Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Drug Metabolism & Disposition
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Drug Metabolism & Disposition

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit dmd on Facebook
  • Follow dmd on Twitter
  • Follow ASPET on LinkedIn
Research ArticleArticle

The Influence of Sex, Ethnicity, and CYP2B6 Genotype on Bupropion Metabolism as an Index of Hepatic CYP2B6 Activity in Humans

Katarina Ilic, Roy L. Hawke, Ranjit K. Thirumaran, Erin G. Schuetz, J. Heyward Hull, Angela D.M. Kashuba, Paul W. Stewart, Celeste M. Lindley and Mei-Ling Chen
Drug Metabolism and Disposition March 2013, 41 (3) 575-581; DOI: https://doi.org/10.1124/dmd.112.048108
Katarina Ilic
Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy (K.I., R.L.H., J.H.H., A.D.M.K., C.M.L), Biostatistics Department, School of Public Health (P.W.S.), University of North Carolina, Chapel Hill, North Carolina; University of Belgrade, School of Pharmacy, Belgrade, Serbia (K.I.); Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (R.K.T., E.G.S.); and Office of Pharmaceutical Science, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland (M.L.C.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Roy L. Hawke
Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy (K.I., R.L.H., J.H.H., A.D.M.K., C.M.L), Biostatistics Department, School of Public Health (P.W.S.), University of North Carolina, Chapel Hill, North Carolina; University of Belgrade, School of Pharmacy, Belgrade, Serbia (K.I.); Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (R.K.T., E.G.S.); and Office of Pharmaceutical Science, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland (M.L.C.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ranjit K. Thirumaran
Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy (K.I., R.L.H., J.H.H., A.D.M.K., C.M.L), Biostatistics Department, School of Public Health (P.W.S.), University of North Carolina, Chapel Hill, North Carolina; University of Belgrade, School of Pharmacy, Belgrade, Serbia (K.I.); Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (R.K.T., E.G.S.); and Office of Pharmaceutical Science, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland (M.L.C.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Erin G. Schuetz
Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy (K.I., R.L.H., J.H.H., A.D.M.K., C.M.L), Biostatistics Department, School of Public Health (P.W.S.), University of North Carolina, Chapel Hill, North Carolina; University of Belgrade, School of Pharmacy, Belgrade, Serbia (K.I.); Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (R.K.T., E.G.S.); and Office of Pharmaceutical Science, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland (M.L.C.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J. Heyward Hull
Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy (K.I., R.L.H., J.H.H., A.D.M.K., C.M.L), Biostatistics Department, School of Public Health (P.W.S.), University of North Carolina, Chapel Hill, North Carolina; University of Belgrade, School of Pharmacy, Belgrade, Serbia (K.I.); Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (R.K.T., E.G.S.); and Office of Pharmaceutical Science, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland (M.L.C.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Angela D.M. Kashuba
Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy (K.I., R.L.H., J.H.H., A.D.M.K., C.M.L), Biostatistics Department, School of Public Health (P.W.S.), University of North Carolina, Chapel Hill, North Carolina; University of Belgrade, School of Pharmacy, Belgrade, Serbia (K.I.); Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (R.K.T., E.G.S.); and Office of Pharmaceutical Science, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland (M.L.C.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Paul W. Stewart
Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy (K.I., R.L.H., J.H.H., A.D.M.K., C.M.L), Biostatistics Department, School of Public Health (P.W.S.), University of North Carolina, Chapel Hill, North Carolina; University of Belgrade, School of Pharmacy, Belgrade, Serbia (K.I.); Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (R.K.T., E.G.S.); and Office of Pharmaceutical Science, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland (M.L.C.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Celeste M. Lindley
Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy (K.I., R.L.H., J.H.H., A.D.M.K., C.M.L), Biostatistics Department, School of Public Health (P.W.S.), University of North Carolina, Chapel Hill, North Carolina; University of Belgrade, School of Pharmacy, Belgrade, Serbia (K.I.); Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (R.K.T., E.G.S.); and Office of Pharmaceutical Science, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland (M.L.C.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mei-Ling Chen
Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy (K.I., R.L.H., J.H.H., A.D.M.K., C.M.L), Biostatistics Department, School of Public Health (P.W.S.), University of North Carolina, Chapel Hill, North Carolina; University of Belgrade, School of Pharmacy, Belgrade, Serbia (K.I.); Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (R.K.T., E.G.S.); and Office of Pharmaceutical Science, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland (M.L.C.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF + SI
  • PDF
Loading

Article Information

vol. 41 no. 3 575-581
DOI 
https://doi.org/10.1124/dmd.112.048108
PubMed 
23238783

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received July 31, 2012
  • Accepted December 13, 2012
  • Published online February 15, 2013.

Article Versions

  • Earlier version (December 13, 2012 - 07:00).
  • You are viewing the most recent version of this article.
Copyright & Usage 
U.S. Government work not protected by U.S. copyright

Author Information

  1. Katarina Ilic1,
  2. Roy L. Hawke,
  3. Ranjit K. Thirumaran,
  4. Erin G. Schuetz,
  5. J. Heyward Hull,
  6. Angela D.M. Kashuba,
  7. Paul W. Stewart,
  8. Celeste M. Lindley, and
  9. Mei-Ling Chen
  1. Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy (K.I., R.L.H., J.H.H., A.D.M.K., C.M.L), Biostatistics Department, School of Public Health (P.W.S.), University of North Carolina, Chapel Hill, North Carolina; University of Belgrade, School of Pharmacy, Belgrade, Serbia (K.I.); Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (R.K.T., E.G.S.); and Office of Pharmaceutical Science, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland (M.L.C.)
  1. Address correspondence to:
    Roy L. Hawke, Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, CB #7569, Kerr Hall Rm 3310, Chapel Hill, NC 27599-7360. E-mail: rhawke{at}email.unc.edu
  1. Parts of the data in this article were presented at the American Society for Clinical Pharmacology and Therapeutics Annual Meeting; 2–5 April 2008; Orlando, FL. [published in abstract form: Ilic K, Hogeland G, Rezk N, White N, Lamba J, Lee C, Kasuba ADM, Schuetz EG, Lindley CM, Chen ML, and Hawke RL (2008) The influence of sex, race/ethnicity and CYP2B6 genotype on bupropion metabolism. Clin Pharm Ther 83:81].

  • ↵1 Current affiliation: School of Pharmacy, University of Belgrade, Belgrade, Serbia.

View Full Text

Statistics from Altmetric.com

Article usage

Article usage: December 2012 to May 2022

AbstractFullPdf
Dec 2012354064
Jan 2013222062
Feb 20134993391
Mar 20133831737
Apr 20131871629
May 2013911324
Jun 201355713
Jul 2013701019
Aug 2013351917
Sep 2013731529
Oct 2013522323
Nov 2013481216
Dec 201329117
Jan 201430129
Feb 20142686
Mar 2014461921
Apr 2014442825
May 2014712834
Jun 2014271925
Jul 2014331512
Aug 2014342012
Sep 2014292318
Oct 201427379
Nov 201431227
Dec 2014281116
Jan 201525209
Feb 201519178
Mar 201523166
Apr 20153073
May 201516158
Jun 201524155
Jul 2015251411
Aug 201514108
Sep 20153895
Oct 2015271310
Nov 20151666
Dec 201513106
Jan 2016171014
Feb 201612169
Mar 201616716
Apr 201614128
May 201611410
Jun 20161179
Jul 2016556
Aug 201619512
Sep 2016101211
Oct 20161149
Nov 201692118
Dec 201612922
Jan 20171432
Feb 201724510
Mar 201723515
Apr 201741110
May 201702312
Jun 20170118
Jul 2017168
Aug 20170129
Sep 20174109
Oct 20171173
Nov 20170174
Dec 20172134
Jan 20181133
Feb 2018162
Mar 20182306
Apr 20182197
May 20181913
Jun 201841512
Jul 201801213
Aug 2018085
Sep 2018074
Oct 2018175
Nov 2018198
Dec 20181920
Jan 20191422
Feb 20191419
Mar 20191835
Apr 201916210
May 201920010
Jun 20192605
Jul 20191332
Aug 20192053
Sep 20191802
Oct 2019811
Nov 20191826
Dec 20192886
Jan 20203553
Feb 20201800
Mar 20202033
Apr 20201939
May 2020900
Jun 20202022
Jul 20201820
Aug 2020513
Sep 20202752
Oct 20201127
Nov 20201923
Dec 20202124
Jan 202116410
Feb 20212757
Mar 20211421
Apr 20211352
May 20212832
Jun 20211411
Jul 20211433
Aug 20212468
Sep 20211814
Oct 20214731
Nov 20215715
Dec 20213331
Jan 20223921
Feb 20229510
Mar 202212511
Apr 20223453
May 20221712

PreviousNext
Back to top

In this issue

Drug Metabolism and Disposition: 41 (3)
Drug Metabolism and Disposition
Vol. 41, Issue 3
1 Mar 2013
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Drug Metabolism & Disposition article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
The Influence of Sex, Ethnicity, and CYP2B6 Genotype on Bupropion Metabolism as an Index of Hepatic CYP2B6 Activity in Humans
(Your Name) has forwarded a page to you from Drug Metabolism & Disposition
(Your Name) thought you would be interested in this article in Drug Metabolism & Disposition.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleArticle

Influences on CYP2B6 Activity Using Bupropion

Katarina Ilic, Roy L. Hawke, Ranjit K. Thirumaran, Erin G. Schuetz, J. Heyward Hull, Angela D.M. Kashuba, Paul W. Stewart, Celeste M. Lindley and Mei-Ling Chen
Drug Metabolism and Disposition March 1, 2013, 41 (3) 575-581; DOI: https://doi.org/10.1124/dmd.112.048108

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research ArticleArticle

Influences on CYP2B6 Activity Using Bupropion

Katarina Ilic, Roy L. Hawke, Ranjit K. Thirumaran, Erin G. Schuetz, J. Heyward Hull, Angela D.M. Kashuba, Paul W. Stewart, Celeste M. Lindley and Mei-Ling Chen
Drug Metabolism and Disposition March 1, 2013, 41 (3) 575-581; DOI: https://doi.org/10.1124/dmd.112.048108
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Acknowledgments
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF + SI
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • Role of Human MSRA on Sulindac Activation
  • Determination of Acyl-, O-, and N-Glucuronide
  • Uptake as the RDS in Pevonedistat Hepatic Clearance
Show more Articles

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About DMD
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Journal of Pharmacology and Experimental Therapeutics
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-009X (Online)

Copyright © 2022 by the American Society for Pharmacology and Experimental Therapeutics