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Research ArticleSpecial Section on Prediction of Human Pharmacokinetic Parameters from In Vitro Systems

Stereoselective Inhibition of CYP2C19 and CYP3A4 by Fluoxetine and Its Metabolite: Implications for Risk Assessment of Multiple Time-Dependent Inhibitor Systems

Justin D. Lutz, Brooke M. VandenBrink, Katipudi N. Babu, Wendel L. Nelson, Kent L. Kunze and Nina Isoherranen
Drug Metabolism and Disposition December 2013, 41 (12) 2056-2065; DOI: https://doi.org/10.1124/dmd.113.052639

Article Information

vol. 41 no. 12 2056-2065
DOI 
https://doi.org/10.1124/dmd.113.052639
PubMed 
23785064
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received April 30, 2013
  • Accepted June 19, 2013
  • Published online November 14, 2013.

Article Versions

Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Justin D. Lutz,
  2. Brooke M. VandenBrink1,
  3. Katipudi N. Babu2,
  4. Wendel L. Nelson,
  5. Kent L. Kunze, and
  6. Nina Isoherranen
  1. Department of Pharmaceutics (J.D.L., N.I.) and Department of Medicinal Chemistry (B.M.V., K.N.B., W.L.N., K.L.K.), School of Pharmacy, University of Washington, Seattle, Washington
  1. Address correspondence to:
    Dr. Nina Isoherranen, University of Washington, Department of Pharmaceutics, Box #357610, 1959 NE Pacific Street, Seattle, WA 98195. E-mail: ni2{at}uw.edu
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Research ArticleSpecial Section on Prediction of Human Pharmacokinetic Parameters from In Vitro Systems

Prediction of Fluoxetine Drug-Drug Interactions

Justin D. Lutz, Brooke M. VandenBrink, Katipudi N. Babu, Wendel L. Nelson, Kent L. Kunze and Nina Isoherranen
Drug Metabolism and Disposition December 1, 2013, 41 (12) 2056-2065; DOI: https://doi.org/10.1124/dmd.113.052639
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