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Assessment of Vandetanib as an Inhibitor of Various Human Renal Transporters: Inhibition of Multidrug and Toxin Extrusion as a Possible Mechanism Leading to Decreased Cisplatin and Creatinine Clearance

Hong Shen, Zheng Yang, Weiping Zhao, Yueping Zhang and A. David Rodrigues
Drug Metabolism and Disposition December 2013, 41 (12) 2095-2103; DOI: https://doi.org/10.1124/dmd.113.053215

Article Information

vol. 41 no. 12 2095-2103
DOI 
https://doi.org/10.1124/dmd.113.053215
PubMed 
24026623
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received June 6, 2013
  • Accepted September 11, 2013
  • Published online November 14, 2013.

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Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Hong Shen,
  2. Zheng Yang,
  3. Weiping Zhao,
  4. Yueping Zhang, and
  5. A. David Rodrigues
  1. Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research and Development, Princeton, New Jersey
  1. Address correspondence to:
    Hong Shen, F1.3811, Route 206 & Province Line Road, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000. E-mail: hong.shen1{at}bms.com
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Inhibition of MATE1 and MATE2K by Vandetanib

Hong Shen, Zheng Yang, Weiping Zhao, Yueping Zhang and A. David Rodrigues
Drug Metabolism and Disposition December 1, 2013, 41 (12) 2095-2103; DOI: https://doi.org/10.1124/dmd.113.053215
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