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Drug Metabolism & Disposition

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Index by author

December 01, 2013; Volume 41,Issue 12
  • A
  • B
  • C
  • D
  • E
  • F
  • G
  • H
  • I
  • J
  • K
  • L
  • M
  • N
  • O
  • P
  • Q
  • R
  • S
  • T
  • U
  • V
  • W
  • X
  • Y
  • Z

A

  1. Adams, Jerry L.

    1. You have access
      Metabolism and Disposition of Oral Dabrafenib in Cancer Patients: Proposed Participation of Aryl Nitrogen in Carbon-Carbon Bond Cleavage via Decarboxylation following Enzymatic Oxidation
      David A. Bershas, Daniele Ouellet, Donna B. Mamaril-Fishman, Noelia Nebot, Stanley W. Carson, Samuel C. Blackman, Royce A. Morrison, Jerry L. Adams, Kristen E. Jurusik, Dana M. Knecht, Peter D. Gorycki and Lauren E. Richards-Peterson
      Drug Metabolism and Disposition December 2013, 41 (12) 2215-2224; DOI: https://doi.org/10.1124/dmd.113.053785
  2. Adreani, Christine

    1. You have access
      Lymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and Rats
      Yan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. Reddy
      Drug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524
  3. Alicke, Bruno

    1. You have access
      Learning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins Antagonist
      Harvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. Fairbrother
      Drug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926
  4. Atkinson, Karen

    1. You have access
      In Vitro–In Vivo Correlation for Low-Clearance Compounds Using Hepatocyte Relay Method
      Li Di, Karen Atkinson, Christine C. Orozco, Carrie Funk, Hui Zhang, Thomas S. McDonald, Beijing Tan, Jian Lin, Cheng Chang and R. Scott Obach
      Drug Metabolism and Disposition December 2013, 41 (12) 2018-2023; DOI: https://doi.org/10.1124/dmd.113.053322

B

  1. Babu, Katipudi N.

    1. You have access
      Stereoselective Inhibition of CYP2C19 and CYP3A4 by Fluoxetine and Its Metabolite: Implications for Risk Assessment of Multiple Time-Dependent Inhibitor Systems
      Justin D. Lutz, Brooke M. VandenBrink, Katipudi N. Babu, Wendel L. Nelson, Kent L. Kunze and Nina Isoherranen
      Drug Metabolism and Disposition December 2013, 41 (12) 2056-2065; DOI: https://doi.org/10.1124/dmd.113.052639
  2. Bartolomé, José M.

    1. You have access
      Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions
      Anna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott Daniels
      Drug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662
  3. Bateman, Thomas J.

    1. You have access
      Lymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and Rats
      Yan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. Reddy
      Drug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524
  4. Bershas, David A.

    1. You have access
      Metabolism and Disposition of Oral Dabrafenib in Cancer Patients: Proposed Participation of Aryl Nitrogen in Carbon-Carbon Bond Cleavage via Decarboxylation following Enzymatic Oxidation
      David A. Bershas, Daniele Ouellet, Donna B. Mamaril-Fishman, Noelia Nebot, Stanley W. Carson, Samuel C. Blackman, Royce A. Morrison, Jerry L. Adams, Kristen E. Jurusik, Dana M. Knecht, Peter D. Gorycki and Lauren E. Richards-Peterson
      Drug Metabolism and Disposition December 2013, 41 (12) 2215-2224; DOI: https://doi.org/10.1124/dmd.113.053785
  5. Blackman, Samuel C.

    1. You have access
      Metabolism and Disposition of Oral Dabrafenib in Cancer Patients: Proposed Participation of Aryl Nitrogen in Carbon-Carbon Bond Cleavage via Decarboxylation following Enzymatic Oxidation
      David A. Bershas, Daniele Ouellet, Donna B. Mamaril-Fishman, Noelia Nebot, Stanley W. Carson, Samuel C. Blackman, Royce A. Morrison, Jerry L. Adams, Kristen E. Jurusik, Dana M. Knecht, Peter D. Gorycki and Lauren E. Richards-Peterson
      Drug Metabolism and Disposition December 2013, 41 (12) 2215-2224; DOI: https://doi.org/10.1124/dmd.113.053785
  6. Blobaum, Anna L.

    1. You have access
      Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions
      Anna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott Daniels
      Drug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662
  7. Bloomer, Jackie C.

    1. You have access
      Impact of Physiologically Based Pharmacokinetic Modeling and Simulation in Drug Development
      Carole E. Shardlow, Grant T. Generaux, Aarti H. Patel, Guoying Tai, Thuy Tran and Jackie C. Bloomer
      Drug Metabolism and Disposition December 2013, 41 (12) 1994-2003; DOI: https://doi.org/10.1124/dmd.113.052803
  8. Bonifácio, Maria João

    1. You have access
      N-Acetylation of Etamicastat, a Reversible Dopamine-β-Hydroxylase Inhibitor
      Ana I. Loureiro, Carlos Fernandes-Lopes, Maria João Bonifácio, Lyndon C. Wright and Patrício Soares-da-Silva
      Drug Metabolism and Disposition December 2013, 41 (12) 2081-2086; DOI: https://doi.org/10.1124/dmd.113.053736
  9. Bouchene, Salim

    1. You have access
      Utility of In Vitro Systems and Preclinical Data for the Prediction of Human Intestinal First-Pass Metabolism during Drug Discovery and Preclinical Development
      Fredrik H. Karlsson, Salim Bouchene, Constanze Hilgendorf, Hugues Dolgos and Sheila Annie Peters
      Drug Metabolism and Disposition December 2013, 41 (12) 2033-2046; DOI: https://doi.org/10.1124/dmd.113.051664
  10. Braun, Matthew

    1. You have access
      Lymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and Rats
      Yan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. Reddy
      Drug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524
  11. Bridges, Thomas M.

    1. You have access
      Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions
      Anna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott Daniels
      Drug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662
  12. Budha, Nageshwar

    1. You have access
      Learning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins Antagonist
      Harvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. Fairbrother
      Drug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926
  13. Byers, Frank W.

    1. You have access
      Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions
      Anna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott Daniels
      Drug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662

C

  1. Callegari, Ernesto

    1. You have access
      Drug Metabolites as Cytochrome P450 Inhibitors: A Retrospective Analysis and Proposed Algorithm for Evaluation of the Pharmacokinetic Interaction Potential of Metabolites in Drug Discovery and Development
      Ernesto Callegari, Amit S. Kalgutkar, Louis Leung, R. Scott Obach, David R. Plowchalk and Susanna Tse
      Drug Metabolism and Disposition December 2013, 41 (12) 2047-2055; DOI: https://doi.org/10.1124/dmd.113.052241
  2. Carson, Stanley W.

    1. You have access
      Metabolism and Disposition of Oral Dabrafenib in Cancer Patients: Proposed Participation of Aryl Nitrogen in Carbon-Carbon Bond Cleavage via Decarboxylation following Enzymatic Oxidation
      David A. Bershas, Daniele Ouellet, Donna B. Mamaril-Fishman, Noelia Nebot, Stanley W. Carson, Samuel C. Blackman, Royce A. Morrison, Jerry L. Adams, Kristen E. Jurusik, Dana M. Knecht, Peter D. Gorycki and Lauren E. Richards-Peterson
      Drug Metabolism and Disposition December 2013, 41 (12) 2215-2224; DOI: https://doi.org/10.1124/dmd.113.053785
  3. Chan, Tom S.

    1. You have access
      Meeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPac
      Tom S. Chan, Hongbin Yu, Amanda Moore, Salman R. Khetani and Donald Tweedie
      Drug Metabolism and Disposition December 2013, 41 (12) 2024-2032; DOI: https://doi.org/10.1124/dmd.113.053397
  4. Chang, Cheng

    1. You have access
      In Vitro–In Vivo Correlation for Low-Clearance Compounds Using Hepatocyte Relay Method
      Li Di, Karen Atkinson, Christine C. Orozco, Carrie Funk, Hui Zhang, Thomas S. McDonald, Beijing Tan, Jian Lin, Cheng Chang and R. Scott Obach
      Drug Metabolism and Disposition December 2013, 41 (12) 2018-2023; DOI: https://doi.org/10.1124/dmd.113.053322
  5. Christine, Amy

    1. You have access
      Lymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and Rats
      Yan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. Reddy
      Drug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524
  6. Cole, Susan P.C.

    1. You have access
      Two Polymorphic Variants of ABCC1 Selectively Alter Drug Resistance and Inhibitor Sensitivity of the Multidrug and Organic Anion Transporter Multidrug Resistance Protein 1
      Gwenaëlle Conseil and Susan P.C. Cole
      Drug Metabolism and Disposition December 2013, 41 (12) 2187-2196; DOI: https://doi.org/10.1124/dmd.113.054213
  7. Collin, Pierre

    1. You have access
      Modulation of the UGT2B7 Enzyme Activity by C-Terminally Truncated Proteins Derived from Alternative Splicing
      Vincent Ménard, Pierre Collin, Guillaume Margaillan and Chantal Guillemette
      Drug Metabolism and Disposition December 2013, 41 (12) 2197-2205; DOI: https://doi.org/10.1124/dmd.113.053876
  8. Conn, P. Jeffrey

    1. You have access
      Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions
      Anna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott Daniels
      Drug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662
  9. Conseil, Gwenaëlle

    1. You have access
      Two Polymorphic Variants of ABCC1 Selectively Alter Drug Resistance and Inhibitor Sensitivity of the Multidrug and Organic Anion Transporter Multidrug Resistance Protein 1
      Gwenaëlle Conseil and Susan P.C. Cole
      Drug Metabolism and Disposition December 2013, 41 (12) 2187-2196; DOI: https://doi.org/10.1124/dmd.113.054213
  10. Cui, Julia Y.

