Drug Metabolism and Disposition: 41 (2)

February 01, 2013; Volume 41,Issue 2

Special Section on Drug Metabolizing Enzymes and Transporters in Pregnancy

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Drug Metabolism and Transport During Pregnancy: How Does Drug Disposition Change during Pregnancy and What Are the Mechanisms that Cause Such Changes?
Nina Isoherranen and Kenneth E. Thummel

Drug Metabolism and Disposition February 2013, 41 (2) 256-262; DOI: https://doi.org/10.1124/dmd.112.050245
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Isoform-Specific Regulation of Cytochromes P450 Expression by Estradiol and Progesterone
Su-Young Choi, Kwi Hye Koh and Hyunyoung Jeong

Drug Metabolism and Disposition February 2013, 41 (2) 263-269; DOI: https://doi.org/10.1124/dmd.112.046276
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Quantitative Prediction of CYP2B6 Induction by Estradiol During Pregnancy: Potential Explanation for Increased Methadone Clearance During Pregnancy
Leslie J Dickmann and Nina Isoherranen

Drug Metabolism and Disposition February 2013, 41 (2) 270-274; DOI: https://doi.org/10.1124/dmd.112.047118
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Induction of Hepatic Multidrug Resistance-Associated Protein 3 by Ethynylestradiol Is Independent of Cholestasis and Mediated by Estrogen Receptor
María L. Ruiz, Juan P. Rigalli, Agostina Arias, Silvina Villanueva, Claudia Banchio, Mary Vore, Aldo D. Mottino and Viviana A. Catania

Drug Metabolism and Disposition February 2013, 41 (2) 275-280; DOI: https://doi.org/10.1124/dmd.112.047357
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Induction of Hepatic CYP3A Enzymes by Pregnancy-Related Hormones: Studies in Human Hepatocytes and Hepatic Cell Lines
Ioannis Papageorgiou, Susan Grepper and Jashvant D. Unadkat

Drug Metabolism and Disposition February 2013, 41 (2) 281-290; DOI: https://doi.org/10.1124/dmd.112.049015
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Tissue Distribution and Relative Gene Expression of UDP-Glucuronosyltransferases (2B7, 2B15, 2B17) in the Human Fetus
Lena Ekström, Maria Johansson and Anders Rane

Drug Metabolism and Disposition February 2013, 41 (2) 291-295; DOI: https://doi.org/10.1124/dmd.112.049197
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Hepatobiliary Disposition of 17-OHPC and Taurocholate in Fetal Human Hepatocytes: A Comparison with Adult Human Hepatocytes
Shringi Sharma, Ewa C. S. Ellis, Roberto Gramignoli, Kenneth Dorko, Veysel Tahan, Marc Hansel, Donald R. Mattison, Steve N. Caritis, Ronald N. Hines, Raman Venkataramanan and Stephen C. Strom

Drug Metabolism and Disposition February 2013, 41 (2) 296-304; DOI: https://doi.org/10.1124/dmd.112.044891
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Cotinine in Human Placenta Predicts Induction of Gene Expression in Fetal Tissues
Carrie A. Vyhlidal, Amanda K. Riffel, Kathleen J. Haley, Sunita Sharma, Hongying Dai, Kelan G. Tantisira, Scott T. Weiss and J. Steven Leeder

Drug Metabolism and Disposition February 2013, 41 (2) 305-311; DOI: https://doi.org/10.1124/dmd.112.049999
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Hepatic Cyp2d and Cyp26a1 mRNAs and Activities Are Increased During Mouse Pregnancy
Ariel R. Topletz, Huong N. Le, Nora Lee, John D. Chapman, Edward J. Kelly, Joanne Wang and Nina Isoherranen

Drug Metabolism and Disposition February 2013, 41 (2) 312-319; DOI: https://doi.org/10.1124/dmd.112.049379
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Down-Regulation of Brush Border Efflux Transporter Expression in the Kidneys of Pregnant Mice
Lindsay L. Yacovino, Christopher J. Gibson and Lauren M. Aleksunes

Drug Metabolism and Disposition February 2013, 41 (2) 320-325; DOI: https://doi.org/10.1124/dmd.112.047092
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Alteration of the Expression of Pesticide-Metabolizing Enzymes in Pregnant Mice: Potential Role in the Increased Vulnerability of the Developing Brain
Marie C. Fortin, Lauren M. Aleksunes and Jason R. Richardson

Drug Metabolism and Disposition February 2013, 41 (2) 326-331; DOI: https://doi.org/10.1124/dmd.112.049395
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Gestational Age-Dependent Changes in Gene Expression of Metabolic Enzymes and Transporters in Pregnant Mice
Diana L. Shuster, Theo K. Bammler, Richard P. Beyer, James W. MacDonald, Jesse M. Tsai, Frederico M. Farin, Mary F. Hebert, Kenneth E. Thummel and Qingcheng Mao

Drug Metabolism and Disposition February 2013, 41 (2) 332-342; DOI: https://doi.org/10.1124/dmd.112.049718

Articles

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Prediction of Crizotinib-Midazolam Interaction Using the Simcyp Population-Based Simulator: Comparison of CYP3A Time-Dependent Inhibition between Human Liver Microsomes versus Hepatocytes
Jialin Mao, Theodore R. Johnson, Zhongzhou Shen and Shinji Yamazaki

Drug Metabolism and Disposition February 2013, 41 (2) 343-352; DOI: https://doi.org/10.1124/dmd.112.049114
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In Vitro Investigations into the Roles of Drug Transporters and Metabolizing Enzymes in the Disposition and Drug Interactions of Dolutegravir, a HIV Integrase Inhibitor
Melinda J. Reese, Paul M. Savina, Grant T. Generaux, Helen Tracey, Joan E. Humphreys, Eri Kanaoka, Lindsey O. Webster, Kelly A. Harmon, James D. Clarke and Joseph W. Polli

Drug Metabolism and Disposition February 2013, 41 (2) 353-361; DOI: https://doi.org/10.1124/dmd.112.048918
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Analysis of the Repaglinide Concentration Increase Produced by Gemfibrozil and Itraconazole Based on the Inhibition of the Hepatic Uptake Transporter and Metabolic Enzymes
Toshiyuki Kudo, Akihiro Hisaka, Yuichi Sugiyama and Kiyomi Ito

Drug Metabolism and Disposition February 2013, 41 (2) 362-371; DOI: https://doi.org/10.1124/dmd.112.049460
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Species Differences in Biliary Clearance and Possible Relevance of Hepatic Uptake and Efflux Transporters Involvement
Ken Grime and Stuart W. Paine

Drug Metabolism and Disposition February 2013, 41 (2) 372-378; DOI: https://doi.org/10.1124/dmd.112.049312
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Metabolic Pathways of Inhaled Glucocorticoids by the CYP3A Enzymes
Chad D. Moore, Jessica K. Roberts, Christopher R. Orton, Takahiro Murai, Trevor P. Fidler, Christopher A. Reilly, Robert M. Ward and Garold S. Yost

Drug Metabolism and Disposition February 2013, 41 (2) 379-389; DOI: https://doi.org/10.1124/dmd.112.046318
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In Vitro Cytochrome P450 Activity Decreases in Children with High Pediatric End-Stage Liver Disease Scores
Lies De Bock, Koen Boussery, Myriam Van Winckel, Peter De Paepe, Xavier Rogiers, Xavier Stephenne, Etienne Sokal and Jan Van Bocxlaer

Drug Metabolism and Disposition February 2013, 41 (2) 390-397; DOI: https://doi.org/10.1124/dmd.112.048504
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RBCK1, an E3 Ubiquitin Ligase, Interacts with and Ubiquinates the Human Pregnane X Receptor
Ritu Rana, Sherry Coulter, Harriet Kinyamu and Joyce A. Goldstein

Drug Metabolism and Disposition February 2013, 41 (2) 398-405; DOI: https://doi.org/10.1124/dmd.112.048728
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Cytochrome P450 Regulation by α-Tocopherol in Pxr-Null and PXR-Humanized Mice
Caroline H. Johnson, Jessica A. Bonzo, Jie Cheng, Kristopher W. Krausz, Dong Wook Kang, Hans Luecke, Jeffrey R. Idle and Frank J. Gonzalez

Drug Metabolism and Disposition February 2013, 41 (2) 406-413; DOI: https://doi.org/10.1124/dmd.112.048009
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Metabolic Transformation of Antitumor Acridinone C-1305 but Not C-1311 via Selective Cellular Expression of UGT1A10 Increases Cytotoxic Response: Implications for Clinical Use
Monika Pawlowska, Rong Chu, Barbara Fedejko-Kap, Ewa Augustin, Zofia Mazerska, Anna Radominska-Pandya and Timothy C. Chambers

Drug Metabolism and Disposition February 2013, 41 (2) 414-421; DOI: https://doi.org/10.1124/dmd.112.047811
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Compartmentalization and Antiviral Effect of Efavirenz Metabolites in Blood Plasma, Seminal Plasma, and Cerebrospinal Fluid
Lindsay B. Avery, Jennifer L. VanAusdall, Craig W. Hendrix and Namandjé N. Bumpus

Drug Metabolism and Disposition February 2013, 41 (2) 422-429; DOI: https://doi.org/10.1124/dmd.112.049601
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Metabolism and Pharmacokinetics of 3-n-Butylphthalide (NBP) in Humans: The Role of Cytochrome P450s and Alcohol Dehydrogenase in Biotransformation
Xingxing Diao, Pan Deng, Cen Xie, Xiuli Li, Dafang Zhong, Yifan Zhang and Xiaoyan Chen

