Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Drug Metabolism & Disposition
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Drug Metabolism & Disposition

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit dmd on Facebook
  • Follow dmd on Twitter
  • Follow ASPET on LinkedIn
Research ArticleArticle

Pharmacokinetics, Metabolism, and Excretion of the Antidiabetic Agent Ertugliflozin (PF-04971729) in Healthy Male Subjects

Zhuang Miao, Gianluca Nucci, Neeta Amin, Raman Sharma, Vincent Mascitti, Meera Tugnait, Alfin D. Vaz, Ernesto Callegari and Amit S. Kalgutkar
Drug Metabolism and Disposition February 2013, 41 (2) 445-456; DOI: https://doi.org/10.1124/dmd.112.049551
Zhuang Miao
Pharmacokinetics, Dynamics and Metabolism, New Chemical Entities, Groton, Connecticut (Z.M., R.S., M.T., A.D.V., E.C.) and Cambridge, Massachusetts (A.S.K.); Cardiovascular, Metabolic and Endocrine Diseases Research Unit (N.A.); Clinical Pharmacology, Cambridge, Massachusetts (G.N.); and Worldwide Medicinal Chemistry, Pfizer Inc., Groton, Connecticut (V.M.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gianluca Nucci
Pharmacokinetics, Dynamics and Metabolism, New Chemical Entities, Groton, Connecticut (Z.M., R.S., M.T., A.D.V., E.C.) and Cambridge, Massachusetts (A.S.K.); Cardiovascular, Metabolic and Endocrine Diseases Research Unit (N.A.); Clinical Pharmacology, Cambridge, Massachusetts (G.N.); and Worldwide Medicinal Chemistry, Pfizer Inc., Groton, Connecticut (V.M.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Neeta Amin
Pharmacokinetics, Dynamics and Metabolism, New Chemical Entities, Groton, Connecticut (Z.M., R.S., M.T., A.D.V., E.C.) and Cambridge, Massachusetts (A.S.K.); Cardiovascular, Metabolic and Endocrine Diseases Research Unit (N.A.); Clinical Pharmacology, Cambridge, Massachusetts (G.N.); and Worldwide Medicinal Chemistry, Pfizer Inc., Groton, Connecticut (V.M.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Raman Sharma
Pharmacokinetics, Dynamics and Metabolism, New Chemical Entities, Groton, Connecticut (Z.M., R.S., M.T., A.D.V., E.C.) and Cambridge, Massachusetts (A.S.K.); Cardiovascular, Metabolic and Endocrine Diseases Research Unit (N.A.); Clinical Pharmacology, Cambridge, Massachusetts (G.N.); and Worldwide Medicinal Chemistry, Pfizer Inc., Groton, Connecticut (V.M.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Vincent Mascitti
Pharmacokinetics, Dynamics and Metabolism, New Chemical Entities, Groton, Connecticut (Z.M., R.S., M.T., A.D.V., E.C.) and Cambridge, Massachusetts (A.S.K.); Cardiovascular, Metabolic and Endocrine Diseases Research Unit (N.A.); Clinical Pharmacology, Cambridge, Massachusetts (G.N.); and Worldwide Medicinal Chemistry, Pfizer Inc., Groton, Connecticut (V.M.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Meera Tugnait
Pharmacokinetics, Dynamics and Metabolism, New Chemical Entities, Groton, Connecticut (Z.M., R.S., M.T., A.D.V., E.C.) and Cambridge, Massachusetts (A.S.K.); Cardiovascular, Metabolic and Endocrine Diseases Research Unit (N.A.); Clinical Pharmacology, Cambridge, Massachusetts (G.N.); and Worldwide Medicinal Chemistry, Pfizer Inc., Groton, Connecticut (V.M.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alfin D. Vaz
Pharmacokinetics, Dynamics and Metabolism, New Chemical Entities, Groton, Connecticut (Z.M., R.S., M.T., A.D.V., E.C.) and Cambridge, Massachusetts (A.S.K.); Cardiovascular, Metabolic and Endocrine Diseases Research Unit (N.A.); Clinical Pharmacology, Cambridge, Massachusetts (G.N.); and Worldwide Medicinal Chemistry, Pfizer Inc., Groton, Connecticut (V.M.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ernesto Callegari
Pharmacokinetics, Dynamics and Metabolism, New Chemical Entities, Groton, Connecticut (Z.M., R.S., M.T., A.D.V., E.C.) and Cambridge, Massachusetts (A.S.K.); Cardiovascular, Metabolic and Endocrine Diseases Research Unit (N.A.); Clinical Pharmacology, Cambridge, Massachusetts (G.N.); and Worldwide Medicinal Chemistry, Pfizer Inc., Groton, Connecticut (V.M.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Amit S. Kalgutkar
Pharmacokinetics, Dynamics and Metabolism, New Chemical Entities, Groton, Connecticut (Z.M., R.S., M.T., A.D.V., E.C.) and Cambridge, Massachusetts (A.S.K.); Cardiovascular, Metabolic and Endocrine Diseases Research Unit (N.A.); Clinical Pharmacology, Cambridge, Massachusetts (G.N.); and Worldwide Medicinal Chemistry, Pfizer Inc., Groton, Connecticut (V.M.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF + SI
  • PDF
Loading

Article Information

vol. 41 no. 2 445-456
DOI 
https://doi.org/10.1124/dmd.112.049551
PubMed 
23169609

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received October 9, 2012
  • Accepted November 20, 2012
  • Published online January 17, 2013.

