Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Drug Metabolism & Disposition
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Drug Metabolism & Disposition

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit dmd on Facebook
  • Follow dmd on Twitter
  • Follow ASPET on LinkedIn

Table of Contents

April 01, 2013; Volume 41,Issue 4

Short Communications

  • You have access
    Retrospective Analysis of P-Glycoprotein–Mediated Drug-Drug Interactions at the Blood-Brain Barrier in Humans
    Hiroshi Sugimoto, Hideki Hirabayashi, Nobuyuki Amano and Toshiya Moriwaki
    Drug Metabolism and Disposition April 2013, 41 (4) 683-688; DOI: https://doi.org/10.1124/dmd.112.049577
  • You have access
    Interleukins-12 and -23 Do Not Alter Expression or Activity of Multiple Cytochrome P450 Enzymes in Cryopreserved Human Hepatocytes
    Shannon Dallas, Souvik Chattopadhyay, Carlo Sensenhauser, Ameesha Batheja, Monica Singer and Jose Silva
    Drug Metabolism and Disposition April 2013, 41 (4) 689-693; DOI: https://doi.org/10.1124/dmd.112.048884
  • You have access
    The Relative Protein Abundance of UGT1A Alternative Splice Variants as a Key Determinant of Glucuronidation Activity In Vitro
    Mélanie Rouleau, Joannie Roberge, Sarah-Ann Falardeau, Lyne Villeneuve and Chantal Guillemette
    Drug Metabolism and Disposition April 2013, 41 (4) 694-697; DOI: https://doi.org/10.1124/dmd.112.050468
  • You have access
    Reversible Inhibition of Human Carboxylesterases by Acyl Glucuronides
    Natalie R. Inoue, Adrian Hall, W. George Lai and Eric T. Williams
    Drug Metabolism and Disposition April 2013, 41 (4) 698-703; DOI: https://doi.org/10.1124/dmd.112.050252
  • You have access
    Serum Levels of 25-Hydroxyvitamin D and the CYP3A Biomarker 4β-Hydroxycholesterol in a High-Dose Vitamin D Supplementation Study
    Linda Björkhem-Bergman, Hanna Nylén, Anna-Carin Norlin, Jonatan D. Lindh, Lena Ekström, Erik Eliasson, Peter Bergman and Ulf Diczfalusy
    Drug Metabolism and Disposition April 2013, 41 (4) 704-708; DOI: https://doi.org/10.1124/dmd.113.051136

