P-Glycoprotein Increases Portal Bioavailability of Loperamide in Mouse by Reducing First-Pass Intestinal Metabolism

Matthew B. Dufek; Beverly M. Knight; Arlene S. Bridges; Dhiren R. Thakker

doi:10.1124/dmd.112.049965

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P-Glycoprotein Increases Portal Bioavailability of Loperamide in Mouse by Reducing First-Pass Intestinal Metabolism

Matthew B. Dufek, Beverly M. Knight, Arlene S. Bridges and Dhiren R. Thakker

Drug Metabolism and Disposition March 2013, 41 (3) 642-650; DOI: https://doi.org/10.1124/dmd.112.049965

Matthew B. Dufek

Division of Molecular Pharmaceutics (M.B.D., B.M.K.) and Division of Pharmacotherapy and Experimental Therapeutics (D.R.T.), UNC Eshelman School of Pharmacy; and Department of Pathology and Laboratory Medicine, School of Medicine (A.S.B.), The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

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Beverly M. Knight

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Arlene S. Bridges

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Dhiren R. Thakker

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Drug Metabolism and Disposition

Vol. 41, Issue 3

1 Mar 2013

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