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Research ArticleArticle

In Vitro Investigations into the Roles of Drug Transporters and Metabolizing Enzymes in the Disposition and Drug Interactions of Dolutegravir, a HIV Integrase Inhibitor

Melinda J. Reese, Paul M. Savina, Grant T. Generaux, Helen Tracey, Joan E. Humphreys, Eri Kanaoka, Lindsey O. Webster, Kelly A. Harmon, James D. Clarke and Joseph W. Polli
Drug Metabolism and Disposition February 2013, 41 (2) 353-361; DOI: https://doi.org/10.1124/dmd.112.048918
Melinda J. Reese
Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, North Carolina (M.J.R., P.M.S., G.T.G., J.E.H., L.O.W., K.A.H., J.W.P.); Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Ware, United Kingdom (H.T., J.D.C.); and Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan (E.K.)
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Paul M. Savina
Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, North Carolina (M.J.R., P.M.S., G.T.G., J.E.H., L.O.W., K.A.H., J.W.P.); Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Ware, United Kingdom (H.T., J.D.C.); and Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan (E.K.)
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Grant T. Generaux
Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, North Carolina (M.J.R., P.M.S., G.T.G., J.E.H., L.O.W., K.A.H., J.W.P.); Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Ware, United Kingdom (H.T., J.D.C.); and Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan (E.K.)
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Helen Tracey
Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, North Carolina (M.J.R., P.M.S., G.T.G., J.E.H., L.O.W., K.A.H., J.W.P.); Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Ware, United Kingdom (H.T., J.D.C.); and Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan (E.K.)
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Joan E. Humphreys
Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, North Carolina (M.J.R., P.M.S., G.T.G., J.E.H., L.O.W., K.A.H., J.W.P.); Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Ware, United Kingdom (H.T., J.D.C.); and Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan (E.K.)
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Eri Kanaoka
Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, North Carolina (M.J.R., P.M.S., G.T.G., J.E.H., L.O.W., K.A.H., J.W.P.); Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Ware, United Kingdom (H.T., J.D.C.); and Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan (E.K.)
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Lindsey O. Webster
Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, North Carolina (M.J.R., P.M.S., G.T.G., J.E.H., L.O.W., K.A.H., J.W.P.); Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Ware, United Kingdom (H.T., J.D.C.); and Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan (E.K.)
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Kelly A. Harmon
Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, North Carolina (M.J.R., P.M.S., G.T.G., J.E.H., L.O.W., K.A.H., J.W.P.); Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Ware, United Kingdom (H.T., J.D.C.); and Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan (E.K.)
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James D. Clarke
Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, North Carolina (M.J.R., P.M.S., G.T.G., J.E.H., L.O.W., K.A.H., J.W.P.); Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Ware, United Kingdom (H.T., J.D.C.); and Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan (E.K.)
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Joseph W. Polli
Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, North Carolina (M.J.R., P.M.S., G.T.G., J.E.H., L.O.W., K.A.H., J.W.P.); Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Ware, United Kingdom (H.T., J.D.C.); and Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan (E.K.)
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Article Information

vol. 41 no. 2 353-361
DOI 
https://doi.org/10.1124/dmd.112.048918
PubMed 
23132334

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received September 7, 2012
  • Accepted November 6, 2012
  • Published online January 17, 2013.

Article Versions

  • Earlier version (November 6, 2012 - 07:05).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Melinda J. Reese,
  2. Paul M. Savina,
  3. Grant T. Generaux,
  4. Helen Tracey,
  5. Joan E. Humphreys,
  6. Eri Kanaoka,
  7. Lindsey O. Webster,
  8. Kelly A. Harmon,
  9. James D. Clarke, and
  10. Joseph W. Polli
  1. Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, North Carolina (M.J.R., P.M.S., G.T.G., J.E.H., L.O.W., K.A.H., J.W.P.); Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Ware, United Kingdom (H.T., J.D.C.); and Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan (E.K.)
  1. Address correspondence to:
    Melinda J. Reese, Preclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Inc. Room: 2.4075.1, Research Triangle Park, NC 27709. E-mail: mindy.j.reese{at}gsk.com
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Drug Metabolism and Disposition: 41 (2)
Drug Metabolism and Disposition
Vol. 41, Issue 2
1 Feb 2013
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Research ArticleArticle

In Vitro Investigations with Dolutegravir

Melinda J. Reese, Paul M. Savina, Grant T. Generaux, Helen Tracey, Joan E. Humphreys, Eri Kanaoka, Lindsey O. Webster, Kelly A. Harmon, James D. Clarke and Joseph W. Polli
Drug Metabolism and Disposition February 1, 2013, 41 (2) 353-361; DOI: https://doi.org/10.1124/dmd.112.048918

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Research ArticleArticle

In Vitro Investigations with Dolutegravir

Melinda J. Reese, Paul M. Savina, Grant T. Generaux, Helen Tracey, Joan E. Humphreys, Eri Kanaoka, Lindsey O. Webster, Kelly A. Harmon, James D. Clarke and Joseph W. Polli
Drug Metabolism and Disposition February 1, 2013, 41 (2) 353-361; DOI: https://doi.org/10.1124/dmd.112.048918
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