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Index by author

December 01, 2013; Volume 41,Issue 12

A

  1. Adams, Jerry L.

    1. Metabolism and Disposition of Oral Dabrafenib in Cancer Patients: Proposed Participation of Aryl Nitrogen in Carbon-Carbon Bond Cleavage via Decarboxylation following Enzymatic Oxidation
      David A. Bershas, Daniele Ouellet, Donna B. Mamaril-Fishman, Noelia Nebot, Stanley W. Carson, Samuel C. Blackman, Royce A. Morrison, Jerry L. Adams, Kristen E. Jurusik, Dana M. Knecht, Peter D. Gorycki and Lauren E. Richards-Peterson
      Drug Metabolism and Disposition December 2013, 41 (12) 2215-2224; DOI: https://doi.org/10.1124/dmd.113.053785

  2. Adreani, Christine

    1. Lymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and Rats
      Yan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. Reddy
      Drug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524

  3. Alicke, Bruno

    1. Learning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins Antagonist
      Harvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. Fairbrother
      Drug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926

  4. Atkinson, Karen

    1. In Vitro–In Vivo Correlation for Low-Clearance Compounds Using Hepatocyte Relay Method
      Li Di, Karen Atkinson, Christine C. Orozco, Carrie Funk, Hui Zhang, Thomas S. McDonald, Beijing Tan, Jian Lin, Cheng Chang and R. Scott Obach
      Drug Metabolism and Disposition December 2013, 41 (12) 2018-2023; DOI: https://doi.org/10.1124/dmd.113.053322

B

  1. Babu, Katipudi N.

    1. Stereoselective Inhibition of CYP2C19 and CYP3A4 by Fluoxetine and Its Metabolite: Implications for Risk Assessment of Multiple Time-Dependent Inhibitor Systems
      Justin D. Lutz, Brooke M. VandenBrink, Katipudi N. Babu, Wendel L. Nelson, Kent L. Kunze and Nina Isoherranen
      Drug Metabolism and Disposition December 2013, 41 (12) 2056-2065; DOI: https://doi.org/10.1124/dmd.113.052639

  2. Bartolomé, José M.

    1. Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions
      Anna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott Daniels
      Drug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662

  3. Bateman, Thomas J.

    1. Lymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and Rats
      Yan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. Reddy
      Drug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524

  4. Bershas, David A.

    1. Metabolism and Disposition of Oral Dabrafenib in Cancer Patients: Proposed Participation of Aryl Nitrogen in Carbon-Carbon Bond Cleavage via Decarboxylation following Enzymatic Oxidation
      David A. Bershas, Daniele Ouellet, Donna B. Mamaril-Fishman, Noelia Nebot, Stanley W. Carson, Samuel C. Blackman, Royce A. Morrison, Jerry L. Adams, Kristen E. Jurusik, Dana M. Knecht, Peter D. Gorycki and Lauren E. Richards-Peterson
      Drug Metabolism and Disposition December 2013, 41 (12) 2215-2224; DOI: https://doi.org/10.1124/dmd.113.053785

  5. Blackman, Samuel C.

    1. Metabolism and Disposition of Oral Dabrafenib in Cancer Patients: Proposed Participation of Aryl Nitrogen in Carbon-Carbon Bond Cleavage via Decarboxylation following Enzymatic Oxidation
      David A. Bershas, Daniele Ouellet, Donna B. Mamaril-Fishman, Noelia Nebot, Stanley W. Carson, Samuel C. Blackman, Royce A. Morrison, Jerry L. Adams, Kristen E. Jurusik, Dana M. Knecht, Peter D. Gorycki and Lauren E. Richards-Peterson
      Drug Metabolism and Disposition December 2013, 41 (12) 2215-2224; DOI: https://doi.org/10.1124/dmd.113.053785

  6. Blobaum, Anna L.

    1. Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions
      Anna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott Daniels
      Drug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662

  7. Bloomer, Jackie C.

    1. Impact of Physiologically Based Pharmacokinetic Modeling and Simulation in Drug Development
      Carole E. Shardlow, Grant T. Generaux, Aarti H. Patel, Guoying Tai, Thuy Tran and Jackie C. Bloomer
      Drug Metabolism and Disposition December 2013, 41 (12) 1994-2003; DOI: https://doi.org/10.1124/dmd.113.052803

  8. Bonifácio, Maria João

    1. N-Acetylation of Etamicastat, a Reversible Dopamine-β-Hydroxylase Inhibitor
      Ana I. Loureiro, Carlos Fernandes-Lopes, Maria João Bonifácio, Lyndon C. Wright and Patrício Soares-da-Silva
      Drug Metabolism and Disposition December 2013, 41 (12) 2081-2086; DOI: https://doi.org/10.1124/dmd.113.053736

  9. Bouchene, Salim

    1. Utility of In Vitro Systems and Preclinical Data for the Prediction of Human Intestinal First-Pass Metabolism during Drug Discovery and Preclinical Development
      Fredrik H. Karlsson, Salim Bouchene, Constanze Hilgendorf, Hugues Dolgos and Sheila Annie Peters
      Drug Metabolism and Disposition December 2013, 41 (12) 2033-2046; DOI: https://doi.org/10.1124/dmd.113.051664

  10. Braun, Matthew

    1. Lymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and Rats
      Yan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. Reddy
      Drug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524

  11. Bridges, Thomas M.

    1. Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions
      Anna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott Daniels
      Drug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662

  12. Budha, Nageshwar

    1. Learning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins Antagonist
      Harvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. Fairbrother
      Drug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926

  13. Byers, Frank W.

    1. Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions
      Anna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott Daniels
      Drug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662

C

  1. Callegari, Ernesto

    1. Drug Metabolites as Cytochrome P450 Inhibitors: A Retrospective Analysis and Proposed Algorithm for Evaluation of the Pharmacokinetic Interaction Potential of Metabolites in Drug Discovery and Development
      Ernesto Callegari, Amit S. Kalgutkar, Louis Leung, R. Scott Obach, David R. Plowchalk and Susanna Tse
      Drug Metabolism and Disposition December 2013, 41 (12) 2047-2055; DOI: https://doi.org/10.1124/dmd.113.052241

  2. Carson, Stanley W.

    1. Metabolism and Disposition of Oral Dabrafenib in Cancer Patients: Proposed Participation of Aryl Nitrogen in Carbon-Carbon Bond Cleavage via Decarboxylation following Enzymatic Oxidation
      David A. Bershas, Daniele Ouellet, Donna B. Mamaril-Fishman, Noelia Nebot, Stanley W. Carson, Samuel C. Blackman, Royce A. Morrison, Jerry L. Adams, Kristen E. Jurusik, Dana M. Knecht, Peter D. Gorycki and Lauren E. Richards-Peterson
      Drug Metabolism and Disposition December 2013, 41 (12) 2215-2224; DOI: https://doi.org/10.1124/dmd.113.053785

  3. Chan, Tom S.

    1. Meeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPac
      Tom S. Chan, Hongbin Yu, Amanda Moore, Salman R. Khetani and Donald Tweedie
      Drug Metabolism and Disposition December 2013, 41 (12) 2024-2032; DOI: https://doi.org/10.1124/dmd.113.053397

  4. Chang, Cheng

    1. In Vitro–In Vivo Correlation for Low-Clearance Compounds Using Hepatocyte Relay Method
      Li Di, Karen Atkinson, Christine C. Orozco, Carrie Funk, Hui Zhang, Thomas S. McDonald, Beijing Tan, Jian Lin, Cheng Chang and R. Scott Obach
      Drug Metabolism and Disposition December 2013, 41 (12) 2018-2023; DOI: https://doi.org/10.1124/dmd.113.053322

  5. Christine, Amy

    1. Lymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and Rats
      Yan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. Reddy
      Drug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524

  6. Cole, Susan P.C.

    1. Two Polymorphic Variants of ABCC1 Selectively Alter Drug Resistance and Inhibitor Sensitivity of the Multidrug and Organic Anion Transporter Multidrug Resistance Protein 1
      Gwenaëlle Conseil and Susan P.C. Cole
      Drug Metabolism and Disposition December 2013, 41 (12) 2187-2196; DOI: https://doi.org/10.1124/dmd.113.054213

  7. Collin, Pierre

    1. Modulation of the UGT2B7 Enzyme Activity by C-Terminally Truncated Proteins Derived from Alternative Splicing
      Vincent Ménard, Pierre Collin, Guillaume Margaillan and Chantal Guillemette
      Drug Metabolism and Disposition December 2013, 41 (12) 2197-2205; DOI: https://doi.org/10.1124/dmd.113.053876

  8. Conn, P. Jeffrey

    1. Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions
      Anna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott Daniels
      Drug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662

  9. Conseil, Gwenaëlle

    1. Two Polymorphic Variants of ABCC1 Selectively Alter Drug Resistance and Inhibitor Sensitivity of the Multidrug and Organic Anion Transporter Multidrug Resistance Protein 1
      Gwenaëlle Conseil and Susan P.C. Cole
      Drug Metabolism and Disposition December 2013, 41 (12) 2187-2196; DOI: https://doi.org/10.1124/dmd.113.054213

  10. Cui, Julia Y.

    1. RNA-Sequencing Quantification of Hepatic Ontogeny of Phase-I Enzymes in Mice
      Lai Peng, Julia Y. Cui, Byunggil Yoo, Sumedha S. Gunewardena, Hong Lu, Curtis D. Klaassen and Xiao-bo Zhong
      Drug Metabolism and Disposition December 2013, 41 (12) 2175-2186; DOI: https://doi.org/10.1124/dmd.113.054635

  11. Cunningham, Paul K.

    1. Lymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and Rats
      Yan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. Reddy
      Drug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524

D

  1. Dai, Jing

    1. Metabolism and Excretion of 6-Chloro-9-(4-methoxy-3,5-dimethylpyridin-2-ylmethyl)-9H-purin-2-ylamine, an HSP90 Inhibitor, in Rats and Dogs and Assessment of Its Metabolic Profile in Plasma of Humans
      Lin Xu, Caroline Woodward, Jing Dai and Chandra Prakash
      Drug Metabolism and Disposition December 2013, 41 (12) 2133-2147; DOI: https://doi.org/10.1124/dmd.113.054023

  2. Daniels, J. Scott

    1. Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions
      Anna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott Daniels
      Drug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662

  3. Darbonne, Walter C.

    1. Learning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins Antagonist
      Harvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. Fairbrother
      Drug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926

  4. de Morais, Sonia M.