Article Versions

  • Earlier version (November 20, 2012 - 08:55).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Zhuang Miao,
  2. Gianluca Nucci,
  3. Neeta Amin,
  4. Raman Sharma,
  5. Vincent Mascitti,
  6. Meera Tugnait,
  7. Alfin D. Vaz,
  8. Ernesto Callegari, and
  9. Amit S. Kalgutkar
  1. Pharmacokinetics, Dynamics and Metabolism, New Chemical Entities, Groton, Connecticut (Z.M., R.S., M.T., A.D.V., E.C.) and Cambridge, Massachusetts (A.S.K.); Cardiovascular, Metabolic and Endocrine Diseases Research Unit (N.A.); Clinical Pharmacology, Cambridge, Massachusetts (G.N.); and Worldwide Medicinal Chemistry, Pfizer Inc., Groton, Connecticut (V.M.).
  1. Address correspondence to:
    Amit S. Kalgutkar, Pharmacokinetics, Dynamics, and Metabolism-New Chemical Entities, Pfizer Worldwide Research and Development, Cambridge, MA 02139. E-mail: amit.kalgutkar{at}pfizer.com
View Full Text

Statistics from Altmetric.com

Article usage

Article usage: August 2017 to November 2023

AbstractFullPdf
Aug 2017223447
Sep 2017164937
Oct 2017176245
Nov 2017135236
Dec 2017134748
Jan 2018256964
Feb 2018327851
Mar 20183310183
Apr 2018369997
May 2018217372
Jun 2018215852
Jul 2018116255
Aug 2018134635
Sep 2018136258
Oct 2018259174
Nov 201835101102
Dec 20181163546
Jan 2019110228
Feb 2019861641
Mar 2019153742
Apr 2019651024
May 201992540
Jun 201950819
Jul 2019521145
Aug 2019471330
Oct 2019681124
Nov 2019135812
Dec 201974511
Jan 202096921
Feb 202046818
Mar 2020142717
May 2020531515
Jun 2020101825
Jul 20204566
Aug 202041315
Sep 202044717
Oct 202057817
Nov 202068625
Dec 202081217
Jan 2021571125
Feb 202152513
Mar 20216839
Apr 2021891216
May 202159310
Jun 20214488
Jul 202162611
Aug 202173615
Sep 202152414
Oct 202151512
Nov 20215769
Dec 202155614
Jan 202255811
Feb 20222846
Mar 202264414
Apr 202241712
May 202256710
Jun 2022591115
Jul 202251628
Aug 20226626
Sep 20225146
Oct 20223844
Nov 20225789
Dec 20225527
Jan 20237146
Feb 20234029
Mar 202353512
Apr 202360414
May 202359816
Jun 20235961
Jul 20237928
Aug 202336613
Sep 202339315
Oct 202349414
Nov 20239619

PreviousNext
Back to top

In this issue

Drug Metabolism and Disposition: 41 (2)
Drug Metabolism and Disposition
Vol. 41, Issue 2
1 Feb 2013
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Drug Metabolism & Disposition article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Pharmacokinetics, Metabolism, and Excretion of the Antidiabetic Agent Ertugliflozin (PF-04971729) in Healthy Male Subjects
(Your Name) has forwarded a page to you from Drug Metabolism & Disposition
(Your Name) thought you would be interested in this article in Drug Metabolism & Disposition.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleArticle

Disposition of Ertugliflozin in Humans

Zhuang Miao, Gianluca Nucci, Neeta Amin, Raman Sharma, Vincent Mascitti, Meera Tugnait, Alfin D. Vaz, Ernesto Callegari and Amit S. Kalgutkar
Drug Metabolism and Disposition February 1, 2013, 41 (2) 445-456; DOI: https://doi.org/10.1124/dmd.112.049551

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research ArticleArticle

Disposition of Ertugliflozin in Humans

Zhuang Miao, Gianluca Nucci, Neeta Amin, Raman Sharma, Vincent Mascitti, Meera Tugnait, Alfin D. Vaz, Ernesto Callegari and Amit S. Kalgutkar
Drug Metabolism and Disposition February 1, 2013, 41 (2) 445-456; DOI: https://doi.org/10.1124/dmd.112.049551
Reddit logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Acknowledgments
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF + SI
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • CYP3A-Catalyzed Deoxycholate and Glycodeoxycholate Oxidation
  • Variants linked with hepatic CYP2D6 expression and activity
  • Cytochrome P450 4F11 in lung cancer
Show more Articles

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About DMD
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Journal of Pharmacology and Experimental Therapeutics
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-009X (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics