Table of Contents

Articles

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  Methadone N-Demethylation by the Common CYP2B6 Allelic Variant CYP2B6.6

  Sarah Gadel, Amanda Crafford, Karen Regina and Evan D. Kharasch

  Drug Metabolism and Disposition April 2013, 41 (4) 709-713; DOI: https://doi.org/10.1124/dmd.112.050625
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  Pharmacokinetics, Metabolism, and Excretion of the Glycogen Synthase Kinase-3 Inhibitor LY2090314 in Rats, Dogs, and Humans: A Case Study in Rapid Clearance by Extensive Metabolism with Low Circulating Metabolite Exposure

  Maciej J. Zamek-Gliszczynski, Trent L. Abraham, Jeffrey J. Alberts, Palaniappan Kulanthaivel, Kimberley A. Jackson, Kay H. Chow, Denis J. McCann, Haitao Hu, Shelby Anderson, Nathan A. Furr, Robert J. Barbuch and Kenneth C. Cassidy

  Drug Metabolism and Disposition April 2013, 41 (4) 714-726; DOI: https://doi.org/10.1124/dmd.112.048488
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  Pharmacokinetic and Pharmacodynamic Modeling of Hedgehog Inhibitor TAK-441 for the Inhibition of Gli1 messenger RNA Expression and Antitumor Efficacy in Xenografted Tumor Model Mice

  Akifumi Kogame, Yoshihiko Tagawa, Sachio Shibata, Hideaki Tojo, Maki Miyamoto, Kimio Tohyama, Takahiro Kondo, Shimoga Prakash, Wen Chyi Shyu and Satoru Asahi

  Drug Metabolism and Disposition April 2013, 41 (4) 727-734; DOI: https://doi.org/10.1124/dmd.112.049650
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  Evaluation of Hepatic Disposition of Paroxetine Using Sandwich-Cultured Rat and Human Hepatocytes

  Norikazu Matsunaga, Ken-ichi Nunoya, Masahiro Okada, Mikio Ogawa and Ikumi Tamai

  Drug Metabolism and Disposition April 2013, 41 (4) 735-743; DOI: https://doi.org/10.1124/dmd.112.049817
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  Application of a Physiologically Based Pharmacokinetic Model to Assess Propofol Hepatic and Renal Glucuronidation in Isolation: Utility of In Vitro and In Vivo Data

  Katherine L. Gill, Michael Gertz, J. Brian Houston and Aleksandra Galetin

  Drug Metabolism and Disposition April 2013, 41 (4) 744-753; DOI: https://doi.org/10.1124/dmd.112.050294
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  Tariquidar and Elacridar Are Dose-Dependently Transported by P-Glycoprotein and Bcrp at the Blood-Brain Barrier: A Small-Animal Positron Emission Tomography and In Vitro Study

  Jens P. Bankstahl, Marion Bankstahl, Kerstin Römermann, Thomas Wanek, Johann Stanek, Albert D. Windhorst, Maren Fedrowitz, Thomas Erker, Markus Müller, Wolfgang Löscher, Oliver Langer and Claudia Kuntner

  Drug Metabolism and Disposition April 2013, 41 (4) 754-762; DOI: https://doi.org/10.1124/dmd.112.049148
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  Characterization of Four New Mouse Cytochrome P450 Enzymes of the CYP2J Subfamily

  Joan P. Graves, Matthew L. Edin, J. Alyce Bradbury, Artiom Gruzdev, Jennifer Cheng, Fred B. Lih, Tiwanda A. Masinde, Wei Qu, Natasha P. Clayton, James P. Morrison, Kenneth B. Tomer and Darryl C. Zeldin

  Drug Metabolism and Disposition April 2013, 41 (4) 763-773; DOI: https://doi.org/10.1124/dmd.112.049429
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  Peginesatide Clearance, Distribution, Metabolism, and Excretion in Monkeys following Intravenous Administration

  Kathryn W. Woodburn, Kei-Lai Fong, Susan D. Wilson, Steven Sloneker, Paul Strzemienski, Eric Solon, Yuu Moriya and Yoshihiko Tagawa

  Drug Metabolism and Disposition April 2013, 41 (4) 774-784; DOI: https://doi.org/10.1124/dmd.112.048033
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  Identification of the Active Components in Shenmai Injection that Differentially Affect Cyp3a4-Mediated 1′-Hydroxylation and 4-Hydroxylation of Midazolam

  Caiwen Zeng, Fang He, Chunhua Xia, Hong Zhang and Yuqing Xiong

  Drug Metabolism and Disposition April 2013, 41 (4) 785-790; DOI: https://doi.org/10.1124/dmd.112.048025
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  Organic Anion Transporter 3 Interacts Selectively with Lipophilic β-Lactam Antibiotics

  Aaron T. Wolman, Michael R. Gionfriddo, Gregory A. Heindel, Paran Mukhija, Sarah Witkowski, Ajay Bommareddy and Adam L. VanWert

  Drug Metabolism and Disposition April 2013, 41 (4) 791-800; DOI: https://doi.org/10.1124/dmd.112.049569
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  A Physiologically Based Pharmacokinetic Model to Predict Disposition of CYP2D6 and CYP1A2 Metabolized Drugs in Pregnant Women

  Alice Ban Ke, Srikanth C. Nallani, Ping Zhao, Amin Rostami-Hodjegan, Nina Isoherranen and Jashvant D. Unadkat

  Drug Metabolism and Disposition April 2013, 41 (4) 801-813; DOI: https://doi.org/10.1124/dmd.112.050161
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  Metabolites of PPI-2458, a Selective, Irreversible Inhibitor of Methionine Aminopeptidase-2: Structure Determination and In Vivo Activity