    1. In Vitro P-glycoprotein Efflux Ratio Can Predict the In Vivo Brain Penetration Regardless of Biopharmaceutics Drug Disposition Classification System Class
      Ryota Kikuchi, Sonia M. de Morais and J. Cory Kalvass
      Drug Metabolism and Disposition December 2013, 41 (12) 2012-2017; DOI: https://doi.org/10.1124/dmd.113.053868

  5. Desta, Zeruesenay

    1. CYP2B6 Pharmacogenetics–Based In Vitro–In Vivo Extrapolation of Efavirenz Clearance by Physiologically Based Pharmacokinetic Modeling
      Cong Xu, Sara K. Quinney, Yingying Guo, Stephen D. Hall, Lang Li and Zeruesenay Desta
      Drug Metabolism and Disposition December 2013, 41 (12) 2004-2011; DOI: https://doi.org/10.1124/dmd.113.051755

  6. Di, Li

    1. A Perspective on the Prediction of Drug Pharmacokinetics and Disposition in Drug Research and Development
      Li Di, Bo Feng, Theunis C. Goosen, Yurong Lai, Stefanus J. Steyn, Manthena V. Varma and R. Scott Obach
      Drug Metabolism and Disposition December 2013, 41 (12) 1975-1993; DOI: https://doi.org/10.1124/dmd.113.054031
    2. In Vitro–In Vivo Correlation for Low-Clearance Compounds Using Hepatocyte Relay Method
      Li Di, Karen Atkinson, Christine C. Orozco, Carrie Funk, Hui Zhang, Thomas S. McDonald, Beijing Tan, Jian Lin, Cheng Chang and R. Scott Obach
      Drug Metabolism and Disposition December 2013, 41 (12) 2018-2023; DOI: https://doi.org/10.1124/dmd.113.053322

  7. Dolgos, Hugues

    1. Utility of In Vitro Systems and Preclinical Data for the Prediction of Human Intestinal First-Pass Metabolism during Drug Discovery and Preclinical Development
      Fredrik H. Karlsson, Salim Bouchene, Constanze Hilgendorf, Hugues Dolgos and Sheila Annie Peters
      Drug Metabolism and Disposition December 2013, 41 (12) 2033-2046; DOI: https://doi.org/10.1124/dmd.113.051664

E

  1. Easterling, Thomas R.

    1. Effect of Gestational Age on mRNA and Protein Expression of Polyspecific Organic Cation Transporters during Pregnancy
      Nora Lee, Mary F. Hebert, Bhagwat Prasad, Thomas R. Easterling, Edward J. Kelly, Jashvant D. Unadkat and Joanne Wang
      Drug Metabolism and Disposition December 2013, 41 (12) 2225-2232; DOI: https://doi.org/10.1124/dmd.113.054072

  2. Eng, Heather

    1. In Vitro Metabolism of the Glucagon-Like Peptide-1 (GLP-1)–Derived Metabolites GLP-1(9-36)amide and GLP-1(28-36)amide in Mouse and Human Hepatocytes
      Raman Sharma, Thomas S. McDonald, Heather Eng, Chris Limberakis, Benjamin D. Stevens, Sheena Patel and Amit S. Kalgutkar
      Drug Metabolism and Disposition December 2013, 41 (12) 2148-2157; DOI: https://doi.org/10.1124/dmd.113.054254

  3. Erickson, Rebecca

    1. Learning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins Antagonist
      Harvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. Fairbrother
      Drug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926

  4. Evangelista, Eric A.

    1. Activity, Inhibition, and Induction of Cytochrome P450 2J2 in Adult Human Primary Cardiomyocytes
      Eric A. Evangelista, Rüdiger Kaspera, Nahush A. Mokadam, J. P. Jones and Rheem A. Totah
      Drug Metabolism and Disposition December 2013, 41 (12) 2087-2094; DOI: https://doi.org/10.1124/dmd.113.053389

F

  1. Fairbrother, Wayne J.

    1. Learning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins Antagonist
      Harvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. Fairbrother
      Drug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926

  2. Fallon, John K.

    1. Targeted Precise Quantification of 12 Human Recombinant Uridine-Diphosphate Glucuronosyl Transferase 1A and 2B Isoforms Using Nano-Ultra-High-Performance Liquid Chromatography/Tandem Mass Spectrometry with Selected Reaction Monitoring
      John K. Fallon, Hendrik Neubert, Theunis C. Goosen and Philip C. Smith
      Drug Metabolism and Disposition December 2013, 41 (12) 2076-2080; DOI: https://doi.org/10.1124/dmd.113.053801

  3. Feng, Bo

    1. A Perspective on the Prediction of Drug Pharmacokinetics and Disposition in Drug Research and Development
      Li Di, Bo Feng, Theunis C. Goosen, Yurong Lai, Stefanus J. Steyn, Manthena V. Varma and R. Scott Obach
      Drug Metabolism and Disposition December 2013, 41 (12) 1975-1993; DOI: https://doi.org/10.1124/dmd.113.054031

  4. Fernandes-Lopes, Carlos

    1. N-Acetylation of Etamicastat, a Reversible Dopamine-β-Hydroxylase Inhibitor
      Ana I. Loureiro, Carlos Fernandes-Lopes, Maria João Bonifácio, Lyndon C. Wright and Patrício Soares-da-Silva
      Drug Metabolism and Disposition December 2013, 41 (12) 2081-2086; DOI: https://doi.org/10.1124/dmd.113.053736

  5. Flygare, John A.

    1. Learning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins Antagonist
      Harvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. Fairbrother
      Drug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926

  6. Fujii, Tomoyuki

    1. Characterization of Transplacental Transfer of Paroxetine in Perfused Human Placenta: Development of a Pharmacokinetic Model to Evaluate Tapered Dosing
      Marie Nagai, Hisakazu Ohtani, Hiroki Satoh, Sayo Matsuoka, Satoko Hori, Tomoyuki Fujii, Yuji Taketani and Yasufumi Sawada
      Drug Metabolism and Disposition December 2013, 41 (12) 2124-2132; DOI: https://doi.org/10.1124/dmd.113.052332

  7. Funk, Carrie

    1. In Vitro–In Vivo Correlation for Low-Clearance Compounds Using Hepatocyte Relay Method
      Li Di, Karen Atkinson, Christine C. Orozco, Carrie Funk, Hui Zhang, Thomas S. McDonald, Beijing Tan, Jian Lin, Cheng Chang and R. Scott Obach
      Drug Metabolism and Disposition December 2013, 41 (12) 2018-2023; DOI: https://doi.org/10.1124/dmd.113.053322

G

  1. Generaux, Grant T.

    1. Impact of Physiologically Based Pharmacokinetic Modeling and Simulation in Drug Development
      Carole E. Shardlow, Grant T. Generaux, Aarti H. Patel, Guoying Tai, Thuy Tran and Jackie C. Bloomer
      Drug Metabolism and Disposition December 2013, 41 (12) 1994-2003; DOI: https://doi.org/10.1124/dmd.113.052803

  2. Goosen, Theunis C.

    1. A Perspective on the Prediction of Drug Pharmacokinetics and Disposition in Drug Research and Development
      Li Di, Bo Feng, Theunis C. Goosen, Yurong Lai, Stefanus J. Steyn, Manthena V. Varma and R. Scott Obach
      Drug Metabolism and Disposition December 2013, 41 (12) 1975-1993; DOI: https://doi.org/10.1124/dmd.113.054031
    2. Targeted Precise Quantification of 12 Human Recombinant Uridine-Diphosphate Glucuronosyl Transferase 1A and 2B Isoforms Using Nano-Ultra-High-Performance Liquid Chromatography/Tandem Mass Spectrometry with Selected Reaction Monitoring
      John K. Fallon, Hendrik Neubert, Theunis C. Goosen and Philip C. Smith
      Drug Metabolism and Disposition December 2013, 41 (12) 2076-2080; DOI: https://doi.org/10.1124/dmd.113.053801