Articles

  • You have access
    Methadone N-Demethylation by the Common CYP2B6 Allelic Variant CYP2B6.6
    Sarah Gadel, Amanda Crafford, Karen Regina and Evan D. Kharasch
    Drug Metabolism and Disposition April 2013, 41 (4) 709-713; DOI: https://doi.org/10.1124/dmd.112.050625
  • You have access
    Pharmacokinetics, Metabolism, and Excretion of the Glycogen Synthase Kinase-3 Inhibitor LY2090314 in Rats, Dogs, and Humans: A Case Study in Rapid Clearance by Extensive Metabolism with Low Circulating Metabolite Exposure
    Maciej J. Zamek-Gliszczynski, Trent L. Abraham, Jeffrey J. Alberts, Palaniappan Kulanthaivel, Kimberley A. Jackson, Kay H. Chow, Denis J. McCann, Haitao Hu, Shelby Anderson, Nathan A. Furr, Robert J. Barbuch and Kenneth C. Cassidy
    Drug Metabolism and Disposition April 2013, 41 (4) 714-726; DOI: https://doi.org/10.1124/dmd.112.048488
  • You have access
    Pharmacokinetic and Pharmacodynamic Modeling of Hedgehog Inhibitor TAK-441 for the Inhibition of Gli1 messenger RNA Expression and Antitumor Efficacy in Xenografted Tumor Model Mice
    Akifumi Kogame, Yoshihiko Tagawa, Sachio Shibata, Hideaki Tojo, Maki Miyamoto, Kimio Tohyama, Takahiro Kondo, Shimoga Prakash, Wen Chyi Shyu and Satoru Asahi
    Drug Metabolism and Disposition April 2013, 41 (4) 727-734; DOI: https://doi.org/10.1124/dmd.112.049650
  • You have access
    Evaluation of Hepatic Disposition of Paroxetine Using Sandwich-Cultured Rat and Human Hepatocytes
    Norikazu Matsunaga, Ken-ichi Nunoya, Masahiro Okada, Mikio Ogawa and Ikumi Tamai
    Drug Metabolism and Disposition April 2013, 41 (4) 735-743; DOI: https://doi.org/10.1124/dmd.112.049817
  • You have access
    Application of a Physiologically Based Pharmacokinetic Model to Assess Propofol Hepatic and Renal Glucuronidation in Isolation: Utility of In Vitro and In Vivo Data
    Katherine L. Gill, Michael Gertz, J. Brian Houston and Aleksandra Galetin
    Drug Metabolism and Disposition April 2013, 41 (4) 744-753; DOI: https://doi.org/10.1124/dmd.112.050294
  • You have access
    Tariquidar and Elacridar Are Dose-Dependently Transported by P-Glycoprotein and Bcrp at the Blood-Brain Barrier: A Small-Animal Positron Emission Tomography and In Vitro Study
    Jens P. Bankstahl, Marion Bankstahl, Kerstin Römermann, Thomas Wanek, Johann Stanek, Albert D. Windhorst, Maren Fedrowitz, Thomas Erker, Markus Müller, Wolfgang Löscher, Oliver Langer and Claudia Kuntner
    Drug Metabolism and Disposition April 2013, 41 (4) 754-762; DOI: https://doi.org/10.1124/dmd.112.049148
  • You have access
    Characterization of Four New Mouse Cytochrome P450 Enzymes of the CYP2J Subfamily
    Joan P. Graves, Matthew L. Edin, J. Alyce Bradbury, Artiom Gruzdev, Jennifer Cheng, Fred B. Lih, Tiwanda A. Masinde, Wei Qu, Natasha P. Clayton, James P. Morrison, Kenneth B. Tomer and Darryl C. Zeldin
    Drug Metabolism and Disposition April 2013, 41 (4) 763-773; DOI: https://doi.org/10.1124/dmd.112.049429
  • You have access
    Peginesatide Clearance, Distribution, Metabolism, and Excretion in Monkeys following Intravenous Administration
    Kathryn W. Woodburn, Kei-Lai Fong, Susan D. Wilson, Steven Sloneker, Paul Strzemienski, Eric Solon, Yuu Moriya and Yoshihiko Tagawa
    Drug Metabolism and Disposition April 2013, 41 (4) 774-784; DOI: https://doi.org/10.1124/dmd.112.048033
  • You have access
    Identification of the Active Components in Shenmai Injection that Differentially Affect Cyp3a4-Mediated 1′-Hydroxylation and 4-Hydroxylation of Midazolam
    Caiwen Zeng, Fang He, Chunhua Xia, Hong Zhang and Yuqing Xiong
    Drug Metabolism and Disposition April 2013, 41 (4) 785-790; DOI: https://doi.org/10.1124/dmd.112.048025
  • You have access
    Organic Anion Transporter 3 Interacts Selectively with Lipophilic β-Lactam Antibiotics
    Aaron T. Wolman, Michael R. Gionfriddo, Gregory A. Heindel, Paran Mukhija, Sarah Witkowski, Ajay Bommareddy and Adam L. VanWert
    Drug Metabolism and Disposition April 2013, 41 (4) 791-800; DOI: https://doi.org/10.1124/dmd.112.049569
  • You have access
    A Physiologically Based Pharmacokinetic Model to Predict Disposition of CYP2D6 and CYP1A2 Metabolized Drugs in Pregnant Women
    Alice Ban Ke, Srikanth C. Nallani, Ping Zhao, Amin Rostami-Hodjegan, Nina Isoherranen and Jashvant D. Unadkat
    Drug Metabolism and Disposition April 2013, 41 (4) 801-813; DOI: https://doi.org/10.1124/dmd.112.050161
  • You have access
    Metabolites of PPI-2458, a Selective, Irreversible Inhibitor of Methionine Aminopeptidase-2: Structure Determination and In Vivo Activity
    Christopher C. Arico-Muendel, Bruce Belanger, Dennis Benjamin, Heather S. Blanchette, Teresa M. Caiazzo, Paolo A. Centrella, Jennifer DeLorey, Elisabeth G. Doyle, Ulrike Gradhand, Sarah T. Griffin, Susan Hill, Matthew T. Labenski, Barry A. Morgan, Gary O’Donovan, Kavirayani Prasad, Steven Skinner, Nazbeh Taghizadeh, Charles D. Thompson, James Wakefield, William Westlin and Kerry F. White
    Drug Metabolism and Disposition April 2013, 41 (4) 814-826; DOI: https://doi.org/10.1124/dmd.112.048355
  • You have access
    Characterization of Efflux Transporters Involved in Distribution and Disposition of Apixaban
    Donglu Zhang, Kan He, John J. Herbst, Janet Kolb, Wilson Shou, Lifei Wang, Praveen V. Balimane, Yong-Hae Han, Jinping Gan, Charles E. Frost and W. Griffith Humphreys
    Drug Metabolism and Disposition April 2013, 41 (4) 827-835; DOI: https://doi.org/10.1124/dmd.112.050260
  • You have access
    Predicting Metabolic Clearance for Drugs That Are Actively Transported into Hepatocytes: Incubational Binding as a Consequence of in Vitro Hepatocyte Concentration Is a Key Factor
    Pär Nordell, Petter Svanberg, James Bird and Ken Grime
    Drug Metabolism and Disposition April 2013, 41 (4) 836-843; DOI: https://doi.org/10.1124/dmd.112.050377
  • You have access
    RNA-Sequencing Quantification of Hepatic Ontogeny and Tissue Distribution of mRNAs of Phase II Enzymes in Mice
    Hong Lu, Sumedha Gunewardena, Julia Y. Cui, Byunggil Yoo, Xiao-bo Zhong and Curtis D. Klaassen
    Drug Metabolism and Disposition April 2013, 41 (4) 844-857; DOI: https://doi.org/10.1124/dmd.112.050211
  • You have access
    The Inactivation of Human CYP2E1 by Phenethyl Isothiocyanate, a Naturally Occurring Chemopreventive Agent, and Its Oxidative Bioactivation
    Yasushi Yoshigae, Chitra Sridar, Ute M. Kent and Paul F. Hollenberg
    Drug Metabolism and Disposition April 2013, 41 (4) 858-869; DOI: https://doi.org/10.1124/dmd.112.050609
  • You have access
    Potential Role of UGT1A4 Promoter SNPs in Anastrozole Pharmacogenomics
    Vineetha Koroth Edavana, Ishwori B. Dhakal, Suzanne Williams, Rosalind Penney, Gunnar Boysen, Aiwei Yao-Borengasser and Susan Kadlubar
    Drug Metabolism and Disposition April 2013, 41 (4) 870-877; DOI: https://doi.org/10.1124/dmd.112.048157
  • You have access
    Absorption, Elimination, and Metabolism of CS-1036, a Novel α-Amylase Inhibitor in Rats and Monkeys, and the Relationship between Gastrointestinal Distribution and Suppression of Glucose Absorption
    Tomohiro Honda, Yoko Kaneno-Urasaki, Takahiro Murai, Masayo Kakuta, Hatsumi Nasu, Eiko Namba, Tetsufumi Koga, Akira Okuno and Takashi Izumi
    Drug Metabolism and Disposition April 2013, 41 (4) 878-887; DOI: https://doi.org/10.1124/dmd.112.050591
  • You have access
    Identification and Characterization of Novel Alternative Splice Variants of Human Constitutive Androstane Receptor in Liver Samples of Koreans and Caucasians
    Eun-Jung Choi, Yin-Jin Jang, Eun-Young Cha, Jae-Gook Shin and Sang Seop Lee
    Drug Metabolism and Disposition April 2013, 41 (4) 888-896; DOI: https://doi.org/10.1124/dmd.112.049791
  • You have access
    Lysosomal Sequestration (Trapping) of Lipophilic Amine (Cationic Amphiphilic) Drugs in Immortalized Human Hepatocytes (Fa2N-4 Cells)
    Faraz Kazmi, Tiffini Hensley, Chad Pope, Ryan S. Funk, Greg J. Loewen, David B. Buckley and Andrew Parkinson
    Drug Metabolism and Disposition April 2013, 41 (4) 897-905; DOI: https://doi.org/10.1124/dmd.112.050054
  • You have access
    Investigating the Enteroenteric Recirculation of Apixaban, a Factor Xa Inhibitor: Administration of Activated Charcoal to Bile Duct-Cannulated Rats and Dogs Receiving an Intravenous Dose and Use of Drug Transporter Knockout Rats
    Donglu Zhang, Charles E. Frost, Kan He, A. David Rodrigues, Xiaoli Wang, Lifei Wang, Theunis C. Goosen and W. Griffith Humphreys
    Drug Metabolism and Disposition April 2013, 41 (4) 906-915; DOI: https://doi.org/10.1124/dmd.112.050575
  • You have access
    Transport of A1 Adenosine Receptor Agonist Tecadenoson by Human and Mouse Nucleoside Transporters: Evidence for Blood-Brain Barrier Transport by Murine Equilibrative Nucleoside Transporter 1 mENT1
    Eve-Irene Lepist, Vijaya L. Damaraju, Jing Zhang, Wendy P. Gati, Sylvia Y.M. Yao, Kyla M. Smith, Edward Karpinski, James D. Young, Kwan H. Leung and Carol E. Cass
    Drug Metabolism and Disposition April 2013, 41 (4) 916-922; DOI: https://doi.org/10.1124/dmd.112.049858