  Christopher C. Arico-Muendel, Bruce Belanger, Dennis Benjamin, Heather S. Blanchette, Teresa M. Caiazzo, Paolo A. Centrella, Jennifer DeLorey, Elisabeth G. Doyle, Ulrike Gradhand, Sarah T. Griffin, Susan Hill, Matthew T. Labenski, Barry A. Morgan, Gary O’Donovan, Kavirayani Prasad, Steven Skinner, Nazbeh Taghizadeh, Charles D. Thompson, James Wakefield, William Westlin and Kerry F. White

  Drug Metabolism and Disposition April 2013, 41 (4) 814-826; DOI: https://doi.org/10.1124/dmd.112.048355
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  Characterization of Efflux Transporters Involved in Distribution and Disposition of Apixaban

  Donglu Zhang, Kan He, John J. Herbst, Janet Kolb, Wilson Shou, Lifei Wang, Praveen V. Balimane, Yong-Hae Han, Jinping Gan, Charles E. Frost and W. Griffith Humphreys

  Drug Metabolism and Disposition April 2013, 41 (4) 827-835; DOI: https://doi.org/10.1124/dmd.112.050260
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  Predicting Metabolic Clearance for Drugs That Are Actively Transported into Hepatocytes: Incubational Binding as a Consequence of in Vitro Hepatocyte Concentration Is a Key Factor

  Pär Nordell, Petter Svanberg, James Bird and Ken Grime

  Drug Metabolism and Disposition April 2013, 41 (4) 836-843; DOI: https://doi.org/10.1124/dmd.112.050377
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  RNA-Sequencing Quantification of Hepatic Ontogeny and Tissue Distribution of mRNAs of Phase II Enzymes in Mice

  Hong Lu, Sumedha Gunewardena, Julia Y. Cui, Byunggil Yoo, Xiao-bo Zhong and Curtis D. Klaassen

  Drug Metabolism and Disposition April 2013, 41 (4) 844-857; DOI: https://doi.org/10.1124/dmd.112.050211
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  The Inactivation of Human CYP2E1 by Phenethyl Isothiocyanate, a Naturally Occurring Chemopreventive Agent, and Its Oxidative Bioactivation

  Yasushi Yoshigae, Chitra Sridar, Ute M. Kent and Paul F. Hollenberg

  Drug Metabolism and Disposition April 2013, 41 (4) 858-869; DOI: https://doi.org/10.1124/dmd.112.050609
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  Potential Role of UGT1A4 Promoter SNPs in Anastrozole Pharmacogenomics

  Vineetha Koroth Edavana, Ishwori B. Dhakal, Suzanne Williams, Rosalind Penney, Gunnar Boysen, Aiwei Yao-Borengasser and Susan Kadlubar

  Drug Metabolism and Disposition April 2013, 41 (4) 870-877; DOI: https://doi.org/10.1124/dmd.112.048157
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  Absorption, Elimination, and Metabolism of CS-1036, a Novel α-Amylase Inhibitor in Rats and Monkeys, and the Relationship between Gastrointestinal Distribution and Suppression of Glucose Absorption

  Tomohiro Honda, Yoko Kaneno-Urasaki, Takahiro Murai, Masayo Kakuta, Hatsumi Nasu, Eiko Namba, Tetsufumi Koga, Akira Okuno and Takashi Izumi

  Drug Metabolism and Disposition April 2013, 41 (4) 878-887; DOI: https://doi.org/10.1124/dmd.112.050591
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  Identification and Characterization of Novel Alternative Splice Variants of Human Constitutive Androstane Receptor in Liver Samples of Koreans and Caucasians

  Eun-Jung Choi, Yin-Jin Jang, Eun-Young Cha, Jae-Gook Shin and Sang Seop Lee

  Drug Metabolism and Disposition April 2013, 41 (4) 888-896; DOI: https://doi.org/10.1124/dmd.112.049791
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  Lysosomal Sequestration (Trapping) of Lipophilic Amine (Cationic Amphiphilic) Drugs in Immortalized Human Hepatocytes (Fa2N-4 Cells)

  Faraz Kazmi, Tiffini Hensley, Chad Pope, Ryan S. Funk, Greg J. Loewen, David B. Buckley and Andrew Parkinson

  Drug Metabolism and Disposition April 2013, 41 (4) 897-905; DOI: https://doi.org/10.1124/dmd.112.050054
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  Investigating the Enteroenteric Recirculation of Apixaban, a Factor Xa Inhibitor: Administration of Activated Charcoal to Bile Duct-Cannulated Rats and Dogs Receiving an Intravenous Dose and Use of Drug Transporter Knockout Rats

  Donglu Zhang, Charles E. Frost, Kan He, A. David Rodrigues, Xiaoli Wang, Lifei Wang, Theunis C. Goosen and W. Griffith Humphreys

  Drug Metabolism and Disposition April 2013, 41 (4) 906-915; DOI: https://doi.org/10.1124/dmd.112.050575
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  Transport of A₁ Adenosine Receptor Agonist Tecadenoson by Human and Mouse Nucleoside Transporters: Evidence for Blood-Brain Barrier Transport by Murine Equilibrative Nucleoside Transporter 1 mENT1

  Eve-Irene Lepist, Vijaya L. Damaraju, Jing Zhang, Wendy P. Gati, Sylvia Y.M. Yao, Kyla M. Smith, Edward Karpinski, James D. Young, Kwan H. Leung and Carol E. Cass

  Drug Metabolism and Disposition April 2013, 41 (4) 916-922; DOI: https://doi.org/10.1124/dmd.112.049858