    1. You have access
      RNA-Sequencing Quantification of Hepatic Ontogeny of Phase-I Enzymes in Mice
      Lai Peng, Julia Y. Cui, Byunggil Yoo, Sumedha S. Gunewardena, Hong Lu, Curtis D. Klaassen and Xiao-bo Zhong
      Drug Metabolism and Disposition December 2013, 41 (12) 2175-2186; DOI: https://doi.org/10.1124/dmd.113.054635
  11. Cunningham, Paul K.

    1. You have access
      Lymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and Rats
      Yan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. Reddy
      Drug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524

D

  1. Dai, Jing

    1. You have access
      Metabolism and Excretion of 6-Chloro-9-(4-methoxy-3,5-dimethylpyridin-2-ylmethyl)-9H-purin-2-ylamine, an HSP90 Inhibitor, in Rats and Dogs and Assessment of Its Metabolic Profile in Plasma of Humans
      Lin Xu, Caroline Woodward, Jing Dai and Chandra Prakash
      Drug Metabolism and Disposition December 2013, 41 (12) 2133-2147; DOI: https://doi.org/10.1124/dmd.113.054023
  2. Daniels, J. Scott

    1. You have access
      Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions
      Anna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott Daniels
      Drug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662
  3. Darbonne, Walter C.

    1. You have access
      Learning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins Antagonist
      Harvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. Fairbrother
      Drug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926
  4. de Morais, Sonia M.

    1. You have access
      In Vitro P-glycoprotein Efflux Ratio Can Predict the In Vivo Brain Penetration Regardless of Biopharmaceutics Drug Disposition Classification System Class
      Ryota Kikuchi, Sonia M. de Morais and J. Cory Kalvass
      Drug Metabolism and Disposition December 2013, 41 (12) 2012-2017; DOI: https://doi.org/10.1124/dmd.113.053868
  5. Desta, Zeruesenay

    1. You have access
      CYP2B6 Pharmacogenetics–Based In Vitro–In Vivo Extrapolation of Efavirenz Clearance by Physiologically Based Pharmacokinetic Modeling
      Cong Xu, Sara K. Quinney, Yingying Guo, Stephen D. Hall, Lang Li and Zeruesenay Desta
      Drug Metabolism and Disposition December 2013, 41 (12) 2004-2011; DOI: https://doi.org/10.1124/dmd.113.051755
  6. Di, Li

    1. You have access
      A Perspective on the Prediction of Drug Pharmacokinetics and Disposition in Drug Research and Development
      Li Di, Bo Feng, Theunis C. Goosen, Yurong Lai, Stefanus J. Steyn, Manthena V. Varma and R. Scott Obach
      Drug Metabolism and Disposition December 2013, 41 (12) 1975-1993; DOI: https://doi.org/10.1124/dmd.113.054031
    2. You have access
      In Vitro–In Vivo Correlation for Low-Clearance Compounds Using Hepatocyte Relay Method
      Li Di, Karen Atkinson, Christine C. Orozco, Carrie Funk, Hui Zhang, Thomas S. McDonald, Beijing Tan, Jian Lin, Cheng Chang and R. Scott Obach
      Drug Metabolism and Disposition December 2013, 41 (12) 2018-2023; DOI: https://doi.org/10.1124/dmd.113.053322
  7. Dolgos, Hugues

    1. You have access
      Utility of In Vitro Systems and Preclinical Data for the Prediction of Human Intestinal First-Pass Metabolism during Drug Discovery and Preclinical Development
      Fredrik H. Karlsson, Salim Bouchene, Constanze Hilgendorf, Hugues Dolgos and Sheila Annie Peters
      Drug Metabolism and Disposition December 2013, 41 (12) 2033-2046; DOI: https://doi.org/10.1124/dmd.113.051664

E

  1. Easterling, Thomas R.

    1. You have access
      Effect of Gestational Age on mRNA and Protein Expression of Polyspecific Organic Cation Transporters during Pregnancy
      Nora Lee, Mary F. Hebert, Bhagwat Prasad, Thomas R. Easterling, Edward J. Kelly, Jashvant D. Unadkat and Joanne Wang
      Drug Metabolism and Disposition December 2013, 41 (12) 2225-2232; DOI: https://doi.org/10.1124/dmd.113.054072
  2. Eng, Heather

    1. You have access
      In Vitro Metabolism of the Glucagon-Like Peptide-1 (GLP-1)–Derived Metabolites GLP-1(9-36)amide and GLP-1(28-36)amide in Mouse and Human Hepatocytes
      Raman Sharma, Thomas S. McDonald, Heather Eng, Chris Limberakis, Benjamin D. Stevens, Sheena Patel and Amit S. Kalgutkar
      Drug Metabolism and Disposition December 2013, 41 (12) 2148-2157; DOI: https://doi.org/10.1124/dmd.113.054254
  3. Erickson, Rebecca

    1. You have access
      Learning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins Antagonist
      Harvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. Fairbrother
      Drug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926
  4. Evangelista, Eric A.

    1. You have access
      Activity, Inhibition, and Induction of Cytochrome P450 2J2 in Adult Human Primary Cardiomyocytes
      Eric A. Evangelista, Rüdiger Kaspera, Nahush A. Mokadam, J. P. Jones and Rheem A. Totah
      Drug Metabolism and Disposition December 2013, 41 (12) 2087-2094; DOI: https://doi.org/10.1124/dmd.113.053389

F

  1. Fairbrother, Wayne J.

    1. You have access
      Learning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins Antagonist
      Harvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. Fairbrother
      Drug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926
  2. Fallon, John K.

    1. You have access
      Targeted Precise Quantification of 12 Human Recombinant Uridine-Diphosphate Glucuronosyl Transferase 1A and 2B Isoforms Using Nano-Ultra-High-Performance Liquid Chromatography/Tandem Mass Spectrometry with Selected Reaction Monitoring
      John K. Fallon, Hendrik Neubert, Theunis C. Goosen and Philip C. Smith
      Drug Metabolism and Disposition December 2013, 41 (12) 2076-2080; DOI: https://doi.org/10.1124/dmd.113.053801
  3. Feng, Bo

    1. You have access
      A Perspective on the Prediction of Drug Pharmacokinetics and Disposition in Drug Research and Development
      Li Di, Bo Feng, Theunis C. Goosen, Yurong Lai, Stefanus J. Steyn, Manthena V. Varma and R. Scott Obach
      Drug Metabolism and Disposition December 2013, 41 (12) 1975-1993; DOI: https://doi.org/10.1124/dmd.113.054031
  4. Fernandes-Lopes, Carlos

    1. You have access
      N-Acetylation of Etamicastat, a Reversible Dopamine-β-Hydroxylase Inhibitor
      Ana I. Loureiro, Carlos Fernandes-Lopes, Maria João Bonifácio, Lyndon C. Wright and Patrício Soares-da-Silva
      Drug Metabolism and Disposition December 2013, 41 (12) 2081-2086; DOI: https://doi.org/10.1124/dmd.113.053736
  5. Flygare, John A.

    1. You have access
      Learning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins Antagonist
      Harvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. Fairbrother
      Drug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926
  6. Fujii, Tomoyuki

    1. You have access
      Characterization of Transplacental Transfer of Paroxetine in Perfused Human Placenta: Development of a Pharmacokinetic Model to Evaluate Tapered Dosing
      Marie Nagai, Hisakazu Ohtani, Hiroki Satoh, Sayo Matsuoka, Satoko Hori, Tomoyuki Fujii, Yuji Taketani and Yasufumi Sawada
      Drug Metabolism and Disposition December 2013, 41 (12) 2124-2132; DOI: https://doi.org/10.1124/dmd.113.052332
  7. Funk, Carrie

    1. You have access
      In Vitro–In Vivo Correlation for Low-Clearance Compounds Using Hepatocyte Relay Method
      Li Di, Karen Atkinson, Christine C. Orozco, Carrie Funk, Hui Zhang, Thomas S. McDonald, Beijing Tan, Jian Lin, Cheng Chang and R. Scott Obach
      Drug Metabolism and Disposition December 2013, 41 (12) 2018-2023; DOI: https://doi.org/10.1124/dmd.113.053322

G

  1. Generaux, Grant T.

    1. You have access
      Impact of Physiologically Based Pharmacokinetic Modeling and Simulation in Drug Development
      Carole E. Shardlow, Grant T. Generaux, Aarti H. Patel, Guoying Tai, Thuy Tran and Jackie C. Bloomer
      Drug Metabolism and Disposition December 2013, 41 (12) 1994-2003; DOI: https://doi.org/10.1124/dmd.113.052803
  2. Goosen, Theunis C.

    1. You have access
      A Perspective on the Prediction of Drug Pharmacokinetics and Disposition in Drug Research and Development
      Li Di, Bo Feng, Theunis C. Goosen, Yurong Lai, Stefanus J. Steyn, Manthena V. Varma and R. Scott Obach
      Drug Metabolism and Disposition December 2013, 41 (12) 1975-1993; DOI: https://doi.org/10.1124/dmd.113.054031
    2. You have access
      Targeted Precise Quantification of 12 Human Recombinant Uridine-Diphosphate Glucuronosyl Transferase 1A and 2B Isoforms Using Nano-Ultra-High-Performance Liquid Chromatography/Tandem Mass Spectrometry with Selected Reaction Monitoring
      John K. Fallon, Hendrik Neubert, Theunis C. Goosen and Philip C. Smith
      Drug Metabolism and Disposition December 2013, 41 (12) 2076-2080; DOI: https://doi.org/10.1124/dmd.113.053801
  3. Gorycki, Peter D.