  3. Gorycki, Peter D.

    1. Metabolism and Disposition of Oral Dabrafenib in Cancer Patients: Proposed Participation of Aryl Nitrogen in Carbon-Carbon Bond Cleavage via Decarboxylation following Enzymatic Oxidation
      David A. Bershas, Daniele Ouellet, Donna B. Mamaril-Fishman, Noelia Nebot, Stanley W. Carson, Samuel C. Blackman, Royce A. Morrison, Jerry L. Adams, Kristen E. Jurusik, Dana M. Knecht, Peter D. Gorycki and Lauren E. Richards-Peterson
      Drug Metabolism and Disposition December 2013, 41 (12) 2215-2224; DOI: https://doi.org/10.1124/dmd.113.053785

  4. Gould, Stephen E.

    1. Learning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins Antagonist
      Harvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. Fairbrother
      Drug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926

  5. Guillemette, Chantal

    1. Modulation of the UGT2B7 Enzyme Activity by C-Terminally Truncated Proteins Derived from Alternative Splicing
      Vincent Ménard, Pierre Collin, Guillaume Margaillan and Chantal Guillemette
      Drug Metabolism and Disposition December 2013, 41 (12) 2197-2205; DOI: https://doi.org/10.1124/dmd.113.053876

  6. Gunewardena, Sumedha S.

    1. RNA-Sequencing Quantification of Hepatic Ontogeny of Phase-I Enzymes in Mice
      Lai Peng, Julia Y. Cui, Byunggil Yoo, Sumedha S. Gunewardena, Hong Lu, Curtis D. Klaassen and Xiao-bo Zhong
      Drug Metabolism and Disposition December 2013, 41 (12) 2175-2186; DOI: https://doi.org/10.1124/dmd.113.054635

  7. Guo, Yingying

    1. CYP2B6 Pharmacogenetics–Based In Vitro–In Vivo Extrapolation of Efavirenz Clearance by Physiologically Based Pharmacokinetic Modeling
      Cong Xu, Sara K. Quinney, Yingying Guo, Stephen D. Hall, Lang Li and Zeruesenay Desta
      Drug Metabolism and Disposition December 2013, 41 (12) 2004-2011; DOI: https://doi.org/10.1124/dmd.113.051755

H

  1. Hall, Stephen D.

    1. CYP2B6 Pharmacogenetics–Based In Vitro–In Vivo Extrapolation of Efavirenz Clearance by Physiologically Based Pharmacokinetic Modeling
      Cong Xu, Sara K. Quinney, Yingying Guo, Stephen D. Hall, Lang Li and Zeruesenay Desta
      Drug Metabolism and Disposition December 2013, 41 (12) 2004-2011; DOI: https://doi.org/10.1124/dmd.113.051755

  2. Halladay, Jason S.

    1. Learning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins Antagonist
      Harvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. Fairbrother
      Drug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926

  3. Hebert, Mary F.

    1. Effect of Gestational Age on mRNA and Protein Expression of Polyspecific Organic Cation Transporters during Pregnancy
      Nora Lee, Mary F. Hebert, Bhagwat Prasad, Thomas R. Easterling, Edward J. Kelly, Jashvant D. Unadkat and Joanne Wang
      Drug Metabolism and Disposition December 2013, 41 (12) 2225-2232; DOI: https://doi.org/10.1124/dmd.113.054072

  4. Hilgendorf, Constanze

    1. Utility of In Vitro Systems and Preclinical Data for the Prediction of Human Intestinal First-Pass Metabolism during Drug Discovery and Preclinical Development
      Fredrik H. Karlsson, Salim Bouchene, Constanze Hilgendorf, Hugues Dolgos and Sheila Annie Peters
      Drug Metabolism and Disposition December 2013, 41 (12) 2033-2046; DOI: https://doi.org/10.1124/dmd.113.051664

  5. Hong, Xuening

    1. Lymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and Rats
      Yan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. Reddy
      Drug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524

  6. Hop, Cornelis E. C. A.

    1. Learning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins Antagonist
      Harvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. Fairbrother
      Drug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926

  7. Hori, Satoko

    1. Characterization of Transplacental Transfer of Paroxetine in Perfused Human Placenta: Development of a Pharmacokinetic Model to Evaluate Tapered Dosing
      Marie Nagai, Hisakazu Ohtani, Hiroki Satoh, Sayo Matsuoka, Satoko Hori, Tomoyuki Fujii, Yuji Taketani and Yasufumi Sawada
      Drug Metabolism and Disposition December 2013, 41 (12) 2124-2132; DOI: https://doi.org/10.1124/dmd.113.052332

  8. Houston, J. Brian

    1. Prediction of Human Pharmacokinetics in 2013 and Beyond
      J. Brian Houston
      Drug Metabolism and Disposition December 2013, 41 (12) 1973-1974; DOI: https://doi.org/10.1124/dmd.113.055376

I

  1. Infante, Jeffery R.

    1. Learning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins Antagonist
      Harvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. Fairbrother
      Drug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926

  2. Isoherranen, Nina

    1. Stereoselective Inhibition of CYP2C19 and CYP3A4 by Fluoxetine and Its Metabolite: Implications for Risk Assessment of Multiple Time-Dependent Inhibitor Systems
      Justin D. Lutz, Brooke M. VandenBrink, Katipudi N. Babu, Wendel L. Nelson, Kent L. Kunze and Nina Isoherranen
      Drug Metabolism and Disposition December 2013, 41 (12) 2056-2065; DOI: https://doi.org/10.1124/dmd.113.052639

J

  1. Jeong, Hyunyoung

    1. Characterization of Inhibition Kinetics of (S)-Warfarin Hydroxylation by Noscapine: Implications in Warfarin Therapy
      Nan Zhang, Ryan P. Seguin, Kent L. Kunze, Yan-Yan Zhang and Hyunyoung Jeong
      Drug Metabolism and Disposition December 2013, 41 (12) 2114-2123; DOI: https://doi.org/10.1124/dmd.113.053330

  2. Johnson, Chris V.

    1. Lymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and Rats
      Yan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. Reddy
      Drug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524

  3. Jones, Carrie K.

    1. Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions
      Anna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott Daniels
      Drug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662

  4. Jones, J. P.

    1. Activity, Inhibition, and Induction of Cytochrome P450 2J2 in Adult Human Primary Cardiomyocytes
      Eric A. Evangelista, Rüdiger Kaspera, Nahush A. Mokadam, J. P. Jones and Rheem A. Totah
      Drug Metabolism and Disposition December 2013, 41 (12) 2087-2094; DOI: https://doi.org/10.1124/dmd.113.053389

  5. Jurusik, Kristen E.

    1. Metabolism and Disposition of Oral Dabrafenib in Cancer Patients: Proposed Participation of Aryl Nitrogen in Carbon-Carbon Bond Cleavage via Decarboxylation following Enzymatic Oxidation
      David A. Bershas, Daniele Ouellet, Donna B. Mamaril-Fishman, Noelia Nebot, Stanley W. Carson, Samuel C. Blackman, Royce A. Morrison, Jerry L. Adams, Kristen E. Jurusik, Dana M. Knecht, Peter D. Gorycki and Lauren E. Richards-Peterson
      Drug Metabolism and Disposition December 2013, 41 (12) 2215-2224; DOI: https://doi.org/10.1124/dmd.113.053785

K

  1. Kadel, Edward E.

    1. Learning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins Antagonist
      Harvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. Fairbrother
      Drug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926

  2. Kalgutkar, Amit S.

    1. Drug Metabolites as Cytochrome P450 Inhibitors: A Retrospective Analysis and Proposed Algorithm for Evaluation of the Pharmacokinetic Interaction Potential of Metabolites in Drug Discovery and Development
      Ernesto Callegari, Amit S. Kalgutkar, Louis Leung, R. Scott Obach, David R. Plowchalk and Susanna Tse
      Drug Metabolism and Disposition December 2013, 41 (12) 2047-2055; DOI: https://doi.org/10.1124/dmd.113.052241
    2. In Vitro Metabolism of the Glucagon-Like Peptide-1 (GLP-1)–Derived Metabolites GLP-1(9-36)amide and GLP-1(28-36)amide in Mouse and Human Hepatocytes
      Raman Sharma, Thomas S. McDonald, Heather Eng, Chris Limberakis, Benjamin D. Stevens, Sheena Patel and Amit S. Kalgutkar
      Drug Metabolism and Disposition December 2013, 41 (12) 2148-2157; DOI: https://doi.org/10.1124/dmd.113.054254

  3. Kalvass, J. Cory

    1. In Vitro P-glycoprotein Efflux Ratio Can Predict the In Vivo Brain Penetration Regardless of Biopharmaceutics Drug Disposition Classification System Class
      Ryota Kikuchi, Sonia M. de Morais and J. Cory Kalvass
      Drug Metabolism and Disposition December 2013, 41 (12) 2012-2017; DOI: https://doi.org/10.1124/dmd.113.053868

  4. Karlsson, Fredrik H.

    1. Utility of In Vitro Systems and Preclinical Data for the Prediction of Human Intestinal First-Pass Metabolism during Drug Discovery and Preclinical Development
      Fredrik H. Karlsson, Salim Bouchene, Constanze Hilgendorf, Hugues Dolgos and Sheila Annie Peters
      Drug Metabolism and Disposition December 2013, 41 (12) 2033-2046; DOI: https://doi.org/10.1124/dmd.113.051664

