Research ArticleArticle
In Vitro Cytochrome P450 Activity Decreases in Children with High Pediatric End-Stage Liver Disease Scores
Lies De Bock, Koen Boussery, Myriam Van Winckel, Peter De Paepe, Xavier Rogiers, Xavier Stephenne, Etienne Sokal and Jan Van Bocxlaer
Drug Metabolism and Disposition February 2013, 41 (2) 390-397; DOI: https://doi.org/10.1124/dmd.112.048504
Lies De Bock
Laboratory of Medical Biochemistry and Clinical Analysis, Faculty of Pharmaceutical Sciences, Ghent University (L.D.B., K.B., J.V.B.), Paediatric Gastroenterology Department, Ghent University Hospital (M.V.W.), Heymans Institute of Pharmacology, Ghent University (P.D.P.), and Surgery Department, Ghent University Hospital, De Pintelaan Gent (X.R.), Ghent, Belgium; and Paediatric Department, Paediatrics Unit, Laboratory of Paediatric Hepatology and Cell Therapy, Catholic University of Louvain and St. Luc Clinics, Brussels (X.S., E.S.), Belgium
Koen Boussery
Laboratory of Medical Biochemistry and Clinical Analysis, Faculty of Pharmaceutical Sciences, Ghent University (L.D.B., K.B., J.V.B.), Paediatric Gastroenterology Department, Ghent University Hospital (M.V.W.), Heymans Institute of Pharmacology, Ghent University (P.D.P.), and Surgery Department, Ghent University Hospital, De Pintelaan Gent (X.R.), Ghent, Belgium; and Paediatric Department, Paediatrics Unit, Laboratory of Paediatric Hepatology and Cell Therapy, Catholic University of Louvain and St. Luc Clinics, Brussels (X.S., E.S.), Belgium
Myriam Van Winckel
Laboratory of Medical Biochemistry and Clinical Analysis, Faculty of Pharmaceutical Sciences, Ghent University (L.D.B., K.B., J.V.B.), Paediatric Gastroenterology Department, Ghent University Hospital (M.V.W.), Heymans Institute of Pharmacology, Ghent University (P.D.P.), and Surgery Department, Ghent University Hospital, De Pintelaan Gent (X.R.), Ghent, Belgium; and Paediatric Department, Paediatrics Unit, Laboratory of Paediatric Hepatology and Cell Therapy, Catholic University of Louvain and St. Luc Clinics, Brussels (X.S., E.S.), Belgium
Peter De Paepe
Laboratory of Medical Biochemistry and Clinical Analysis, Faculty of Pharmaceutical Sciences, Ghent University (L.D.B., K.B., J.V.B.), Paediatric Gastroenterology Department, Ghent University Hospital (M.V.W.), Heymans Institute of Pharmacology, Ghent University (P.D.P.), and Surgery Department, Ghent University Hospital, De Pintelaan Gent (X.R.), Ghent, Belgium; and Paediatric Department, Paediatrics Unit, Laboratory of Paediatric Hepatology and Cell Therapy, Catholic University of Louvain and St. Luc Clinics, Brussels (X.S., E.S.), Belgium
Xavier Rogiers
Laboratory of Medical Biochemistry and Clinical Analysis, Faculty of Pharmaceutical Sciences, Ghent University (L.D.B., K.B., J.V.B.), Paediatric Gastroenterology Department, Ghent University Hospital (M.V.W.), Heymans Institute of Pharmacology, Ghent University (P.D.P.), and Surgery Department, Ghent University Hospital, De Pintelaan Gent (X.R.), Ghent, Belgium; and Paediatric Department, Paediatrics Unit, Laboratory of Paediatric Hepatology and Cell Therapy, Catholic University of Louvain and St. Luc Clinics, Brussels (X.S., E.S.), Belgium
Xavier Stephenne
Laboratory of Medical Biochemistry and Clinical Analysis, Faculty of Pharmaceutical Sciences, Ghent University (L.D.B., K.B., J.V.B.), Paediatric Gastroenterology Department, Ghent University Hospital (M.V.W.), Heymans Institute of Pharmacology, Ghent University (P.D.P.), and Surgery Department, Ghent University Hospital, De Pintelaan Gent (X.R.), Ghent, Belgium; and Paediatric Department, Paediatrics Unit, Laboratory of Paediatric Hepatology and Cell Therapy, Catholic University of Louvain and St. Luc Clinics, Brussels (X.S., E.S.), Belgium
Etienne Sokal
Laboratory of Medical Biochemistry and Clinical Analysis, Faculty of Pharmaceutical Sciences, Ghent University (L.D.B., K.B., J.V.B.), Paediatric Gastroenterology Department, Ghent University Hospital (M.V.W.), Heymans Institute of Pharmacology, Ghent University (P.D.P.), and Surgery Department, Ghent University Hospital, De Pintelaan Gent (X.R.), Ghent, Belgium; and Paediatric Department, Paediatrics Unit, Laboratory of Paediatric Hepatology and Cell Therapy, Catholic University of Louvain and St. Luc Clinics, Brussels (X.S., E.S.), Belgium
Jan Van Bocxlaer
Laboratory of Medical Biochemistry and Clinical Analysis, Faculty of Pharmaceutical Sciences, Ghent University (L.D.B., K.B., J.V.B.), Paediatric Gastroenterology Department, Ghent University Hospital (M.V.W.), Heymans Institute of Pharmacology, Ghent University (P.D.P.), and Surgery Department, Ghent University Hospital, De Pintelaan Gent (X.R.), Ghent, Belgium; and Paediatric Department, Paediatrics Unit, Laboratory of Paediatric Hepatology and Cell Therapy, Catholic University of Louvain and St. Luc Clinics, Brussels (X.S., E.S.), Belgium

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Research ArticleArticle
Decreasing P450 Activity with Increasing PELD Score
Lies De Bock, Koen Boussery, Myriam Van Winckel, Peter De Paepe, Xavier Rogiers, Xavier Stephenne, Etienne Sokal and Jan Van Bocxlaer
Drug Metabolism and Disposition February 1, 2013, 41 (2) 390-397; DOI: https://doi.org/10.1124/dmd.112.048504
Research ArticleArticle
Decreasing P450 Activity with Increasing PELD Score
Lies De Bock, Koen Boussery, Myriam Van Winckel, Peter De Paepe, Xavier Rogiers, Xavier Stephenne, Etienne Sokal and Jan Van Bocxlaer
Drug Metabolism and Disposition February 1, 2013, 41 (2) 390-397; DOI: https://doi.org/10.1124/dmd.112.048504
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