    1. You have access
      Metabolism and Disposition of Oral Dabrafenib in Cancer Patients: Proposed Participation of Aryl Nitrogen in Carbon-Carbon Bond Cleavage via Decarboxylation following Enzymatic Oxidation
      David A. Bershas, Daniele Ouellet, Donna B. Mamaril-Fishman, Noelia Nebot, Stanley W. Carson, Samuel C. Blackman, Royce A. Morrison, Jerry L. Adams, Kristen E. Jurusik, Dana M. Knecht, Peter D. Gorycki and Lauren E. Richards-Peterson
      Drug Metabolism and Disposition December 2013, 41 (12) 2215-2224; DOI: https://doi.org/10.1124/dmd.113.053785
  4. Gould, Stephen E.

    1. You have access
      Learning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins Antagonist
      Harvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. Fairbrother
      Drug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926
  5. Guillemette, Chantal

    1. You have access
      Modulation of the UGT2B7 Enzyme Activity by C-Terminally Truncated Proteins Derived from Alternative Splicing
      Vincent Ménard, Pierre Collin, Guillaume Margaillan and Chantal Guillemette
      Drug Metabolism and Disposition December 2013, 41 (12) 2197-2205; DOI: https://doi.org/10.1124/dmd.113.053876
  6. Gunewardena, Sumedha S.

    1. You have access
      RNA-Sequencing Quantification of Hepatic Ontogeny of Phase-I Enzymes in Mice
      Lai Peng, Julia Y. Cui, Byunggil Yoo, Sumedha S. Gunewardena, Hong Lu, Curtis D. Klaassen and Xiao-bo Zhong
      Drug Metabolism and Disposition December 2013, 41 (12) 2175-2186; DOI: https://doi.org/10.1124/dmd.113.054635
  7. Guo, Yingying

    1. You have access
      CYP2B6 Pharmacogenetics–Based In Vitro–In Vivo Extrapolation of Efavirenz Clearance by Physiologically Based Pharmacokinetic Modeling
      Cong Xu, Sara K. Quinney, Yingying Guo, Stephen D. Hall, Lang Li and Zeruesenay Desta
      Drug Metabolism and Disposition December 2013, 41 (12) 2004-2011; DOI: https://doi.org/10.1124/dmd.113.051755

H

  1. Hall, Stephen D.

    1. You have access
      CYP2B6 Pharmacogenetics–Based In Vitro–In Vivo Extrapolation of Efavirenz Clearance by Physiologically Based Pharmacokinetic Modeling
      Cong Xu, Sara K. Quinney, Yingying Guo, Stephen D. Hall, Lang Li and Zeruesenay Desta
      Drug Metabolism and Disposition December 2013, 41 (12) 2004-2011; DOI: https://doi.org/10.1124/dmd.113.051755
  2. Halladay, Jason S.

    1. You have access
      Learning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins Antagonist
      Harvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. Fairbrother
      Drug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926
  3. Hebert, Mary F.

    1. You have access
      Effect of Gestational Age on mRNA and Protein Expression of Polyspecific Organic Cation Transporters during Pregnancy
      Nora Lee, Mary F. Hebert, Bhagwat Prasad, Thomas R. Easterling, Edward J. Kelly, Jashvant D. Unadkat and Joanne Wang
      Drug Metabolism and Disposition December 2013, 41 (12) 2225-2232; DOI: https://doi.org/10.1124/dmd.113.054072
  4. Hilgendorf, Constanze

    1. You have access
      Utility of In Vitro Systems and Preclinical Data for the Prediction of Human Intestinal First-Pass Metabolism during Drug Discovery and Preclinical Development
      Fredrik H. Karlsson, Salim Bouchene, Constanze Hilgendorf, Hugues Dolgos and Sheila Annie Peters
      Drug Metabolism and Disposition December 2013, 41 (12) 2033-2046; DOI: https://doi.org/10.1124/dmd.113.051664
  5. Hong, Xuening

    1. You have access
      Lymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and Rats
      Yan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. Reddy
      Drug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524
  6. Hop, Cornelis E. C. A.

    1. You have access
      Learning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins Antagonist
      Harvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. Fairbrother
      Drug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926
  7. Hori, Satoko

    1. You have access
      Characterization of Transplacental Transfer of Paroxetine in Perfused Human Placenta: Development of a Pharmacokinetic Model to Evaluate Tapered Dosing
      Marie Nagai, Hisakazu Ohtani, Hiroki Satoh, Sayo Matsuoka, Satoko Hori, Tomoyuki Fujii, Yuji Taketani and Yasufumi Sawada
      Drug Metabolism and Disposition December 2013, 41 (12) 2124-2132; DOI: https://doi.org/10.1124/dmd.113.052332
  8. Houston, J. Brian

    1. You have access
      Prediction of Human Pharmacokinetics in 2013 and Beyond
      J. Brian Houston
      Drug Metabolism and Disposition December 2013, 41 (12) 1973-1974; DOI: https://doi.org/10.1124/dmd.113.055376

I

  1. Infante, Jeffery R.

    1. You have access
      Learning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins Antagonist
      Harvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. Fairbrother
      Drug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926
  2. Isoherranen, Nina

    1. You have access
      Stereoselective Inhibition of CYP2C19 and CYP3A4 by Fluoxetine and Its Metabolite: Implications for Risk Assessment of Multiple Time-Dependent Inhibitor Systems
      Justin D. Lutz, Brooke M. VandenBrink, Katipudi N. Babu, Wendel L. Nelson, Kent L. Kunze and Nina Isoherranen
      Drug Metabolism and Disposition December 2013, 41 (12) 2056-2065; DOI: https://doi.org/10.1124/dmd.113.052639

J

  1. Jeong, Hyunyoung

    1. You have access
      Characterization of Inhibition Kinetics of (S)-Warfarin Hydroxylation by Noscapine: Implications in Warfarin Therapy
      Nan Zhang, Ryan P. Seguin, Kent L. Kunze, Yan-Yan Zhang and Hyunyoung Jeong
      Drug Metabolism and Disposition December 2013, 41 (12) 2114-2123; DOI: https://doi.org/10.1124/dmd.113.053330
  2. Johnson, Chris V.

    1. You have access
      Lymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and Rats
      Yan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. Reddy
      Drug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524
  3. Jones, Carrie K.

    1. You have access
      Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions
      Anna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott Daniels
      Drug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662
  4. Jones, J. P.

    1. You have access
      Activity, Inhibition, and Induction of Cytochrome P450 2J2 in Adult Human Primary Cardiomyocytes
      Eric A. Evangelista, Rüdiger Kaspera, Nahush A. Mokadam, J. P. Jones and Rheem A. Totah
      Drug Metabolism and Disposition December 2013, 41 (12) 2087-2094; DOI: https://doi.org/10.1124/dmd.113.053389
  5. Jurusik, Kristen E.

    1. You have access
      Metabolism and Disposition of Oral Dabrafenib in Cancer Patients: Proposed Participation of Aryl Nitrogen in Carbon-Carbon Bond Cleavage via Decarboxylation following Enzymatic Oxidation
      David A. Bershas, Daniele Ouellet, Donna B. Mamaril-Fishman, Noelia Nebot, Stanley W. Carson, Samuel C. Blackman, Royce A. Morrison, Jerry L. Adams, Kristen E. Jurusik, Dana M. Knecht, Peter D. Gorycki and Lauren E. Richards-Peterson
      Drug Metabolism and Disposition December 2013, 41 (12) 2215-2224; DOI: https://doi.org/10.1124/dmd.113.053785

K

  1. Kadel, Edward E.

    1. You have access
      Learning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins Antagonist
      Harvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. Fairbrother
      Drug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926
  2. Kalgutkar, Amit S.

    1. You have access
      Drug Metabolites as Cytochrome P450 Inhibitors: A Retrospective Analysis and Proposed Algorithm for Evaluation of the Pharmacokinetic Interaction Potential of Metabolites in Drug Discovery and Development
      Ernesto Callegari, Amit S. Kalgutkar, Louis Leung, R. Scott Obach, David R. Plowchalk and Susanna Tse
      Drug Metabolism and Disposition December 2013, 41 (12) 2047-2055; DOI: https://doi.org/10.1124/dmd.113.052241
    2. You have access
      In Vitro Metabolism of the Glucagon-Like Peptide-1 (GLP-1)–Derived Metabolites GLP-1(9-36)amide and GLP-1(28-36)amide in Mouse and Human Hepatocytes
      Raman Sharma, Thomas S. McDonald, Heather Eng, Chris Limberakis, Benjamin D. Stevens, Sheena Patel and Amit S. Kalgutkar
      Drug Metabolism and Disposition December 2013, 41 (12) 2148-2157; DOI: https://doi.org/10.1124/dmd.113.054254
  3. Kalvass, J. Cory

    1. You have access
      In Vitro P-glycoprotein Efflux Ratio Can Predict the In Vivo Brain Penetration Regardless of Biopharmaceutics Drug Disposition Classification System Class
      Ryota Kikuchi, Sonia M. de Morais and J. Cory Kalvass
      Drug Metabolism and Disposition December 2013, 41 (12) 2012-2017; DOI: https://doi.org/10.1124/dmd.113.053868
  4. Karlsson, Fredrik H.

    1. You have access
      Utility of In Vitro Systems and Preclinical Data for the Prediction of Human Intestinal First-Pass Metabolism during Drug Discovery and Preclinical Development
      Fredrik H. Karlsson, Salim Bouchene, Constanze Hilgendorf, Hugues Dolgos and Sheila Annie Peters
      Drug Metabolism and Disposition December 2013, 41 (12) 2033-2046; DOI: https://doi.org/10.1124/dmd.113.051664
  5. Kaspera, Rüdiger

    1. You have access
      Activity, Inhibition, and Induction of Cytochrome P450 2J2 in Adult Human Primary Cardiomyocytes
      Eric A. Evangelista, Rüdiger Kaspera, Nahush A. Mokadam, J. P. Jones and Rheem A. Totah
      Drug Metabolism and Disposition December 2013, 41 (12) 2087-2094; DOI: https://doi.org/10.1124/dmd.113.053389
  6. Kelly, Edward J.

