Research ArticleArticle
Phase 1 and Phase 2 Drug Metabolism and Bile Acid Production of HepaRG Cells in a Bioartificial Liver in Absence of Dimethyl Sulfoxide
Ruurdtje Hoekstra, Geert A.A. Nibourg, Tessa V. van der Hoeven, Gabrielle Plomer, Jurgen Seppen, Mariëtte T. Ackermans, Sandrine Camus, Wim Kulik, Thomas M. van Gulik, Ronald P. Oude Elferink and Robert A.F.M. Chamuleau
Drug Metabolism and Disposition March 2013, 41 (3) 562-567; DOI: https://doi.org/10.1124/dmd.112.049098
Ruurdtje Hoekstra
Tytgat Institute for Liver and Intestinal Research (R.H., G.A.A.N., T.V.v.d.H., G.P., J.S., R.P.O.E., R.A.F.M.C), Surgical Laboratory (R.H., G.A.A.N., T.V.v.d.H., G.P., T.M.v.G.) Department of Clinical Chemistry, Laboratory of Endocrinology (M.T.A.), Department of Genetic Metabolic Diseases (W.K.) Academic Medical Center, Meibergdreef, Amsterdam, The Netherlands; and Biopredic International, Rennes, France (S.C.)
Geert A.A. Nibourg
Tytgat Institute for Liver and Intestinal Research (R.H., G.A.A.N., T.V.v.d.H., G.P., J.S., R.P.O.E., R.A.F.M.C), Surgical Laboratory (R.H., G.A.A.N., T.V.v.d.H., G.P., T.M.v.G.) Department of Clinical Chemistry, Laboratory of Endocrinology (M.T.A.), Department of Genetic Metabolic Diseases (W.K.) Academic Medical Center, Meibergdreef, Amsterdam, The Netherlands; and Biopredic International, Rennes, France (S.C.)
Tessa V. van der Hoeven
Tytgat Institute for Liver and Intestinal Research (R.H., G.A.A.N., T.V.v.d.H., G.P., J.S., R.P.O.E., R.A.F.M.C), Surgical Laboratory (R.H., G.A.A.N., T.V.v.d.H., G.P., T.M.v.G.) Department of Clinical Chemistry, Laboratory of Endocrinology (M.T.A.), Department of Genetic Metabolic Diseases (W.K.) Academic Medical Center, Meibergdreef, Amsterdam, The Netherlands; and Biopredic International, Rennes, France (S.C.)
Gabrielle Plomer
Tytgat Institute for Liver and Intestinal Research (R.H., G.A.A.N., T.V.v.d.H., G.P., J.S., R.P.O.E., R.A.F.M.C), Surgical Laboratory (R.H., G.A.A.N., T.V.v.d.H., G.P., T.M.v.G.) Department of Clinical Chemistry, Laboratory of Endocrinology (M.T.A.), Department of Genetic Metabolic Diseases (W.K.) Academic Medical Center, Meibergdreef, Amsterdam, The Netherlands; and Biopredic International, Rennes, France (S.C.)
Jurgen Seppen
Tytgat Institute for Liver and Intestinal Research (R.H., G.A.A.N., T.V.v.d.H., G.P., J.S., R.P.O.E., R.A.F.M.C), Surgical Laboratory (R.H., G.A.A.N., T.V.v.d.H., G.P., T.M.v.G.) Department of Clinical Chemistry, Laboratory of Endocrinology (M.T.A.), Department of Genetic Metabolic Diseases (W.K.) Academic Medical Center, Meibergdreef, Amsterdam, The Netherlands; and Biopredic International, Rennes, France (S.C.)
Mariëtte T. Ackermans
Tytgat Institute for Liver and Intestinal Research (R.H., G.A.A.N., T.V.v.d.H., G.P., J.S., R.P.O.E., R.A.F.M.C), Surgical Laboratory (R.H., G.A.A.N., T.V.v.d.H., G.P., T.M.v.G.) Department of Clinical Chemistry, Laboratory of Endocrinology (M.T.A.), Department of Genetic Metabolic Diseases (W.K.) Academic Medical Center, Meibergdreef, Amsterdam, The Netherlands; and Biopredic International, Rennes, France (S.C.)
