Drug Metabolites as Cytochrome P450 Inhibitors: A Retrospective Analysis and Proposed Algorithm for Evaluation of the Pharmacokinetic Interaction Potential of Metabolites in Drug Discovery and Development

Ernesto Callegari; Amit S. Kalgutkar; Louis Leung; R. Scott Obach; David R. Plowchalk; Susanna Tse

doi:10.1124/dmd.113.052241

Research ArticleSpecial Section on Prediction of Human Pharmacokinetic Parameters from In Vitro Systems

Drug Metabolites as Cytochrome P450 Inhibitors: A Retrospective Analysis and Proposed Algorithm for Evaluation of the Pharmacokinetic Interaction Potential of Metabolites in Drug Discovery and Development

Ernesto Callegari, Amit S. Kalgutkar, Louis Leung, R. Scott Obach, David R. Plowchalk and Susanna Tse

Drug Metabolism and Disposition December 2013, 41 (12) 2047-2055; DOI: https://doi.org/10.1124/dmd.113.052241

Ernesto Callegari

Pharmacokinetics, Dynamics and Metabolism–New Chemical Entities (E.C., L.L., R.S.O., S.T.) and Clinical Pharmacology (D.R.P.), Pfizer Inc., Groton, Connecticut; and Pharmacokinetics, Dynamics and Metabolism–New Chemical Entities, Pfizer Inc., Cambridge, Massachusetts (A.S.K.)

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Amit S. Kalgutkar

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Louis Leung

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R. Scott Obach

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David R. Plowchalk

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Susanna Tse

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Drug Metabolism and Disposition

Vol. 41, Issue 12

1 Dec 2013

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Research ArticleSpecial Section on Prediction of Human Pharmacokinetic Parameters from In Vitro Systems

Drug Metabolites as Cytochrome P450 Inhibitors

Ernesto Callegari, Amit S. Kalgutkar, Louis Leung, R. Scott Obach, David R. Plowchalk and Susanna Tse

Drug Metabolism and Disposition December 1, 2013, 41 (12) 2047-2055; DOI: https://doi.org/10.1124/dmd.113.052241

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Research ArticleSpecial Section on Prediction of Human Pharmacokinetic Parameters from In Vitro Systems

Drug Metabolites as Cytochrome P450 Inhibitors

Ernesto Callegari, Amit S. Kalgutkar, Louis Leung, R. Scott Obach, David R. Plowchalk and Susanna Tse

Drug Metabolism and Disposition December 1, 2013, 41 (12) 2047-2055; DOI: https://doi.org/10.1124/dmd.113.052241

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