In Vitro Investigations into the Roles of Drug Transporters and Metabolizing Enzymes in the Disposition and Drug Interactions of Dolutegravir, a HIV Integrase Inhibitor

Melinda J. Reese; Paul M. Savina; Grant T. Generaux; Helen Tracey; Joan E. Humphreys; Eri Kanaoka; Lindsey O. Webster; Kelly A. Harmon; James D. Clarke; Joseph W. Polli

doi:10.1124/dmd.112.048918

Research ArticleArticle

In Vitro Investigations into the Roles of Drug Transporters and Metabolizing Enzymes in the Disposition and Drug Interactions of Dolutegravir, a HIV Integrase Inhibitor

Melinda J. Reese, Paul M. Savina, Grant T. Generaux, Helen Tracey, Joan E. Humphreys, Eri Kanaoka, Lindsey O. Webster, Kelly A. Harmon, James D. Clarke and Joseph W. Polli

Drug Metabolism and Disposition February 2013, 41 (2) 353-361; DOI: https://doi.org/10.1124/dmd.112.048918

Melinda J. Reese

Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, North Carolina (M.J.R., P.M.S., G.T.G., J.E.H., L.O.W., K.A.H., J.W.P.); Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Ware, United Kingdom (H.T., J.D.C.); and Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan (E.K.)

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Paul M. Savina

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Grant T. Generaux

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Helen Tracey

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Joan E. Humphreys

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Eri Kanaoka

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Lindsey O. Webster

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Kelly A. Harmon

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James D. Clarke

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Joseph W. Polli

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Drug Metabolism and Disposition

Vol. 41, Issue 2

1 Feb 2013

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Research ArticleArticle

In Vitro Investigations with Dolutegravir

Melinda J. Reese, Paul M. Savina, Grant T. Generaux, Helen Tracey, Joan E. Humphreys, Eri Kanaoka, Lindsey O. Webster, Kelly A. Harmon, James D. Clarke and Joseph W. Polli

Drug Metabolism and Disposition February 1, 2013, 41 (2) 353-361; DOI: https://doi.org/10.1124/dmd.112.048918

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Research ArticleArticle

In Vitro Investigations with Dolutegravir

Melinda J. Reese, Paul M. Savina, Grant T. Generaux, Helen Tracey, Joan E. Humphreys, Eri Kanaoka, Lindsey O. Webster, Kelly A. Harmon, James D. Clarke and Joseph W. Polli

Drug Metabolism and Disposition February 1, 2013, 41 (2) 353-361; DOI: https://doi.org/10.1124/dmd.112.048918

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