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Research ArticleArticle

P-Glycoprotein Increases Portal Bioavailability of Loperamide in Mouse by Reducing First-Pass Intestinal Metabolism

Matthew B. Dufek, Beverly M. Knight, Arlene S. Bridges and Dhiren R. Thakker
Drug Metabolism and Disposition March 2013, 41 (3) 642-650; DOI: https://doi.org/10.1124/dmd.112.049965

Article Information

vol. 41 no. 3 642-650
DOI 
https://doi.org/10.1124/dmd.112.049965
PubMed 
23288866
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received November 5, 2012
  • Accepted January 3, 2013
  • Published online February 15, 2013.

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Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Matthew B. Dufek1,
  2. Beverly M. Knight,
  3. Arlene S. Bridges, and
  4. Dhiren R. Thakker
  1. Division of Molecular Pharmaceutics (M.B.D., B.M.K.) and Division of Pharmacotherapy and Experimental Therapeutics (D.R.T.), UNC Eshelman School of Pharmacy; and Department of Pathology and Laboratory Medicine, School of Medicine (A.S.B.), The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
  1. Address correspondence to:
    Dr. Dhiren R. Thakker, UNC Eshelman School of Pharmacy, CB#7355, 100L Beard Hall, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599-7360. E-mail: dhiren_thakker{at}unc.edu

  • ↵1 Current affiliation: Department of Clinical Pharmacology, Genentech, Inc., San Francisco, California.

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Research ArticleArticle

Enhancement of the Bioavailability of Loperamide by P-gp

Matthew B. Dufek, Beverly M. Knight, Arlene S. Bridges and Dhiren R. Thakker
Drug Metabolism and Disposition March 1, 2013, 41 (3) 642-650; DOI: https://doi.org/10.1124/dmd.112.049965
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