    1. You have access
      Effect of Gestational Age on mRNA and Protein Expression of Polyspecific Organic Cation Transporters during Pregnancy
      Nora Lee, Mary F. Hebert, Bhagwat Prasad, Thomas R. Easterling, Edward J. Kelly, Jashvant D. Unadkat and Joanne Wang
      Drug Metabolism and Disposition December 2013, 41 (12) 2225-2232; DOI: https://doi.org/10.1124/dmd.113.054072
  7. Kharasch, Evan D.

    1. You have access
      Cytochrome P4503A Does Not Mediate the Interaction between Methadone and Ritonavir-Lopinavir
      Evan D. Kharasch and Kristi Stubbert
      Drug Metabolism and Disposition December 2013, 41 (12) 2166-2174; DOI: https://doi.org/10.1124/dmd.113.053991
  8. Khetani, Salman R.

    1. You have access
      Meeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPac
      Tom S. Chan, Hongbin Yu, Amanda Moore, Salman R. Khetani and Donald Tweedie
      Drug Metabolism and Disposition December 2013, 41 (12) 2024-2032; DOI: https://doi.org/10.1124/dmd.113.053397
  9. Kikuchi, Ryota

    1. You have access
      In Vitro P-glycoprotein Efflux Ratio Can Predict the In Vivo Brain Penetration Regardless of Biopharmaceutics Drug Disposition Classification System Class
      Ryota Kikuchi, Sonia M. de Morais and J. Cory Kalvass
      Drug Metabolism and Disposition December 2013, 41 (12) 2012-2017; DOI: https://doi.org/10.1124/dmd.113.053868
  10. Klaassen, Curtis D.

    1. You have access
      RNA-Sequencing Quantification of Hepatic Ontogeny of Phase-I Enzymes in Mice
      Lai Peng, Julia Y. Cui, Byunggil Yoo, Sumedha S. Gunewardena, Hong Lu, Curtis D. Klaassen and Xiao-bo Zhong
      Drug Metabolism and Disposition December 2013, 41 (12) 2175-2186; DOI: https://doi.org/10.1124/dmd.113.054635
  11. Knecht, Dana M.

    1. You have access
      Metabolism and Disposition of Oral Dabrafenib in Cancer Patients: Proposed Participation of Aryl Nitrogen in Carbon-Carbon Bond Cleavage via Decarboxylation following Enzymatic Oxidation
      David A. Bershas, Daniele Ouellet, Donna B. Mamaril-Fishman, Noelia Nebot, Stanley W. Carson, Samuel C. Blackman, Royce A. Morrison, Jerry L. Adams, Kristen E. Jurusik, Dana M. Knecht, Peter D. Gorycki and Lauren E. Richards-Peterson
      Drug Metabolism and Disposition December 2013, 41 (12) 2215-2224; DOI: https://doi.org/10.1124/dmd.113.053785
  12. Kumar, Sanjeev

    1. You have access
      Lymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and Rats
      Yan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. Reddy
      Drug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524
  13. Kunze, Kent L.

    1. You have access
      Stereoselective Inhibition of CYP2C19 and CYP3A4 by Fluoxetine and Its Metabolite: Implications for Risk Assessment of Multiple Time-Dependent Inhibitor Systems
      Justin D. Lutz, Brooke M. VandenBrink, Katipudi N. Babu, Wendel L. Nelson, Kent L. Kunze and Nina Isoherranen
      Drug Metabolism and Disposition December 2013, 41 (12) 2056-2065; DOI: https://doi.org/10.1124/dmd.113.052639
    2. You have access
      Characterization of Inhibition Kinetics of (S)-Warfarin Hydroxylation by Noscapine: Implications in Warfarin Therapy
      Nan Zhang, Ryan P. Seguin, Kent L. Kunze, Yan-Yan Zhang and Hyunyoung Jeong
      Drug Metabolism and Disposition December 2013, 41 (12) 2114-2123; DOI: https://doi.org/10.1124/dmd.113.053330

L

  1. La, Hank

    1. You have access
      Learning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins Antagonist
      Harvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. Fairbrother
      Drug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926
  2. Lai, Yurong

    1. You have access
      A Perspective on the Prediction of Drug Pharmacokinetics and Disposition in Drug Research and Development
      Li Di, Bo Feng, Theunis C. Goosen, Yurong Lai, Stefanus J. Steyn, Manthena V. Varma and R. Scott Obach
      Drug Metabolism and Disposition December 2013, 41 (12) 1975-1993; DOI: https://doi.org/10.1124/dmd.113.054031
  3. Lavreysen, Hilde

    1. You have access
      Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions
      Anna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott Daniels
      Drug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662
  4. Lee, Nora

    1. You have access
      Effect of Gestational Age on mRNA and Protein Expression of Polyspecific Organic Cation Transporters during Pregnancy
      Nora Lee, Mary F. Hebert, Bhagwat Prasad, Thomas R. Easterling, Edward J. Kelly, Jashvant D. Unadkat and Joanne Wang
      Drug Metabolism and Disposition December 2013, 41 (12) 2225-2232; DOI: https://doi.org/10.1124/dmd.113.054072
  5. Leung, Louis

    1. You have access
      Drug Metabolites as Cytochrome P450 Inhibitors: A Retrospective Analysis and Proposed Algorithm for Evaluation of the Pharmacokinetic Interaction Potential of Metabolites in Drug Discovery and Development
      Ernesto Callegari, Amit S. Kalgutkar, Louis Leung, R. Scott Obach, David R. Plowchalk and Susanna Tse
      Drug Metabolism and Disposition December 2013, 41 (12) 2047-2055; DOI: https://doi.org/10.1124/dmd.113.052241
  6. Li, Hua

    1. You have access
      Assessment of the Roles of P-glycoprotein and Cytochrome P450 in Triptolide-induced Liver Toxicity in Sandwich-Cultured Rat Hepatocyte Model
      Xiao-Mei Zhuang, Guo-Lin Shen, Wei-Bin Xiao, Yan Tan, Chuang Lu and Hua Li
      Drug Metabolism and Disposition December 2013, 41 (12) 2158-2165; DOI: https://doi.org/10.1124/dmd.113.054056
  7. Li, Lang

    1. You have access
      CYP2B6 Pharmacogenetics–Based In Vitro–In Vivo Extrapolation of Efavirenz Clearance by Physiologically Based Pharmacokinetic Modeling
      Cong Xu, Sara K. Quinney, Yingying Guo, Stephen D. Hall, Lang Li and Zeruesenay Desta
      Drug Metabolism and Disposition December 2013, 41 (12) 2004-2011; DOI: https://doi.org/10.1124/dmd.113.051755
  8. Limberakis, Chris

    1. You have access
      In Vitro Metabolism of the Glucagon-Like Peptide-1 (GLP-1)–Derived Metabolites GLP-1(9-36)amide and GLP-1(28-36)amide in Mouse and Human Hepatocytes
      Raman Sharma, Thomas S. McDonald, Heather Eng, Chris Limberakis, Benjamin D. Stevens, Sheena Patel and Amit S. Kalgutkar
      Drug Metabolism and Disposition December 2013, 41 (12) 2148-2157; DOI: https://doi.org/10.1124/dmd.113.054254
  9. Lin, Jian

    1. You have access
      In Vitro–In Vivo Correlation for Low-Clearance Compounds Using Hepatocyte Relay Method
      Li Di, Karen Atkinson, Christine C. Orozco, Carrie Funk, Hui Zhang, Thomas S. McDonald, Beijing Tan, Jian Lin, Cheng Chang and R. Scott Obach
      Drug Metabolism and Disposition December 2013, 41 (12) 2018-2023; DOI: https://doi.org/10.1124/dmd.113.053322
  10. Lindsley, Craig W.

    1. You have access
      Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions
      Anna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott Daniels
      Drug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662
  11. Loureiro, Ana I.

    1. You have access
      N-Acetylation of Etamicastat, a Reversible Dopamine-β-Hydroxylase Inhibitor
      Ana I. Loureiro, Carlos Fernandes-Lopes, Maria João Bonifácio, Lyndon C. Wright and Patrício Soares-da-Silva
      Drug Metabolism and Disposition December 2013, 41 (12) 2081-2086; DOI: https://doi.org/10.1124/dmd.113.053736
  12. Lu, Chuang

    1. You have access
      Assessment of the Roles of P-glycoprotein and Cytochrome P450 in Triptolide-induced Liver Toxicity in Sandwich-Cultured Rat Hepatocyte Model
      Xiao-Mei Zhuang, Guo-Lin Shen, Wei-Bin Xiao, Yan Tan, Chuang Lu and Hua Li
      Drug Metabolism and Disposition December 2013, 41 (12) 2158-2165; DOI: https://doi.org/10.1124/dmd.113.054056
  13. Lu, Hong

    1. You have access
      RNA-Sequencing Quantification of Hepatic Ontogeny of Phase-I Enzymes in Mice
      Lai Peng, Julia Y. Cui, Byunggil Yoo, Sumedha S. Gunewardena, Hong Lu, Curtis D. Klaassen and Xiao-bo Zhong
      Drug Metabolism and Disposition December 2013, 41 (12) 2175-2186; DOI: https://doi.org/10.1124/dmd.113.054635
  14. Lutz, Justin D.

