Advertisement
Research ArticleArticle

In Vitro Investigations into the Roles of Drug Transporters and Metabolizing Enzymes in the Disposition and Drug Interactions of Dolutegravir, a HIV Integrase Inhibitor

Melinda J. Reese, Paul M. Savina, Grant T. Generaux, Helen Tracey, Joan E. Humphreys, Eri Kanaoka, Lindsey O. Webster, Kelly A. Harmon, James D. Clarke and Joseph W. Polli
Drug Metabolism and Disposition February 2013, 41 (2) 353-361; DOI: https://doi.org/10.1124/dmd.112.048918

Article Information

vol. 41 no. 2 353-361
DOI 
https://doi.org/10.1124/dmd.112.048918
PubMed 
23132334
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received September 7, 2012
  • Accepted November 6, 2012
  • Published online January 17, 2013.

Article Versions

Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Melinda J. Reese,
  2. Paul M. Savina,
  3. Grant T. Generaux,
  4. Helen Tracey,
  5. Joan E. Humphreys,
  6. Eri Kanaoka,
  7. Lindsey O. Webster,
  8. Kelly A. Harmon,
  9. James D. Clarke, and
  10. Joseph W. Polli
  1. Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, North Carolina (M.J.R., P.M.S., G.T.G., J.E.H., L.O.W., K.A.H., J.W.P.); Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Ware, United Kingdom (H.T., J.D.C.); and Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan (E.K.)
  1. Address correspondence to:
    Melinda J. Reese, Preclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Inc. Room: 2.4075.1, Research Triangle Park, NC 27709. E-mail: mindy.j.reese{at}gsk.com
View Full Text

Statistics from Altmetric.com

Article usage

Article usage: November 2012 to January 2022

AbstractFullPdf
Nov 20124680257
Dec 20121600112
Jan 201382427160
Feb 20135914399
Mar 201326836104
Apr 20131904085
May 20131352247
Jun 20131011445
Jul 20131442456
Aug 20131033273
Sep 20131512256
Oct 20131351841
Nov 2013941727
Dec 2013901733
Jan 20141262443
Feb 20141063566
Mar 2014735771
Apr 2014777187
May 2014384854
Jun 20146254286
Jul 20141135263
Aug 2014596152
Sep 2014787177
Oct 20141064460
Nov 2014717171
Dec 2014424240
Jan 2015695259
Feb 2015484229
Mar 2015614851
Apr 2015554438
May 2015495041
Jun 2015554651
Jul 2015546156
Aug 2015539647
Sep 2015514833
Oct 2015503537
Nov 2015417236
Dec 2015513735
Jan 2016643437
Feb 2016325040
Mar 2016425454
Apr 2016366642
May 2016314139
Jun 2016534647
Jul 2016413855
Aug 2016434942
Sep 2016224338
Oct 2016254834
Nov 2016175139
Dec 2016204139
Jan 2017117253
Feb 201705348
Mar 201707849
Apr 201706533
May 201715379
Jun 201743349
Jul 2017153538
Aug 201794927
Sep 201765641
Oct 201796634
Nov 2017107954
Dec 201795023
Jan 2018114440
Feb 2018125836
Mar 2018168844
Apr 201865553
May 2018188149
Jun 201894335
Jul 2018145157
Aug 2018135362
Sep 201844745
Oct 2018194249
Nov 2018144452
Dec 2018541747
Jan 2019412215
Feb 2019611315
Mar 2019673036
Apr 2019821836
May 2019382422
Jun 2019441225
Jul 2019551334
Aug 201961911
Sep 2019351017
Oct 2019381319
Nov 201975714
Dec 20195236
Jan 202068816
Feb 202085912
Mar 2020871316
Apr 2020381010
May 2020922223
Jun 202089558
Jul 2020321013
Aug 202058814
Sep 2020741310
Oct 2020701416
Nov 20209956
Dec 202069710
Jan 20211142920
Feb 2021641712
Mar 202172810
Apr 2021104187
May 202166103
Jun 202152128
Jul 202161713
Aug 202160109
Sep 20213792
Oct 20213642
Nov 2021461311
Dec 2021611814
Jan 20225042

Back to top

In this issue

Download PDF
Article Alerts
Email Article
Citation Tools

Research ArticleArticle

In Vitro Investigations with Dolutegravir

Melinda J. Reese, Paul M. Savina, Grant T. Generaux, Helen Tracey, Joan E. Humphreys, Eri Kanaoka, Lindsey O. Webster, Kelly A. Harmon, James D. Clarke and Joseph W. Polli
Drug Metabolism and Disposition February 1, 2013, 41 (2) 353-361; DOI: https://doi.org/10.1124/dmd.112.048918
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo

Jump to section

Advertisement