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Drug Metabolism & Disposition

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Table of Contents

March 01, 2013; Volume 41,Issue 3

Commentary

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    A Perspective on the Contribution of Metabolites to Drug-Drug Interaction Potential: The Need to Consider Both Circulating Levels and Inhibition Potency
    Hongbin Yu and Donald Tweedie
    Drug Metabolism and Disposition March 2013, 41 (3) 536-540; DOI: https://doi.org/10.1124/dmd.112.048892

Short Communications

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    Pharmacogenomics of Gemcitabine Metabolism: Functional Analysis of Genetic Variants in Cytidine Deaminase and Deoxycytidine Kinase
    Jessica A. Roseberry Baker, Enaksha R. Wickremsinhe, Claire H. Li, Olukayode A. Oluyedun, Anne H. Dantzig, Stephen D. Hall, Yue-wei Qian, Barbara J. Ring, Steven A. Wrighton and Yingying Guo
    Drug Metabolism and Disposition March 2013, 41 (3) 541-545; DOI: https://doi.org/10.1124/dmd.112.048769
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    The Bovine ATP-Binding Cassette Transporter ABCG2 Tyr581Ser Single-Nucleotide Polymorphism Increases Milk Secretion of the Fluoroquinolone Danofloxacin
    Jon A. Otero, Rebeca Real, Álvaro de la Fuente, Julio G. Prieto, Margarita Marqués, Ana I. Álvarez and Gracia Merino
    Drug Metabolism and Disposition March 2013, 41 (3) 546-549; DOI: https://doi.org/10.1124/dmd.112.049056
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    Nicotinamide N-Oxidation by CYP2E1 in Human Liver Microsomes
    Alexander Michael Real, Shangyu Hong and Pavlos Pissios
    Drug Metabolism and Disposition March 2013, 41 (3) 550-553; DOI: https://doi.org/10.1124/dmd.112.049734