Sandrine Camus
Tytgat Institute for Liver and Intestinal Research (R.H., G.A.A.N., T.V.v.d.H., G.P., J.S., R.P.O.E., R.A.F.M.C), Surgical Laboratory (R.H., G.A.A.N., T.V.v.d.H., G.P., T.M.v.G.) Department of Clinical Chemistry, Laboratory of Endocrinology (M.T.A.), Department of Genetic Metabolic Diseases (W.K.) Academic Medical Center, Meibergdreef, Amsterdam, The Netherlands; and Biopredic International, Rennes, France (S.C.)
Wim Kulik
Tytgat Institute for Liver and Intestinal Research (R.H., G.A.A.N., T.V.v.d.H., G.P., J.S., R.P.O.E., R.A.F.M.C), Surgical Laboratory (R.H., G.A.A.N., T.V.v.d.H., G.P., T.M.v.G.) Department of Clinical Chemistry, Laboratory of Endocrinology (M.T.A.), Department of Genetic Metabolic Diseases (W.K.) Academic Medical Center, Meibergdreef, Amsterdam, The Netherlands; and Biopredic International, Rennes, France (S.C.)
Thomas M. van Gulik
Tytgat Institute for Liver and Intestinal Research (R.H., G.A.A.N., T.V.v.d.H., G.P., J.S., R.P.O.E., R.A.F.M.C), Surgical Laboratory (R.H., G.A.A.N., T.V.v.d.H., G.P., T.M.v.G.) Department of Clinical Chemistry, Laboratory of Endocrinology (M.T.A.), Department of Genetic Metabolic Diseases (W.K.) Academic Medical Center, Meibergdreef, Amsterdam, The Netherlands; and Biopredic International, Rennes, France (S.C.)
Ronald P. Oude Elferink
Tytgat Institute for Liver and Intestinal Research (R.H., G.A.A.N., T.V.v.d.H., G.P., J.S., R.P.O.E., R.A.F.M.C), Surgical Laboratory (R.H., G.A.A.N., T.V.v.d.H., G.P., T.M.v.G.) Department of Clinical Chemistry, Laboratory of Endocrinology (M.T.A.), Department of Genetic Metabolic Diseases (W.K.) Academic Medical Center, Meibergdreef, Amsterdam, The Netherlands; and Biopredic International, Rennes, France (S.C.)
Robert A.F.M. Chamuleau
Tytgat Institute for Liver and Intestinal Research (R.H., G.A.A.N., T.V.v.d.H., G.P., J.S., R.P.O.E., R.A.F.M.C), Surgical Laboratory (R.H., G.A.A.N., T.V.v.d.H., G.P., T.M.v.G.) Department of Clinical Chemistry, Laboratory of Endocrinology (M.T.A.), Department of Genetic Metabolic Diseases (W.K.) Academic Medical Center, Meibergdreef, Amsterdam, The Netherlands; and Biopredic International, Rennes, France (S.C.)
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Research ArticleArticle
Drug Metabolism and Bile acid Formation of HepaRG Bioreactor
Ruurdtje Hoekstra, Geert A.A. Nibourg, Tessa V. van der Hoeven, Gabrielle Plomer, Jurgen Seppen, Mariëtte T. Ackermans, Sandrine Camus, Wim Kulik, Thomas M. van Gulik, Ronald P. Oude Elferink and Robert A.F.M. Chamuleau
Drug Metabolism and Disposition March 1, 2013, 41 (3) 562-567; DOI: https://doi.org/10.1124/dmd.112.049098
Research ArticleArticle
Drug Metabolism and Bile acid Formation of HepaRG Bioreactor
Ruurdtje Hoekstra, Geert A.A. Nibourg, Tessa V. van der Hoeven, Gabrielle Plomer, Jurgen Seppen, Mariëtte T. Ackermans, Sandrine Camus, Wim Kulik, Thomas M. van Gulik, Ronald P. Oude Elferink and Robert A.F.M. Chamuleau
Drug Metabolism and Disposition March 1, 2013, 41 (3) 562-567; DOI: https://doi.org/10.1124/dmd.112.049098
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