  5. Kaspera, Rüdiger

    1. Activity, Inhibition, and Induction of Cytochrome P450 2J2 in Adult Human Primary Cardiomyocytes
      Eric A. Evangelista, Rüdiger Kaspera, Nahush A. Mokadam, J. P. Jones and Rheem A. Totah
      Drug Metabolism and Disposition December 2013, 41 (12) 2087-2094; DOI: https://doi.org/10.1124/dmd.113.053389

  6. Kelly, Edward J.

    1. Effect of Gestational Age on mRNA and Protein Expression of Polyspecific Organic Cation Transporters during Pregnancy
      Nora Lee, Mary F. Hebert, Bhagwat Prasad, Thomas R. Easterling, Edward J. Kelly, Jashvant D. Unadkat and Joanne Wang
      Drug Metabolism and Disposition December 2013, 41 (12) 2225-2232; DOI: https://doi.org/10.1124/dmd.113.054072

  7. Kharasch, Evan D.

    1. Cytochrome P4503A Does Not Mediate the Interaction between Methadone and Ritonavir-Lopinavir
      Evan D. Kharasch and Kristi Stubbert
      Drug Metabolism and Disposition December 2013, 41 (12) 2166-2174; DOI: https://doi.org/10.1124/dmd.113.053991

  8. Khetani, Salman R.

    1. Meeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPac
      Tom S. Chan, Hongbin Yu, Amanda Moore, Salman R. Khetani and Donald Tweedie
      Drug Metabolism and Disposition December 2013, 41 (12) 2024-2032; DOI: https://doi.org/10.1124/dmd.113.053397

  9. Kikuchi, Ryota

    1. In Vitro P-glycoprotein Efflux Ratio Can Predict the In Vivo Brain Penetration Regardless of Biopharmaceutics Drug Disposition Classification System Class
      Ryota Kikuchi, Sonia M. de Morais and J. Cory Kalvass
      Drug Metabolism and Disposition December 2013, 41 (12) 2012-2017; DOI: https://doi.org/10.1124/dmd.113.053868

  10. Klaassen, Curtis D.

    1. RNA-Sequencing Quantification of Hepatic Ontogeny of Phase-I Enzymes in Mice
      Lai Peng, Julia Y. Cui, Byunggil Yoo, Sumedha S. Gunewardena, Hong Lu, Curtis D. Klaassen and Xiao-bo Zhong
      Drug Metabolism and Disposition December 2013, 41 (12) 2175-2186; DOI: https://doi.org/10.1124/dmd.113.054635

  11. Knecht, Dana M.

    1. Metabolism and Disposition of Oral Dabrafenib in Cancer Patients: Proposed Participation of Aryl Nitrogen in Carbon-Carbon Bond Cleavage via Decarboxylation following Enzymatic Oxidation
      David A. Bershas, Daniele Ouellet, Donna B. Mamaril-Fishman, Noelia Nebot, Stanley W. Carson, Samuel C. Blackman, Royce A. Morrison, Jerry L. Adams, Kristen E. Jurusik, Dana M. Knecht, Peter D. Gorycki and Lauren E. Richards-Peterson
      Drug Metabolism and Disposition December 2013, 41 (12) 2215-2224; DOI: https://doi.org/10.1124/dmd.113.053785

  12. Kumar, Sanjeev

    1. Lymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and Rats
      Yan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. Reddy
      Drug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524

  13. Kunze, Kent L.

    1. Stereoselective Inhibition of CYP2C19 and CYP3A4 by Fluoxetine and Its Metabolite: Implications for Risk Assessment of Multiple Time-Dependent Inhibitor Systems
      Justin D. Lutz, Brooke M. VandenBrink, Katipudi N. Babu, Wendel L. Nelson, Kent L. Kunze and Nina Isoherranen
      Drug Metabolism and Disposition December 2013, 41 (12) 2056-2065; DOI: https://doi.org/10.1124/dmd.113.052639
    2. Characterization of Inhibition Kinetics of (S)-Warfarin Hydroxylation by Noscapine: Implications in Warfarin Therapy
      Nan Zhang, Ryan P. Seguin, Kent L. Kunze, Yan-Yan Zhang and Hyunyoung Jeong
      Drug Metabolism and Disposition December 2013, 41 (12) 2114-2123; DOI: https://doi.org/10.1124/dmd.113.053330

L

  1. La, Hank

    1. Learning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins Antagonist
      Harvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. Fairbrother
      Drug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926

  2. Lai, Yurong

    1. A Perspective on the Prediction of Drug Pharmacokinetics and Disposition in Drug Research and Development
      Li Di, Bo Feng, Theunis C. Goosen, Yurong Lai, Stefanus J. Steyn, Manthena V. Varma and R. Scott Obach
      Drug Metabolism and Disposition December 2013, 41 (12) 1975-1993; DOI: https://doi.org/10.1124/dmd.113.054031

  3. Lavreysen, Hilde

    1. Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions
      Anna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott Daniels
      Drug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662

  4. Lee, Nora

    1. Effect of Gestational Age on mRNA and Protein Expression of Polyspecific Organic Cation Transporters during Pregnancy
      Nora Lee, Mary F. Hebert, Bhagwat Prasad, Thomas R. Easterling, Edward J. Kelly, Jashvant D. Unadkat and Joanne Wang
      Drug Metabolism and Disposition December 2013, 41 (12) 2225-2232; DOI: https://doi.org/10.1124/dmd.113.054072

  5. Leung, Louis

    1. Drug Metabolites as Cytochrome P450 Inhibitors: A Retrospective Analysis and Proposed Algorithm for Evaluation of the Pharmacokinetic Interaction Potential of Metabolites in Drug Discovery and Development
      Ernesto Callegari, Amit S. Kalgutkar, Louis Leung, R. Scott Obach, David R. Plowchalk and Susanna Tse
      Drug Metabolism and Disposition December 2013, 41 (12) 2047-2055; DOI: https://doi.org/10.1124/dmd.113.052241

  6. Li, Hua

    1. Assessment of the Roles of P-glycoprotein and Cytochrome P450 in Triptolide-induced Liver Toxicity in Sandwich-Cultured Rat Hepatocyte Model
      Xiao-Mei Zhuang, Guo-Lin Shen, Wei-Bin Xiao, Yan Tan, Chuang Lu and Hua Li
      Drug Metabolism and Disposition December 2013, 41 (12) 2158-2165; DOI: https://doi.org/10.1124/dmd.113.054056

  7. Li, Lang

    1. CYP2B6 Pharmacogenetics–Based In Vitro–In Vivo Extrapolation of Efavirenz Clearance by Physiologically Based Pharmacokinetic Modeling
      Cong Xu, Sara K. Quinney, Yingying Guo, Stephen D. Hall, Lang Li and Zeruesenay Desta
      Drug Metabolism and Disposition December 2013, 41 (12) 2004-2011; DOI: https://doi.org/10.1124/dmd.113.051755

  8. Limberakis, Chris

    1. In Vitro Metabolism of the Glucagon-Like Peptide-1 (GLP-1)–Derived Metabolites GLP-1(9-36)amide and GLP-1(28-36)amide in Mouse and Human Hepatocytes
      Raman Sharma, Thomas S. McDonald, Heather Eng, Chris Limberakis, Benjamin D. Stevens, Sheena Patel and Amit S. Kalgutkar
      Drug Metabolism and Disposition December 2013, 41 (12) 2148-2157; DOI: https://doi.org/10.1124/dmd.113.054254

  9. Lin, Jian

    1. In Vitro–In Vivo Correlation for Low-Clearance Compounds Using Hepatocyte Relay Method
      Li Di, Karen Atkinson, Christine C. Orozco, Carrie Funk, Hui Zhang, Thomas S. McDonald, Beijing Tan, Jian Lin, Cheng Chang and R. Scott Obach
      Drug Metabolism and Disposition December 2013, 41 (12) 2018-2023; DOI: https://doi.org/10.1124/dmd.113.053322

  10. Lindsley, Craig W.

    1. Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions
      Anna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott Daniels
      Drug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662

  11. Loureiro, Ana I.

    1. N-Acetylation of Etamicastat, a Reversible Dopamine-β-Hydroxylase Inhibitor
      Ana I. Loureiro, Carlos Fernandes-Lopes, Maria João Bonifácio, Lyndon C. Wright and Patrício Soares-da-Silva
      Drug Metabolism and Disposition December 2013, 41 (12) 2081-2086; DOI: https://doi.org/10.1124/dmd.113.053736

  12. Lu, Chuang

    1. Assessment of the Roles of P-glycoprotein and Cytochrome P450 in Triptolide-induced Liver Toxicity in Sandwich-Cultured Rat Hepatocyte Model
      Xiao-Mei Zhuang, Guo-Lin Shen, Wei-Bin Xiao, Yan Tan, Chuang Lu and Hua Li
      Drug Metabolism and Disposition December 2013, 41 (12) 2158-2165; DOI: https://doi.org/10.1124/dmd.113.054056

  13. Lu, Hong

    1. RNA-Sequencing Quantification of Hepatic Ontogeny of Phase-I Enzymes in Mice
      Lai Peng, Julia Y. Cui, Byunggil Yoo, Sumedha S. Gunewardena, Hong Lu, Curtis D. Klaassen and Xiao-bo Zhong
      Drug Metabolism and Disposition December 2013, 41 (12) 2175-2186; DOI: https://doi.org/10.1124/dmd.113.054635

  14. Lutz, Justin D.

    1. Stereoselective Inhibition of CYP2C19 and CYP3A4 by Fluoxetine and Its Metabolite: Implications for Risk Assessment of Multiple Time-Dependent Inhibitor Systems
      Justin D. Lutz, Brooke M. VandenBrink, Katipudi N. Babu, Wendel L. Nelson, Kent L. Kunze and Nina Isoherranen
      Drug Metabolism and Disposition December 2013, 41 (12) 2056-2065; DOI: https://doi.org/10.1124/dmd.113.052639

M

  1. MacDonald, Gregor J.

    1. Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions
      Anna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott Daniels
      Drug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662

  2. Mackie, Claire

    1. Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions
      Anna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott Daniels
      Drug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662

  3. Mamaril-Fishman, Donna B.

    1. Metabolism and Disposition of Oral Dabrafenib in Cancer Patients: Proposed Participation of Aryl Nitrogen in Carbon-Carbon Bond Cleavage via Decarboxylation following Enzymatic Oxidation
      David A. Bershas, Daniele Ouellet, Donna B. Mamaril-Fishman, Noelia Nebot, Stanley W. Carson, Samuel C. Blackman, Royce A. Morrison, Jerry L. Adams, Kristen E. Jurusik, Dana M. Knecht, Peter D. Gorycki and Lauren E. Richards-Peterson
      Drug Metabolism and Disposition December 2013, 41 (12) 2215-2224; DOI: https://doi.org/10.1124/dmd.113.053785

  4. Mamounas, Michael

    1. Learning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins Antagonist
      Harvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. Fairbrother
      Drug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926

  5. Margaillan, Guillaume

    1. Modulation of the UGT2B7 Enzyme Activity by C-Terminally Truncated Proteins Derived from Alternative Splicing
      Vincent Ménard, Pierre Collin, Guillaume Margaillan and Chantal Guillemette
      Drug Metabolism and Disposition December 2013, 41 (12) 2197-2205; DOI: https://doi.org/10.1124/dmd.113.053876

  6. Matsuoka, Sayo

    1. Characterization of Transplacental Transfer of Paroxetine in Perfused Human Placenta: Development of a Pharmacokinetic Model to Evaluate Tapered Dosing
      Marie Nagai, Hisakazu Ohtani, Hiroki Satoh, Sayo Matsuoka, Satoko Hori, Tomoyuki Fujii, Yuji Taketani and Yasufumi Sawada
      Drug Metabolism and Disposition December 2013, 41 (12) 2124-2132; DOI: https://doi.org/10.1124/dmd.113.052332

  7. Mattmann, Margrith E.

    1. Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions
      Anna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott Daniels
      Drug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662

  8. McDonald, Thomas S.

    1. In Vitro Metabolism of the Glucagon-Like Peptide-1 (GLP-1)–Derived Metabolites GLP-1(9-36)amide and GLP-1(28-36)amide in Mouse and Human Hepatocytes
      Raman Sharma, Thomas S. McDonald, Heather Eng, Chris Limberakis, Benjamin D. Stevens, Sheena Patel and Amit S. Kalgutkar
      Drug Metabolism and Disposition December 2013, 41 (12) 2148-2157; DOI: https://doi.org/10.1124/dmd.113.054254
    2. In Vitro–In Vivo Correlation for Low-Clearance Compounds Using Hepatocyte Relay Method
      Li Di, Karen Atkinson, Christine C. Orozco, Carrie Funk, Hui Zhang, Thomas S. McDonald, Beijing Tan, Jian Lin, Cheng Chang and R. Scott Obach
      Drug Metabolism and Disposition December 2013, 41 (12) 2018-2023; DOI: https://doi.org/10.1124/dmd.113.053322

  9. Ménard, Vincent

    1. Modulation of the UGT2B7 Enzyme Activity by C-Terminally Truncated Proteins Derived from Alternative Splicing
      Vincent Ménard, Pierre Collin, Guillaume Margaillan and Chantal Guillemette
      Drug Metabolism and Disposition December 2013, 41 (12) 2197-2205; DOI: https://doi.org/10.1124/dmd.113.053876

  10. Mokadam, Nahush A.

    1. Activity, Inhibition, and Induction of Cytochrome P450 2J2 in Adult Human Primary Cardiomyocytes
      Eric A. Evangelista, Rüdiger Kaspera, Nahush A. Mokadam, J. P. Jones and Rheem A. Totah
      Drug Metabolism and Disposition December 2013, 41 (12) 2087-2094; DOI: https://doi.org/10.1124/dmd.113.053389

  11. Moore, Amanda

    1. Meeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPac
      Tom S. Chan, Hongbin Yu, Amanda Moore, Salman R. Khetani and Donald Tweedie
      Drug Metabolism and Disposition December 2013, 41 (12) 2024-2032; DOI: https://doi.org/10.1124/dmd.113.053397

  12. Morrison, Royce A.

    1. Metabolism and Disposition of Oral Dabrafenib in Cancer Patients: Proposed Participation of Aryl Nitrogen in Carbon-Carbon Bond Cleavage via Decarboxylation following Enzymatic Oxidation
      David A. Bershas, Daniele Ouellet, Donna B. Mamaril-Fishman, Noelia Nebot, Stanley W. Carson, Samuel C. Blackman, Royce A. Morrison, Jerry L. Adams, Kristen E. Jurusik, Dana M. Knecht, Peter D. Gorycki and Lauren E. Richards-Peterson
      Drug Metabolism and Disposition December 2013, 41 (12) 2215-2224; DOI: https://doi.org/10.1124/dmd.113.053785

  13. Morrison, Ryan D.

    1. Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions
      Anna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott Daniels
      Drug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662

N

  1. Nagai, Marie

    1. Characterization of Transplacental Transfer of Paroxetine in Perfused Human Placenta: Development of a Pharmacokinetic Model to Evaluate Tapered Dosing
      Marie Nagai, Hisakazu Ohtani, Hiroki Satoh, Sayo Matsuoka, Satoko Hori, Tomoyuki Fujii, Yuji Taketani and Yasufumi Sawada
      Drug Metabolism and Disposition December 2013, 41 (12) 2124-2132; DOI: https://doi.org/10.1124/dmd.113.052332

  2. Nebot, Noelia

    1. Metabolism and Disposition of Oral Dabrafenib in Cancer Patients: Proposed Participation of Aryl Nitrogen in Carbon-Carbon Bond Cleavage via Decarboxylation following Enzymatic Oxidation
      David A. Bershas, Daniele Ouellet, Donna B. Mamaril-Fishman, Noelia Nebot, Stanley W. Carson, Samuel C. Blackman, Royce A. Morrison, Jerry L. Adams, Kristen E. Jurusik, Dana M. Knecht, Peter D. Gorycki and Lauren E. Richards-Peterson
      Drug Metabolism and Disposition December 2013, 41 (12) 2215-2224; DOI: https://doi.org/10.1124/dmd.113.053785

  3. Nelson, Wendel L.

    1. Stereoselective Inhibition of CYP2C19 and CYP3A4 by Fluoxetine and Its Metabolite: Implications for Risk Assessment of Multiple Time-Dependent Inhibitor Systems
      Justin D. Lutz, Brooke M. VandenBrink, Katipudi N. Babu, Wendel L. Nelson, Kent L. Kunze and Nina Isoherranen
      Drug Metabolism and Disposition December 2013, 41 (12) 2056-2065; DOI: https://doi.org/10.1124/dmd.113.052639

  4. Neubert, Hendrik

    1. Targeted Precise Quantification of 12 Human Recombinant Uridine-Diphosphate Glucuronosyl Transferase 1A and 2B Isoforms Using Nano-Ultra-High-Performance Liquid Chromatography/Tandem Mass Spectrometry with Selected Reaction Monitoring
      John K. Fallon, Hendrik Neubert, Theunis C. Goosen and Philip C. Smith
      Drug Metabolism and Disposition December 2013, 41 (12) 2076-2080; DOI: https://doi.org/10.1124/dmd.113.053801

  5. Niswender, Colleen M.

    1. Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions
      Anna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott Daniels
      Drug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662

  6. Nunes, Christian N.

    1. Lymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and Rats
      Yan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. Reddy
      Drug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524

O

  1. Obach, R. Scott

    1. Drug Metabolites as Cytochrome P450 Inhibitors: A Retrospective Analysis and Proposed Algorithm for Evaluation of the Pharmacokinetic Interaction Potential of Metabolites in Drug Discovery and Development
      Ernesto Callegari, Amit S. Kalgutkar, Louis Leung, R. Scott Obach, David R. Plowchalk and Susanna Tse
      Drug Metabolism and Disposition December 2013, 41 (12) 2047-2055; DOI: https://doi.org/10.1124/dmd.113.052241
    2. A Perspective on the Prediction of Drug Pharmacokinetics and Disposition in Drug Research and Development
      Li Di, Bo Feng, Theunis C. Goosen, Yurong Lai, Stefanus J. Steyn, Manthena V. Varma and R. Scott Obach
      Drug Metabolism and Disposition December 2013, 41 (12) 1975-1993; DOI: https://doi.org/10.1124/dmd.113.054031
    3. In Vitro–In Vivo Correlation for Low-Clearance Compounds Using Hepatocyte Relay Method
      Li Di, Karen Atkinson, Christine C. Orozco, Carrie Funk, Hui Zhang, Thomas S. McDonald, Beijing Tan, Jian Lin, Cheng Chang and R. Scott Obach
      Drug Metabolism and Disposition December 2013, 41 (12) 2018-2023; DOI: https://doi.org/10.1124/dmd.113.053322

