Research ArticleArticle
P-Glycoprotein Increases Portal Bioavailability of Loperamide in Mouse by Reducing First-Pass Intestinal Metabolism
Matthew B. Dufek, Beverly M. Knight, Arlene S. Bridges and Dhiren R. Thakker
Drug Metabolism and Disposition March 2013, 41 (3) 642-650; DOI: https://doi.org/10.1124/dmd.112.049965
Matthew B. Dufek
Division of Molecular Pharmaceutics (M.B.D., B.M.K.) and Division of Pharmacotherapy and Experimental Therapeutics (D.R.T.), UNC Eshelman School of Pharmacy; and Department of Pathology and Laboratory Medicine, School of Medicine (A.S.B.), The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Beverly M. Knight
Division of Molecular Pharmaceutics (M.B.D., B.M.K.) and Division of Pharmacotherapy and Experimental Therapeutics (D.R.T.), UNC Eshelman School of Pharmacy; and Department of Pathology and Laboratory Medicine, School of Medicine (A.S.B.), The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Arlene S. Bridges
Division of Molecular Pharmaceutics (M.B.D., B.M.K.) and Division of Pharmacotherapy and Experimental Therapeutics (D.R.T.), UNC Eshelman School of Pharmacy; and Department of Pathology and Laboratory Medicine, School of Medicine (A.S.B.), The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Dhiren R. Thakker
Division of Molecular Pharmaceutics (M.B.D., B.M.K.) and Division of Pharmacotherapy and Experimental Therapeutics (D.R.T.), UNC Eshelman School of Pharmacy; and Department of Pathology and Laboratory Medicine, School of Medicine (A.S.B.), The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

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Research ArticleArticle
Enhancement of the Bioavailability of Loperamide by P-gp
Matthew B. Dufek, Beverly M. Knight, Arlene S. Bridges and Dhiren R. Thakker
Drug Metabolism and Disposition March 1, 2013, 41 (3) 642-650; DOI: https://doi.org/10.1124/dmd.112.049965