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Research ArticleArticle

Phase 1 and Phase 2 Drug Metabolism and Bile Acid Production of HepaRG Cells in a Bioartificial Liver in Absence of Dimethyl Sulfoxide

Ruurdtje Hoekstra, Geert A.A. Nibourg, Tessa V. van der Hoeven, Gabrielle Plomer, Jurgen Seppen, Mariëtte T. Ackermans, Sandrine Camus, Wim Kulik, Thomas M. van Gulik, Ronald P. Oude Elferink and Robert A.F.M. Chamuleau
Drug Metabolism and Disposition March 2013, 41 (3) 562-567; DOI: https://doi.org/10.1124/dmd.112.049098
Ruurdtje Hoekstra
Tytgat Institute for Liver and Intestinal Research (R.H., G.A.A.N., T.V.v.d.H., G.P., J.S., R.P.O.E., R.A.F.M.C), Surgical Laboratory (R.H., G.A.A.N., T.V.v.d.H., G.P., T.M.v.G.) Department of Clinical Chemistry, Laboratory of Endocrinology (M.T.A.), Department of Genetic Metabolic Diseases (W.K.) Academic Medical Center, Meibergdreef, Amsterdam, The Netherlands; and Biopredic International, Rennes, France (S.C.)
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Geert A.A. Nibourg
Tytgat Institute for Liver and Intestinal Research (R.H., G.A.A.N., T.V.v.d.H., G.P., J.S., R.P.O.E., R.A.F.M.C), Surgical Laboratory (R.H., G.A.A.N., T.V.v.d.H., G.P., T.M.v.G.) Department of Clinical Chemistry, Laboratory of Endocrinology (M.T.A.), Department of Genetic Metabolic Diseases (W.K.) Academic Medical Center, Meibergdreef, Amsterdam, The Netherlands; and Biopredic International, Rennes, France (S.C.)
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Tessa V. van der Hoeven
Tytgat Institute for Liver and Intestinal Research (R.H., G.A.A.N., T.V.v.d.H., G.P., J.S., R.P.O.E., R.A.F.M.C), Surgical Laboratory (R.H., G.A.A.N., T.V.v.d.H., G.P., T.M.v.G.) Department of Clinical Chemistry, Laboratory of Endocrinology (M.T.A.), Department of Genetic Metabolic Diseases (W.K.) Academic Medical Center, Meibergdreef, Amsterdam, The Netherlands; and Biopredic International, Rennes, France (S.C.)
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Gabrielle Plomer
Tytgat Institute for Liver and Intestinal Research (R.H., G.A.A.N., T.V.v.d.H., G.P., J.S., R.P.O.E., R.A.F.M.C), Surgical Laboratory (R.H., G.A.A.N., T.V.v.d.H., G.P., T.M.v.G.) Department of Clinical Chemistry, Laboratory of Endocrinology (M.T.A.), Department of Genetic Metabolic Diseases (W.K.) Academic Medical Center, Meibergdreef, Amsterdam, The Netherlands; and Biopredic International, Rennes, France (S.C.)
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Jurgen Seppen
Tytgat Institute for Liver and Intestinal Research (R.H., G.A.A.N., T.V.v.d.H., G.P., J.S., R.P.O.E., R.A.F.M.C), Surgical Laboratory (R.H., G.A.A.N., T.V.v.d.H., G.P., T.M.v.G.) Department of Clinical Chemistry, Laboratory of Endocrinology (M.T.A.), Department of Genetic Metabolic Diseases (W.K.) Academic Medical Center, Meibergdreef, Amsterdam, The Netherlands; and Biopredic International, Rennes, France (S.C.)
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Mariëtte T. Ackermans
Tytgat Institute for Liver and Intestinal Research (R.H., G.A.A.N., T.V.v.d.H., G.P., J.S., R.P.O.E., R.A.F.M.C), Surgical Laboratory (R.H., G.A.A.N., T.V.v.d.H., G.P., T.M.v.G.) Department of Clinical Chemistry, Laboratory of Endocrinology (M.T.A.), Department of Genetic Metabolic Diseases (W.K.) Academic Medical Center, Meibergdreef, Amsterdam, The Netherlands; and Biopredic International, Rennes, France (S.C.)
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Sandrine Camus
Tytgat Institute for Liver and Intestinal Research (R.H., G.A.A.N., T.V.v.d.H., G.P., J.S., R.P.O.E., R.A.F.M.C), Surgical Laboratory (R.H., G.A.A.N., T.V.v.d.H., G.P., T.M.v.G.) Department of Clinical Chemistry, Laboratory of Endocrinology (M.T.A.), Department of Genetic Metabolic Diseases (W.K.) Academic Medical Center, Meibergdreef, Amsterdam, The Netherlands; and Biopredic International, Rennes, France (S.C.)
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Wim Kulik
Tytgat Institute for Liver and Intestinal Research (R.H., G.A.A.N., T.V.v.d.H., G.P., J.S., R.P.O.E., R.A.F.M.C), Surgical Laboratory (R.H., G.A.A.N., T.V.v.d.H., G.P., T.M.v.G.) Department of Clinical Chemistry, Laboratory of Endocrinology (M.T.A.), Department of Genetic Metabolic Diseases (W.K.) Academic Medical Center, Meibergdreef, Amsterdam, The Netherlands; and Biopredic International, Rennes, France (S.C.)
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Thomas M. van Gulik
Tytgat Institute for Liver and Intestinal Research (R.H., G.A.A.N., T.V.v.d.H., G.P., J.S., R.P.O.E., R.A.F.M.C), Surgical Laboratory (R.H., G.A.A.N., T.V.v.d.H., G.P., T.M.v.G.) Department of Clinical Chemistry, Laboratory of Endocrinology (M.T.A.), Department of Genetic Metabolic Diseases (W.K.) Academic Medical Center, Meibergdreef, Amsterdam, The Netherlands; and Biopredic International, Rennes, France (S.C.)
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Ronald P. Oude Elferink
Tytgat Institute for Liver and Intestinal Research (R.H., G.A.A.N., T.V.v.d.H., G.P., J.S., R.P.O.E., R.A.F.M.C), Surgical Laboratory (R.H., G.A.A.N., T.V.v.d.H., G.P., T.M.v.G.) Department of Clinical Chemistry, Laboratory of Endocrinology (M.T.A.), Department of Genetic Metabolic Diseases (W.K.) Academic Medical Center, Meibergdreef, Amsterdam, The Netherlands; and Biopredic International, Rennes, France (S.C.)
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Robert A.F.M. Chamuleau
Tytgat Institute for Liver and Intestinal Research (R.H., G.A.A.N., T.V.v.d.H., G.P., J.S., R.P.O.E., R.A.F.M.C), Surgical Laboratory (R.H., G.A.A.N., T.V.v.d.H., G.P., T.M.v.G.) Department of Clinical Chemistry, Laboratory of Endocrinology (M.T.A.), Department of Genetic Metabolic Diseases (W.K.) Academic Medical Center, Meibergdreef, Amsterdam, The Netherlands; and Biopredic International, Rennes, France (S.C.)
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Article Information