  2. Ohtani, Hisakazu

    1. Characterization of Transplacental Transfer of Paroxetine in Perfused Human Placenta: Development of a Pharmacokinetic Model to Evaluate Tapered Dosing
      Marie Nagai, Hisakazu Ohtani, Hiroki Satoh, Sayo Matsuoka, Satoko Hori, Tomoyuki Fujii, Yuji Taketani and Yasufumi Sawada
      Drug Metabolism and Disposition December 2013, 41 (12) 2124-2132; DOI: https://doi.org/10.1124/dmd.113.052332

  3. Orozco, Christine C.

    1. In Vitro–In Vivo Correlation for Low-Clearance Compounds Using Hepatocyte Relay Method
      Li Di, Karen Atkinson, Christine C. Orozco, Carrie Funk, Hui Zhang, Thomas S. McDonald, Beijing Tan, Jian Lin, Cheng Chang and R. Scott Obach
      Drug Metabolism and Disposition December 2013, 41 (12) 2018-2023; DOI: https://doi.org/10.1124/dmd.113.053322

  4. Ouellet, Daniele

    1. Metabolism and Disposition of Oral Dabrafenib in Cancer Patients: Proposed Participation of Aryl Nitrogen in Carbon-Carbon Bond Cleavage via Decarboxylation following Enzymatic Oxidation
      David A. Bershas, Daniele Ouellet, Donna B. Mamaril-Fishman, Noelia Nebot, Stanley W. Carson, Samuel C. Blackman, Royce A. Morrison, Jerry L. Adams, Kristen E. Jurusik, Dana M. Knecht, Peter D. Gorycki and Lauren E. Richards-Peterson
      Drug Metabolism and Disposition December 2013, 41 (12) 2215-2224; DOI: https://doi.org/10.1124/dmd.113.053785

P

  1. Patel, Aarti H.

    1. Impact of Physiologically Based Pharmacokinetic Modeling and Simulation in Drug Development
      Carole E. Shardlow, Grant T. Generaux, Aarti H. Patel, Guoying Tai, Thuy Tran and Jackie C. Bloomer
      Drug Metabolism and Disposition December 2013, 41 (12) 1994-2003; DOI: https://doi.org/10.1124/dmd.113.052803

  2. Patel, Sheena

    1. In Vitro Metabolism of the Glucagon-Like Peptide-1 (GLP-1)–Derived Metabolites GLP-1(9-36)amide and GLP-1(28-36)amide in Mouse and Human Hepatocytes
      Raman Sharma, Thomas S. McDonald, Heather Eng, Chris Limberakis, Benjamin D. Stevens, Sheena Patel and Amit S. Kalgutkar
      Drug Metabolism and Disposition December 2013, 41 (12) 2148-2157; DOI: https://doi.org/10.1124/dmd.113.054254

  3. Peng, Lai

    1. RNA-Sequencing Quantification of Hepatic Ontogeny of Phase-I Enzymes in Mice
      Lai Peng, Julia Y. Cui, Byunggil Yoo, Sumedha S. Gunewardena, Hong Lu, Curtis D. Klaassen and Xiao-bo Zhong
      Drug Metabolism and Disposition December 2013, 41 (12) 2175-2186; DOI: https://doi.org/10.1124/dmd.113.054635

  4. Peters, Sheila Annie

    1. Utility of In Vitro Systems and Preclinical Data for the Prediction of Human Intestinal First-Pass Metabolism during Drug Discovery and Preclinical Development
      Fredrik H. Karlsson, Salim Bouchene, Constanze Hilgendorf, Hugues Dolgos and Sheila Annie Peters
      Drug Metabolism and Disposition December 2013, 41 (12) 2033-2046; DOI: https://doi.org/10.1124/dmd.113.051664

  5. Plowchalk, David R.

    1. Drug Metabolites as Cytochrome P450 Inhibitors: A Retrospective Analysis and Proposed Algorithm for Evaluation of the Pharmacokinetic Interaction Potential of Metabolites in Drug Discovery and Development
      Ernesto Callegari, Amit S. Kalgutkar, Louis Leung, R. Scott Obach, David R. Plowchalk and Susanna Tse
      Drug Metabolism and Disposition December 2013, 41 (12) 2047-2055; DOI: https://doi.org/10.1124/dmd.113.052241

  6. Portera, Chia

    1. Learning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins Antagonist
      Harvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. Fairbrother
      Drug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926

  7. Prakash, Chandra

    1. Metabolism and Excretion of 6-Chloro-9-(4-methoxy-3,5-dimethylpyridin-2-ylmethyl)-9H-purin-2-ylamine, an HSP90 Inhibitor, in Rats and Dogs and Assessment of Its Metabolic Profile in Plasma of Humans
      Lin Xu, Caroline Woodward, Jing Dai and Chandra Prakash
      Drug Metabolism and Disposition December 2013, 41 (12) 2133-2147; DOI: https://doi.org/10.1124/dmd.113.054023

  8. Prasad, Bhagwat

    1. Effect of Gestational Age on mRNA and Protein Expression of Polyspecific Organic Cation Transporters during Pregnancy
      Nora Lee, Mary F. Hebert, Bhagwat Prasad, Thomas R. Easterling, Edward J. Kelly, Jashvant D. Unadkat and Joanne Wang
      Drug Metabolism and Disposition December 2013, 41 (12) 2225-2232; DOI: https://doi.org/10.1124/dmd.113.054072

Q

  1. Quinney, Sara K.

    1. CYP2B6 Pharmacogenetics–Based In Vitro–In Vivo Extrapolation of Efavirenz Clearance by Physiologically Based Pharmacokinetic Modeling
      Cong Xu, Sara K. Quinney, Yingying Guo, Stephen D. Hall, Lang Li and Zeruesenay Desta
      Drug Metabolism and Disposition December 2013, 41 (12) 2004-2011; DOI: https://doi.org/10.1124/dmd.113.051755

R

  1. Reddy, Vijay Bhasker G.

    1. Lymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and Rats
      Yan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. Reddy
      Drug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524

  2. Richards-Peterson, Lauren E.

    1. Metabolism and Disposition of Oral Dabrafenib in Cancer Patients: Proposed Participation of Aryl Nitrogen in Carbon-Carbon Bond Cleavage via Decarboxylation following Enzymatic Oxidation
      David A. Bershas, Daniele Ouellet, Donna B. Mamaril-Fishman, Noelia Nebot, Stanley W. Carson, Samuel C. Blackman, Royce A. Morrison, Jerry L. Adams, Kristen E. Jurusik, Dana M. Knecht, Peter D. Gorycki and Lauren E. Richards-Peterson
      Drug Metabolism and Disposition December 2013, 41 (12) 2215-2224; DOI: https://doi.org/10.1124/dmd.113.053785

  3. Rodrigues, A. David

    1. Assessment of Vandetanib as an Inhibitor of Various Human Renal Transporters: Inhibition of Multidrug and Toxin Extrusion as a Possible Mechanism Leading to Decreased Cisplatin and Creatinine Clearance
      Hong Shen, Zheng Yang, Weiping Zhao, Yueping Zhang and A. David Rodrigues
      Drug Metabolism and Disposition December 2013, 41 (12) 2095-2103; DOI: https://doi.org/10.1124/dmd.113.053215

S

  1. Satoh, Hiroki

    1. Characterization of Transplacental Transfer of Paroxetine in Perfused Human Placenta: Development of a Pharmacokinetic Model to Evaluate Tapered Dosing
      Marie Nagai, Hisakazu Ohtani, Hiroki Satoh, Sayo Matsuoka, Satoko Hori, Tomoyuki Fujii, Yuji Taketani and Yasufumi Sawada
      Drug Metabolism and Disposition December 2013, 41 (12) 2124-2132; DOI: https://doi.org/10.1124/dmd.113.052332

  2. Sawada, Yasufumi

    1. Characterization of Transplacental Transfer of Paroxetine in Perfused Human Placenta: Development of a Pharmacokinetic Model to Evaluate Tapered Dosing
      Marie Nagai, Hisakazu Ohtani, Hiroki Satoh, Sayo Matsuoka, Satoko Hori, Tomoyuki Fujii, Yuji Taketani and Yasufumi Sawada
      Drug Metabolism and Disposition December 2013, 41 (12) 2124-2132; DOI: https://doi.org/10.1124/dmd.113.052332

  3. Seguin, Ryan P.

    1. Characterization of Inhibition Kinetics of (S)-Warfarin Hydroxylation by Noscapine: Implications in Warfarin Therapy
      Nan Zhang, Ryan P. Seguin, Kent L. Kunze, Yan-Yan Zhang and Hyunyoung Jeong
      Drug Metabolism and Disposition December 2013, 41 (12) 2114-2123; DOI: https://doi.org/10.1124/dmd.113.053330

  4. Shardlow, Carole E.

    1. Impact of Physiologically Based Pharmacokinetic Modeling and Simulation in Drug Development
      Carole E. Shardlow, Grant T. Generaux, Aarti H. Patel, Guoying Tai, Thuy Tran and Jackie C. Bloomer
      Drug Metabolism and Disposition December 2013, 41 (12) 1994-2003; DOI: https://doi.org/10.1124/dmd.113.052803

  5. Sharma, Raman

    1. In Vitro Metabolism of the Glucagon-Like Peptide-1 (GLP-1)–Derived Metabolites GLP-1(9-36)amide and GLP-1(28-36)amide in Mouse and Human Hepatocytes
      Raman Sharma, Thomas S. McDonald, Heather Eng, Chris Limberakis, Benjamin D. Stevens, Sheena Patel and Amit S. Kalgutkar
      Drug Metabolism and Disposition December 2013, 41 (12) 2148-2157; DOI: https://doi.org/10.1124/dmd.113.054254

  6. Shen, Guo-Lin

    1. Assessment of the Roles of P-glycoprotein and Cytochrome P450 in Triptolide-induced Liver Toxicity in Sandwich-Cultured Rat Hepatocyte Model
      Xiao-Mei Zhuang, Guo-Lin Shen, Wei-Bin Xiao, Yan Tan, Chuang Lu and Hua Li
      Drug Metabolism and Disposition December 2013, 41 (12) 2158-2165; DOI: https://doi.org/10.1124/dmd.113.054056

  7. Shen, Hong

    1. Assessment of Vandetanib as an Inhibitor of Various Human Renal Transporters: Inhibition of Multidrug and Toxin Extrusion as a Possible Mechanism Leading to Decreased Cisplatin and Creatinine Clearance
      Hong Shen, Zheng Yang, Weiping Zhao, Yueping Zhang and A. David Rodrigues
      Drug Metabolism and Disposition December 2013, 41 (12) 2095-2103; DOI: https://doi.org/10.1124/dmd.113.053215

  8. Shen, Xiaolan

    1. Lymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and Rats
      Yan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. Reddy
      Drug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524

  9. Smith, Philip C.

    1. Targeted Precise Quantification of 12 Human Recombinant Uridine-Diphosphate Glucuronosyl Transferase 1A and 2B Isoforms Using Nano-Ultra-High-Performance Liquid Chromatography/Tandem Mass Spectrometry with Selected Reaction Monitoring
      John K. Fallon, Hendrik Neubert, Theunis C. Goosen and Philip C. Smith
      Drug Metabolism and Disposition December 2013, 41 (12) 2076-2080; DOI: https://doi.org/10.1124/dmd.113.053801

  10. Soares-da-Silva, Patrício

    1. N-Acetylation of Etamicastat, a Reversible Dopamine-β-Hydroxylase Inhibitor
      Ana I. Loureiro, Carlos Fernandes-Lopes, Maria João Bonifácio, Lyndon C. Wright and Patrício Soares-da-Silva
      Drug Metabolism and Disposition December 2013, 41 (12) 2081-2086; DOI: https://doi.org/10.1124/dmd.113.053736

  11. Staskiewicz, Steve J.

    1. Lymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and Rats
      Yan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. Reddy
      Drug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524

  12. Stauffer, Shaun R.

    1. Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions
      Anna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott Daniels
      Drug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662

  13. Steckler, Thomas

    1. Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions
      Anna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott Daniels
      Drug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662

  14. Stevens, Benjamin D.

    1. In Vitro Metabolism of the Glucagon-Like Peptide-1 (GLP-1)–Derived Metabolites GLP-1(9-36)amide and GLP-1(28-36)amide in Mouse and Human Hepatocytes
      Raman Sharma, Thomas S. McDonald, Heather Eng, Chris Limberakis, Benjamin D. Stevens, Sheena Patel and Amit S. Kalgutkar
      Drug Metabolism and Disposition December 2013, 41 (12) 2148-2157; DOI: https://doi.org/10.1124/dmd.113.054254

  15. Steyn, Stefanus J.

    1. A Perspective on the Prediction of Drug Pharmacokinetics and Disposition in Drug Research and Development
      Li Di, Bo Feng, Theunis C. Goosen, Yurong Lai, Stefanus J. Steyn, Manthena V. Varma and R. Scott Obach
      Drug Metabolism and Disposition December 2013, 41 (12) 1975-1993; DOI: https://doi.org/10.1124/dmd.113.054031

  16. Stubbert, Kristi

    1. Cytochrome P4503A Does Not Mediate the Interaction between Methadone and Ritonavir-Lopinavir
      Evan D. Kharasch and Kristi Stubbert
      Drug Metabolism and Disposition December 2013, 41 (12) 2166-2174; DOI: https://doi.org/10.1124/dmd.113.053991

T

  1. Tai, Guoying

    1. Impact of Physiologically Based Pharmacokinetic Modeling and Simulation in Drug Development
      Carole E. Shardlow, Grant T. Generaux, Aarti H. Patel, Guoying Tai, Thuy Tran and Jackie C. Bloomer
      Drug Metabolism and Disposition December 2013, 41 (12) 1994-2003; DOI: https://doi.org/10.1124/dmd.113.052803

  2. Taketani, Yuji

    1. Characterization of Transplacental Transfer of Paroxetine in Perfused Human Placenta: Development of a Pharmacokinetic Model to Evaluate Tapered Dosing
      Marie Nagai, Hisakazu Ohtani, Hiroki Satoh, Sayo Matsuoka, Satoko Hori, Tomoyuki Fujii, Yuji Taketani and Yasufumi Sawada
      Drug Metabolism and Disposition December 2013, 41 (12) 2124-2132; DOI: https://doi.org/10.1124/dmd.113.052332

  3. Tan, Beijing

    1. In Vitro–In Vivo Correlation for Low-Clearance Compounds Using Hepatocyte Relay Method
      Li Di, Karen Atkinson, Christine C. Orozco, Carrie Funk, Hui Zhang, Thomas S. McDonald, Beijing Tan, Jian Lin, Cheng Chang and R. Scott Obach
      Drug Metabolism and Disposition December 2013, 41 (12) 2018-2023; DOI: https://doi.org/10.1124/dmd.113.053322

  4. Tan, Yan

    1. Assessment of the Roles of P-glycoprotein and Cytochrome P450 in Triptolide-induced Liver Toxicity in Sandwich-Cultured Rat Hepatocyte Model
      Xiao-Mei Zhuang, Guo-Lin Shen, Wei-Bin Xiao, Yan Tan, Chuang Lu and Hua Li
      Drug Metabolism and Disposition December 2013, 41 (12) 2158-2165; DOI: https://doi.org/10.1124/dmd.113.054056

  5. Tolcher, Anthony W.

    1. Learning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins Antagonist
      Harvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. Fairbrother
      Drug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926

  6. Totah, Rheem A.

    1. Activity, Inhibition, and Induction of Cytochrome P450 2J2 in Adult Human Primary Cardiomyocytes
      Eric A. Evangelista, Rüdiger Kaspera, Nahush A. Mokadam, J. P. Jones and Rheem A. Totah
      Drug Metabolism and Disposition December 2013, 41 (12) 2087-2094; DOI: https://doi.org/10.1124/dmd.113.053389

  7. Tran, Thuy

    1. Impact of Physiologically Based Pharmacokinetic Modeling and Simulation in Drug Development
      Carole E. Shardlow, Grant T. Generaux, Aarti H. Patel, Guoying Tai, Thuy Tran and Jackie C. Bloomer
      Drug Metabolism and Disposition December 2013, 41 (12) 1994-2003; DOI: https://doi.org/10.1124/dmd.113.052803

  8. Trinh, Tu

    1. Lymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and Rats
      Yan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. Reddy
      Drug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524

  9. Tse, Susanna

    1. Drug Metabolites as Cytochrome P450 Inhibitors: A Retrospective Analysis and Proposed Algorithm for Evaluation of the Pharmacokinetic Interaction Potential of Metabolites in Drug Discovery and Development
      Ernesto Callegari, Amit S. Kalgutkar, Louis Leung, R. Scott Obach, David R. Plowchalk and Susanna Tse
      Drug Metabolism and Disposition December 2013, 41 (12) 2047-2055; DOI: https://doi.org/10.1124/dmd.113.052241

  10. Turlington, Mark L.

    1. Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions
      Anna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott Daniels
      Drug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662

  11. Tweedie, Donald

    1. Meeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPac
      Tom S. Chan, Hongbin Yu, Amanda Moore, Salman R. Khetani and Donald Tweedie
      Drug Metabolism and Disposition December 2013, 41 (12) 2024-2032; DOI: https://doi.org/10.1124/dmd.113.053397

U

  1. Unadkat, Jashvant D.

    1. Effect of Gestational Age on mRNA and Protein Expression of Polyspecific Organic Cation Transporters during Pregnancy
      Nora Lee, Mary F. Hebert, Bhagwat Prasad, Thomas R. Easterling, Edward J. Kelly, Jashvant D. Unadkat and Joanne Wang
      Drug Metabolism and Disposition December 2013, 41 (12) 2225-2232; DOI: https://doi.org/10.1124/dmd.113.054072

