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A Perspective on the Contribution of Metabolites to Drug-Drug Interaction Potential: The Need to Consider Both Circulating Levels and Inhibition Potency

Hongbin Yu and Donald Tweedie
Drug Metabolism and Disposition March 2013, 41 (3) 536-540; DOI: https://doi.org/10.1124/dmd.112.048892

Article Information

vol. 41 no. 3 536-540
DOI 
https://doi.org/10.1124/dmd.112.048892
PubMed 
23143892
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received September 7, 2012
  • Accepted November 9, 2012
  • Published online February 15, 2013.

Article Versions

Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Hongbin Yu and
  2. Donald Tweedie
  1. Department of Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut
  1. Address correspondence to:
    Hongbin Yu, Department of Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, CT 06877. E-mail: hongbin.yu{at}boehringer-ingelheim.com
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Metabolite Contribution to DDI: Levels and Potency

Hongbin Yu and Donald Tweedie
Drug Metabolism and Disposition March 1, 2013, 41 (3) 536-540; DOI: https://doi.org/10.1124/dmd.112.048892
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