    1. You have access
      Stereoselective Inhibition of CYP2C19 and CYP3A4 by Fluoxetine and Its Metabolite: Implications for Risk Assessment of Multiple Time-Dependent Inhibitor Systems
      Justin D. Lutz, Brooke M. VandenBrink, Katipudi N. Babu, Wendel L. Nelson, Kent L. Kunze and Nina Isoherranen
      Drug Metabolism and Disposition December 2013, 41 (12) 2056-2065; DOI: https://doi.org/10.1124/dmd.113.052639

M

  1. MacDonald, Gregor J.

    1. You have access
      Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions
      Anna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott Daniels
      Drug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662
  2. Mackie, Claire

    1. You have access
      Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions
      Anna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott Daniels
      Drug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662
  3. Mamaril-Fishman, Donna B.

    1. You have access
      Metabolism and Disposition of Oral Dabrafenib in Cancer Patients: Proposed Participation of Aryl Nitrogen in Carbon-Carbon Bond Cleavage via Decarboxylation following Enzymatic Oxidation
      David A. Bershas, Daniele Ouellet, Donna B. Mamaril-Fishman, Noelia Nebot, Stanley W. Carson, Samuel C. Blackman, Royce A. Morrison, Jerry L. Adams, Kristen E. Jurusik, Dana M. Knecht, Peter D. Gorycki and Lauren E. Richards-Peterson
      Drug Metabolism and Disposition December 2013, 41 (12) 2215-2224; DOI: https://doi.org/10.1124/dmd.113.053785
  4. Mamounas, Michael

    1. You have access
      Learning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins Antagonist
      Harvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. Fairbrother
      Drug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926
  5. Margaillan, Guillaume

    1. You have access
      Modulation of the UGT2B7 Enzyme Activity by C-Terminally Truncated Proteins Derived from Alternative Splicing
      Vincent Ménard, Pierre Collin, Guillaume Margaillan and Chantal Guillemette
      Drug Metabolism and Disposition December 2013, 41 (12) 2197-2205; DOI: https://doi.org/10.1124/dmd.113.053876
  6. Matsuoka, Sayo

    1. You have access
      Characterization of Transplacental Transfer of Paroxetine in Perfused Human Placenta: Development of a Pharmacokinetic Model to Evaluate Tapered Dosing
      Marie Nagai, Hisakazu Ohtani, Hiroki Satoh, Sayo Matsuoka, Satoko Hori, Tomoyuki Fujii, Yuji Taketani and Yasufumi Sawada
      Drug Metabolism and Disposition December 2013, 41 (12) 2124-2132; DOI: https://doi.org/10.1124/dmd.113.052332
  7. Mattmann, Margrith E.

    1. You have access
      Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions
      Anna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott Daniels
      Drug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662
  8. McDonald, Thomas S.

    1. You have access
      In Vitro Metabolism of the Glucagon-Like Peptide-1 (GLP-1)–Derived Metabolites GLP-1(9-36)amide and GLP-1(28-36)amide in Mouse and Human Hepatocytes
      Raman Sharma, Thomas S. McDonald, Heather Eng, Chris Limberakis, Benjamin D. Stevens, Sheena Patel and Amit S. Kalgutkar
      Drug Metabolism and Disposition December 2013, 41 (12) 2148-2157; DOI: https://doi.org/10.1124/dmd.113.054254
    2. You have access
      In Vitro–In Vivo Correlation for Low-Clearance Compounds Using Hepatocyte Relay Method
      Li Di, Karen Atkinson, Christine C. Orozco, Carrie Funk, Hui Zhang, Thomas S. McDonald, Beijing Tan, Jian Lin, Cheng Chang and R. Scott Obach
      Drug Metabolism and Disposition December 2013, 41 (12) 2018-2023; DOI: https://doi.org/10.1124/dmd.113.053322
  9. Ménard, Vincent

    1. You have access
      Modulation of the UGT2B7 Enzyme Activity by C-Terminally Truncated Proteins Derived from Alternative Splicing
      Vincent Ménard, Pierre Collin, Guillaume Margaillan and Chantal Guillemette
      Drug Metabolism and Disposition December 2013, 41 (12) 2197-2205; DOI: https://doi.org/10.1124/dmd.113.053876
  10. Mokadam, Nahush A.

    1. You have access
      Activity, Inhibition, and Induction of Cytochrome P450 2J2 in Adult Human Primary Cardiomyocytes
      Eric A. Evangelista, Rüdiger Kaspera, Nahush A. Mokadam, J. P. Jones and Rheem A. Totah
      Drug Metabolism and Disposition December 2013, 41 (12) 2087-2094; DOI: https://doi.org/10.1124/dmd.113.053389
  11. Moore, Amanda

    1. You have access
      Meeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPac
      Tom S. Chan, Hongbin Yu, Amanda Moore, Salman R. Khetani and Donald Tweedie
      Drug Metabolism and Disposition December 2013, 41 (12) 2024-2032; DOI: https://doi.org/10.1124/dmd.113.053397
  12. Morrison, Royce A.

    1. You have access
      Metabolism and Disposition of Oral Dabrafenib in Cancer Patients: Proposed Participation of Aryl Nitrogen in Carbon-Carbon Bond Cleavage via Decarboxylation following Enzymatic Oxidation
      David A. Bershas, Daniele Ouellet, Donna B. Mamaril-Fishman, Noelia Nebot, Stanley W. Carson, Samuel C. Blackman, Royce A. Morrison, Jerry L. Adams, Kristen E. Jurusik, Dana M. Knecht, Peter D. Gorycki and Lauren E. Richards-Peterson
      Drug Metabolism and Disposition December 2013, 41 (12) 2215-2224; DOI: https://doi.org/10.1124/dmd.113.053785
  13. Morrison, Ryan D.

    1. You have access
      Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions
      Anna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott Daniels
      Drug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662

N

  1. Nagai, Marie

    1. You have access
      Characterization of Transplacental Transfer of Paroxetine in Perfused Human Placenta: Development of a Pharmacokinetic Model to Evaluate Tapered Dosing
      Marie Nagai, Hisakazu Ohtani, Hiroki Satoh, Sayo Matsuoka, Satoko Hori, Tomoyuki Fujii, Yuji Taketani and Yasufumi Sawada
      Drug Metabolism and Disposition December 2013, 41 (12) 2124-2132; DOI: https://doi.org/10.1124/dmd.113.052332
  2. Nebot, Noelia

    1. You have access
      Metabolism and Disposition of Oral Dabrafenib in Cancer Patients: Proposed Participation of Aryl Nitrogen in Carbon-Carbon Bond Cleavage via Decarboxylation following Enzymatic Oxidation
      David A. Bershas, Daniele Ouellet, Donna B. Mamaril-Fishman, Noelia Nebot, Stanley W. Carson, Samuel C. Blackman, Royce A. Morrison, Jerry L. Adams, Kristen E. Jurusik, Dana M. Knecht, Peter D. Gorycki and Lauren E. Richards-Peterson
      Drug Metabolism and Disposition December 2013, 41 (12) 2215-2224; DOI: https://doi.org/10.1124/dmd.113.053785
  3. Nelson, Wendel L.

    1. You have access
      Stereoselective Inhibition of CYP2C19 and CYP3A4 by Fluoxetine and Its Metabolite: Implications for Risk Assessment of Multiple Time-Dependent Inhibitor Systems
      Justin D. Lutz, Brooke M. VandenBrink, Katipudi N. Babu, Wendel L. Nelson, Kent L. Kunze and Nina Isoherranen
      Drug Metabolism and Disposition December 2013, 41 (12) 2056-2065; DOI: https://doi.org/10.1124/dmd.113.052639
  4. Neubert, Hendrik

    1. You have access
      Targeted Precise Quantification of 12 Human Recombinant Uridine-Diphosphate Glucuronosyl Transferase 1A and 2B Isoforms Using Nano-Ultra-High-Performance Liquid Chromatography/Tandem Mass Spectrometry with Selected Reaction Monitoring
      John K. Fallon, Hendrik Neubert, Theunis C. Goosen and Philip C. Smith
      Drug Metabolism and Disposition December 2013, 41 (12) 2076-2080; DOI: https://doi.org/10.1124/dmd.113.053801
  5. Niswender, Colleen M.

    1. You have access
      Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions
      Anna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott Daniels
      Drug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662
  6. Nunes, Christian N.

    1. You have access
      Lymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and Rats
      Yan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. Reddy
      Drug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524

O

  1. Obach, R. Scott

    1. You have access
      Drug Metabolites as Cytochrome P450 Inhibitors: A Retrospective Analysis and Proposed Algorithm for Evaluation of the Pharmacokinetic Interaction Potential of Metabolites in Drug Discovery and Development
      Ernesto Callegari, Amit S. Kalgutkar, Louis Leung, R. Scott Obach, David R. Plowchalk and Susanna Tse
      Drug Metabolism and Disposition December 2013, 41 (12) 2047-2055; DOI: https://doi.org/10.1124/dmd.113.052241
    2. You have access
      A Perspective on the Prediction of Drug Pharmacokinetics and Disposition in Drug Research and Development
      Li Di, Bo Feng, Theunis C. Goosen, Yurong Lai, Stefanus J. Steyn, Manthena V. Varma and R. Scott Obach
      Drug Metabolism and Disposition December 2013, 41 (12) 1975-1993; DOI: https://doi.org/10.1124/dmd.113.054031
    3. You have access
      In Vitro–In Vivo Correlation for Low-Clearance Compounds Using Hepatocyte Relay Method
      Li Di, Karen Atkinson, Christine C. Orozco, Carrie Funk, Hui Zhang, Thomas S. McDonald, Beijing Tan, Jian Lin, Cheng Chang and R. Scott Obach
      Drug Metabolism and Disposition December 2013, 41 (12) 2018-2023; DOI: https://doi.org/10.1124/dmd.113.053322
  2. Ohtani, Hisakazu

    1. You have access
      Characterization of Transplacental Transfer of Paroxetine in Perfused Human Placenta: Development of a Pharmacokinetic Model to Evaluate Tapered Dosing
      Marie Nagai, Hisakazu Ohtani, Hiroki Satoh, Sayo Matsuoka, Satoko Hori, Tomoyuki Fujii, Yuji Taketani and Yasufumi Sawada
      Drug Metabolism and Disposition December 2013, 41 (12) 2124-2132; DOI: https://doi.org/10.1124/dmd.113.052332
  3. Orozco, Christine C.

    1. You have access
      In Vitro–In Vivo Correlation for Low-Clearance Compounds Using Hepatocyte Relay Method
      Li Di, Karen Atkinson, Christine C. Orozco, Carrie Funk, Hui Zhang, Thomas S. McDonald, Beijing Tan, Jian Lin, Cheng Chang and R. Scott Obach
      Drug Metabolism and Disposition December 2013, 41 (12) 2018-2023; DOI: https://doi.org/10.1124/dmd.113.053322
  4. Ouellet, Daniele

    1. You have access
      Metabolism and Disposition of Oral Dabrafenib in Cancer Patients: Proposed Participation of Aryl Nitrogen in Carbon-Carbon Bond Cleavage via Decarboxylation following Enzymatic Oxidation
      David A. Bershas, Daniele Ouellet, Donna B. Mamaril-Fishman, Noelia Nebot, Stanley W. Carson, Samuel C. Blackman, Royce A. Morrison, Jerry L. Adams, Kristen E. Jurusik, Dana M. Knecht, Peter D. Gorycki and Lauren E. Richards-Peterson
      Drug Metabolism and Disposition December 2013, 41 (12) 2215-2224; DOI: https://doi.org/10.1124/dmd.113.053785

P

  1. Patel, Aarti H.

    1. You have access
      Impact of Physiologically Based Pharmacokinetic Modeling and Simulation in Drug Development
      Carole E. Shardlow, Grant T. Generaux, Aarti H. Patel, Guoying Tai, Thuy Tran and Jackie C. Bloomer
      Drug Metabolism and Disposition December 2013, 41 (12) 1994-2003; DOI: https://doi.org/10.1124/dmd.113.052803
  2. Patel, Sheena

    1. You have access
      In Vitro Metabolism of the Glucagon-Like Peptide-1 (GLP-1)–Derived Metabolites GLP-1(9-36)amide and GLP-1(28-36)amide in Mouse and Human Hepatocytes
      Raman Sharma, Thomas S. McDonald, Heather Eng, Chris Limberakis, Benjamin D. Stevens, Sheena Patel and Amit S. Kalgutkar
      Drug Metabolism and Disposition December 2013, 41 (12) 2148-2157; DOI: https://doi.org/10.1124/dmd.113.054254
  3. Peng, Lai

    1. You have access
      RNA-Sequencing Quantification of Hepatic Ontogeny of Phase-I Enzymes in Mice
      Lai Peng, Julia Y. Cui, Byunggil Yoo, Sumedha S. Gunewardena, Hong Lu, Curtis D. Klaassen and Xiao-bo Zhong
      Drug Metabolism and Disposition December 2013, 41 (12) 2175-2186; DOI: https://doi.org/10.1124/dmd.113.054635
  4. Peters, Sheila Annie

    1. You have access
      Utility of In Vitro Systems and Preclinical Data for the Prediction of Human Intestinal First-Pass Metabolism during Drug Discovery and Preclinical Development
      Fredrik H. Karlsson, Salim Bouchene, Constanze Hilgendorf, Hugues Dolgos and Sheila Annie Peters
      Drug Metabolism and Disposition December 2013, 41 (12) 2033-2046; DOI: https://doi.org/10.1124/dmd.113.051664
  5. Plowchalk, David R.

    1. You have access
      Drug Metabolites as Cytochrome P450 Inhibitors: A Retrospective Analysis and Proposed Algorithm for Evaluation of the Pharmacokinetic Interaction Potential of Metabolites in Drug Discovery and Development
      Ernesto Callegari, Amit S. Kalgutkar, Louis Leung, R. Scott Obach, David R. Plowchalk and Susanna Tse
      Drug Metabolism and Disposition December 2013, 41 (12) 2047-2055; DOI: https://doi.org/10.1124/dmd.113.052241
  6. Portera, Chia

    1. You have access
      Learning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins Antagonist
      Harvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. Fairbrother
      Drug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926
  7. Prakash, Chandra

    1. You have access
      Metabolism and Excretion of 6-Chloro-9-(4-methoxy-3,5-dimethylpyridin-2-ylmethyl)-9H-purin-2-ylamine, an HSP90 Inhibitor, in Rats and Dogs and Assessment of Its Metabolic Profile in Plasma of Humans
      Lin Xu, Caroline Woodward, Jing Dai and Chandra Prakash
      Drug Metabolism and Disposition December 2013, 41 (12) 2133-2147; DOI: https://doi.org/10.1124/dmd.113.054023
  8. Prasad, Bhagwat

    1. You have access
      Effect of Gestational Age on mRNA and Protein Expression of Polyspecific Organic Cation Transporters during Pregnancy
      Nora Lee, Mary F. Hebert, Bhagwat Prasad, Thomas R. Easterling, Edward J. Kelly, Jashvant D. Unadkat and Joanne Wang
      Drug Metabolism and Disposition December 2013, 41 (12) 2225-2232; DOI: https://doi.org/10.1124/dmd.113.054072

Q

  1. Quinney, Sara K.

    1. You have access
      CYP2B6 Pharmacogenetics–Based In Vitro–In Vivo Extrapolation of Efavirenz Clearance by Physiologically Based Pharmacokinetic Modeling
      Cong Xu, Sara K. Quinney, Yingying Guo, Stephen D. Hall, Lang Li and Zeruesenay Desta
      Drug Metabolism and Disposition December 2013, 41 (12) 2004-2011; DOI: https://doi.org/10.1124/dmd.113.051755

R

  1. Reddy, Vijay Bhasker G.

    1. You have access
      Lymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and Rats
      Yan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. Reddy
      Drug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524
  2. Richards-Peterson, Lauren E.

    1. You have access
      Metabolism and Disposition of Oral Dabrafenib in Cancer Patients: Proposed Participation of Aryl Nitrogen in Carbon-Carbon Bond Cleavage via Decarboxylation following Enzymatic Oxidation
      David A. Bershas, Daniele Ouellet, Donna B. Mamaril-Fishman, Noelia Nebot, Stanley W. Carson, Samuel C. Blackman, Royce A. Morrison, Jerry L. Adams, Kristen E. Jurusik, Dana M. Knecht, Peter D. Gorycki and Lauren E. Richards-Peterson
      Drug Metabolism and Disposition December 2013, 41 (12) 2215-2224; DOI: https://doi.org/10.1124/dmd.113.053785
  3. Rodrigues, A. David

    1. You have access
      Assessment of Vandetanib as an Inhibitor of Various Human Renal Transporters: Inhibition of Multidrug and Toxin Extrusion as a Possible Mechanism Leading to Decreased Cisplatin and Creatinine Clearance
      Hong Shen, Zheng Yang, Weiping Zhao, Yueping Zhang and A. David Rodrigues
      Drug Metabolism and Disposition December 2013, 41 (12) 2095-2103; DOI: https://doi.org/10.1124/dmd.113.053215

S

  1. Satoh, Hiroki

    1. You have access
      Characterization of Transplacental Transfer of Paroxetine in Perfused Human Placenta: Development of a Pharmacokinetic Model to Evaluate Tapered Dosing
      Marie Nagai, Hisakazu Ohtani, Hiroki Satoh, Sayo Matsuoka, Satoko Hori, Tomoyuki Fujii, Yuji Taketani and Yasufumi Sawada
      Drug Metabolism and Disposition December 2013, 41 (12) 2124-2132; DOI: https://doi.org/10.1124/dmd.113.052332
  2. Sawada, Yasufumi

    1. You have access
      Characterization of Transplacental Transfer of Paroxetine in Perfused Human Placenta: Development of a Pharmacokinetic Model to Evaluate Tapered Dosing
      Marie Nagai, Hisakazu Ohtani, Hiroki Satoh, Sayo Matsuoka, Satoko Hori, Tomoyuki Fujii, Yuji Taketani and Yasufumi Sawada
      Drug Metabolism and Disposition December 2013, 41 (12) 2124-2132; DOI: https://doi.org/10.1124/dmd.113.052332
  3. Seguin, Ryan P.

    1. You have access
      Characterization of Inhibition Kinetics of (S)-Warfarin Hydroxylation by Noscapine: Implications in Warfarin Therapy
      Nan Zhang, Ryan P. Seguin, Kent L. Kunze, Yan-Yan Zhang and Hyunyoung Jeong
      Drug Metabolism and Disposition December 2013, 41 (12) 2114-2123; DOI: https://doi.org/10.1124/dmd.113.053330
  4. Shardlow, Carole E.