V

  1. VandenBrink, Brooke M.

    1. Stereoselective Inhibition of CYP2C19 and CYP3A4 by Fluoxetine and Its Metabolite: Implications for Risk Assessment of Multiple Time-Dependent Inhibitor Systems
      Justin D. Lutz, Brooke M. VandenBrink, Katipudi N. Babu, Wendel L. Nelson, Kent L. Kunze and Nina Isoherranen
      Drug Metabolism and Disposition December 2013, 41 (12) 2056-2065; DOI: https://doi.org/10.1124/dmd.113.052639

  2. Varma, Manthena V.

    1. A Perspective on the Prediction of Drug Pharmacokinetics and Disposition in Drug Research and Development
      Li Di, Bo Feng, Theunis C. Goosen, Yurong Lai, Stefanus J. Steyn, Manthena V. Varma and R. Scott Obach
      Drug Metabolism and Disposition December 2013, 41 (12) 1975-1993; DOI: https://doi.org/10.1124/dmd.113.054031

W

  1. Wang, Bo

    1. Lymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and Rats
      Yan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. Reddy
      Drug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524

  2. Wang, Joanne

    1. Effect of Gestational Age on mRNA and Protein Expression of Polyspecific Organic Cation Transporters during Pregnancy
      Nora Lee, Mary F. Hebert, Bhagwat Prasad, Thomas R. Easterling, Edward J. Kelly, Jashvant D. Unadkat and Joanne Wang
      Drug Metabolism and Disposition December 2013, 41 (12) 2225-2232; DOI: https://doi.org/10.1124/dmd.113.054072

  3. Wong, Harvey

    1. Learning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins Antagonist
      Harvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. Fairbrother
      Drug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926

  4. Woodward, Caroline

    1. Metabolism and Excretion of 6-Chloro-9-(4-methoxy-3,5-dimethylpyridin-2-ylmethyl)-9H-purin-2-ylamine, an HSP90 Inhibitor, in Rats and Dogs and Assessment of Its Metabolic Profile in Plasma of Humans
      Lin Xu, Caroline Woodward, Jing Dai and Chandra Prakash
      Drug Metabolism and Disposition December 2013, 41 (12) 2133-2147; DOI: https://doi.org/10.1124/dmd.113.054023

  5. Wright, Lyndon C.

    1. N-Acetylation of Etamicastat, a Reversible Dopamine-β-Hydroxylase Inhibitor
      Ana I. Loureiro, Carlos Fernandes-Lopes, Maria João Bonifácio, Lyndon C. Wright and Patrício Soares-da-Silva
      Drug Metabolism and Disposition December 2013, 41 (12) 2081-2086; DOI: https://doi.org/10.1124/dmd.113.053736

X

  1. Xiao, Wei-Bin

    1. Assessment of the Roles of P-glycoprotein and Cytochrome P450 in Triptolide-induced Liver Toxicity in Sandwich-Cultured Rat Hepatocyte Model
      Xiao-Mei Zhuang, Guo-Lin Shen, Wei-Bin Xiao, Yan Tan, Chuang Lu and Hua Li
      Drug Metabolism and Disposition December 2013, 41 (12) 2158-2165; DOI: https://doi.org/10.1124/dmd.113.054056

  2. Xu, Cong

    1. CYP2B6 Pharmacogenetics–Based In Vitro–In Vivo Extrapolation of Efavirenz Clearance by Physiologically Based Pharmacokinetic Modeling
      Cong Xu, Sara K. Quinney, Yingying Guo, Stephen D. Hall, Lang Li and Zeruesenay Desta
      Drug Metabolism and Disposition December 2013, 41 (12) 2004-2011; DOI: https://doi.org/10.1124/dmd.113.051755

  3. Xu, Lin

    1. Metabolism and Excretion of 6-Chloro-9-(4-methoxy-3,5-dimethylpyridin-2-ylmethyl)-9H-purin-2-ylamine, an HSP90 Inhibitor, in Rats and Dogs and Assessment of Its Metabolic Profile in Plasma of Humans
      Lin Xu, Caroline Woodward, Jing Dai and Chandra Prakash
      Drug Metabolism and Disposition December 2013, 41 (12) 2133-2147; DOI: https://doi.org/10.1124/dmd.113.054023

Y

  1. Yang, Zheng

    1. Assessment of Vandetanib as an Inhibitor of Various Human Renal Transporters: Inhibition of Multidrug and Toxin Extrusion as a Possible Mechanism Leading to Decreased Cisplatin and Creatinine Clearance
      Hong Shen, Zheng Yang, Weiping Zhao, Yueping Zhang and A. David Rodrigues
      Drug Metabolism and Disposition December 2013, 41 (12) 2095-2103; DOI: https://doi.org/10.1124/dmd.113.053215

  2. Yoo, Byunggil

    1. RNA-Sequencing Quantification of Hepatic Ontogeny of Phase-I Enzymes in Mice
      Lai Peng, Julia Y. Cui, Byunggil Yoo, Sumedha S. Gunewardena, Hong Lu, Curtis D. Klaassen and Xiao-bo Zhong
      Drug Metabolism and Disposition December 2013, 41 (12) 2175-2186; DOI: https://doi.org/10.1124/dmd.113.054635

  3. Yu, Hongbin

    1. Meeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPac
      Tom S. Chan, Hongbin Yu, Amanda Moore, Salman R. Khetani and Donald Tweedie
      Drug Metabolism and Disposition December 2013, 41 (12) 2024-2032; DOI: https://doi.org/10.1124/dmd.113.053397

Z

  1. Zhang, Andy S.

    1. Lymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and Rats
      Yan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. Reddy
      Drug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524

  2. Zhang, Hui

    1. In Vitro–In Vivo Correlation for Low-Clearance Compounds Using Hepatocyte Relay Method
      Li Di, Karen Atkinson, Christine C. Orozco, Carrie Funk, Hui Zhang, Thomas S. McDonald, Beijing Tan, Jian Lin, Cheng Chang and R. Scott Obach
      Drug Metabolism and Disposition December 2013, 41 (12) 2018-2023; DOI: https://doi.org/10.1124/dmd.113.053322

  3. Zhang, Nan

    1. Characterization of Inhibition Kinetics of (S)-Warfarin Hydroxylation by Noscapine: Implications in Warfarin Therapy
      Nan Zhang, Ryan P. Seguin, Kent L. Kunze, Yan-Yan Zhang and Hyunyoung Jeong
      Drug Metabolism and Disposition December 2013, 41 (12) 2114-2123; DOI: https://doi.org/10.1124/dmd.113.053330

  4. Zhang, Yan-Yan

    1. Characterization of Inhibition Kinetics of (S)-Warfarin Hydroxylation by Noscapine: Implications in Warfarin Therapy
      Nan Zhang, Ryan P. Seguin, Kent L. Kunze, Yan-Yan Zhang and Hyunyoung Jeong
      Drug Metabolism and Disposition December 2013, 41 (12) 2114-2123; DOI: https://doi.org/10.1124/dmd.113.053330

  5. Zhang, Yueping

    1. Assessment of Vandetanib as an Inhibitor of Various Human Renal Transporters: Inhibition of Multidrug and Toxin Extrusion as a Possible Mechanism Leading to Decreased Cisplatin and Creatinine Clearance
      Hong Shen, Zheng Yang, Weiping Zhao, Yueping Zhang and A. David Rodrigues
      Drug Metabolism and Disposition December 2013, 41 (12) 2095-2103; DOI: https://doi.org/10.1124/dmd.113.053215

  6. Zhao, Weiping

    1. Assessment of Vandetanib as an Inhibitor of Various Human Renal Transporters: Inhibition of Multidrug and Toxin Extrusion as a Possible Mechanism Leading to Decreased Cisplatin and Creatinine Clearance
      Hong Shen, Zheng Yang, Weiping Zhao, Yueping Zhang and A. David Rodrigues
      Drug Metabolism and Disposition December 2013, 41 (12) 2095-2103; DOI: https://doi.org/10.1124/dmd.113.053215

  7. Zhong, Xiao-bo

    1. RNA-Sequencing Quantification of Hepatic Ontogeny of Phase-I Enzymes in Mice
      Lai Peng, Julia Y. Cui, Byunggil Yoo, Sumedha S. Gunewardena, Hong Lu, Curtis D. Klaassen and Xiao-bo Zhong
      Drug Metabolism and Disposition December 2013, 41 (12) 2175-2186; DOI: https://doi.org/10.1124/dmd.113.054635

  8. Zhuang, Xiao-Mei

    1. Assessment of the Roles of P-glycoprotein and Cytochrome P450 in Triptolide-induced Liver Toxicity in Sandwich-Cultured Rat Hepatocyte Model
      Xiao-Mei Zhuang, Guo-Lin Shen, Wei-Bin Xiao, Yan Tan, Chuang Lu and Hua Li
      Drug Metabolism and Disposition December 2013, 41 (12) 2158-2165; DOI: https://doi.org/10.1124/dmd.113.054056

  9. Zou, Yan

    1. Lymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and Rats
      Yan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. Reddy
      Drug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524
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