Research ArticleArticle
Metabolic Transformation of Antitumor Acridinone C-1305 but Not C-1311 via Selective Cellular Expression of UGT1A10 Increases Cytotoxic Response: Implications for Clinical Use
Monika Pawlowska, Rong Chu, Barbara Fedejko-Kap, Ewa Augustin, Zofia Mazerska, Anna Radominska-Pandya and Timothy C. Chambers
Drug Metabolism and Disposition February 2013, 41 (2) 414-421; DOI: https://doi.org/10.1124/dmd.112.047811
Monika Pawlowska
Department of Pharmaceutical Technology and Biochemistry, Chemical Faculty, Gdańsk University of Technology, Gdańsk, Poland (M.P., B.F.-K., E.A., Z.M.); and Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas (R.C., A.R.-P., T.C.C.)
Rong Chu
Department of Pharmaceutical Technology and Biochemistry, Chemical Faculty, Gdańsk University of Technology, Gdańsk, Poland (M.P., B.F.-K., E.A., Z.M.); and Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas (R.C., A.R.-P., T.C.C.)
Barbara Fedejko-Kap
Department of Pharmaceutical Technology and Biochemistry, Chemical Faculty, Gdańsk University of Technology, Gdańsk, Poland (M.P., B.F.-K., E.A., Z.M.); and Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas (R.C., A.R.-P., T.C.C.)
Ewa Augustin
Department of Pharmaceutical Technology and Biochemistry, Chemical Faculty, Gdańsk University of Technology, Gdańsk, Poland (M.P., B.F.-K., E.A., Z.M.); and Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas (R.C., A.R.-P., T.C.C.)
Zofia Mazerska
Department of Pharmaceutical Technology and Biochemistry, Chemical Faculty, Gdańsk University of Technology, Gdańsk, Poland (M.P., B.F.-K., E.A., Z.M.); and Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas (R.C., A.R.-P., T.C.C.)
Anna Radominska-Pandya
Department of Pharmaceutical Technology and Biochemistry, Chemical Faculty, Gdańsk University of Technology, Gdańsk, Poland (M.P., B.F.-K., E.A., Z.M.); and Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas (R.C., A.R.-P., T.C.C.)
Timothy C. Chambers
Department of Pharmaceutical Technology and Biochemistry, Chemical Faculty, Gdańsk University of Technology, Gdańsk, Poland (M.P., B.F.-K., E.A., Z.M.); and Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas (R.C., A.R.-P., T.C.C.)

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Research ArticleArticle
Glucuronidation of Acridinones Increases Cytotoxic Response
Monika Pawlowska, Rong Chu, Barbara Fedejko-Kap, Ewa Augustin, Zofia Mazerska, Anna Radominska-Pandya and Timothy C. Chambers
Drug Metabolism and Disposition February 1, 2013, 41 (2) 414-421; DOI: https://doi.org/10.1124/dmd.112.047811
Research ArticleArticle
Glucuronidation of Acridinones Increases Cytotoxic Response
Monika Pawlowska, Rong Chu, Barbara Fedejko-Kap, Ewa Augustin, Zofia Mazerska, Anna Radominska-Pandya and Timothy C. Chambers
Drug Metabolism and Disposition February 1, 2013, 41 (2) 414-421; DOI: https://doi.org/10.1124/dmd.112.047811
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