Accelerated Communication

  • You have access
    Drug Transporters on Arachnoid Barrier Cells Contribute to the Blood–Cerebrospinal Fluid Barrier
    Kazuto Yasuda, Cynthia Cline, Peter Vogel, Mihaela Onciu, Soghra Fatima, Brian P. Sorrentino, Ranjit K. Thirumaran, Sean Ekins, Yoshihiro Urade, Ko Fujimori and Erin G. Schuetz
    Drug Metabolism and Disposition April 2013, 41 (4) 923-931; DOI: https://doi.org/10.1124/dmd.112.050344

Erratum

  • You have access
    Correction to “Characterization of Human Cytochrome P450s Involved in the Bioactivation of Clozapine”
    Drug Metabolism and Disposition April 2013, 41 (4) 932; DOI: https://doi.org/10.1124/dmd.112.04er13
Back to top
PreviousNext

In this issue

Drug Metabolism and Disposition: 41 (4)
Drug Metabolism and Disposition
Vol. 41, Issue 4
1 Apr 2013
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
Sign up for alerts

Jump to

  • Short Communications
  • Articles
  • Accelerated Communication
  • Erratum
  • Most Cited
  • Most Read
Loading
  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
More...
Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About DMD
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Journal of Pharmacology and Experimental Therapeutics
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-009X (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics