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Research ArticleArticle

In Vitro Investigations into the Roles of Drug Transporters and Metabolizing Enzymes in the Disposition and Drug Interactions of Dolutegravir, a HIV Integrase Inhibitor

Melinda J. Reese, Paul M. Savina, Grant T. Generaux, Helen Tracey, Joan E. Humphreys, Eri Kanaoka, Lindsey O. Webster, Kelly A. Harmon, James D. Clarke and Joseph W. Polli
Drug Metabolism and Disposition February 2013, 41 (2) 353-361; DOI: https://doi.org/10.1124/dmd.112.048918
Melinda J. Reese
Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, North Carolina (M.J.R., P.M.S., G.T.G., J.E.H., L.O.W., K.A.H., J.W.P.); Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Ware, United Kingdom (H.T., J.D.C.); and Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan (E.K.)
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Paul M. Savina
Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, North Carolina (M.J.R., P.M.S., G.T.G., J.E.H., L.O.W., K.A.H., J.W.P.); Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Ware, United Kingdom (H.T., J.D.C.); and Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan (E.K.)
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Grant T. Generaux
Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, North Carolina (M.J.R., P.M.S., G.T.G., J.E.H., L.O.W., K.A.H., J.W.P.); Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Ware, United Kingdom (H.T., J.D.C.); and Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan (E.K.)
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Helen Tracey
Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, North Carolina (M.J.R., P.M.S., G.T.G., J.E.H., L.O.W., K.A.H., J.W.P.); Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Ware, United Kingdom (H.T., J.D.C.); and Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan (E.K.)
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Joan E. Humphreys
Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, North Carolina (M.J.R., P.M.S., G.T.G., J.E.H., L.O.W., K.A.H., J.W.P.); Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Ware, United Kingdom (H.T., J.D.C.); and Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan (E.K.)
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Eri Kanaoka
Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, North Carolina (M.J.R., P.M.S., G.T.G., J.E.H., L.O.W., K.A.H., J.W.P.); Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Ware, United Kingdom (H.T., J.D.C.); and Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan (E.K.)
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Lindsey O. Webster
Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, North Carolina (M.J.R., P.M.S., G.T.G., J.E.H., L.O.W., K.A.H., J.W.P.); Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Ware, United Kingdom (H.T., J.D.C.); and Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan (E.K.)
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Kelly A. Harmon
Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, North Carolina (M.J.R., P.M.S., G.T.G., J.E.H., L.O.W., K.A.H., J.W.P.); Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Ware, United Kingdom (H.T., J.D.C.); and Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan (E.K.)
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James D. Clarke
Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, North Carolina (M.J.R., P.M.S., G.T.G., J.E.H., L.O.W., K.A.H., J.W.P.); Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Ware, United Kingdom (H.T., J.D.C.); and Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan (E.K.)
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Joseph W. Polli
Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, North Carolina (M.J.R., P.M.S., G.T.G., J.E.H., L.O.W., K.A.H., J.W.P.); Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Ware, United Kingdom (H.T., J.D.C.); and Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan (E.K.)
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Drug Metabolism and Disposition: 41 (2)
Drug Metabolism and Disposition
Vol. 41, Issue 2
1 Feb 2013
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Research ArticleArticle

In Vitro Investigations with Dolutegravir

Melinda J. Reese, Paul M. Savina, Grant T. Generaux, Helen Tracey, Joan E. Humphreys, Eri Kanaoka, Lindsey O. Webster, Kelly A. Harmon, James D. Clarke and Joseph W. Polli
Drug Metabolism and Disposition February 1, 2013, 41 (2) 353-361; DOI: https://doi.org/10.1124/dmd.112.048918

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Research ArticleArticle

In Vitro Investigations with Dolutegravir

Melinda J. Reese, Paul M. Savina, Grant T. Generaux, Helen Tracey, Joan E. Humphreys, Eri Kanaoka, Lindsey O. Webster, Kelly A. Harmon, James D. Clarke and Joseph W. Polli
Drug Metabolism and Disposition February 1, 2013, 41 (2) 353-361; DOI: https://doi.org/10.1124/dmd.112.048918
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