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Research ArticleArticle

Cytochrome P450 Regulation by α-Tocopherol in Pxr-Null and PXR-Humanized Mice

Caroline H. Johnson, Jessica A. Bonzo, Jie Cheng, Kristopher W. Krausz, Dong Wook Kang, Hans Luecke, Jeffrey R. Idle and Frank J. Gonzalez
Drug Metabolism and Disposition February 2013, 41 (2) 406-413; DOI: https://doi.org/10.1124/dmd.112.048009
Caroline H. Johnson
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (C.H.J., J.A.B., J.C., K.W.K., F.J.G.); Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland (D.W.K., H.L.); and Hepatology Research Group, Department of Clinical Research, University of Bern, Bern, Switzerland (J.R.I.)
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Jessica A. Bonzo
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (C.H.J., J.A.B., J.C., K.W.K., F.J.G.); Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland (D.W.K., H.L.); and Hepatology Research Group, Department of Clinical Research, University of Bern, Bern, Switzerland (J.R.I.)
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Jie Cheng
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (C.H.J., J.A.B., J.C., K.W.K., F.J.G.); Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland (D.W.K., H.L.); and Hepatology Research Group, Department of Clinical Research, University of Bern, Bern, Switzerland (J.R.I.)
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Kristopher W. Krausz
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (C.H.J., J.A.B., J.C., K.W.K., F.J.G.); Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland (D.W.K., H.L.); and Hepatology Research Group, Department of Clinical Research, University of Bern, Bern, Switzerland (J.R.I.)
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Dong Wook Kang
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (C.H.J., J.A.B., J.C., K.W.K., F.J.G.); Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland (D.W.K., H.L.); and Hepatology Research Group, Department of Clinical Research, University of Bern, Bern, Switzerland (J.R.I.)
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Hans Luecke
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (C.H.J., J.A.B., J.C., K.W.K., F.J.G.); Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland (D.W.K., H.L.); and Hepatology Research Group, Department of Clinical Research, University of Bern, Bern, Switzerland (J.R.I.)
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Jeffrey R. Idle
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (C.H.J., J.A.B., J.C., K.W.K., F.J.G.); Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland (D.W.K., H.L.); and Hepatology Research Group, Department of Clinical Research, University of Bern, Bern, Switzerland (J.R.I.)
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Frank J. Gonzalez
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (C.H.J., J.A.B., J.C., K.W.K., F.J.G.); Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland (D.W.K., H.L.); and Hepatology Research Group, Department of Clinical Research, University of Bern, Bern, Switzerland (J.R.I.)
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Article Information

vol. 41 no. 2 406-413
DOI 
https://doi.org/10.1124/dmd.112.048009
PubMed 
23160821

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received July 20, 2012
  • Accepted November 15, 2012
  • Published online January 17, 2013.

Article Versions

  • Earlier version (November 16, 2012 - 09:06).
  • You are viewing the most recent version of this article.
Copyright & Usage 
U.S. Government work not protected by U.S. copyright

Author Information

  1. Caroline H. Johnson1,
  2. Jessica A. Bonzo,
  3. Jie Cheng,
  4. Kristopher W. Krausz,
  5. Dong Wook Kang2,
  6. Hans Luecke,
  7. Jeffrey R. Idle, and
  8. Frank J. Gonzalez
  1. Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (C.H.J., J.A.B., J.C., K.W.K., F.J.G.); Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland (D.W.K., H.L.); and Hepatology Research Group, Department of Clinical Research, University of Bern, Bern, Switzerland (J.R.I.)
  1. Address correspondence to:
    Frank J. Gonzalez, National Cancer Institute, Building 37, Room 3106, Bethesda, MD 20892. E-mail: fjgonz{at}helix.nih.gov
  1. C.H.J. and J.A.B. contributed equally to the work.

  • ↵1 Current affiliation: Scripps Center for Metabolomics and Mass Spectrometry, Scripps Research Institute, La Jolla, California.

  • ↵2 Current affiliation: Department of Pharmaceutical Science and Technology, Catholic University of Deagu, Gyeongsan City, South Korea.

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Drug Metabolism and Disposition: 41 (2)
Drug Metabolism and Disposition
Vol. 41, Issue 2
1 Feb 2013
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Research ArticleArticle

The Regulation of P450 Gene Expression by α-Tocopherol

Caroline H. Johnson, Jessica A. Bonzo, Jie Cheng, Kristopher W. Krausz, Dong Wook Kang, Hans Luecke, Jeffrey R. Idle and Frank J. Gonzalez
Drug Metabolism and Disposition February 1, 2013, 41 (2) 406-413; DOI: https://doi.org/10.1124/dmd.112.048009

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Research ArticleArticle

The Regulation of P450 Gene Expression by α-Tocopherol

Caroline H. Johnson, Jessica A. Bonzo, Jie Cheng, Kristopher W. Krausz, Dong Wook Kang, Hans Luecke, Jeffrey R. Idle and Frank J. Gonzalez
Drug Metabolism and Disposition February 1, 2013, 41 (2) 406-413; DOI: https://doi.org/10.1124/dmd.112.048009
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