vol. 41 no. 3 562-567
DOI 
https://doi.org/10.1124/dmd.112.049098
PubMed 
23238784

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received October 12, 2012
  • Accepted December 10, 2012
  • Published online February 15, 2013.

Article Versions

  • Earlier version (December 13, 2012 - 07:00).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Ruurdtje Hoekstra,
  2. Geert A.A. Nibourg,
  3. Tessa V. van der Hoeven,
  4. Gabrielle Plomer,
  5. Jurgen Seppen,
  6. Mariëtte T. Ackermans,
  7. Sandrine Camus,
  8. Wim Kulik,
  9. Thomas M. van Gulik,
  10. Ronald P. Oude Elferink, and
  11. Robert A.F.M. Chamuleau
  1. Tytgat Institute for Liver and Intestinal Research (R.H., G.A.A.N., T.V.v.d.H., G.P., J.S., R.P.O.E., R.A.F.M.C), Surgical Laboratory (R.H., G.A.A.N., T.V.v.d.H., G.P., T.M.v.G.) Department of Clinical Chemistry, Laboratory of Endocrinology (M.T.A.), Department of Genetic Metabolic Diseases (W.K.) Academic Medical Center, Meibergdreef, Amsterdam, The Netherlands; and Biopredic International, Rennes, France (S.C.)
  1. Address correspondence to:
    R. Hoekstra, Surgical Laboratory, IWO-1-172, AMC, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. E-mail: r.hoekstra{at}amc.uva.nl
  1. This work was also presented as Nibourg GAA (2012) Human Liver Cell Lines for the AMC-Bioartificial Liver. Doctoral dissertation, University of Amsterdam, Amsterdam, The Netherlands.

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Research ArticleArticle

Drug Metabolism and Bile acid Formation of HepaRG Bioreactor

Ruurdtje Hoekstra, Geert A.A. Nibourg, Tessa V. van der Hoeven, Gabrielle Plomer, Jurgen Seppen, Mariëtte T. Ackermans, Sandrine Camus, Wim Kulik, Thomas M. van Gulik, Ronald P. Oude Elferink and Robert A.F.M. Chamuleau
Drug Metabolism and Disposition March 1, 2013, 41 (3) 562-567; DOI: https://doi.org/10.1124/dmd.112.049098

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Research ArticleArticle

Drug Metabolism and Bile acid Formation of HepaRG Bioreactor

Ruurdtje Hoekstra, Geert A.A. Nibourg, Tessa V. van der Hoeven, Gabrielle Plomer, Jurgen Seppen, Mariëtte T. Ackermans, Sandrine Camus, Wim Kulik, Thomas M. van Gulik, Ronald P. Oude Elferink and Robert A.F.M. Chamuleau
Drug Metabolism and Disposition March 1, 2013, 41 (3) 562-567; DOI: https://doi.org/10.1124/dmd.112.049098
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