    1. You have access
      Impact of Physiologically Based Pharmacokinetic Modeling and Simulation in Drug Development
      Carole E. Shardlow, Grant T. Generaux, Aarti H. Patel, Guoying Tai, Thuy Tran and Jackie C. Bloomer
      Drug Metabolism and Disposition December 2013, 41 (12) 1994-2003; DOI: https://doi.org/10.1124/dmd.113.052803
  5. Sharma, Raman

    1. You have access
      In Vitro Metabolism of the Glucagon-Like Peptide-1 (GLP-1)–Derived Metabolites GLP-1(9-36)amide and GLP-1(28-36)amide in Mouse and Human Hepatocytes
      Raman Sharma, Thomas S. McDonald, Heather Eng, Chris Limberakis, Benjamin D. Stevens, Sheena Patel and Amit S. Kalgutkar
      Drug Metabolism and Disposition December 2013, 41 (12) 2148-2157; DOI: https://doi.org/10.1124/dmd.113.054254
  6. Shen, Guo-Lin

    1. You have access
      Assessment of the Roles of P-glycoprotein and Cytochrome P450 in Triptolide-induced Liver Toxicity in Sandwich-Cultured Rat Hepatocyte Model
      Xiao-Mei Zhuang, Guo-Lin Shen, Wei-Bin Xiao, Yan Tan, Chuang Lu and Hua Li
      Drug Metabolism and Disposition December 2013, 41 (12) 2158-2165; DOI: https://doi.org/10.1124/dmd.113.054056
  7. Shen, Hong

    1. You have access
      Assessment of Vandetanib as an Inhibitor of Various Human Renal Transporters: Inhibition of Multidrug and Toxin Extrusion as a Possible Mechanism Leading to Decreased Cisplatin and Creatinine Clearance
      Hong Shen, Zheng Yang, Weiping Zhao, Yueping Zhang and A. David Rodrigues
      Drug Metabolism and Disposition December 2013, 41 (12) 2095-2103; DOI: https://doi.org/10.1124/dmd.113.053215
  8. Shen, Xiaolan

    1. You have access
      Lymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and Rats
      Yan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. Reddy
      Drug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524
  9. Smith, Philip C.

    1. You have access
      Targeted Precise Quantification of 12 Human Recombinant Uridine-Diphosphate Glucuronosyl Transferase 1A and 2B Isoforms Using Nano-Ultra-High-Performance Liquid Chromatography/Tandem Mass Spectrometry with Selected Reaction Monitoring
      John K. Fallon, Hendrik Neubert, Theunis C. Goosen and Philip C. Smith
      Drug Metabolism and Disposition December 2013, 41 (12) 2076-2080; DOI: https://doi.org/10.1124/dmd.113.053801
  10. Soares-da-Silva, Patrício

    1. You have access
      N-Acetylation of Etamicastat, a Reversible Dopamine-β-Hydroxylase Inhibitor
      Ana I. Loureiro, Carlos Fernandes-Lopes, Maria João Bonifácio, Lyndon C. Wright and Patrício Soares-da-Silva
      Drug Metabolism and Disposition December 2013, 41 (12) 2081-2086; DOI: https://doi.org/10.1124/dmd.113.053736
  11. Staskiewicz, Steve J.

    1. You have access
      Lymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and Rats
      Yan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. Reddy
      Drug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524
  12. Stauffer, Shaun R.

    1. You have access
      Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions
      Anna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott Daniels
      Drug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662
  13. Steckler, Thomas

    1. You have access
      Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions
      Anna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott Daniels
      Drug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662
  14. Stevens, Benjamin D.

    1. You have access
      In Vitro Metabolism of the Glucagon-Like Peptide-1 (GLP-1)–Derived Metabolites GLP-1(9-36)amide and GLP-1(28-36)amide in Mouse and Human Hepatocytes
      Raman Sharma, Thomas S. McDonald, Heather Eng, Chris Limberakis, Benjamin D. Stevens, Sheena Patel and Amit S. Kalgutkar
      Drug Metabolism and Disposition December 2013, 41 (12) 2148-2157; DOI: https://doi.org/10.1124/dmd.113.054254
  15. Steyn, Stefanus J.

    1. You have access
      A Perspective on the Prediction of Drug Pharmacokinetics and Disposition in Drug Research and Development
      Li Di, Bo Feng, Theunis C. Goosen, Yurong Lai, Stefanus J. Steyn, Manthena V. Varma and R. Scott Obach
      Drug Metabolism and Disposition December 2013, 41 (12) 1975-1993; DOI: https://doi.org/10.1124/dmd.113.054031
  16. Stubbert, Kristi

    1. You have access
      Cytochrome P4503A Does Not Mediate the Interaction between Methadone and Ritonavir-Lopinavir
      Evan D. Kharasch and Kristi Stubbert
      Drug Metabolism and Disposition December 2013, 41 (12) 2166-2174; DOI: https://doi.org/10.1124/dmd.113.053991

T

  1. Tai, Guoying

    1. You have access
      Impact of Physiologically Based Pharmacokinetic Modeling and Simulation in Drug Development
      Carole E. Shardlow, Grant T. Generaux, Aarti H. Patel, Guoying Tai, Thuy Tran and Jackie C. Bloomer
      Drug Metabolism and Disposition December 2013, 41 (12) 1994-2003; DOI: https://doi.org/10.1124/dmd.113.052803
  2. Taketani, Yuji

    1. You have access
      Characterization of Transplacental Transfer of Paroxetine in Perfused Human Placenta: Development of a Pharmacokinetic Model to Evaluate Tapered Dosing
      Marie Nagai, Hisakazu Ohtani, Hiroki Satoh, Sayo Matsuoka, Satoko Hori, Tomoyuki Fujii, Yuji Taketani and Yasufumi Sawada
      Drug Metabolism and Disposition December 2013, 41 (12) 2124-2132; DOI: https://doi.org/10.1124/dmd.113.052332
  3. Tan, Beijing

    1. You have access
      In Vitro–In Vivo Correlation for Low-Clearance Compounds Using Hepatocyte Relay Method
      Li Di, Karen Atkinson, Christine C. Orozco, Carrie Funk, Hui Zhang, Thomas S. McDonald, Beijing Tan, Jian Lin, Cheng Chang and R. Scott Obach
      Drug Metabolism and Disposition December 2013, 41 (12) 2018-2023; DOI: https://doi.org/10.1124/dmd.113.053322
  4. Tan, Yan

    1. You have access
      Assessment of the Roles of P-glycoprotein and Cytochrome P450 in Triptolide-induced Liver Toxicity in Sandwich-Cultured Rat Hepatocyte Model
      Xiao-Mei Zhuang, Guo-Lin Shen, Wei-Bin Xiao, Yan Tan, Chuang Lu and Hua Li
      Drug Metabolism and Disposition December 2013, 41 (12) 2158-2165; DOI: https://doi.org/10.1124/dmd.113.054056
  5. Tolcher, Anthony W.

    1. You have access
      Learning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins Antagonist
      Harvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. Fairbrother
      Drug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926
  6. Totah, Rheem A.

    1. You have access
      Activity, Inhibition, and Induction of Cytochrome P450 2J2 in Adult Human Primary Cardiomyocytes
      Eric A. Evangelista, Rüdiger Kaspera, Nahush A. Mokadam, J. P. Jones and Rheem A. Totah
      Drug Metabolism and Disposition December 2013, 41 (12) 2087-2094; DOI: https://doi.org/10.1124/dmd.113.053389
  7. Tran, Thuy

    1. You have access
      Impact of Physiologically Based Pharmacokinetic Modeling and Simulation in Drug Development
      Carole E. Shardlow, Grant T. Generaux, Aarti H. Patel, Guoying Tai, Thuy Tran and Jackie C. Bloomer
      Drug Metabolism and Disposition December 2013, 41 (12) 1994-2003; DOI: https://doi.org/10.1124/dmd.113.052803
  8. Trinh, Tu

    1. You have access
      Lymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and Rats
      Yan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. Reddy
      Drug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524
  9. Tse, Susanna

    1. You have access
      Drug Metabolites as Cytochrome P450 Inhibitors: A Retrospective Analysis and Proposed Algorithm for Evaluation of the Pharmacokinetic Interaction Potential of Metabolites in Drug Discovery and Development
      Ernesto Callegari, Amit S. Kalgutkar, Louis Leung, R. Scott Obach, David R. Plowchalk and Susanna Tse
      Drug Metabolism and Disposition December 2013, 41 (12) 2047-2055; DOI: https://doi.org/10.1124/dmd.113.052241
  10. Turlington, Mark L.

    1. You have access
      Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions
      Anna L. Blobaum, Thomas M. Bridges, Frank W. Byers, Mark L. Turlington, Margrith E. Mattmann, Ryan D. Morrison, Claire Mackie, Hilde Lavreysen, José M. Bartolomé, Gregor J. MacDonald, Thomas Steckler, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer and J. Scott Daniels
      Drug Metabolism and Disposition December 2013, 41 (12) 2066-2075; DOI: https://doi.org/10.1124/dmd.113.052662
  11. Tweedie, Donald

    1. You have access
      Meeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPac
      Tom S. Chan, Hongbin Yu, Amanda Moore, Salman R. Khetani and Donald Tweedie
      Drug Metabolism and Disposition December 2013, 41 (12) 2024-2032; DOI: https://doi.org/10.1124/dmd.113.053397

U

  1. Unadkat, Jashvant D.

    1. You have access
      Effect of Gestational Age on mRNA and Protein Expression of Polyspecific Organic Cation Transporters during Pregnancy
      Nora Lee, Mary F. Hebert, Bhagwat Prasad, Thomas R. Easterling, Edward J. Kelly, Jashvant D. Unadkat and Joanne Wang
      Drug Metabolism and Disposition December 2013, 41 (12) 2225-2232; DOI: https://doi.org/10.1124/dmd.113.054072

V

  1. VandenBrink, Brooke M.

    1. You have access
      Stereoselective Inhibition of CYP2C19 and CYP3A4 by Fluoxetine and Its Metabolite: Implications for Risk Assessment of Multiple Time-Dependent Inhibitor Systems
      Justin D. Lutz, Brooke M. VandenBrink, Katipudi N. Babu, Wendel L. Nelson, Kent L. Kunze and Nina Isoherranen
      Drug Metabolism and Disposition December 2013, 41 (12) 2056-2065; DOI: https://doi.org/10.1124/dmd.113.052639
  2. Varma, Manthena V.

    1. You have access
      A Perspective on the Prediction of Drug Pharmacokinetics and Disposition in Drug Research and Development
      Li Di, Bo Feng, Theunis C. Goosen, Yurong Lai, Stefanus J. Steyn, Manthena V. Varma and R. Scott Obach
      Drug Metabolism and Disposition December 2013, 41 (12) 1975-1993; DOI: https://doi.org/10.1124/dmd.113.054031

W

  1. Wang, Bo

    1. You have access
      Lymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and Rats
      Yan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. Reddy
      Drug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524
  2. Wang, Joanne

    1. You have access
      Effect of Gestational Age on mRNA and Protein Expression of Polyspecific Organic Cation Transporters during Pregnancy
      Nora Lee, Mary F. Hebert, Bhagwat Prasad, Thomas R. Easterling, Edward J. Kelly, Jashvant D. Unadkat and Joanne Wang
      Drug Metabolism and Disposition December 2013, 41 (12) 2225-2232; DOI: https://doi.org/10.1124/dmd.113.054072
  3. Wong, Harvey

    1. You have access
      Learning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins Antagonist
      Harvey Wong, Stephen E. Gould, Nageshwar Budha, Walter C. Darbonne, Edward E. Kadel, Hank La, Bruno Alicke, Jason S. Halladay, Rebecca Erickson, Chia Portera, Anthony W. Tolcher, Jeffery R. Infante, Michael Mamounas, John A. Flygare, Cornelis E. C. A. Hop and Wayne J. Fairbrother
      Drug Metabolism and Disposition December 2013, 41 (12) 2104-2113; DOI: https://doi.org/10.1124/dmd.113.053926
  4. Woodward, Caroline

    1. You have access
      Metabolism and Excretion of 6-Chloro-9-(4-methoxy-3,5-dimethylpyridin-2-ylmethyl)-9H-purin-2-ylamine, an HSP90 Inhibitor, in Rats and Dogs and Assessment of Its Metabolic Profile in Plasma of Humans
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  5. Wright, Lyndon C.

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      N-Acetylation of Etamicastat, a Reversible Dopamine-β-Hydroxylase Inhibitor
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      Drug Metabolism and Disposition December 2013, 41 (12) 2081-2086; DOI: https://doi.org/10.1124/dmd.113.053736

X

  1. Xiao, Wei-Bin

    1. You have access
      Assessment of the Roles of P-glycoprotein and Cytochrome P450 in Triptolide-induced Liver Toxicity in Sandwich-Cultured Rat Hepatocyte Model
      Xiao-Mei Zhuang, Guo-Lin Shen, Wei-Bin Xiao, Yan Tan, Chuang Lu and Hua Li
      Drug Metabolism and Disposition December 2013, 41 (12) 2158-2165; DOI: https://doi.org/10.1124/dmd.113.054056
  2. Xu, Cong

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      CYP2B6 Pharmacogenetics–Based In Vitro–In Vivo Extrapolation of Efavirenz Clearance by Physiologically Based Pharmacokinetic Modeling
      Cong Xu, Sara K. Quinney, Yingying Guo, Stephen D. Hall, Lang Li and Zeruesenay Desta
      Drug Metabolism and Disposition December 2013, 41 (12) 2004-2011; DOI: https://doi.org/10.1124/dmd.113.051755
  3. Xu, Lin

    1. You have access
      Metabolism and Excretion of 6-Chloro-9-(4-methoxy-3,5-dimethylpyridin-2-ylmethyl)-9H-purin-2-ylamine, an HSP90 Inhibitor, in Rats and Dogs and Assessment of Its Metabolic Profile in Plasma of Humans
      Lin Xu, Caroline Woodward, Jing Dai and Chandra Prakash
      Drug Metabolism and Disposition December 2013, 41 (12) 2133-2147; DOI: https://doi.org/10.1124/dmd.113.054023

Y

  1. Yang, Zheng

    1. You have access
      Assessment of Vandetanib as an Inhibitor of Various Human Renal Transporters: Inhibition of Multidrug and Toxin Extrusion as a Possible Mechanism Leading to Decreased Cisplatin and Creatinine Clearance
      Hong Shen, Zheng Yang, Weiping Zhao, Yueping Zhang and A. David Rodrigues
      Drug Metabolism and Disposition December 2013, 41 (12) 2095-2103; DOI: https://doi.org/10.1124/dmd.113.053215
  2. Yoo, Byunggil

    1. You have access
      RNA-Sequencing Quantification of Hepatic Ontogeny of Phase-I Enzymes in Mice
      Lai Peng, Julia Y. Cui, Byunggil Yoo, Sumedha S. Gunewardena, Hong Lu, Curtis D. Klaassen and Xiao-bo Zhong
      Drug Metabolism and Disposition December 2013, 41 (12) 2175-2186; DOI: https://doi.org/10.1124/dmd.113.054635
  3. Yu, Hongbin

    1. You have access
      Meeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPac
      Tom S. Chan, Hongbin Yu, Amanda Moore, Salman R. Khetani and Donald Tweedie
      Drug Metabolism and Disposition December 2013, 41 (12) 2024-2032; DOI: https://doi.org/10.1124/dmd.113.053397

Z

  1. Zhang, Andy S.

    1. You have access
      Lymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and Rats
      Yan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. Reddy
      Drug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524
  2. Zhang, Hui

    1. You have access
      In Vitro–In Vivo Correlation for Low-Clearance Compounds Using Hepatocyte Relay Method
      Li Di, Karen Atkinson, Christine C. Orozco, Carrie Funk, Hui Zhang, Thomas S. McDonald, Beijing Tan, Jian Lin, Cheng Chang and R. Scott Obach
      Drug Metabolism and Disposition December 2013, 41 (12) 2018-2023; DOI: https://doi.org/10.1124/dmd.113.053322
  3. Zhang, Nan

    1. You have access
      Characterization of Inhibition Kinetics of (S)-Warfarin Hydroxylation by Noscapine: Implications in Warfarin Therapy
      Nan Zhang, Ryan P. Seguin, Kent L. Kunze, Yan-Yan Zhang and Hyunyoung Jeong
      Drug Metabolism and Disposition December 2013, 41 (12) 2114-2123; DOI: https://doi.org/10.1124/dmd.113.053330
  4. Zhang, Yan-Yan

    1. You have access
      Characterization of Inhibition Kinetics of (S)-Warfarin Hydroxylation by Noscapine: Implications in Warfarin Therapy
      Nan Zhang, Ryan P. Seguin, Kent L. Kunze, Yan-Yan Zhang and Hyunyoung Jeong
      Drug Metabolism and Disposition December 2013, 41 (12) 2114-2123; DOI: https://doi.org/10.1124/dmd.113.053330
  5. Zhang, Yueping

    1. You have access
      Assessment of Vandetanib as an Inhibitor of Various Human Renal Transporters: Inhibition of Multidrug and Toxin Extrusion as a Possible Mechanism Leading to Decreased Cisplatin and Creatinine Clearance
      Hong Shen, Zheng Yang, Weiping Zhao, Yueping Zhang and A. David Rodrigues
      Drug Metabolism and Disposition December 2013, 41 (12) 2095-2103; DOI: https://doi.org/10.1124/dmd.113.053215
  6. Zhao, Weiping

    1. You have access
      Assessment of Vandetanib as an Inhibitor of Various Human Renal Transporters: Inhibition of Multidrug and Toxin Extrusion as a Possible Mechanism Leading to Decreased Cisplatin and Creatinine Clearance
      Hong Shen, Zheng Yang, Weiping Zhao, Yueping Zhang and A. David Rodrigues
      Drug Metabolism and Disposition December 2013, 41 (12) 2095-2103; DOI: https://doi.org/10.1124/dmd.113.053215
  7. Zhong, Xiao-bo

    1. You have access
      RNA-Sequencing Quantification of Hepatic Ontogeny of Phase-I Enzymes in Mice
      Lai Peng, Julia Y. Cui, Byunggil Yoo, Sumedha S. Gunewardena, Hong Lu, Curtis D. Klaassen and Xiao-bo Zhong
      Drug Metabolism and Disposition December 2013, 41 (12) 2175-2186; DOI: https://doi.org/10.1124/dmd.113.054635
  8. Zhuang, Xiao-Mei

    1. You have access
      Assessment of the Roles of P-glycoprotein and Cytochrome P450 in Triptolide-induced Liver Toxicity in Sandwich-Cultured Rat Hepatocyte Model
      Xiao-Mei Zhuang, Guo-Lin Shen, Wei-Bin Xiao, Yan Tan, Chuang Lu and Hua Li
      Drug Metabolism and Disposition December 2013, 41 (12) 2158-2165; DOI: https://doi.org/10.1124/dmd.113.054056
  9. Zou, Yan

    1. You have access
      Lymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and Rats
      Yan Zou, Thomas J. Bateman, Christine Adreani, Xiaolan Shen, Paul K. Cunningham, Bo Wang, Tu Trinh, Amy Christine, Xuening Hong, Christian N. Nunes, Chris V. Johnson, Andy S. Zhang, Steve J. Staskiewicz, Matthew Braun, Sanjeev Kumar and Vijay Bhasker G. Reddy
      Drug Metabolism and Disposition December 2013, 41 (12) 2206-2214; DOI: https://doi.org/10.1124/dmd.113.051524
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Drug Metabolism and Disposition: 41 (12)
Drug Metabolism and Disposition
Vol. 41, Issue 12
1 Dec 2013
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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