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Research ArticleSpecial Section on Prediction of Human Pharmacokinetic Parameters from In Vitro Systems

Drug Metabolites as Cytochrome P450 Inhibitors: A Retrospective Analysis and Proposed Algorithm for Evaluation of the Pharmacokinetic Interaction Potential of Metabolites in Drug Discovery and Development

Ernesto Callegari, Amit S. Kalgutkar, Louis Leung, R. Scott Obach, David R. Plowchalk and Susanna Tse
Drug Metabolism and Disposition December 2013, 41 (12) 2047-2055; DOI: https://doi.org/10.1124/dmd.113.052241

Article Information

vol. 41 no. 12 2047-2055
DOI 
https://doi.org/10.1124/dmd.113.052241
PubMed 
23792812
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received April 9, 2013
  • Accepted June 21, 2013
  • Published online November 14, 2013.

Article Versions

Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Ernesto Callegari,
  2. Amit S. Kalgutkar,
  3. Louis Leung,
  4. R. Scott Obach,
  5. David R. Plowchalk, and
  6. Susanna Tse
  1. Pharmacokinetics, Dynamics and Metabolism–New Chemical Entities (E.C., L.L., R.S.O., S.T.) and Clinical Pharmacology (D.R.P.), Pfizer Inc., Groton, Connecticut; and Pharmacokinetics, Dynamics and Metabolism–New Chemical Entities, Pfizer Inc., Cambridge, Massachusetts (A.S.K.)
  1. Address correspondence to:
    Ernesto Callegari, Pharmacokinetics, Dynamics, and Metabolism–New Chemical Entities, Pfizer Worldwide Research and Development, Groton, CT. E-mail: ernesto.callegari{at}pfizer.com
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Research ArticleSpecial Section on Prediction of Human Pharmacokinetic Parameters from In Vitro Systems

Drug Metabolites as Cytochrome P450 Inhibitors

Ernesto Callegari, Amit S. Kalgutkar, Louis Leung, R. Scott Obach, David R. Plowchalk and Susanna Tse
Drug Metabolism and Disposition December 1, 2013, 41 (12) 2047-2055; DOI: https://doi.org/10.1124/dmd.113.052241
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