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In Vitro Investigations into the Roles of Drug Transporters and Metabolizing Enzymes in the Disposition and Drug Interactions of Dolutegravir, a HIV Integrase Inhibitor

Melinda J. Reese, Paul M. Savina, Grant T. Generaux, Helen Tracey, Joan E. Humphreys, Eri Kanaoka, Lindsey O. Webster, Kelly A. Harmon, James D. Clarke and Joseph W. Polli
Drug Metabolism and Disposition February 2013, 41 (2) 353-361; DOI: https://doi.org/10.1124/dmd.112.048918

Article Information

vol. 41 no. 2 353-361
DOI 
https://doi.org/10.1124/dmd.112.048918
PubMed 
23132334
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received September 7, 2012
  • Accepted November 6, 2012
  • Published online January 17, 2013.

Article Versions

Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Melinda J. Reese,
  2. Paul M. Savina,
  3. Grant T. Generaux,
  4. Helen Tracey,
  5. Joan E. Humphreys,
  6. Eri Kanaoka,
  7. Lindsey O. Webster,
  8. Kelly A. Harmon,
  9. James D. Clarke, and
  10. Joseph W. Polli
  1. Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, North Carolina (M.J.R., P.M.S., G.T.G., J.E.H., L.O.W., K.A.H., J.W.P.); Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Ware, United Kingdom (H.T., J.D.C.); and Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan (E.K.)
  1. Address correspondence to:
    Melinda J. Reese, Preclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Inc. Room: 2.4075.1, Research Triangle Park, NC 27709. E-mail: mindy.j.reese{at}gsk.com
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In Vitro Investigations with Dolutegravir

Melinda J. Reese, Paul M. Savina, Grant T. Generaux, Helen Tracey, Joan E. Humphreys, Eri Kanaoka, Lindsey O. Webster, Kelly A. Harmon, James D. Clarke and Joseph W. Polli
Drug Metabolism and Disposition February 1, 2013, 41 (2) 353-361; DOI: https://doi.org/10.1124/dmd.112.048918
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