Peterson

Drug Metabolism and Disposition December 2013, 41 (12) 2215-2224; DOI: https://doi.org/10.1124/dmd.113.053785
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Effect of Gestational Age on mRNA and Protein Expression of Polyspecific Organic Cation Transporters during Pregnancy
Nora Lee, Mary F. Hebert, Bhagwat Prasad, Thomas R. Easterling, Edward J. Kelly, Jashvant D. Unadkat and Joanne Wang

Drug Metabolism and Disposition December 2013, 41 (12) 2225-2232; DOI: https://doi.org/10.1124/dmd.113.054072

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Special Section on Prediction of Human Pharmacokinetic Parameters from In Vitro Systems

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