Articles

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    Altered UDP-Glucuronosyltransferase and Sulfotransferase Expression and Function during Progressive Stages of Human Nonalcoholic Fatty Liver Disease
    Rhiannon N. Hardwick, Daniel W. Ferreira, Vijay R. More, April D. Lake, Zhenqiang Lu, Jose E. Manautou, Angela L. Slitt and Nathan J. Cherrington
    Drug Metabolism and Disposition March 2013, 41 (3) 554-561; DOI: https://doi.org/10.1124/dmd.112.048439
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    Phase 1 and Phase 2 Drug Metabolism and Bile Acid Production of HepaRG Cells in a Bioartificial Liver in Absence of Dimethyl Sulfoxide
    Ruurdtje Hoekstra, Geert A.A. Nibourg, Tessa V. van der Hoeven, Gabrielle Plomer, Jurgen Seppen, Mariëtte T. Ackermans, Sandrine Camus, Wim Kulik, Thomas M. van Gulik, Ronald P. Oude Elferink and Robert A.F.M. Chamuleau
    Drug Metabolism and Disposition March 2013, 41 (3) 562-567; DOI: https://doi.org/10.1124/dmd.112.049098
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    Involvement of UDP-Glucuronosyltransferases UGT1A9 and UGT2B7 in Ethanol Glucuronidation, and Interactions with Common Drugs of Abuse
    Alaa Al Saabi, Delphine Allorge, François-Ludovic Sauvage, Gilles Tournel, Jean-michel Gaulier, Pierre Marquet and Nicolas Picard
    Drug Metabolism and Disposition March 2013, 41 (3) 568-574; DOI: https://doi.org/10.1124/dmd.112.047878
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    The Influence of Sex, Ethnicity, and CYP2B6 Genotype on Bupropion Metabolism as an Index of Hepatic CYP2B6 Activity in Humans
    Katarina Ilic, Roy L. Hawke, Ranjit K. Thirumaran, Erin G. Schuetz, J. Heyward Hull, Angela D.M. Kashuba, Paul W. Stewart, Celeste M. Lindley and Mei-Ling Chen
    Drug Metabolism and Disposition March 2013, 41 (3) 575-581; DOI: https://doi.org/10.1124/dmd.112.048108
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    Regiospecificity and Stereospecificity of Human UDP-Glucuronosyltransferases in the Glucuronidation of Estriol, 16-Epiestriol, 17-Epiestriol, and 13-Epiestradiol
    Nina Sneitz, Mikko Vahermo, Johanna Mosorin, Liisa Laakkonen, Donald Poirier and Moshe Finel
    Drug Metabolism and Disposition March 2013, 41 (3) 582-591; DOI: https://doi.org/10.1124/dmd.112.049072
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    Drug-Drug Interactions between Rosuvastatin and Oral Antidiabetic Drugs Occurring at the Level of OATP1B1
    E. van de Steeg, R. Greupink, M. Schreurs, I.H.G. Nooijen, K.C.M. Verhoeckx, R. Hanemaaijer, D. Ripken, M. Monshouwer, M.L.H. Vlaming, J. DeGroot, M. Verwei, F.G.M. Russel, M.T. Huisman and H.M. Wortelboer
    Drug Metabolism and Disposition March 2013, 41 (3) 592-601; DOI: https://doi.org/10.1124/dmd.112.049023
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    Identification of Multiple Binding Sites for Substrate Transport in Bovine Organic Anion Transporting Polypeptide 1a2
    Xiaoxiao Liu, Jiujiu Huang, Yongxue Sun, Kai Zhan, Zheren Zhang and Mei Hong
    Drug Metabolism and Disposition March 2013, 41 (3) 602-607; DOI: https://doi.org/10.1124/dmd.112.047910
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    Significance of Peptide Transporter 1 in the Intestinal Permeability of Valacyclovir in Wild-Type and PepT1 Knockout Mice
    Bei Yang and David E. Smith
    Drug Metabolism and Disposition March 2013, 41 (3) 608-614; DOI: https://doi.org/10.1124/dmd.112.049239
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    Long-Lasting Inhibitory Effect of Apple and Orange Juices, but Not Grapefruit Juice, on OATP2B1-Mediated Drug Absorption
    Yoshiyuki Shirasaka, Megumi Shichiri, Yukiko Murata, Takanori Mori, Takeo Nakanishi and Ikumi Tamai
    Drug Metabolism and Disposition March 2013, 41 (3) 615-621; DOI: https://doi.org/10.1124/dmd.112.049635
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    Metabolism of Saikosaponin a in Rats: Diverse Oxidations on the Aglycone Moiety in Liver and Intestine in Addition to Hydrolysis of Glycosidic Bonds
    Guoqiang Liu, Yuan Tian, Geng Li, Lei Xu, Rui Song and Zunjian Zhang
    Drug Metabolism and Disposition March 2013, 41 (3) 622-633; DOI: https://doi.org/10.1124/dmd.112.048975
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    Amide Hydrolysis of a Novel Chemical Series of Microsomal Prostaglandin E Synthase-1 Inhibitors Induces Kidney Toxicity in the Rat
    Johan Bylund, Anita Annas, Dennis Hellgren, Sivert Bjurström, Håkan Andersson and Alexander Svanhagen
    Drug Metabolism and Disposition March 2013, 41 (3) 634-641; DOI: https://doi.org/10.1124/dmd.112.048983
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    P-Glycoprotein Increases Portal Bioavailability of Loperamide in Mouse by Reducing First-Pass Intestinal Metabolism
    Matthew B. Dufek, Beverly M. Knight, Arlene S. Bridges and Dhiren R. Thakker
    Drug Metabolism and Disposition March 2013, 41 (3) 642-650; DOI: https://doi.org/10.1124/dmd.112.049965
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    Characterization of Human Cytochrome P450s Involved in the Bioactivation of Clozapine
    Sanja Dragovic, Patrina Gunness, Magnus Ingelman-Sundberg, Nico P.E. Vermeulen and Jan N. M. Commandeur
    Drug Metabolism and Disposition March 2013, 41 (3) 651-658; DOI: https://doi.org/10.1124/dmd.112.050484
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    Brain Efflux Index To Investigate the Influence of Active Efflux on Brain Distribution of Pemetrexed and Methotrexate
    Li Li, Sagar Agarwal and William F. Elmquist
    Drug Metabolism and Disposition March 2013, 41 (3) 659-667; DOI: https://doi.org/10.1124/dmd.112.049254
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    In Vitro Assessment of Drug-Drug Interaction Potential of Boceprevir Associated with Drug Metabolizing Enzymes and Transporters
    Xiaoyan Chu, Xiaoxin Cai, Donghui Cui, Cuyue Tang, Anima Ghosal, Grace Chan, Mitchell D Green, Yuhsin Kuo, Yuexia Liang, Cheri M Maciolek, Jairam Palamanda, Raymond Evers and Thomayant Prueksaritanont
    Drug Metabolism and Disposition March 2013, 41 (3) 668-681; DOI: https://doi.org/10.1124/dmd.112.049668

Erratum

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    Correction to “Gestational Age-Dependent Changes in Gene Expression of Metabolic Enzymes and Transporters in Pregnant Mice”
    Drug Metabolism and Disposition March 2013, 41 (3) 682; DOI: https://doi.org/10.1124/dmd.112.03er13
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Drug Metabolism and Disposition: 41 (3)
Drug Metabolism and Disposition
Vol. 41, Issue 3
1 Mar 2013
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