Drug Metabolism and Disposition February 2013, 41 (2) 430-444; DOI: https://doi.org/10.1124/dmd.112.049684
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Pharmacokinetics, Metabolism, and Excretion of the Antidiabetic Agent Ertugliflozin (PF-04971729) in Healthy Male Subjects
Zhuang Miao, Gianluca Nucci, Neeta Amin, Raman Sharma, Vincent Mascitti, Meera Tugnait, Alfin D. Vaz, Ernesto Callegari and Amit S. Kalgutkar

Drug Metabolism and Disposition February 2013, 41 (2) 445-456; DOI: https://doi.org/10.1124/dmd.112.049551
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The Role of Cytochrome P450–Dependent Metabolism in the Regulation of Mouse Hepatic Growth Hormone Signaling Components and Target Genes by 3-Methylcholanthrene
Chunja Lee, Xinxin Ding and David S. Riddick

Drug Metabolism and Disposition February 2013, 41 (2) 457-465; DOI: https://doi.org/10.1124/dmd.112.048835
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RETRACTION: Immunohistochemical and Functional Characterization of Peptide, Organic Cation, Neutral and Basic Amino Acid, and Monocarboxylate Drug Transporters in Human Ocular Tissues
Rajendra S. Kadam, Sunil K. Vooturi and Uday B. Kompella

Drug Metabolism and Disposition February 2013, 41 (2) 466-474; DOI: https://doi.org/10.1124/dmd.112.045674
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Intraindividual and Interindividual Variabilities in Endogenous Cortisol 6β-Hydroxylation Clearance as an Index for In Vivo CYP3A Phenotyping in Humans
Hiromi Shibasaki, Kaori Hosoda, Mari Goto, Atsushi Suzuki, Akitomo Yokokawa, Kazuo Ishii and Takashi Furuta

Drug Metabolism and Disposition February 2013, 41 (2) 475-479; DOI: https://doi.org/10.1124/dmd.112.048561
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Increased Hospital Stay and Allograft Disfunction in Renal Transplant Recipients with Cyp2c19 AA Variant in SNP rs4244285
Virginia Bosó, María José Herrero, Sergio Bea, María Galiana, Patricia Marrero, María Remedios Marqués, Julio Hernández, Jaime Sánchez-Plumed, José Luis Poveda and Salvador F. Aliño

Drug Metabolism and Disposition February 2013, 41 (2) 480-487; DOI: https://doi.org/10.1124/dmd.112.047977
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The Potential of Sutherlandia frutescens for Herb-Drug Interaction
Pius S. Fasinu, Heike Gutmann, Hilmar Schiller, Alexander-David James, Patrick J. Bouic and Bernd Rosenkranz

Drug Metabolism and Disposition February 2013, 41 (2) 488-497; DOI: https://doi.org/10.1124/dmd.112.049593
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Application of Hybrid Approach Based on Empirical and Physiological Concept for Predicting Pharmacokinetics in Humans—Usefulness of Exponent on Prospective Evaluation of Predictability
Hiroyuki Sayama, Hiroshi Komura and Motohiro Kogayu

Drug Metabolism and Disposition February 2013, 41 (2) 498-507; DOI: https://doi.org/10.1124/dmd.112.048819
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Evaluation of Metabolism and Disposition of GDC-0152 in Rats Using ¹⁴C Labeling Strategy at Two Different Positions: A Novel Formation of Hippuric Acid from 4-Phenyl-5-Amino-1,2,3-Thiadiazole
Qin Yue, Teresa Mulder, Patrick J. Rudewicz, Eric Solon, Nageshwar Budha, Joseph A Ware, Joseph Lyssikatos, Cornelis E.C.A. Hop, Harvey Wong and S. Cyrus Khojasteh

Drug Metabolism and Disposition February 2013, 41 (2) 508-517; DOI: https://doi.org/10.1124/dmd.112.047019
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Compartmental and Enzyme Kinetic Modeling To Elucidate the Biotransformation Pathway of a Centrally Acting Antitrypanosomal Prodrug
Claudia N. Generaux, Garrett R. Ainslie, Arlene S. Bridges, Mohamed A. Ismail, David W. Boykin, Richard R. Tidwell, Dhiren R. Thakker and Mary F. Paine

Drug Metabolism and Disposition February 2013, 41 (2) 518-528; DOI: https://doi.org/10.1124/dmd.112.048231

Short Communication

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Dietary Regulation of Mouse Intestinal P450 Expression and Drug Metabolism
Peng Zhang, Kunzhi Jia, Cheng Fang, Xin Zhou, Xinxin Ding and Qing-Yu Zhang

Drug Metabolism and Disposition February 2013, 41 (2) 529-535; DOI: https://doi.org/10.1124/dmd.112.049403

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Special Section on Drug Metabolizing Enzymes and Transporters in Pregnancy

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