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Rapid CommunicationSpecial Section on Drug Metabolizing Enzymes and Transporters in Pregnancy

Induction of Hepatic Multidrug Resistance-Associated Protein 3 by Ethynylestradiol Is Independent of Cholestasis and Mediated by Estrogen Receptor

María L. Ruiz, Juan P. Rigalli, Agostina Arias, Silvina Villanueva, Claudia Banchio, Mary Vore, Aldo D. Mottino and Viviana A. Catania
Drug Metabolism and Disposition February 2013, 41 (2) 275-280; DOI: https://doi.org/10.1124/dmd.112.047357
María L. Ruiz
Instituto de Fisiología Experimenta(M.L.R., J.P.R., A.A., S.V., A.D.M., V.A.C.) and Instituto de Biología Molecular y Celular de Rosario (CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Rosario, Argentina (C.B.); and Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky (M.V.)
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Juan P. Rigalli
Instituto de Fisiología Experimenta(M.L.R., J.P.R., A.A., S.V., A.D.M., V.A.C.) and Instituto de Biología Molecular y Celular de Rosario (CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Rosario, Argentina (C.B.); and Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky (M.V.)
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Agostina Arias
Instituto de Fisiología Experimenta(M.L.R., J.P.R., A.A., S.V., A.D.M., V.A.C.) and Instituto de Biología Molecular y Celular de Rosario (CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Rosario, Argentina (C.B.); and Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky (M.V.)
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Silvina Villanueva
Instituto de Fisiología Experimenta(M.L.R., J.P.R., A.A., S.V., A.D.M., V.A.C.) and Instituto de Biología Molecular y Celular de Rosario (CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Rosario, Argentina (C.B.); and Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky (M.V.)
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Claudia Banchio
Instituto de Fisiología Experimenta(M.L.R., J.P.R., A.A., S.V., A.D.M., V.A.C.) and Instituto de Biología Molecular y Celular de Rosario (CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Rosario, Argentina (C.B.); and Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky (M.V.)
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Mary Vore
Instituto de Fisiología Experimenta(M.L.R., J.P.R., A.A., S.V., A.D.M., V.A.C.) and Instituto de Biología Molecular y Celular de Rosario (CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Rosario, Argentina (C.B.); and Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky (M.V.)
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Aldo D. Mottino
Instituto de Fisiología Experimenta(M.L.R., J.P.R., A.A., S.V., A.D.M., V.A.C.) and Instituto de Biología Molecular y Celular de Rosario (CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Rosario, Argentina (C.B.); and Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky (M.V.)
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Viviana A. Catania
Instituto de Fisiología Experimenta(M.L.R., J.P.R., A.A., S.V., A.D.M., V.A.C.) and Instituto de Biología Molecular y Celular de Rosario (CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Rosario, Argentina (C.B.); and Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky (M.V.)
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Article Information

vol. 41 no. 2 275-280
DOI 
https://doi.org/10.1124/dmd.112.047357
PubMed 
23077105

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received June 19, 2012
  • Accepted October 17, 2012
  • Published online January 17, 2013.

Article Versions

  • Earlier version (October 17, 2012 - 06:19).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. María L. Ruiz,
  2. Juan P. Rigalli,
  3. Agostina Arias,
  4. Silvina Villanueva,
  5. Claudia Banchio,
  6. Mary Vore,
  7. Aldo D. Mottino, and
  8. Viviana A. Catania
  1. Instituto de Fisiología Experimenta(M.L.R., J.P.R., A.A., S.V., A.D.M., V.A.C.) and Instituto de Biología Molecular y Celular de Rosario (CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Rosario, Argentina (C.B.); and Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky (M.V.)
  1. Address correspondence to:
    Dr. Viviana A. Catania, Instituto de Fisiología Experimental (CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas (UNR), Suipacha 570, (2000) Rosario, Argentina. E-mail: vcatania{at}fbioyf.unr.edu.ar or catania{at}ifise-conicet.gov.ar
  1. This work was previously presented as a poster presentation at the following workshop: Ruiz ML, Rigalli JP, Arias A, Villanueva SS, Banchio C, Vore M, Mottino AD, and Catania VA (2012) Molecular basis for hepatic multidrug resistance-associated protein 3 induction by ethynylestradiol. 47th Annual Meeting of the European Association for the Study of the Liver: International Liver Congress; 2012 April 18–22; Barcelona, Spain.

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Drug Metabolism and Disposition: 41 (2)
Drug Metabolism and Disposition
Vol. 41, Issue 2
1 Feb 2013
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Rapid CommunicationSpecial Section on Drug Metabolizing Enzymes and Transporters in Pregnancy

Estrogen Receptor Mediates Mrp3 Induction by Ethynylestradiol

María L. Ruiz, Juan P. Rigalli, Agostina Arias, Silvina Villanueva, Claudia Banchio, Mary Vore, Aldo D. Mottino and Viviana A. Catania
Drug Metabolism and Disposition February 1, 2013, 41 (2) 275-280; DOI: https://doi.org/10.1124/dmd.112.047357

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Rapid CommunicationSpecial Section on Drug Metabolizing Enzymes and Transporters in Pregnancy

Estrogen Receptor Mediates Mrp3 Induction by Ethynylestradiol

María L. Ruiz, Juan P. Rigalli, Agostina Arias, Silvina Villanueva, Claudia Banchio, Mary Vore, Aldo D. Mottino and Viviana A. Catania
Drug Metabolism and Disposition February 1, 2013, 41 (2) 275-280; DOI: https://doi.org/10.1124/dmd.112.047357
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