Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Drug Metabolism & Disposition
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Drug Metabolism & Disposition

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit dmd on Facebook
  • Follow dmd on Twitter
  • Follow ASPET on LinkedIn
Research ArticleSpecial Section on Prediction of Human Pharmacokinetic Parameters from In Vitro Systems

Drug Metabolites as Cytochrome P450 Inhibitors: A Retrospective Analysis and Proposed Algorithm for Evaluation of the Pharmacokinetic Interaction Potential of Metabolites in Drug Discovery and Development

Ernesto Callegari, Amit S. Kalgutkar, Louis Leung, R. Scott Obach, David R. Plowchalk and Susanna Tse
Drug Metabolism and Disposition December 2013, 41 (12) 2047-2055; DOI: https://doi.org/10.1124/dmd.113.052241
Ernesto Callegari
Pharmacokinetics, Dynamics and Metabolism–New Chemical Entities (E.C., L.L., R.S.O., S.T.) and Clinical Pharmacology (D.R.P.), Pfizer Inc., Groton, Connecticut; and Pharmacokinetics, Dynamics and Metabolism–New Chemical Entities, Pfizer Inc., Cambridge, Massachusetts (A.S.K.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Amit S. Kalgutkar
Pharmacokinetics, Dynamics and Metabolism–New Chemical Entities (E.C., L.L., R.S.O., S.T.) and Clinical Pharmacology (D.R.P.), Pfizer Inc., Groton, Connecticut; and Pharmacokinetics, Dynamics and Metabolism–New Chemical Entities, Pfizer Inc., Cambridge, Massachusetts (A.S.K.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Louis Leung
Pharmacokinetics, Dynamics and Metabolism–New Chemical Entities (E.C., L.L., R.S.O., S.T.) and Clinical Pharmacology (D.R.P.), Pfizer Inc., Groton, Connecticut; and Pharmacokinetics, Dynamics and Metabolism–New Chemical Entities, Pfizer Inc., Cambridge, Massachusetts (A.S.K.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
R. Scott Obach
Pharmacokinetics, Dynamics and Metabolism–New Chemical Entities (E.C., L.L., R.S.O., S.T.) and Clinical Pharmacology (D.R.P.), Pfizer Inc., Groton, Connecticut; and Pharmacokinetics, Dynamics and Metabolism–New Chemical Entities, Pfizer Inc., Cambridge, Massachusetts (A.S.K.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David R. Plowchalk
Pharmacokinetics, Dynamics and Metabolism–New Chemical Entities (E.C., L.L., R.S.O., S.T.) and Clinical Pharmacology (D.R.P.), Pfizer Inc., Groton, Connecticut; and Pharmacokinetics, Dynamics and Metabolism–New Chemical Entities, Pfizer Inc., Cambridge, Massachusetts (A.S.K.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Susanna Tse
Pharmacokinetics, Dynamics and Metabolism–New Chemical Entities (E.C., L.L., R.S.O., S.T.) and Clinical Pharmacology (D.R.P.), Pfizer Inc., Groton, Connecticut; and Pharmacokinetics, Dynamics and Metabolism–New Chemical Entities, Pfizer Inc., Cambridge, Massachusetts (A.S.K.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Article Information

vol. 41 no. 12 2047-2055
DOI 
https://doi.org/10.1124/dmd.113.052241
PubMed 
23792812

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received April 9, 2013
  • Accepted June 21, 2013
  • Published online November 14, 2013.

Article Versions

  • Earlier version (June 21, 2013 - 08:41).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Ernesto Callegari,
  2. Amit S. Kalgutkar,
  3. Louis Leung,
  4. R. Scott Obach,
  5. David R. Plowchalk, and
  6. Susanna Tse
  1. Pharmacokinetics, Dynamics and Metabolism–New Chemical Entities (E.C., L.L., R.S.O., S.T.) and Clinical Pharmacology (D.R.P.), Pfizer Inc., Groton, Connecticut; and Pharmacokinetics, Dynamics and Metabolism–New Chemical Entities, Pfizer Inc., Cambridge, Massachusetts (A.S.K.)
  1. Address correspondence to:
    Ernesto Callegari, Pharmacokinetics, Dynamics, and Metabolism–New Chemical Entities, Pfizer Worldwide Research and Development, Groton, CT. E-mail: ernesto.callegari{at}pfizer.com
View Full Text

Statistics from Altmetric.com

Article usage

Article usage: August 2017 to January 2023

AbstractFullPdf
Aug 20170177
Sep 2017443223
Oct 201701679
Nov 201713413
Dec 20175166
Jan 201832817
Feb 201812110
Mar 20180199
Apr 20181155
May 201822410
Jun 20182184
Jul 20181107
Aug 201802210
Sep 201812514
Oct 20181207
Nov 201811914
Dec 20181594
Jan 20192458
Feb 20191222
Mar 20191725
Apr 201923211
May 2019635
Jun 2019141114
Jul 20195812
Aug 20192147
Oct 20191837
Nov 20191724
Dec 20192464
Jan 20201450
Feb 20201622
Mar 20201022
May 20201154
Jun 20201521
Jul 2020700
Aug 20201407
Sep 20203277
Oct 202022172
Nov 20201377
Dec 2020763
Jan 202120195
Feb 20212684
Mar 20211953
Apr 20211451
May 20211861
Jun 20212193
Jul 20212423
Aug 202117122
Sep 2021890
Oct 20211364
Nov 20211810
Dec 20212341
Jan 20222855
Feb 20221110
Mar 20222043
Apr 20221331
May 2022943
Jun 20221521
Jul 202224411
Aug 20221442
Sep 20221940
Oct 20221880
Nov 20221620
Dec 2022846
Jan 20231853

PreviousNext
Back to top

In this issue

Drug Metabolism and Disposition: 41 (12)
Drug Metabolism and Disposition
Vol. 41, Issue 12
1 Dec 2013
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Drug Metabolism & Disposition article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Drug Metabolites as Cytochrome P450 Inhibitors: A Retrospective Analysis and Proposed Algorithm for Evaluation of the Pharmacokinetic Interaction Potential of Metabolites in Drug Discovery and Development
(Your Name) has forwarded a page to you from Drug Metabolism & Disposition
(Your Name) thought you would be interested in this article in Drug Metabolism & Disposition.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleSpecial Section on Prediction of Human Pharmacokinetic Parameters from In Vitro Systems

Drug Metabolites as Cytochrome P450 Inhibitors

Ernesto Callegari, Amit S. Kalgutkar, Louis Leung, R. Scott Obach, David R. Plowchalk and Susanna Tse
Drug Metabolism and Disposition December 1, 2013, 41 (12) 2047-2055; DOI: https://doi.org/10.1124/dmd.113.052241

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research ArticleSpecial Section on Prediction of Human Pharmacokinetic Parameters from In Vitro Systems

Drug Metabolites as Cytochrome P450 Inhibitors

Ernesto Callegari, Amit S. Kalgutkar, Louis Leung, R. Scott Obach, David R. Plowchalk and Susanna Tse
Drug Metabolism and Disposition December 1, 2013, 41 (12) 2047-2055; DOI: https://doi.org/10.1124/dmd.113.052241
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Acknowledgments
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • In Vitro–In Vivo Correlation of P-gp Efflux Ratio
  • Heterotropic Activation of CYP3A by a Novel mGlu5 PAM
  • IVIVC of Low Clearance
Show more Special Section on Prediction of Human Pharmacokinetic Parameters from In Vitro Systems

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About DMD
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Journal of Pharmacology and Experimental Therapeutics
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-009X (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics