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Index by author

April 01, 2013; Volume 41,Issue 4

A

  1. Abraham, Trent L.

    1. Pharmacokinetics, Metabolism, and Excretion of the Glycogen Synthase Kinase-3 Inhibitor LY2090314 in Rats, Dogs, and Humans: A Case Study in Rapid Clearance by Extensive Metabolism with Low Circulating Metabolite Exposure
      Maciej J. Zamek-Gliszczynski, Trent L. Abraham, Jeffrey J. Alberts, Palaniappan Kulanthaivel, Kimberley A. Jackson, Kay H. Chow, Denis J. McCann, Haitao Hu, Shelby Anderson, Nathan A. Furr, Robert J. Barbuch and Kenneth C. Cassidy
      Drug Metabolism and Disposition April 2013, 41 (4) 714-726; DOI: https://doi.org/10.1124/dmd.112.048488

  2. Alberts, Jeffrey J.

    1. Pharmacokinetics, Metabolism, and Excretion of the Glycogen Synthase Kinase-3 Inhibitor LY2090314 in Rats, Dogs, and Humans: A Case Study in Rapid Clearance by Extensive Metabolism with Low Circulating Metabolite Exposure
      Maciej J. Zamek-Gliszczynski, Trent L. Abraham, Jeffrey J. Alberts, Palaniappan Kulanthaivel, Kimberley A. Jackson, Kay H. Chow, Denis J. McCann, Haitao Hu, Shelby Anderson, Nathan A. Furr, Robert J. Barbuch and Kenneth C. Cassidy
      Drug Metabolism and Disposition April 2013, 41 (4) 714-726; DOI: https://doi.org/10.1124/dmd.112.048488

  3. Amano, Nobuyuki

    1. Retrospective Analysis of P-Glycoprotein–Mediated Drug-Drug Interactions at the Blood-Brain Barrier in Humans
      Hiroshi Sugimoto, Hideki Hirabayashi, Nobuyuki Amano and Toshiya Moriwaki
      Drug Metabolism and Disposition April 2013, 41 (4) 683-688; DOI: https://doi.org/10.1124/dmd.112.049577

  4. Anderson, Shelby

    1. Pharmacokinetics, Metabolism, and Excretion of the Glycogen Synthase Kinase-3 Inhibitor LY2090314 in Rats, Dogs, and Humans: A Case Study in Rapid Clearance by Extensive Metabolism with Low Circulating Metabolite Exposure
      Maciej J. Zamek-Gliszczynski, Trent L. Abraham, Jeffrey J. Alberts, Palaniappan Kulanthaivel, Kimberley A. Jackson, Kay H. Chow, Denis J. McCann, Haitao Hu, Shelby Anderson, Nathan A. Furr, Robert J. Barbuch and Kenneth C. Cassidy
      Drug Metabolism and Disposition April 2013, 41 (4) 714-726; DOI: https://doi.org/10.1124/dmd.112.048488

  5. Arico-Muendel, Christopher C.

    1. Metabolites of PPI-2458, a Selective, Irreversible Inhibitor of Methionine Aminopeptidase-2: Structure Determination and In Vivo Activity
      Christopher C. Arico-Muendel, Bruce Belanger, Dennis Benjamin, Heather S. Blanchette, Teresa M. Caiazzo, Paolo A. Centrella, Jennifer DeLorey, Elisabeth G. Doyle, Ulrike Gradhand, Sarah T. Griffin, Susan Hill, Matthew T. Labenski, Barry A. Morgan, Gary O’Donovan, Kavirayani Prasad, Steven Skinner, Nazbeh Taghizadeh, Charles D. Thompson, James Wakefield, William Westlin and Kerry F. White
      Drug Metabolism and Disposition April 2013, 41 (4) 814-826; DOI: https://doi.org/10.1124/dmd.112.048355

  6. Asahi, Satoru

    1. Pharmacokinetic and Pharmacodynamic Modeling of Hedgehog Inhibitor TAK-441 for the Inhibition of Gli1 messenger RNA Expression and Antitumor Efficacy in Xenografted Tumor Model Mice
      Akifumi Kogame, Yoshihiko Tagawa, Sachio Shibata, Hideaki Tojo, Maki Miyamoto, Kimio Tohyama, Takahiro Kondo, Shimoga Prakash, Wen Chyi Shyu and Satoru Asahi
      Drug Metabolism and Disposition April 2013, 41 (4) 727-734; DOI: https://doi.org/10.1124/dmd.112.049650

B

  1. Balimane, Praveen V.

    1. Characterization of Efflux Transporters Involved in Distribution and Disposition of Apixaban
      Donglu Zhang, Kan He, John J. Herbst, Janet Kolb, Wilson Shou, Lifei Wang, Praveen V. Balimane, Yong-Hae Han, Jinping Gan, Charles E. Frost and W. Griffith Humphreys
      Drug Metabolism and Disposition April 2013, 41 (4) 827-835; DOI: https://doi.org/10.1124/dmd.112.050260

  2. Bankstahl, Jens P.

    1. Tariquidar and Elacridar Are Dose-Dependently Transported by P-Glycoprotein and Bcrp at the Blood-Brain Barrier: A Small-Animal Positron Emission Tomography and In Vitro Study
      Jens P. Bankstahl, Marion Bankstahl, Kerstin Römermann, Thomas Wanek, Johann Stanek, Albert D. Windhorst, Maren Fedrowitz, Thomas Erker, Markus Müller, Wolfgang Löscher, Oliver Langer and Claudia Kuntner
      Drug Metabolism and Disposition April 2013, 41 (4) 754-762; DOI: https://doi.org/10.1124/dmd.112.049148

  3. Bankstahl, Marion

    1. Tariquidar and Elacridar Are Dose-Dependently Transported by P-Glycoprotein and Bcrp at the Blood-Brain Barrier: A Small-Animal Positron Emission Tomography and In Vitro Study
      Jens P. Bankstahl, Marion Bankstahl, Kerstin Römermann, Thomas Wanek, Johann Stanek, Albert D. Windhorst, Maren Fedrowitz, Thomas Erker, Markus Müller, Wolfgang Löscher, Oliver Langer and Claudia Kuntner
      Drug Metabolism and Disposition April 2013, 41 (4) 754-762; DOI: https://doi.org/10.1124/dmd.112.049148

  4. Barbuch, Robert J.

    1. Pharmacokinetics, Metabolism, and Excretion of the Glycogen Synthase Kinase-3 Inhibitor LY2090314 in Rats, Dogs, and Humans: A Case Study in Rapid Clearance by Extensive Metabolism with Low Circulating Metabolite Exposure
      Maciej J. Zamek-Gliszczynski, Trent L. Abraham, Jeffrey J. Alberts, Palaniappan Kulanthaivel, Kimberley A. Jackson, Kay H. Chow, Denis J. McCann, Haitao Hu, Shelby Anderson, Nathan A. Furr, Robert J. Barbuch and Kenneth C. Cassidy
      Drug Metabolism and Disposition April 2013, 41 (4) 714-726; DOI: https://doi.org/10.1124/dmd.112.048488

  5. Batheja, Ameesha

    1. Interleukins-12 and -23 Do Not Alter Expression or Activity of Multiple Cytochrome P450 Enzymes in Cryopreserved Human Hepatocytes
      Shannon Dallas, Souvik Chattopadhyay, Carlo Sensenhauser, Ameesha Batheja, Monica Singer and Jose Silva
      Drug Metabolism and Disposition April 2013, 41 (4) 689-693; DOI: https://doi.org/10.1124/dmd.112.048884

  6. Belanger, Bruce

    1. Metabolites of PPI-2458, a Selective, Irreversible Inhibitor of Methionine Aminopeptidase-2: Structure Determination and In Vivo Activity
      Christopher C. Arico-Muendel, Bruce Belanger, Dennis Benjamin, Heather S. Blanchette, Teresa M. Caiazzo, Paolo A. Centrella, Jennifer DeLorey, Elisabeth G. Doyle, Ulrike Gradhand, Sarah T. Griffin, Susan Hill, Matthew T. Labenski, Barry A. Morgan, Gary O’Donovan, Kavirayani Prasad, Steven Skinner, Nazbeh Taghizadeh, Charles D. Thompson, James Wakefield, William Westlin and Kerry F. White
      Drug Metabolism and Disposition April 2013, 41 (4) 814-826; DOI: https://doi.org/10.1124/dmd.112.048355

  7. Benjamin, Dennis

    1. Metabolites of PPI-2458, a Selective, Irreversible Inhibitor of Methionine Aminopeptidase-2: Structure Determination and In Vivo Activity
      Christopher C. Arico-Muendel, Bruce Belanger, Dennis Benjamin, Heather S. Blanchette, Teresa M. Caiazzo, Paolo A. Centrella, Jennifer DeLorey, Elisabeth G. Doyle, Ulrike Gradhand, Sarah T. Griffin, Susan Hill, Matthew T. Labenski, Barry A. Morgan, Gary O’Donovan, Kavirayani Prasad, Steven Skinner, Nazbeh Taghizadeh, Charles D. Thompson, James Wakefield, William Westlin and Kerry F. White
      Drug Metabolism and Disposition April 2013, 41 (4) 814-826; DOI: https://doi.org/10.1124/dmd.112.048355

  8. Bergman, Peter

    1. Serum Levels of 25-Hydroxyvitamin D and the CYP3A Biomarker 4β-Hydroxycholesterol in a High-Dose Vitamin D Supplementation Study
      Linda Björkhem-Bergman, Hanna Nylén, Anna-Carin Norlin, Jonatan D. Lindh, Lena Ekström, Erik Eliasson, Peter Bergman and Ulf Diczfalusy
      Drug Metabolism and Disposition April 2013, 41 (4) 704-708; DOI: https://doi.org/10.1124/dmd.113.051136

  9. Bird, James

    1. Predicting Metabolic Clearance for Drugs That Are Actively Transported into Hepatocytes: Incubational Binding as a Consequence of in Vitro Hepatocyte Concentration Is a Key Factor
      Pär Nordell, Petter Svanberg, James Bird and Ken Grime
      Drug Metabolism and Disposition April 2013, 41 (4) 836-843; DOI: https://doi.org/10.1124/dmd.112.050377

  10. Björkhem-Bergman, Linda

    1. Serum Levels of 25-Hydroxyvitamin D and the CYP3A Biomarker 4β-Hydroxycholesterol in a High-Dose Vitamin D Supplementation Study
      Linda Björkhem-Bergman, Hanna Nylén, Anna-Carin Norlin, Jonatan D. Lindh, Lena Ekström, Erik Eliasson, Peter Bergman and Ulf Diczfalusy
      Drug Metabolism and Disposition April 2013, 41 (4) 704-708; DOI: https://doi.org/10.1124/dmd.113.051136

  11. Blanchette, Heather S.

    1. Metabolites of PPI-2458, a Selective, Irreversible Inhibitor of Methionine Aminopeptidase-2: Structure Determination and In Vivo Activity
      Christopher C. Arico-Muendel, Bruce Belanger, Dennis Benjamin, Heather S. Blanchette, Teresa M. Caiazzo, Paolo A. Centrella, Jennifer DeLorey, Elisabeth G. Doyle, Ulrike Gradhand, Sarah T. Griffin, Susan Hill, Matthew T. Labenski, Barry A. Morgan, Gary O’Donovan, Kavirayani Prasad, Steven Skinner, Nazbeh Taghizadeh, Charles D. Thompson, James Wakefield, William Westlin and Kerry F. White
      Drug Metabolism and Disposition April 2013, 41 (4) 814-826; DOI: https://doi.org/10.1124/dmd.112.048355

  12. Bommareddy, Ajay

    1. Organic Anion Transporter 3 Interacts Selectively with Lipophilic β-Lactam Antibiotics
      Aaron T. Wolman, Michael R. Gionfriddo, Gregory A. Heindel, Paran Mukhija, Sarah Witkowski, Ajay Bommareddy and Adam L. VanWert
      Drug Metabolism and Disposition April 2013, 41 (4) 791-800; DOI: https://doi.org/10.1124/dmd.112.049569

  13. Boysen, Gunnar

    1. Potential Role of UGT1A4 Promoter SNPs in Anastrozole Pharmacogenomics
      Vineetha Koroth Edavana, Ishwori B. Dhakal, Suzanne Williams, Rosalind Penney, Gunnar Boysen, Aiwei Yao-Borengasser and Susan Kadlubar
      Drug Metabolism and Disposition April 2013, 41 (4) 870-877; DOI: https://doi.org/10.1124/dmd.112.048157

  14. Bradbury, J. Alyce

    1. Characterization of Four New Mouse Cytochrome P450 Enzymes of the CYP2J Subfamily
      Joan P. Graves, Matthew L. Edin, J. Alyce Bradbury, Artiom Gruzdev, Jennifer Cheng, Fred B. Lih, Tiwanda A. Masinde, Wei Qu, Natasha P. Clayton, James P. Morrison, Kenneth B. Tomer and Darryl C. Zeldin
      Drug Metabolism and Disposition April 2013, 41 (4) 763-773; DOI: https://doi.org/10.1124/dmd.112.049429

  15. Buckley, David B.

    1. Lysosomal Sequestration (Trapping) of Lipophilic Amine (Cationic Amphiphilic) Drugs in Immortalized Human Hepatocytes (Fa2N-4 Cells)
      Faraz Kazmi, Tiffini Hensley, Chad Pope, Ryan S. Funk, Greg J. Loewen, David B. Buckley and Andrew Parkinson
      Drug Metabolism and Disposition April 2013, 41 (4) 897-905; DOI: https://doi.org/10.1124/dmd.112.050054

C

  1. Caiazzo, Teresa M.

    1. Metabolites of PPI-2458, a Selective, Irreversible Inhibitor of Methionine Aminopeptidase-2: Structure Determination and In Vivo Activity
      Christopher C. Arico-Muendel, Bruce Belanger, Dennis Benjamin, Heather S. Blanchette, Teresa M. Caiazzo, Paolo A. Centrella, Jennifer DeLorey, Elisabeth G. Doyle, Ulrike Gradhand, Sarah T. Griffin, Susan Hill, Matthew T. Labenski, Barry A. Morgan, Gary O’Donovan, Kavirayani Prasad, Steven Skinner, Nazbeh Taghizadeh, Charles D. Thompson, James Wakefield, William Westlin and Kerry F. White
      Drug Metabolism and Disposition April 2013, 41 (4) 814-826; DOI: https://doi.org/10.1124/dmd.112.048355

  2. Cass, Carol E.

    1. Transport of A1 Adenosine Receptor Agonist Tecadenoson by Human and Mouse Nucleoside Transporters: Evidence for Blood-Brain Barrier Transport by Murine Equilibrative Nucleoside Transporter 1 mENT1
      Eve-Irene Lepist, Vijaya L. Damaraju, Jing Zhang, Wendy P. Gati, Sylvia Y.M. Yao, Kyla M. Smith, Edward Karpinski, James D. Young, Kwan H. Leung and Carol E. Cass
      Drug Metabolism and Disposition April 2013, 41 (4) 916-922; DOI: https://doi.org/10.1124/dmd.112.049858

  3. Cassidy, Kenneth C.

    1. Pharmacokinetics, Metabolism, and Excretion of the Glycogen Synthase Kinase-3 Inhibitor LY2090314 in Rats, Dogs, and Humans: A Case Study in Rapid Clearance by Extensive Metabolism with Low Circulating Metabolite Exposure
      Maciej J. Zamek-Gliszczynski, Trent L. Abraham, Jeffrey J. Alberts, Palaniappan Kulanthaivel, Kimberley A. Jackson, Kay H. Chow, Denis J. McCann, Haitao Hu, Shelby Anderson, Nathan A. Furr, Robert J. Barbuch and Kenneth C. Cassidy
      Drug Metabolism and Disposition April 2013, 41 (4) 714-726; DOI: https://doi.org/10.1124/dmd.112.048488

  4. Centrella, Paolo A.

    1. Metabolites of PPI-2458, a Selective, Irreversible Inhibitor of Methionine Aminopeptidase-2: Structure Determination and In Vivo Activity
      Christopher C. Arico-Muendel, Bruce Belanger, Dennis Benjamin, Heather S. Blanchette, Teresa M. Caiazzo, Paolo A. Centrella, Jennifer DeLorey, Elisabeth G. Doyle, Ulrike Gradhand, Sarah T. Griffin, Susan Hill, Matthew T. Labenski, Barry A. Morgan, Gary O’Donovan, Kavirayani Prasad, Steven Skinner, Nazbeh Taghizadeh, Charles D. Thompson, James Wakefield, William Westlin and Kerry F. White
      Drug Metabolism and Disposition April 2013, 41 (4) 814-826; DOI: https://doi.org/10.1124/dmd.112.048355

  5. Cha, Eun-Young

    1. Identification and Characterization of Novel Alternative Splice Variants of Human Constitutive Androstane Receptor in Liver Samples of Koreans and Caucasians
      Eun-Jung Choi, Yin-Jin Jang, Eun-Young Cha, Jae-Gook Shin and Sang Seop Lee
      Drug Metabolism and Disposition April 2013, 41 (4) 888-896; DOI: https://doi.org/10.1124/dmd.112.049791

  6. Chattopadhyay, Souvik

    1. Interleukins-12 and -23 Do Not Alter Expression or Activity of Multiple Cytochrome P450 Enzymes in Cryopreserved Human Hepatocytes
      Shannon Dallas, Souvik Chattopadhyay, Carlo Sensenhauser, Ameesha Batheja, Monica Singer and Jose Silva
      Drug Metabolism and Disposition April 2013, 41 (4) 689-693; DOI: https://doi.org/10.1124/dmd.112.048884

  7. Cheng, Jennifer

    1. Characterization of Four New Mouse Cytochrome P450 Enzymes of the CYP2J Subfamily
      Joan P. Graves, Matthew L. Edin, J. Alyce Bradbury, Artiom Gruzdev, Jennifer Cheng, Fred B. Lih, Tiwanda A. Masinde, Wei Qu, Natasha P. Clayton, James P. Morrison, Kenneth B. Tomer and Darryl C. Zeldin
      Drug Metabolism and Disposition April 2013, 41 (4) 763-773; DOI: https://doi.org/10.1124/dmd.112.049429

  8. Choi, Eun-Jung

    1. Identification and Characterization of Novel Alternative Splice Variants of Human Constitutive Androstane Receptor in Liver Samples of Koreans and Caucasians
      Eun-Jung Choi, Yin-Jin Jang, Eun-Young Cha, Jae-Gook Shin and Sang Seop Lee
      Drug Metabolism and Disposition April 2013, 41 (4) 888-896; DOI: https://doi.org/10.1124/dmd.112.049791

  9. Chow, Kay H.

    1. Pharmacokinetics, Metabolism, and Excretion of the Glycogen Synthase Kinase-3 Inhibitor LY2090314 in Rats, Dogs, and Humans: A Case Study in Rapid Clearance by Extensive Metabolism with Low Circulating Metabolite Exposure
      Maciej J. Zamek-Gliszczynski, Trent L. Abraham, Jeffrey J. Alberts, Palaniappan Kulanthaivel, Kimberley A. Jackson, Kay H. Chow, Denis J. McCann, Haitao Hu, Shelby Anderson, Nathan A. Furr, Robert J. Barbuch and Kenneth C. Cassidy
      Drug Metabolism and Disposition April 2013, 41 (4) 714-726; DOI: https://doi.org/10.1124/dmd.112.048488

  10. Clayton, Natasha P.

    1. Characterization of Four New Mouse Cytochrome P450 Enzymes of the CYP2J Subfamily
      Joan P. Graves, Matthew L. Edin, J. Alyce Bradbury, Artiom Gruzdev, Jennifer Cheng, Fred B. Lih, Tiwanda A. Masinde, Wei Qu, Natasha P. Clayton, James P. Morrison, Kenneth B. Tomer and Darryl C. Zeldin
      Drug Metabolism and Disposition April 2013, 41 (4) 763-773; DOI: https://doi.org/10.1124/dmd.112.049429

  11. Cline, Cynthia

    1. Drug Transporters on Arachnoid Barrier Cells Contribute to the Blood–Cerebrospinal Fluid Barrier
      Kazuto Yasuda, Cynthia Cline, Peter Vogel, Mihaela Onciu, Soghra Fatima, Brian P. Sorrentino, Ranjit K. Thirumaran, Sean Ekins, Yoshihiro Urade, Ko Fujimori and Erin G. Schuetz
      Drug Metabolism and Disposition April 2013, 41 (4) 923-931; DOI: https://doi.org/10.1124/dmd.112.050344

  12. Crafford, Amanda

    1. Methadone N-Demethylation by the Common CYP2B6 Allelic Variant CYP2B6.6
      Sarah Gadel, Amanda Crafford, Karen Regina and Evan D. Kharasch
      Drug Metabolism and Disposition April 2013, 41 (4) 709-713; DOI: https://doi.org/10.1124/dmd.112.050625

  13. Cui, Julia Y.

    1. RNA-Sequencing Quantification of Hepatic Ontogeny and Tissue Distribution of mRNAs of Phase II Enzymes in Mice
      Hong Lu, Sumedha Gunewardena, Julia Y. Cui, Byunggil Yoo, Xiao-bo Zhong and Curtis D. Klaassen
      Drug Metabolism and Disposition April 2013, 41 (4) 844-857; DOI: https://doi.org/10.1124/dmd.112.050211

D

  1. Dallas, Shannon

    1. Interleukins-12 and -23 Do Not Alter Expression or Activity of Multiple Cytochrome P450 Enzymes in Cryopreserved Human Hepatocytes
      Shannon Dallas, Souvik Chattopadhyay, Carlo Sensenhauser, Ameesha Batheja, Monica Singer and Jose Silva
      Drug Metabolism and Disposition April 2013, 41 (4) 689-693; DOI: https://doi.org/10.1124/dmd.112.048884

  2. Damaraju, Vijaya L.

    1. Transport of A1 Adenosine Receptor Agonist Tecadenoson by Human and Mouse Nucleoside Transporters: Evidence for Blood-Brain Barrier Transport by Murine Equilibrative Nucleoside Transporter 1 mENT1
      Eve-Irene Lepist, Vijaya L. Damaraju, Jing Zhang, Wendy P. Gati, Sylvia Y.M. Yao, Kyla M. Smith, Edward Karpinski, James D. Young, Kwan H. Leung and Carol E. Cass
      Drug Metabolism and Disposition April 2013, 41 (4) 916-922; DOI: https://doi.org/10.1124/dmd.112.049858

  3. DeLorey, Jennifer

    1. Metabolites of PPI-2458, a Selective, Irreversible Inhibitor of Methionine Aminopeptidase-2: Structure Determination and In Vivo Activity
      Christopher C. Arico-Muendel, Bruce Belanger, Dennis Benjamin, Heather S. Blanchette, Teresa M. Caiazzo, Paolo A. Centrella, Jennifer DeLorey, Elisabeth G. Doyle, Ulrike Gradhand, Sarah T. Griffin, Susan Hill, Matthew T. Labenski, Barry A. Morgan, Gary O’Donovan, Kavirayani Prasad, Steven Skinner, Nazbeh Taghizadeh, Charles D. Thompson, James Wakefield, William Westlin and Kerry F. White
      Drug Metabolism and Disposition April 2013, 41 (4) 814-826; DOI: https://doi.org/10.1124/dmd.112.048355

  4. Dhakal, Ishwori B.

    1. Potential Role of UGT1A4 Promoter SNPs in Anastrozole Pharmacogenomics
      Vineetha Koroth Edavana, Ishwori B. Dhakal, Suzanne Williams, Rosalind Penney, Gunnar Boysen, Aiwei Yao-Borengasser and Susan Kadlubar
      Drug Metabolism and Disposition April 2013, 41 (4) 870-877; DOI: https://doi.org/10.1124/dmd.112.048157

  5. Diczfalusy, Ulf

    1. Serum Levels of 25-Hydroxyvitamin D and the CYP3A Biomarker 4β-Hydroxycholesterol in a High-Dose Vitamin D Supplementation Study
      Linda Björkhem-Bergman, Hanna Nylén, Anna-Carin Norlin, Jonatan D. Lindh, Lena Ekström, Erik Eliasson, Peter Bergman and Ulf Diczfalusy
      Drug Metabolism and Disposition April 2013, 41 (4) 704-708; DOI: https://doi.org/10.1124/dmd.113.051136

  6. Doyle, Elisabeth G.

    1. Metabolites of PPI-2458, a Selective, Irreversible Inhibitor of Methionine Aminopeptidase-2: Structure Determination and In Vivo Activity
      Christopher C. Arico-Muendel, Bruce Belanger, Dennis Benjamin, Heather S. Blanchette, Teresa M. Caiazzo, Paolo A. Centrella, Jennifer DeLorey, Elisabeth G. Doyle, Ulrike Gradhand, Sarah T. Griffin, Susan Hill, Matthew T. Labenski, Barry A. Morgan, Gary O’Donovan, Kavirayani Prasad, Steven Skinner, Nazbeh Taghizadeh, Charles D. Thompson, James Wakefield, William Westlin and Kerry F. White
      Drug Metabolism and Disposition April 2013, 41 (4) 814-826; DOI: https://doi.org/10.1124/dmd.112.048355

E

  1. Edavana, Vineetha Koroth

    1. Potential Role of UGT1A4 Promoter SNPs in Anastrozole Pharmacogenomics
      Vineetha Koroth Edavana, Ishwori B. Dhakal, Suzanne Williams, Rosalind Penney, Gunnar Boysen, Aiwei Yao-Borengasser and Susan Kadlubar
      Drug Metabolism and Disposition April 2013, 41 (4) 870-877; DOI: https://doi.org/10.1124/dmd.112.048157

  2. Edin, Matthew L.

    1. Characterization of Four New Mouse Cytochrome P450 Enzymes of the CYP2J Subfamily
      Joan P. Graves, Matthew L. Edin, J. Alyce Bradbury, Artiom Gruzdev, Jennifer Cheng, Fred B. Lih, Tiwanda A. Masinde, Wei Qu, Natasha P. Clayton, James P. Morrison, Kenneth B. Tomer and Darryl C. Zeldin
      Drug Metabolism and Disposition April 2013, 41 (4) 763-773; DOI: https://doi.org/10.1124/dmd.112.049429

  3. Ekins, Sean

    1. Drug Transporters on Arachnoid Barrier Cells Contribute to the Blood–Cerebrospinal Fluid Barrier
      Kazuto Yasuda, Cynthia Cline, Peter Vogel, Mihaela Onciu, Soghra Fatima, Brian P. Sorrentino, Ranjit K. Thirumaran, Sean Ekins, Yoshihiro Urade, Ko Fujimori and Erin G. Schuetz
      Drug Metabolism and Disposition April 2013, 41 (4) 923-931; DOI: https://doi.org/10.1124/dmd.112.050344

  4. Ekström, Lena

    1. Serum Levels of 25-Hydroxyvitamin D and the CYP3A Biomarker 4β-Hydroxycholesterol in a High-Dose Vitamin D Supplementation Study
      Linda Björkhem-Bergman, Hanna Nylén, Anna-Carin Norlin, Jonatan D. Lindh, Lena Ekström, Erik Eliasson, Peter Bergman and Ulf Diczfalusy
      Drug Metabolism and Disposition April 2013, 41 (4) 704-708; DOI: https://doi.org/10.1124/dmd.113.051136

  5. Eliasson, Erik

    1. Serum Levels of 25-Hydroxyvitamin D and the CYP3A Biomarker 4β-Hydroxycholesterol in a High-Dose Vitamin D Supplementation Study
      Linda Björkhem-Bergman, Hanna Nylén, Anna-Carin Norlin, Jonatan D. Lindh, Lena Ekström, Erik Eliasson, Peter Bergman and Ulf Diczfalusy
      Drug Metabolism and Disposition April 2013, 41 (4) 704-708; DOI: https://doi.org/10.1124/dmd.113.051136

  6. Erker, Thomas

    1. Tariquidar and Elacridar Are Dose-Dependently Transported by P-Glycoprotein and Bcrp at the Blood-Brain Barrier: A Small-Animal Positron Emission Tomography and In Vitro Study
      Jens P. Bankstahl, Marion Bankstahl, Kerstin Römermann, Thomas Wanek, Johann Stanek, Albert D. Windhorst, Maren Fedrowitz, Thomas Erker, Markus Müller, Wolfgang Löscher, Oliver Langer and Claudia Kuntner
      Drug Metabolism and Disposition April 2013, 41 (4) 754-762; DOI: https://doi.org/10.1124/dmd.112.049148

F

  1. Falardeau, Sarah-Ann

    1. The Relative Protein Abundance of UGT1A Alternative Splice Variants as a Key Determinant of Glucuronidation Activity In Vitro
      Mélanie Rouleau, Joannie Roberge, Sarah-Ann Falardeau, Lyne Villeneuve and Chantal Guillemette
      Drug Metabolism and Disposition April 2013, 41 (4) 694-697; DOI: https://doi.org/10.1124/dmd.112.050468

  2. Fatima, Soghra

    1. Drug Transporters on Arachnoid Barrier Cells Contribute to the Blood–Cerebrospinal Fluid Barrier
      Kazuto Yasuda, Cynthia Cline, Peter Vogel, Mihaela Onciu, Soghra Fatima, Brian P. Sorrentino, Ranjit K. Thirumaran, Sean Ekins, Yoshihiro Urade, Ko Fujimori and Erin G. Schuetz
      Drug Metabolism and Disposition April 2013, 41 (4) 923-931; DOI: https://doi.org/10.1124/dmd.112.050344

  3. Fedrowitz, Maren

    1. Tariquidar and Elacridar Are Dose-Dependently Transported by P-Glycoprotein and Bcrp at the Blood-Brain Barrier: A Small-Animal Positron Emission Tomography and In Vitro Study
      Jens P. Bankstahl, Marion Bankstahl, Kerstin Römermann, Thomas Wanek, Johann Stanek, Albert D. Windhorst, Maren Fedrowitz, Thomas Erker, Markus Müller, Wolfgang Löscher, Oliver Langer and Claudia Kuntner
      Drug Metabolism and Disposition April 2013, 41 (4) 754-762; DOI: https://doi.org/10.1124/dmd.112.049148

  4. Fong, Kei-Lai

    1. Peginesatide Clearance, Distribution, Metabolism, and Excretion in Monkeys following Intravenous Administration
      Kathryn W. Woodburn, Kei-Lai Fong, Susan D. Wilson, Steven Sloneker, Paul Strzemienski, Eric Solon, Yuu Moriya and Yoshihiko Tagawa
      Drug Metabolism and Disposition April 2013, 41 (4) 774-784; DOI: https://doi.org/10.1124/dmd.112.048033

  5. Frost, Charles E.

    1. Characterization of Efflux Transporters Involved in Distribution and Disposition of Apixaban
      Donglu Zhang, Kan He, John J. Herbst, Janet Kolb, Wilson Shou, Lifei Wang, Praveen V. Balimane, Yong-Hae Han, Jinping Gan, Charles E. Frost and W. Griffith Humphreys
      Drug Metabolism and Disposition April 2013, 41 (4) 827-835; DOI: https://doi.org/10.1124/dmd.112.050260
    2. Investigating the Enteroenteric Recirculation of Apixaban, a Factor Xa Inhibitor: Administration of Activated Charcoal to Bile Duct-Cannulated Rats and Dogs Receiving an Intravenous Dose and Use of Drug Transporter Knockout Rats
      Donglu Zhang, Charles E. Frost, Kan He, A. David Rodrigues, Xiaoli Wang, Lifei Wang, Theunis C. Goosen and W. Griffith Humphreys
      Drug Metabolism and Disposition April 2013, 41 (4) 906-915; DOI: https://doi.org/10.1124/dmd.112.050575

  6. Fujimori, Ko

    1. Drug Transporters on Arachnoid Barrier Cells Contribute to the Blood–Cerebrospinal Fluid Barrier
      Kazuto Yasuda, Cynthia Cline, Peter Vogel, Mihaela Onciu, Soghra Fatima, Brian P. Sorrentino, Ranjit K. Thirumaran, Sean Ekins, Yoshihiro Urade, Ko Fujimori and Erin G. Schuetz
      Drug Metabolism and Disposition April 2013, 41 (4) 923-931; DOI: https://doi.org/10.1124/dmd.112.050344

  7. Funk, Ryan S.

    1. Lysosomal Sequestration (Trapping) of Lipophilic Amine (Cationic Amphiphilic) Drugs in Immortalized Human Hepatocytes (Fa2N-4 Cells)
      Faraz Kazmi, Tiffini Hensley, Chad Pope, Ryan S. Funk, Greg J. Loewen, David B. Buckley and Andrew Parkinson
      Drug Metabolism and Disposition April 2013, 41 (4) 897-905; DOI: https://doi.org/10.1124/dmd.112.050054

  8. Furr, Nathan A.

    1. Pharmacokinetics, Metabolism, and Excretion of the Glycogen Synthase Kinase-3 Inhibitor LY2090314 in Rats, Dogs, and Humans: A Case Study in Rapid Clearance by Extensive Metabolism with Low Circulating Metabolite Exposure
      Maciej J. Zamek-Gliszczynski, Trent L. Abraham, Jeffrey J. Alberts, Palaniappan Kulanthaivel, Kimberley A. Jackson, Kay H. Chow, Denis J. McCann, Haitao Hu, Shelby Anderson, Nathan A. Furr, Robert J. Barbuch and Kenneth C. Cassidy
      Drug Metabolism and Disposition April 2013, 41 (4) 714-726; DOI: https://doi.org/10.1124/dmd.112.048488

G

  1. Gadel, Sarah

    1. Methadone N-Demethylation by the Common CYP2B6 Allelic Variant CYP2B6.6
      Sarah Gadel, Amanda Crafford, Karen Regina and Evan D. Kharasch
      Drug Metabolism and Disposition April 2013, 41 (4) 709-713; DOI: https://doi.org/10.1124/dmd.112.050625

  2. Galetin, Aleksandra

    1. Application of a Physiologically Based Pharmacokinetic Model to Assess Propofol Hepatic and Renal Glucuronidation in Isolation: Utility of In Vitro and In Vivo Data
      Katherine L. Gill, Michael Gertz, J. Brian Houston and Aleksandra Galetin
      Drug Metabolism and Disposition April 2013, 41 (4) 744-753; DOI: https://doi.org/10.1124/dmd.112.050294

  3. Gan, Jinping

    1. Characterization of Efflux Transporters Involved in Distribution and Disposition of Apixaban
      Donglu Zhang, Kan He, John J. Herbst, Janet Kolb, Wilson Shou, Lifei Wang, Praveen V. Balimane, Yong-Hae Han, Jinping Gan, Charles E. Frost and W. Griffith Humphreys
      Drug Metabolism and Disposition April 2013, 41 (4) 827-835; DOI: https://doi.org/10.1124/dmd.112.050260

  4. Gati, Wendy P.

    1. Transport of A1 Adenosine Receptor Agonist Tecadenoson by Human and Mouse Nucleoside Transporters: Evidence for Blood-Brain Barrier Transport by Murine Equilibrative Nucleoside Transporter 1 mENT1
      Eve-Irene Lepist, Vijaya L. Damaraju, Jing Zhang, Wendy P. Gati, Sylvia Y.M. Yao, Kyla M. Smith, Edward Karpinski, James D. Young, Kwan H. Leung and Carol E. Cass
      Drug Metabolism and Disposition April 2013, 41 (4) 916-922; DOI: https://doi.org/10.1124/dmd.112.049858

  5. Gertz, Michael

    1. Application of a Physiologically Based Pharmacokinetic Model to Assess Propofol Hepatic and Renal Glucuronidation in Isolation: Utility of In Vitro and In Vivo Data
      Katherine L. Gill, Michael Gertz, J. Brian Houston and Aleksandra Galetin
      Drug Metabolism and Disposition April 2013, 41 (4) 744-753; DOI: https://doi.org/10.1124/dmd.112.050294

  6. Gill, Katherine L.

    1. Application of a Physiologically Based Pharmacokinetic Model to Assess Propofol Hepatic and Renal Glucuronidation in Isolation: Utility of In Vitro and In Vivo Data
      Katherine L. Gill, Michael Gertz, J. Brian Houston and Aleksandra Galetin
      Drug Metabolism and Disposition April 2013, 41 (4) 744-753; DOI: https://doi.org/10.1124/dmd.112.050294

  7. Gionfriddo, Michael R.

    1. Organic Anion Transporter 3 Interacts Selectively with Lipophilic β-Lactam Antibiotics
      Aaron T. Wolman, Michael R. Gionfriddo, Gregory A. Heindel, Paran Mukhija, Sarah Witkowski, Ajay Bommareddy and Adam L. VanWert
      Drug Metabolism and Disposition April 2013, 41 (4) 791-800; DOI: https://doi.org/10.1124/dmd.112.049569

  8. Goosen, Theunis C.

    1. Investigating the Enteroenteric Recirculation of Apixaban, a Factor Xa Inhibitor: Administration of Activated Charcoal to Bile Duct-Cannulated Rats and Dogs Receiving an Intravenous Dose and Use of Drug Transporter Knockout Rats
      Donglu Zhang, Charles E. Frost, Kan He, A. David Rodrigues, Xiaoli Wang, Lifei Wang, Theunis C. Goosen and W. Griffith Humphreys
      Drug Metabolism and Disposition April 2013, 41 (4) 906-915; DOI: https://doi.org/10.1124/dmd.112.050575

  9. Gradhand, Ulrike

    1. Metabolites of PPI-2458, a Selective, Irreversible Inhibitor of Methionine Aminopeptidase-2: Structure Determination and In Vivo Activity
      Christopher C. Arico-Muendel, Bruce Belanger, Dennis Benjamin, Heather S. Blanchette, Teresa M. Caiazzo, Paolo A. Centrella, Jennifer DeLorey, Elisabeth G. Doyle, Ulrike Gradhand, Sarah T. Griffin, Susan Hill, Matthew T. Labenski, Barry A. Morgan, Gary O’Donovan, Kavirayani Prasad, Steven Skinner, Nazbeh Taghizadeh, Charles D. Thompson, James Wakefield, William Westlin and Kerry F. White
      Drug Metabolism and Disposition April 2013, 41 (4) 814-826; DOI: https://doi.org/10.1124/dmd.112.048355

  10. Graves, Joan P.

    1. Characterization of Four New Mouse Cytochrome P450 Enzymes of the CYP2J Subfamily
      Joan P. Graves, Matthew L. Edin, J. Alyce Bradbury, Artiom Gruzdev, Jennifer Cheng, Fred B. Lih, Tiwanda A. Masinde, Wei Qu, Natasha P. Clayton, James P. Morrison, Kenneth B. Tomer and Darryl C. Zeldin
      Drug Metabolism and Disposition April 2013, 41 (4) 763-773; DOI: https://doi.org/10.1124/dmd.112.049429

  11. Griffin, Sarah T.

    1. Metabolites of PPI-2458, a Selective, Irreversible Inhibitor of Methionine Aminopeptidase-2: Structure Determination and In Vivo Activity
      Christopher C. Arico-Muendel, Bruce Belanger, Dennis Benjamin, Heather S. Blanchette, Teresa M. Caiazzo, Paolo A. Centrella, Jennifer DeLorey, Elisabeth G. Doyle, Ulrike Gradhand, Sarah T. Griffin, Susan Hill, Matthew T. Labenski, Barry A. Morgan, Gary O’Donovan, Kavirayani Prasad, Steven Skinner, Nazbeh Taghizadeh, Charles D. Thompson, James Wakefield, William Westlin and Kerry F. White
      Drug Metabolism and Disposition April 2013, 41 (4) 814-826; DOI: https://doi.org/10.1124/dmd.112.048355

  12. Grime, Ken

    1. Predicting Metabolic Clearance for Drugs That Are Actively Transported into Hepatocytes: Incubational Binding as a Consequence of in Vitro Hepatocyte Concentration Is a Key Factor
      Pär Nordell, Petter Svanberg, James Bird and Ken Grime
      Drug Metabolism and Disposition April 2013, 41 (4) 836-843; DOI: https://doi.org/10.1124/dmd.112.050377

  13. Gruzdev, Artiom

    1. Characterization of Four New Mouse Cytochrome P450 Enzymes of the CYP2J Subfamily
      Joan P. Graves, Matthew L. Edin, J. Alyce Bradbury, Artiom Gruzdev, Jennifer Cheng, Fred B. Lih, Tiwanda A. Masinde, Wei Qu, Natasha P. Clayton, James P. Morrison, Kenneth B. Tomer and Darryl C. Zeldin
      Drug Metabolism and Disposition April 2013, 41 (4) 763-773; DOI: https://doi.org/10.1124/dmd.112.049429

  14. Guillemette, Chantal

    1. The Relative Protein Abundance of UGT1A Alternative Splice Variants as a Key Determinant of Glucuronidation Activity In Vitro
      Mélanie Rouleau, Joannie Roberge, Sarah-Ann Falardeau, Lyne Villeneuve and Chantal Guillemette
      Drug Metabolism and Disposition April 2013, 41 (4) 694-697; DOI: https://doi.org/10.1124/dmd.112.050468

  15. Gunewardena, Sumedha

    1. RNA-Sequencing Quantification of Hepatic Ontogeny and Tissue Distribution of mRNAs of Phase II Enzymes in Mice
      Hong Lu, Sumedha Gunewardena, Julia Y. Cui, Byunggil Yoo, Xiao-bo Zhong and Curtis D. Klaassen
      Drug Metabolism and Disposition April 2013, 41 (4) 844-857; DOI: https://doi.org/10.1124/dmd.112.050211

H

  1. Hall, Adrian

    1. Reversible Inhibition of Human Carboxylesterases by Acyl Glucuronides
      Natalie R. Inoue, Adrian Hall, W. George Lai and Eric T. Williams
      Drug Metabolism and Disposition April 2013, 41 (4) 698-703; DOI: https://doi.org/10.1124/dmd.112.050252

  2. Han, Yong-Hae

    1. Characterization of Efflux Transporters Involved in Distribution and Disposition of Apixaban
      Donglu Zhang, Kan He, John J. Herbst, Janet Kolb, Wilson Shou, Lifei Wang, Praveen V. Balimane, Yong-Hae Han, Jinping Gan, Charles E. Frost and W. Griffith Humphreys
      Drug Metabolism and Disposition April 2013, 41 (4) 827-835; DOI: https://doi.org/10.1124/dmd.112.050260

  3. He, Fang

    1. Identification of the Active Components in Shenmai Injection that Differentially Affect Cyp3a4-Mediated 1′-Hydroxylation and 4-Hydroxylation of Midazolam
      Caiwen Zeng, Fang He, Chunhua Xia, Hong Zhang and Yuqing Xiong
      Drug Metabolism and Disposition April 2013, 41 (4) 785-790; DOI: https://doi.org/10.1124/dmd.112.048025

  4. He, Kan

    1. Characterization of Efflux Transporters Involved in Distribution and Disposition of Apixaban
      Donglu Zhang, Kan He, John J. Herbst, Janet Kolb, Wilson Shou, Lifei Wang, Praveen V. Balimane, Yong-Hae Han, Jinping Gan, Charles E. Frost and W. Griffith Humphreys
      Drug Metabolism and Disposition April 2013, 41 (4) 827-835; DOI: https://doi.org/10.1124/dmd.112.050260
    2. Investigating the Enteroenteric Recirculation of Apixaban, a Factor Xa Inhibitor: Administration of Activated Charcoal to Bile Duct-Cannulated Rats and Dogs Receiving an Intravenous Dose and Use of Drug Transporter Knockout Rats
      Donglu Zhang, Charles E. Frost, Kan He, A. David Rodrigues, Xiaoli Wang, Lifei Wang, Theunis C. Goosen and W. Griffith Humphreys
      Drug Metabolism and Disposition April 2013, 41 (4) 906-915; DOI: https://doi.org/10.1124/dmd.112.050575

  5. Heindel, Gregory A.

    1. Organic Anion Transporter 3 Interacts Selectively with Lipophilic β-Lactam Antibiotics
      Aaron T. Wolman, Michael R. Gionfriddo, Gregory A. Heindel, Paran Mukhija, Sarah Witkowski, Ajay Bommareddy and Adam L. VanWert
      Drug Metabolism and Disposition April 2013, 41 (4) 791-800; DOI: https://doi.org/10.1124/dmd.112.049569

  6. Hensley, Tiffini

    1. Lysosomal Sequestration (Trapping) of Lipophilic Amine (Cationic Amphiphilic) Drugs in Immortalized Human Hepatocytes (Fa2N-4 Cells)
      Faraz Kazmi, Tiffini Hensley, Chad Pope, Ryan S. Funk, Greg J. Loewen, David B. Buckley and Andrew Parkinson
      Drug Metabolism and Disposition April 2013, 41 (4) 897-905; DOI: https://doi.org/10.1124/dmd.112.050054

  7. Herbst, John J.

    1. Characterization of Efflux Transporters Involved in Distribution and Disposition of Apixaban
      Donglu Zhang, Kan He, John J. Herbst, Janet Kolb, Wilson Shou, Lifei Wang, Praveen V. Balimane, Yong-Hae Han, Jinping Gan, Charles E. Frost and W. Griffith Humphreys
      Drug Metabolism and Disposition April 2013, 41 (4) 827-835; DOI: https://doi.org/10.1124/dmd.112.050260

  8. Hill, Susan

    1. Metabolites of PPI-2458, a Selective, Irreversible Inhibitor of Methionine Aminopeptidase-2: Structure Determination and In Vivo Activity
      Christopher C. Arico-Muendel, Bruce Belanger, Dennis Benjamin, Heather S. Blanchette, Teresa M. Caiazzo, Paolo A. Centrella, Jennifer DeLorey, Elisabeth G. Doyle, Ulrike Gradhand, Sarah T. Griffin, Susan Hill, Matthew T. Labenski, Barry A. Morgan, Gary O’Donovan, Kavirayani Prasad, Steven Skinner, Nazbeh Taghizadeh, Charles D. Thompson, James Wakefield, William Westlin and Kerry F. White
      Drug Metabolism and Disposition April 2013, 41 (4) 814-826; DOI: https://doi.org/10.1124/dmd.112.048355

  9. Hirabayashi, Hideki

    1. Retrospective Analysis of P-Glycoprotein–Mediated Drug-Drug Interactions at the Blood-Brain Barrier in Humans
      Hiroshi Sugimoto, Hideki Hirabayashi, Nobuyuki Amano and Toshiya Moriwaki
      Drug Metabolism and Disposition April 2013, 41 (4) 683-688; DOI: https://doi.org/10.1124/dmd.112.049577

  10. Hollenberg, Paul F.

    1. The Inactivation of Human CYP2E1 by Phenethyl Isothiocyanate, a Naturally Occurring Chemopreventive Agent, and Its Oxidative Bioactivation
      Yasushi Yoshigae, Chitra Sridar, Ute M. Kent and Paul F. Hollenberg
      Drug Metabolism and Disposition April 2013, 41 (4) 858-869; DOI: https://doi.org/10.1124/dmd.112.050609

  11. Honda, Tomohiro

    1. Absorption, Elimination, and Metabolism of CS-1036, a Novel α-Amylase Inhibitor in Rats and Monkeys, and the Relationship between Gastrointestinal Distribution and Suppression of Glucose Absorption
      Tomohiro Honda, Yoko Kaneno-Urasaki, Takahiro Murai, Masayo Kakuta, Hatsumi Nasu, Eiko Namba, Tetsufumi Koga, Akira Okuno and Takashi Izumi
      Drug Metabolism and Disposition April 2013, 41 (4) 878-887; DOI: https://doi.org/10.1124/dmd.112.050591

  12. Houston, J. Brian

    1. Application of a Physiologically Based Pharmacokinetic Model to Assess Propofol Hepatic and Renal Glucuronidation in Isolation: Utility of In Vitro and In Vivo Data
      Katherine L. Gill, Michael Gertz, J. Brian Houston and Aleksandra Galetin
      Drug Metabolism and Disposition April 2013, 41 (4) 744-753; DOI: https://doi.org/10.1124/dmd.112.050294

  13. Hu, Haitao

    1. Pharmacokinetics, Metabolism, and Excretion of the Glycogen Synthase Kinase-3 Inhibitor LY2090314 in Rats, Dogs, and Humans: A Case Study in Rapid Clearance by Extensive Metabolism with Low Circulating Metabolite Exposure
      Maciej J. Zamek-Gliszczynski, Trent L. Abraham, Jeffrey J. Alberts, Palaniappan Kulanthaivel, Kimberley A. Jackson, Kay H. Chow, Denis J. McCann, Haitao Hu, Shelby Anderson, Nathan A. Furr, Robert J. Barbuch and Kenneth C. Cassidy
      Drug Metabolism and Disposition April 2013, 41 (4) 714-726; DOI: https://doi.org/10.1124/dmd.112.048488

  14. Humphreys, W. Griffith

    1. Characterization of Efflux Transporters Involved in Distribution and Disposition of Apixaban
      Donglu Zhang, Kan He, John J. Herbst, Janet Kolb, Wilson Shou, Lifei Wang, Praveen V. Balimane, Yong-Hae Han, Jinping Gan, Charles E. Frost and W. Griffith Humphreys
      Drug Metabolism and Disposition April 2013, 41 (4) 827-835; DOI: https://doi.org/10.1124/dmd.112.050260
    2. Investigating the Enteroenteric Recirculation of Apixaban, a Factor Xa Inhibitor: Administration of Activated Charcoal to Bile Duct-Cannulated Rats and Dogs Receiving an Intravenous Dose and Use of Drug Transporter Knockout Rats
      Donglu Zhang, Charles E. Frost, Kan He, A. David Rodrigues, Xiaoli Wang, Lifei Wang, Theunis C. Goosen and W. Griffith Humphreys
      Drug Metabolism and Disposition April 2013, 41 (4) 906-915; DOI: https://doi.org/10.1124/dmd.112.050575

I

  1. Inoue, Natalie R.

    1. Reversible Inhibition of Human Carboxylesterases by Acyl Glucuronides
      Natalie R. Inoue, Adrian Hall, W. George Lai and Eric T. Williams
      Drug Metabolism and Disposition April 2013, 41 (4) 698-703; DOI: https://doi.org/10.1124/dmd.112.050252

  2. Isoherranen, Nina

    1. A Physiologically Based Pharmacokinetic Model to Predict Disposition of CYP2D6 and CYP1A2 Metabolized Drugs in Pregnant Women
      Alice Ban Ke, Srikanth C. Nallani, Ping Zhao, Amin Rostami-Hodjegan, Nina Isoherranen and Jashvant D. Unadkat
      Drug Metabolism and Disposition April 2013, 41 (4) 801-813; DOI: https://doi.org/10.1124/dmd.112.050161

  3. Izumi, Takashi

    1. Absorption, Elimination, and Metabolism of CS-1036, a Novel α-Amylase Inhibitor in Rats and Monkeys, and the Relationship between Gastrointestinal Distribution and Suppression of Glucose Absorption
      Tomohiro Honda, Yoko Kaneno-Urasaki, Takahiro Murai, Masayo Kakuta, Hatsumi Nasu, Eiko Namba, Tetsufumi Koga, Akira Okuno and Takashi Izumi
      Drug Metabolism and Disposition April 2013, 41 (4) 878-887; DOI: https://doi.org/10.1124/dmd.112.050591

J

  1. Jackson, Kimberley A.

    1. Pharmacokinetics, Metabolism, and Excretion of the Glycogen Synthase Kinase-3 Inhibitor LY2090314 in Rats, Dogs, and Humans: A Case Study in Rapid Clearance by Extensive Metabolism with Low Circulating Metabolite Exposure
      Maciej J. Zamek-Gliszczynski, Trent L. Abraham, Jeffrey J. Alberts, Palaniappan Kulanthaivel, Kimberley A. Jackson, Kay H. Chow, Denis J. McCann, Haitao Hu, Shelby Anderson, Nathan A. Furr, Robert J. Barbuch and Kenneth C. Cassidy
      Drug Metabolism and Disposition April 2013, 41 (4) 714-726; DOI: https://doi.org/10.1124/dmd.112.048488

  2. Jang, Yin-Jin

    1. Identification and Characterization of Novel Alternative Splice Variants of Human Constitutive Androstane Receptor in Liver Samples of Koreans and Caucasians
      Eun-Jung Choi, Yin-Jin Jang, Eun-Young Cha, Jae-Gook Shin and Sang Seop Lee
      Drug Metabolism and Disposition April 2013, 41 (4) 888-896; DOI: https://doi.org/10.1124/dmd.112.049791

K

  1. Kadlubar, Susan

    1. Potential Role of UGT1A4 Promoter SNPs in Anastrozole Pharmacogenomics
      Vineetha Koroth Edavana, Ishwori B. Dhakal, Suzanne Williams, Rosalind Penney, Gunnar Boysen, Aiwei Yao-Borengasser and Susan Kadlubar
      Drug Metabolism and Disposition April 2013, 41 (4) 870-877; DOI: https://doi.org/10.1124/dmd.112.048157

  2. Kakuta, Masayo

    1. Absorption, Elimination, and Metabolism of CS-1036, a Novel α-Amylase Inhibitor in Rats and Monkeys, and the Relationship between Gastrointestinal Distribution and Suppression of Glucose Absorption
      Tomohiro Honda, Yoko Kaneno-Urasaki, Takahiro Murai, Masayo Kakuta, Hatsumi Nasu, Eiko Namba, Tetsufumi Koga, Akira Okuno and Takashi Izumi
      Drug Metabolism and Disposition April 2013, 41 (4) 878-887; DOI: https://doi.org/10.1124/dmd.112.050591

  3. Kaneno-Urasaki, Yoko

    1. Absorption, Elimination, and Metabolism of CS-1036, a Novel α-Amylase Inhibitor in Rats and Monkeys, and the Relationship between Gastrointestinal Distribution and Suppression of Glucose Absorption
      Tomohiro Honda, Yoko Kaneno-Urasaki, Takahiro Murai, Masayo Kakuta, Hatsumi Nasu, Eiko Namba, Tetsufumi Koga, Akira Okuno and Takashi Izumi
      Drug Metabolism and Disposition April 2013, 41 (4) 878-887; DOI: https://doi.org/10.1124/dmd.112.050591

  4. Karpinski, Edward

    1. Transport of A1 Adenosine Receptor Agonist Tecadenoson by Human and Mouse Nucleoside Transporters: Evidence for Blood-Brain Barrier Transport by Murine Equilibrative Nucleoside Transporter 1 mENT1
      Eve-Irene Lepist, Vijaya L. Damaraju, Jing Zhang, Wendy P. Gati, Sylvia Y.M. Yao, Kyla M. Smith, Edward Karpinski, James D. Young, Kwan H. Leung and Carol E. Cass
      Drug Metabolism and Disposition April 2013, 41 (4) 916-922; DOI: https://doi.org/10.1124/dmd.112.049858

  5. Kazmi, Faraz

    1. Lysosomal Sequestration (Trapping) of Lipophilic Amine (Cationic Amphiphilic) Drugs in Immortalized Human Hepatocytes (Fa2N-4 Cells)
      Faraz Kazmi, Tiffini Hensley, Chad Pope, Ryan S. Funk, Greg J. Loewen, David B. Buckley and Andrew Parkinson
      Drug Metabolism and Disposition April 2013, 41 (4) 897-905; DOI: https://doi.org/10.1124/dmd.112.050054

  6. Ke, Alice Ban

    1. A Physiologically Based Pharmacokinetic Model to Predict Disposition of CYP2D6 and CYP1A2 Metabolized Drugs in Pregnant Women
      Alice Ban Ke, Srikanth C. Nallani, Ping Zhao, Amin Rostami-Hodjegan, Nina Isoherranen and Jashvant D. Unadkat
      Drug Metabolism and Disposition April 2013, 41 (4) 801-813; DOI: https://doi.org/10.1124/dmd.112.050161

  7. Kent, Ute M.

    1. The Inactivation of Human CYP2E1 by Phenethyl Isothiocyanate, a Naturally Occurring Chemopreventive Agent, and Its Oxidative Bioactivation
      Yasushi Yoshigae, Chitra Sridar, Ute M. Kent and Paul F. Hollenberg
      Drug Metabolism and Disposition April 2013, 41 (4) 858-869; DOI: https://doi.org/10.1124/dmd.112.050609

  8. Kharasch, Evan D.

    1. Methadone N-Demethylation by the Common CYP2B6 Allelic Variant CYP2B6.6
      Sarah Gadel, Amanda Crafford, Karen Regina and Evan D. Kharasch
      Drug Metabolism and Disposition April 2013, 41 (4) 709-713; DOI: https://doi.org/10.1124/dmd.112.050625

  9. Klaassen, Curtis D.

    1. RNA-Sequencing Quantification of Hepatic Ontogeny and Tissue Distribution of mRNAs of Phase II Enzymes in Mice
      Hong Lu, Sumedha Gunewardena, Julia Y. Cui, Byunggil Yoo, Xiao-bo Zhong and Curtis D. Klaassen
      Drug Metabolism and Disposition April 2013, 41 (4) 844-857; DOI: https://doi.org/10.1124/dmd.112.050211

  10. Koga, Tetsufumi

    1. Absorption, Elimination, and Metabolism of CS-1036, a Novel α-Amylase Inhibitor in Rats and Monkeys, and the Relationship between Gastrointestinal Distribution and Suppression of Glucose Absorption
      Tomohiro Honda, Yoko Kaneno-Urasaki, Takahiro Murai, Masayo Kakuta, Hatsumi Nasu, Eiko Namba, Tetsufumi Koga, Akira Okuno and Takashi Izumi
      Drug Metabolism and Disposition April 2013, 41 (4) 878-887; DOI: https://doi.org/10.1124/dmd.112.050591

  11. Kogame, Akifumi

    1. Pharmacokinetic and Pharmacodynamic Modeling of Hedgehog Inhibitor TAK-441 for the Inhibition of Gli1 messenger RNA Expression and Antitumor Efficacy in Xenografted Tumor Model Mice
      Akifumi Kogame, Yoshihiko Tagawa, Sachio Shibata, Hideaki Tojo, Maki Miyamoto, Kimio Tohyama, Takahiro Kondo, Shimoga Prakash, Wen Chyi Shyu and Satoru Asahi
      Drug Metabolism and Disposition April 2013, 41 (4) 727-734; DOI: https://doi.org/10.1124/dmd.112.049650

  12. Kolb, Janet

    1. Characterization of Efflux Transporters Involved in Distribution and Disposition of Apixaban
      Donglu Zhang, Kan He, John J. Herbst, Janet Kolb, Wilson Shou, Lifei Wang, Praveen V. Balimane, Yong-Hae Han, Jinping Gan, Charles E. Frost and W. Griffith Humphreys
      Drug Metabolism and Disposition April 2013, 41 (4) 827-835; DOI: https://doi.org/10.1124/dmd.112.050260

  13. Kondo, Takahiro

    1. Pharmacokinetic and Pharmacodynamic Modeling of Hedgehog Inhibitor TAK-441 for the Inhibition of Gli1 messenger RNA Expression and Antitumor Efficacy in Xenografted Tumor Model Mice
      Akifumi Kogame, Yoshihiko Tagawa, Sachio Shibata, Hideaki Tojo, Maki Miyamoto, Kimio Tohyama, Takahiro Kondo, Shimoga Prakash, Wen Chyi Shyu and Satoru Asahi
      Drug Metabolism and Disposition April 2013, 41 (4) 727-734; DOI: https://doi.org/10.1124/dmd.112.049650

  14. Kulanthaivel, Palaniappan

    1. Pharmacokinetics, Metabolism, and Excretion of the Glycogen Synthase Kinase-3 Inhibitor LY2090314 in Rats, Dogs, and Humans: A Case Study in Rapid Clearance by Extensive Metabolism with Low Circulating Metabolite Exposure
      Maciej J. Zamek-Gliszczynski, Trent L. Abraham, Jeffrey J. Alberts, Palaniappan Kulanthaivel, Kimberley A. Jackson, Kay H. Chow, Denis J. McCann, Haitao Hu, Shelby Anderson, Nathan A. Furr, Robert J. Barbuch and Kenneth C. Cassidy
      Drug Metabolism and Disposition April 2013, 41 (4) 714-726; DOI: https://doi.org/10.1124/dmd.112.048488

  15. Kuntner, Claudia

    1. Tariquidar and Elacridar Are Dose-Dependently Transported by P-Glycoprotein and Bcrp at the Blood-Brain Barrier: A Small-Animal Positron Emission Tomography and In Vitro Study
      Jens P. Bankstahl, Marion Bankstahl, Kerstin Römermann, Thomas Wanek, Johann Stanek, Albert D. Windhorst, Maren Fedrowitz, Thomas Erker, Markus Müller, Wolfgang Löscher, Oliver Langer and Claudia Kuntner
      Drug Metabolism and Disposition April 2013, 41 (4) 754-762; DOI: https://doi.org/10.1124/dmd.112.049148

L

  1. Labenski, Matthew T.

    1. Metabolites of PPI-2458, a Selective, Irreversible Inhibitor of Methionine Aminopeptidase-2: Structure Determination and In Vivo Activity
      Christopher C. Arico-Muendel, Bruce Belanger, Dennis Benjamin, Heather S. Blanchette, Teresa M. Caiazzo, Paolo A. Centrella, Jennifer DeLorey, Elisabeth G. Doyle, Ulrike Gradhand, Sarah T. Griffin, Susan Hill, Matthew T. Labenski, Barry A. Morgan, Gary O’Donovan, Kavirayani Prasad, Steven Skinner, Nazbeh Taghizadeh, Charles D. Thompson, James Wakefield, William Westlin and Kerry F. White
      Drug Metabolism and Disposition April 2013, 41 (4) 814-826; DOI: https://doi.org/10.1124/dmd.112.048355

  2. Lai, W. George

    1. Reversible Inhibition of Human Carboxylesterases by Acyl Glucuronides
      Natalie R. Inoue, Adrian Hall, W. George Lai and Eric T. Williams
      Drug Metabolism and Disposition April 2013, 41 (4) 698-703; DOI: https://doi.org/10.1124/dmd.112.050252

  3. Langer, Oliver

    1. Tariquidar and Elacridar Are Dose-Dependently Transported by P-Glycoprotein and Bcrp at the Blood-Brain Barrier: A Small-Animal Positron Emission Tomography and In Vitro Study
      Jens P. Bankstahl, Marion Bankstahl, Kerstin Römermann, Thomas Wanek, Johann Stanek, Albert D. Windhorst, Maren Fedrowitz, Thomas Erker, Markus Müller, Wolfgang Löscher, Oliver Langer and Claudia Kuntner
      Drug Metabolism and Disposition April 2013, 41 (4) 754-762; DOI: https://doi.org/10.1124/dmd.112.049148

  4. Lee, Sang Seop

    1. Identification and Characterization of Novel Alternative Splice Variants of Human Constitutive Androstane Receptor in Liver Samples of Koreans and Caucasians
      Eun-Jung Choi, Yin-Jin Jang, Eun-Young Cha, Jae-Gook Shin and Sang Seop Lee
      Drug Metabolism and Disposition April 2013, 41 (4) 888-896; DOI: https://doi.org/10.1124/dmd.112.049791

  5. Lepist, Eve-Irene

    1. Transport of A1 Adenosine Receptor Agonist Tecadenoson by Human and Mouse Nucleoside Transporters: Evidence for Blood-Brain Barrier Transport by Murine Equilibrative Nucleoside Transporter 1 mENT1
      Eve-Irene Lepist, Vijaya L. Damaraju, Jing Zhang, Wendy P. Gati, Sylvia Y.M. Yao, Kyla M. Smith, Edward Karpinski, James D. Young, Kwan H. Leung and Carol E. Cass
      Drug Metabolism and Disposition April 2013, 41 (4) 916-922; DOI: https://doi.org/10.1124/dmd.112.049858

  6. Leung, Kwan H.

    1. Transport of A1 Adenosine Receptor Agonist Tecadenoson by Human and Mouse Nucleoside Transporters: Evidence for Blood-Brain Barrier Transport by Murine Equilibrative Nucleoside Transporter 1 mENT1
      Eve-Irene Lepist, Vijaya L. Damaraju, Jing Zhang, Wendy P. Gati, Sylvia Y.M. Yao, Kyla M. Smith, Edward Karpinski, James D. Young, Kwan H. Leung and Carol E. Cass
      Drug Metabolism and Disposition April 2013, 41 (4) 916-922; DOI: https://doi.org/10.1124/dmd.112.049858

  7. Lih, Fred B.

    1. Characterization of Four New Mouse Cytochrome P450 Enzymes of the CYP2J Subfamily
      Joan P. Graves, Matthew L. Edin, J. Alyce Bradbury, Artiom Gruzdev, Jennifer Cheng, Fred B. Lih, Tiwanda A. Masinde, Wei Qu, Natasha P. Clayton, James P. Morrison, Kenneth B. Tomer and Darryl C. Zeldin
      Drug Metabolism and Disposition April 2013, 41 (4) 763-773; DOI: https://doi.org/10.1124/dmd.112.049429

  8. Lindh, Jonatan D.

    1. Serum Levels of 25-Hydroxyvitamin D and the CYP3A Biomarker 4β-Hydroxycholesterol in a High-Dose Vitamin D Supplementation Study
      Linda Björkhem-Bergman, Hanna Nylén, Anna-Carin Norlin, Jonatan D. Lindh, Lena Ekström, Erik Eliasson, Peter Bergman and Ulf Diczfalusy
      Drug Metabolism and Disposition April 2013, 41 (4) 704-708; DOI: https://doi.org/10.1124/dmd.113.051136

  9. Loewen, Greg J.

    1. Lysosomal Sequestration (Trapping) of Lipophilic Amine (Cationic Amphiphilic) Drugs in Immortalized Human Hepatocytes (Fa2N-4 Cells)
      Faraz Kazmi, Tiffini Hensley, Chad Pope, Ryan S. Funk, Greg J. Loewen, David B. Buckley and Andrew Parkinson
      Drug Metabolism and Disposition April 2013, 41 (4) 897-905; DOI: https://doi.org/10.1124/dmd.112.050054

  10. Löscher, Wolfgang

    1. Tariquidar and Elacridar Are Dose-Dependently Transported by P-Glycoprotein and Bcrp at the Blood-Brain Barrier: A Small-Animal Positron Emission Tomography and In Vitro Study
      Jens P. Bankstahl, Marion Bankstahl, Kerstin Römermann, Thomas Wanek, Johann Stanek, Albert D. Windhorst, Maren Fedrowitz, Thomas Erker, Markus Müller, Wolfgang Löscher, Oliver Langer and Claudia Kuntner
      Drug Metabolism and Disposition April 2013, 41 (4) 754-762; DOI: https://doi.org/10.1124/dmd.112.049148

  11. Lu, Hong

    1. RNA-Sequencing Quantification of Hepatic Ontogeny and Tissue Distribution of mRNAs of Phase II Enzymes in Mice
      Hong Lu, Sumedha Gunewardena, Julia Y. Cui, Byunggil Yoo, Xiao-bo Zhong and Curtis D. Klaassen
      Drug Metabolism and Disposition April 2013, 41 (4) 844-857; DOI: https://doi.org/10.1124/dmd.112.050211

M

  1. Masinde, Tiwanda A.

    1. Characterization of Four New Mouse Cytochrome P450 Enzymes of the CYP2J Subfamily
      Joan P. Graves, Matthew L. Edin, J. Alyce Bradbury, Artiom Gruzdev, Jennifer Cheng, Fred B. Lih, Tiwanda A. Masinde, Wei Qu, Natasha P. Clayton, James P. Morrison, Kenneth B. Tomer and Darryl C. Zeldin
      Drug Metabolism and Disposition April 2013, 41 (4) 763-773; DOI: https://doi.org/10.1124/dmd.112.049429

  2. Matsunaga, Norikazu

    1. Evaluation of Hepatic Disposition of Paroxetine Using Sandwich-Cultured Rat and Human Hepatocytes
      Norikazu Matsunaga, Ken-ichi Nunoya, Masahiro Okada, Mikio Ogawa and Ikumi Tamai
      Drug Metabolism and Disposition April 2013, 41 (4) 735-743; DOI: https://doi.org/10.1124/dmd.112.049817

  3. McCann, Denis J.

    1. Pharmacokinetics, Metabolism, and Excretion of the Glycogen Synthase Kinase-3 Inhibitor LY2090314 in Rats, Dogs, and Humans: A Case Study in Rapid Clearance by Extensive Metabolism with Low Circulating Metabolite Exposure
      Maciej J. Zamek-Gliszczynski, Trent L. Abraham, Jeffrey J. Alberts, Palaniappan Kulanthaivel, Kimberley A. Jackson, Kay H. Chow, Denis J. McCann, Haitao Hu, Shelby Anderson, Nathan A. Furr, Robert J. Barbuch and Kenneth C. Cassidy
      Drug Metabolism and Disposition April 2013, 41 (4) 714-726; DOI: https://doi.org/10.1124/dmd.112.048488

  4. Miyamoto, Maki

    1. Pharmacokinetic and Pharmacodynamic Modeling of Hedgehog Inhibitor TAK-441 for the Inhibition of Gli1 messenger RNA Expression and Antitumor Efficacy in Xenografted Tumor Model Mice
      Akifumi Kogame, Yoshihiko Tagawa, Sachio Shibata, Hideaki Tojo, Maki Miyamoto, Kimio Tohyama, Takahiro Kondo, Shimoga Prakash, Wen Chyi Shyu and Satoru Asahi
      Drug Metabolism and Disposition April 2013, 41 (4) 727-734; DOI: https://doi.org/10.1124/dmd.112.049650

  5. Morgan, Barry A.

    1. Metabolites of PPI-2458, a Selective, Irreversible Inhibitor of Methionine Aminopeptidase-2: Structure Determination and In Vivo Activity
      Christopher C. Arico-Muendel, Bruce Belanger, Dennis Benjamin, Heather S. Blanchette, Teresa M. Caiazzo, Paolo A. Centrella, Jennifer DeLorey, Elisabeth G. Doyle, Ulrike Gradhand, Sarah T. Griffin, Susan Hill, Matthew T. Labenski, Barry A. Morgan, Gary O’Donovan, Kavirayani Prasad, Steven Skinner, Nazbeh Taghizadeh, Charles D. Thompson, James Wakefield, William Westlin and Kerry F. White
      Drug Metabolism and Disposition April 2013, 41 (4) 814-826; DOI: https://doi.org/10.1124/dmd.112.048355

  6. Moriwaki, Toshiya

    1. Retrospective Analysis of P-Glycoprotein–Mediated Drug-Drug Interactions at the Blood-Brain Barrier in Humans
      Hiroshi Sugimoto, Hideki Hirabayashi, Nobuyuki Amano and Toshiya Moriwaki
      Drug Metabolism and Disposition April 2013, 41 (4) 683-688; DOI: https://doi.org/10.1124/dmd.112.049577

  7. Moriya, Yuu

    1. Peginesatide Clearance, Distribution, Metabolism, and Excretion in Monkeys following Intravenous Administration
      Kathryn W. Woodburn, Kei-Lai Fong, Susan D. Wilson, Steven Sloneker, Paul Strzemienski, Eric Solon, Yuu Moriya and Yoshihiko Tagawa
      Drug Metabolism and Disposition April 2013, 41 (4) 774-784; DOI: https://doi.org/10.1124/dmd.112.048033

  8. Morrison, James P.

    1. Characterization of Four New Mouse Cytochrome P450 Enzymes of the CYP2J Subfamily
      Joan P. Graves, Matthew L. Edin, J. Alyce Bradbury, Artiom Gruzdev, Jennifer Cheng, Fred B. Lih, Tiwanda A. Masinde, Wei Qu, Natasha P. Clayton, James P. Morrison, Kenneth B. Tomer and Darryl C. Zeldin
      Drug Metabolism and Disposition April 2013, 41 (4) 763-773; DOI: https://doi.org/10.1124/dmd.112.049429

  9. Mukhija, Paran

    1. Organic Anion Transporter 3 Interacts Selectively with Lipophilic β-Lactam Antibiotics
      Aaron T. Wolman, Michael R. Gionfriddo, Gregory A. Heindel, Paran Mukhija, Sarah Witkowski, Ajay Bommareddy and Adam L. VanWert
      Drug Metabolism and Disposition April 2013, 41 (4) 791-800; DOI: https://doi.org/10.1124/dmd.112.049569

  10. Müller, Markus

    1. Tariquidar and Elacridar Are Dose-Dependently Transported by P-Glycoprotein and Bcrp at the Blood-Brain Barrier: A Small-Animal Positron Emission Tomography and In Vitro Study
      Jens P. Bankstahl, Marion Bankstahl, Kerstin Römermann, Thomas Wanek, Johann Stanek, Albert D. Windhorst, Maren Fedrowitz, Thomas Erker, Markus Müller, Wolfgang Löscher, Oliver Langer and Claudia Kuntner
      Drug Metabolism and Disposition April 2013, 41 (4) 754-762; DOI: https://doi.org/10.1124/dmd.112.049148

  11. Murai, Takahiro

    1. Absorption, Elimination, and Metabolism of CS-1036, a Novel α-Amylase Inhibitor in Rats and Monkeys, and the Relationship between Gastrointestinal Distribution and Suppression of Glucose Absorption
      Tomohiro Honda, Yoko Kaneno-Urasaki, Takahiro Murai, Masayo Kakuta, Hatsumi Nasu, Eiko Namba, Tetsufumi Koga, Akira Okuno and Takashi Izumi
      Drug Metabolism and Disposition April 2013, 41 (4) 878-887; DOI: https://doi.org/10.1124/dmd.112.050591

N

  1. Nallani, Srikanth C.

    1. A Physiologically Based Pharmacokinetic Model to Predict Disposition of CYP2D6 and CYP1A2 Metabolized Drugs in Pregnant Women
      Alice Ban Ke, Srikanth C. Nallani, Ping Zhao, Amin Rostami-Hodjegan, Nina Isoherranen and Jashvant D. Unadkat
      Drug Metabolism and Disposition April 2013, 41 (4) 801-813; DOI: https://doi.org/10.1124/dmd.112.050161

  2. Namba, Eiko

    1. Absorption, Elimination, and Metabolism of CS-1036, a Novel α-Amylase Inhibitor in Rats and Monkeys, and the Relationship between Gastrointestinal Distribution and Suppression of Glucose Absorption
      Tomohiro Honda, Yoko Kaneno-Urasaki, Takahiro Murai, Masayo Kakuta, Hatsumi Nasu, Eiko Namba, Tetsufumi Koga, Akira Okuno and Takashi Izumi
      Drug Metabolism and Disposition April 2013, 41 (4) 878-887; DOI: https://doi.org/10.1124/dmd.112.050591

  3. Nasu, Hatsumi

    1. Absorption, Elimination, and Metabolism of CS-1036, a Novel α-Amylase Inhibitor in Rats and Monkeys, and the Relationship between Gastrointestinal Distribution and Suppression of Glucose Absorption
      Tomohiro Honda, Yoko Kaneno-Urasaki, Takahiro Murai, Masayo Kakuta, Hatsumi Nasu, Eiko Namba, Tetsufumi Koga, Akira Okuno and Takashi Izumi
      Drug Metabolism and Disposition April 2013, 41 (4) 878-887; DOI: https://doi.org/10.1124/dmd.112.050591

  4. Nordell, Pär

    1. Predicting Metabolic Clearance for Drugs That Are Actively Transported into Hepatocytes: Incubational Binding as a Consequence of in Vitro Hepatocyte Concentration Is a Key Factor
      Pär Nordell, Petter Svanberg, James Bird and Ken Grime
      Drug Metabolism and Disposition April 2013, 41 (4) 836-843; DOI: https://doi.org/10.1124/dmd.112.050377

  5. Norlin, Anna-Carin

    1. Serum Levels of 25-Hydroxyvitamin D and the CYP3A Biomarker 4β-Hydroxycholesterol in a High-Dose Vitamin D Supplementation Study
      Linda Björkhem-Bergman, Hanna Nylén, Anna-Carin Norlin, Jonatan D. Lindh, Lena Ekström, Erik Eliasson, Peter Bergman and Ulf Diczfalusy
      Drug Metabolism and Disposition April 2013, 41 (4) 704-708; DOI: https://doi.org/10.1124/dmd.113.051136

  6. Nunoya, Ken-ichi

    1. Evaluation of Hepatic Disposition of Paroxetine Using Sandwich-Cultured Rat and Human Hepatocytes
      Norikazu Matsunaga, Ken-ichi Nunoya, Masahiro Okada, Mikio Ogawa and Ikumi Tamai
      Drug Metabolism and Disposition April 2013, 41 (4) 735-743; DOI: https://doi.org/10.1124/dmd.112.049817

  7. Nylén, Hanna

    1. Serum Levels of 25-Hydroxyvitamin D and the CYP3A Biomarker 4β-Hydroxycholesterol in a High-Dose Vitamin D Supplementation Study
      Linda Björkhem-Bergman, Hanna Nylén, Anna-Carin Norlin, Jonatan D. Lindh, Lena Ekström, Erik Eliasson, Peter Bergman and Ulf Diczfalusy
      Drug Metabolism and Disposition April 2013, 41 (4) 704-708; DOI: https://doi.org/10.1124/dmd.113.051136

O

  1. O’Donovan, Gary

    1. Metabolites of PPI-2458, a Selective, Irreversible Inhibitor of Methionine Aminopeptidase-2: Structure Determination and In Vivo Activity
      Christopher C. Arico-Muendel, Bruce Belanger, Dennis Benjamin, Heather S. Blanchette, Teresa M. Caiazzo, Paolo A. Centrella, Jennifer DeLorey, Elisabeth G. Doyle, Ulrike Gradhand, Sarah T. Griffin, Susan Hill, Matthew T. Labenski, Barry A. Morgan, Gary O’Donovan, Kavirayani Prasad, Steven Skinner, Nazbeh Taghizadeh, Charles D. Thompson, James Wakefield, William Westlin and Kerry F. White
      Drug Metabolism and Disposition April 2013, 41 (4) 814-826; DOI: https://doi.org/10.1124/dmd.112.048355

  2. Ogawa, Mikio

    1. Evaluation of Hepatic Disposition of Paroxetine Using Sandwich-Cultured Rat and Human Hepatocytes
      Norikazu Matsunaga, Ken-ichi Nunoya, Masahiro Okada, Mikio Ogawa and Ikumi Tamai
      Drug Metabolism and Disposition April 2013, 41 (4) 735-743; DOI: https://doi.org/10.1124/dmd.112.049817

  3. Okada, Masahiro

    1. Evaluation of Hepatic Disposition of Paroxetine Using Sandwich-Cultured Rat and Human Hepatocytes
      Norikazu Matsunaga, Ken-ichi Nunoya, Masahiro Okada, Mikio Ogawa and Ikumi Tamai
      Drug Metabolism and Disposition April 2013, 41 (4) 735-743; DOI: https://doi.org/10.1124/dmd.112.049817

  4. Okuno, Akira

    1. Absorption, Elimination, and Metabolism of CS-1036, a Novel α-Amylase Inhibitor in Rats and Monkeys, and the Relationship between Gastrointestinal Distribution and Suppression of Glucose Absorption
      Tomohiro Honda, Yoko Kaneno-Urasaki, Takahiro Murai, Masayo Kakuta, Hatsumi Nasu, Eiko Namba, Tetsufumi Koga, Akira Okuno and Takashi Izumi
      Drug Metabolism and Disposition April 2013, 41 (4) 878-887; DOI: https://doi.org/10.1124/dmd.112.050591

  5. Onciu, Mihaela

    1. Drug Transporters on Arachnoid Barrier Cells Contribute to the Blood–Cerebrospinal Fluid Barrier
      Kazuto Yasuda, Cynthia Cline, Peter Vogel, Mihaela Onciu, Soghra Fatima, Brian P. Sorrentino, Ranjit K. Thirumaran, Sean Ekins, Yoshihiro Urade, Ko Fujimori and Erin G. Schuetz
      Drug Metabolism and Disposition April 2013, 41 (4) 923-931; DOI: https://doi.org/10.1124/dmd.112.050344

P

  1. Parkinson, Andrew

    1. Lysosomal Sequestration (Trapping) of Lipophilic Amine (Cationic Amphiphilic) Drugs in Immortalized Human Hepatocytes (Fa2N-4 Cells)
      Faraz Kazmi, Tiffini Hensley, Chad Pope, Ryan S. Funk, Greg J. Loewen, David B. Buckley and Andrew Parkinson
      Drug Metabolism and Disposition April 2013, 41 (4) 897-905; DOI: https://doi.org/10.1124/dmd.112.050054

  2. Penney, Rosalind

    1. Potential Role of UGT1A4 Promoter SNPs in Anastrozole Pharmacogenomics
      Vineetha Koroth Edavana, Ishwori B. Dhakal, Suzanne Williams, Rosalind Penney, Gunnar Boysen, Aiwei Yao-Borengasser and Susan Kadlubar
      Drug Metabolism and Disposition April 2013, 41 (4) 870-877; DOI: https://doi.org/10.1124/dmd.112.048157

  3. Pope, Chad

    1. Lysosomal Sequestration (Trapping) of Lipophilic Amine (Cationic Amphiphilic) Drugs in Immortalized Human Hepatocytes (Fa2N-4 Cells)
      Faraz Kazmi, Tiffini Hensley, Chad Pope, Ryan S. Funk, Greg J. Loewen, David B. Buckley and Andrew Parkinson
      Drug Metabolism and Disposition April 2013, 41 (4) 897-905; DOI: https://doi.org/10.1124/dmd.112.050054

  4. Prakash, Shimoga

    1. Pharmacokinetic and Pharmacodynamic Modeling of Hedgehog Inhibitor TAK-441 for the Inhibition of Gli1 messenger RNA Expression and Antitumor Efficacy in Xenografted Tumor Model Mice
      Akifumi Kogame, Yoshihiko Tagawa, Sachio Shibata, Hideaki Tojo, Maki Miyamoto, Kimio Tohyama, Takahiro Kondo, Shimoga Prakash, Wen Chyi Shyu and Satoru Asahi
      Drug Metabolism and Disposition April 2013, 41 (4) 727-734; DOI: https://doi.org/10.1124/dmd.112.049650

  5. Prasad, Kavirayani

    1. Metabolites of PPI-2458, a Selective, Irreversible Inhibitor of Methionine Aminopeptidase-2: Structure Determination and In Vivo Activity
      Christopher C. Arico-Muendel, Bruce Belanger, Dennis Benjamin, Heather S. Blanchette, Teresa M. Caiazzo, Paolo A. Centrella, Jennifer DeLorey, Elisabeth G. Doyle, Ulrike Gradhand, Sarah T. Griffin, Susan Hill, Matthew T. Labenski, Barry A. Morgan, Gary O’Donovan, Kavirayani Prasad, Steven Skinner, Nazbeh Taghizadeh, Charles D. Thompson, James Wakefield, William Westlin and Kerry F. White
      Drug Metabolism and Disposition April 2013, 41 (4) 814-826; DOI: https://doi.org/10.1124/dmd.112.048355

Q

  1. Qu, Wei

    1. Characterization of Four New Mouse Cytochrome P450 Enzymes of the CYP2J Subfamily
      Joan P. Graves, Matthew L. Edin, J. Alyce Bradbury, Artiom Gruzdev, Jennifer Cheng, Fred B. Lih, Tiwanda A. Masinde, Wei Qu, Natasha P. Clayton, James P. Morrison, Kenneth B. Tomer and Darryl C. Zeldin
      Drug Metabolism and Disposition April 2013, 41 (4) 763-773; DOI: https://doi.org/10.1124/dmd.112.049429

R

  1. Regina, Karen

    1. Methadone N-Demethylation by the Common CYP2B6 Allelic Variant CYP2B6.6
      Sarah Gadel, Amanda Crafford, Karen Regina and Evan D. Kharasch
      Drug Metabolism and Disposition April 2013, 41 (4) 709-713; DOI: https://doi.org/10.1124/dmd.112.050625

  2. Roberge, Joannie

    1. The Relative Protein Abundance of UGT1A Alternative Splice Variants as a Key Determinant of Glucuronidation Activity In Vitro
      Mélanie Rouleau, Joannie Roberge, Sarah-Ann Falardeau, Lyne Villeneuve and Chantal Guillemette
      Drug Metabolism and Disposition April 2013, 41 (4) 694-697; DOI: https://doi.org/10.1124/dmd.112.050468

  3. Rodrigues, A. David

    1. Investigating the Enteroenteric Recirculation of Apixaban, a Factor Xa Inhibitor: Administration of Activated Charcoal to Bile Duct-Cannulated Rats and Dogs Receiving an Intravenous Dose and Use of Drug Transporter Knockout Rats
      Donglu Zhang, Charles E. Frost, Kan He, A. David Rodrigues, Xiaoli Wang, Lifei Wang, Theunis C. Goosen and W. Griffith Humphreys
      Drug Metabolism and Disposition April 2013, 41 (4) 906-915; DOI: https://doi.org/10.1124/dmd.112.050575

  4. Römermann, Kerstin

    1. Tariquidar and Elacridar Are Dose-Dependently Transported by P-Glycoprotein and Bcrp at the Blood-Brain Barrier: A Small-Animal Positron Emission Tomography and In Vitro Study
      Jens P. Bankstahl, Marion Bankstahl, Kerstin Römermann, Thomas Wanek, Johann Stanek, Albert D. Windhorst, Maren Fedrowitz, Thomas Erker, Markus Müller, Wolfgang Löscher, Oliver Langer and Claudia Kuntner
      Drug Metabolism and Disposition April 2013, 41 (4) 754-762; DOI: https://doi.org/10.1124/dmd.112.049148

  5. Rostami-Hodjegan, Amin

    1. A Physiologically Based Pharmacokinetic Model to Predict Disposition of CYP2D6 and CYP1A2 Metabolized Drugs in Pregnant Women
      Alice Ban Ke, Srikanth C. Nallani, Ping Zhao, Amin Rostami-Hodjegan, Nina Isoherranen and Jashvant D. Unadkat
      Drug Metabolism and Disposition April 2013, 41 (4) 801-813; DOI: https://doi.org/10.1124/dmd.112.050161

  6. Rouleau, Mélanie

    1. The Relative Protein Abundance of UGT1A Alternative Splice Variants as a Key Determinant of Glucuronidation Activity In Vitro
      Mélanie Rouleau, Joannie Roberge, Sarah-Ann Falardeau, Lyne Villeneuve and Chantal Guillemette
      Drug Metabolism and Disposition April 2013, 41 (4) 694-697; DOI: https://doi.org/10.1124/dmd.112.050468

S

  1. Schuetz, Erin G.

    1. Drug Transporters on Arachnoid Barrier Cells Contribute to the Blood–Cerebrospinal Fluid Barrier
      Kazuto Yasuda, Cynthia Cline, Peter Vogel, Mihaela Onciu, Soghra Fatima, Brian P. Sorrentino, Ranjit K. Thirumaran, Sean Ekins, Yoshihiro Urade, Ko Fujimori and Erin G. Schuetz
      Drug Metabolism and Disposition April 2013, 41 (4) 923-931; DOI: https://doi.org/10.1124/dmd.112.050344

  2. Sensenhauser, Carlo

    1. Interleukins-12 and -23 Do Not Alter Expression or Activity of Multiple Cytochrome P450 Enzymes in Cryopreserved Human Hepatocytes
      Shannon Dallas, Souvik Chattopadhyay, Carlo Sensenhauser, Ameesha Batheja, Monica Singer and Jose Silva
      Drug Metabolism and Disposition April 2013, 41 (4) 689-693; DOI: https://doi.org/10.1124/dmd.112.048884

  3. Shibata, Sachio

    1. Pharmacokinetic and Pharmacodynamic Modeling of Hedgehog Inhibitor TAK-441 for the Inhibition of Gli1 messenger RNA Expression and Antitumor Efficacy in Xenografted Tumor Model Mice
      Akifumi Kogame, Yoshihiko Tagawa, Sachio Shibata, Hideaki Tojo, Maki Miyamoto, Kimio Tohyama, Takahiro Kondo, Shimoga Prakash, Wen Chyi Shyu and Satoru Asahi
      Drug Metabolism and Disposition April 2013, 41 (4) 727-734; DOI: https://doi.org/10.1124/dmd.112.049650

  4. Shin, Jae-Gook

    1. Identification and Characterization of Novel Alternative Splice Variants of Human Constitutive Androstane Receptor in Liver Samples of Koreans and Caucasians
      Eun-Jung Choi, Yin-Jin Jang, Eun-Young Cha, Jae-Gook Shin and Sang Seop Lee
      Drug Metabolism and Disposition April 2013, 41 (4) 888-896; DOI: https://doi.org/10.1124/dmd.112.049791

  5. Shou, Wilson

    1. Characterization of Efflux Transporters Involved in Distribution and Disposition of Apixaban
      Donglu Zhang, Kan He, John J. Herbst, Janet Kolb, Wilson Shou, Lifei Wang, Praveen V. Balimane, Yong-Hae Han, Jinping Gan, Charles E. Frost and W. Griffith Humphreys
      Drug Metabolism and Disposition April 2013, 41 (4) 827-835; DOI: https://doi.org/10.1124/dmd.112.050260

  6. Shyu, Wen Chyi

    1. Pharmacokinetic and Pharmacodynamic Modeling of Hedgehog Inhibitor TAK-441 for the Inhibition of Gli1 messenger RNA Expression and Antitumor Efficacy in Xenografted Tumor Model Mice
      Akifumi Kogame, Yoshihiko Tagawa, Sachio Shibata, Hideaki Tojo, Maki Miyamoto, Kimio Tohyama, Takahiro Kondo, Shimoga Prakash, Wen Chyi Shyu and Satoru Asahi
      Drug Metabolism and Disposition April 2013, 41 (4) 727-734; DOI: https://doi.org/10.1124/dmd.112.049650

  7. Silva, Jose

    1. Interleukins-12 and -23 Do Not Alter Expression or Activity of Multiple Cytochrome P450 Enzymes in Cryopreserved Human Hepatocytes
      Shannon Dallas, Souvik Chattopadhyay, Carlo Sensenhauser, Ameesha Batheja, Monica Singer and Jose Silva
      Drug Metabolism and Disposition April 2013, 41 (4) 689-693; DOI: https://doi.org/10.1124/dmd.112.048884

  8. Singer, Monica

    1. Interleukins-12 and -23 Do Not Alter Expression or Activity of Multiple Cytochrome P450 Enzymes in Cryopreserved Human Hepatocytes
      Shannon Dallas, Souvik Chattopadhyay, Carlo Sensenhauser, Ameesha Batheja, Monica Singer and Jose Silva
      Drug Metabolism and Disposition April 2013, 41 (4) 689-693; DOI: https://doi.org/10.1124/dmd.112.048884

  9. Skinner, Steven

    1. Metabolites of PPI-2458, a Selective, Irreversible Inhibitor of Methionine Aminopeptidase-2: Structure Determination and In Vivo Activity
      Christopher C. Arico-Muendel, Bruce Belanger, Dennis Benjamin, Heather S. Blanchette, Teresa M. Caiazzo, Paolo A. Centrella, Jennifer DeLorey, Elisabeth G. Doyle, Ulrike Gradhand, Sarah T. Griffin, Susan Hill, Matthew T. Labenski, Barry A. Morgan, Gary O’Donovan, Kavirayani Prasad, Steven Skinner, Nazbeh Taghizadeh, Charles D. Thompson, James Wakefield, William Westlin and Kerry F. White
      Drug Metabolism and Disposition April 2013, 41 (4) 814-826; DOI: https://doi.org/10.1124/dmd.112.048355

  10. Sloneker, Steven

    1. Peginesatide Clearance, Distribution, Metabolism, and Excretion in Monkeys following Intravenous Administration
      Kathryn W. Woodburn, Kei-Lai Fong, Susan D. Wilson, Steven Sloneker, Paul Strzemienski, Eric Solon, Yuu Moriya and Yoshihiko Tagawa
      Drug Metabolism and Disposition April 2013, 41 (4) 774-784; DOI: https://doi.org/10.1124/dmd.112.048033

  11. Smith, Kyla M.

    1. Transport of A1 Adenosine Receptor Agonist Tecadenoson by Human and Mouse Nucleoside Transporters: Evidence for Blood-Brain Barrier Transport by Murine Equilibrative Nucleoside Transporter 1 mENT1
      Eve-Irene Lepist, Vijaya L. Damaraju, Jing Zhang, Wendy P. Gati, Sylvia Y.M. Yao, Kyla M. Smith, Edward Karpinski, James D. Young, Kwan H. Leung and Carol E. Cass
      Drug Metabolism and Disposition April 2013, 41 (4) 916-922; DOI: https://doi.org/10.1124/dmd.112.049858

  12. Solon, Eric

    1. Peginesatide Clearance, Distribution, Metabolism, and Excretion in Monkeys following Intravenous Administration
      Kathryn W. Woodburn, Kei-Lai Fong, Susan D. Wilson, Steven Sloneker, Paul Strzemienski, Eric Solon, Yuu Moriya and Yoshihiko Tagawa
      Drug Metabolism and Disposition April 2013, 41 (4) 774-784; DOI: https://doi.org/10.1124/dmd.112.048033

  13. Sorrentino, Brian P.

    1. Drug Transporters on Arachnoid Barrier Cells Contribute to the Blood–Cerebrospinal Fluid Barrier
      Kazuto Yasuda, Cynthia Cline, Peter Vogel, Mihaela Onciu, Soghra Fatima, Brian P. Sorrentino, Ranjit K. Thirumaran, Sean Ekins, Yoshihiro Urade, Ko Fujimori and Erin G. Schuetz
      Drug Metabolism and Disposition April 2013, 41 (4) 923-931; DOI: https://doi.org/10.1124/dmd.112.050344

  14. Sridar, Chitra

    1. The Inactivation of Human CYP2E1 by Phenethyl Isothiocyanate, a Naturally Occurring Chemopreventive Agent, and Its Oxidative Bioactivation
      Yasushi Yoshigae, Chitra Sridar, Ute M. Kent and Paul F. Hollenberg
      Drug Metabolism and Disposition April 2013, 41 (4) 858-869; DOI: https://doi.org/10.1124/dmd.112.050609

  15. Stanek, Johann

    1. Tariquidar and Elacridar Are Dose-Dependently Transported by P-Glycoprotein and Bcrp at the Blood-Brain Barrier: A Small-Animal Positron Emission Tomography and In Vitro Study
      Jens P. Bankstahl, Marion Bankstahl, Kerstin Römermann, Thomas Wanek, Johann Stanek, Albert D. Windhorst, Maren Fedrowitz, Thomas Erker, Markus Müller, Wolfgang Löscher, Oliver Langer and Claudia Kuntner
      Drug Metabolism and Disposition April 2013, 41 (4) 754-762; DOI: https://doi.org/10.1124/dmd.112.049148

  16. Strzemienski, Paul

    1. Peginesatide Clearance, Distribution, Metabolism, and Excretion in Monkeys following Intravenous Administration
      Kathryn W. Woodburn, Kei-Lai Fong, Susan D. Wilson, Steven Sloneker, Paul Strzemienski, Eric Solon, Yuu Moriya and Yoshihiko Tagawa
      Drug Metabolism and Disposition April 2013, 41 (4) 774-784; DOI: https://doi.org/10.1124/dmd.112.048033

  17. Sugimoto, Hiroshi

    1. Retrospective Analysis of P-Glycoprotein–Mediated Drug-Drug Interactions at the Blood-Brain Barrier in Humans
      Hiroshi Sugimoto, Hideki Hirabayashi, Nobuyuki Amano and Toshiya Moriwaki
      Drug Metabolism and Disposition April 2013, 41 (4) 683-688; DOI: https://doi.org/10.1124/dmd.112.049577

  18. Svanberg, Petter

    1. Predicting Metabolic Clearance for Drugs That Are Actively Transported into Hepatocytes: Incubational Binding as a Consequence of in Vitro Hepatocyte Concentration Is a Key Factor
      Pär Nordell, Petter Svanberg, James Bird and Ken Grime
      Drug Metabolism and Disposition April 2013, 41 (4) 836-843; DOI: https://doi.org/10.1124/dmd.112.050377

T

  1. Tagawa, Yoshihiko

    1. Peginesatide Clearance, Distribution, Metabolism, and Excretion in Monkeys following Intravenous Administration
      Kathryn W. Woodburn, Kei-Lai Fong, Susan D. Wilson, Steven Sloneker, Paul Strzemienski, Eric Solon, Yuu Moriya and Yoshihiko Tagawa
      Drug Metabolism and Disposition April 2013, 41 (4) 774-784; DOI: https://doi.org/10.1124/dmd.112.048033
    2. Pharmacokinetic and Pharmacodynamic Modeling of Hedgehog Inhibitor TAK-441 for the Inhibition of Gli1 messenger RNA Expression and Antitumor Efficacy in Xenografted Tumor Model Mice
      Akifumi Kogame, Yoshihiko Tagawa, Sachio Shibata, Hideaki Tojo, Maki Miyamoto, Kimio Tohyama, Takahiro Kondo, Shimoga Prakash, Wen Chyi Shyu and Satoru Asahi
      Drug Metabolism and Disposition April 2013, 41 (4) 727-734; DOI: https://doi.org/10.1124/dmd.112.049650

  2. Taghizadeh, Nazbeh

    1. Metabolites of PPI-2458, a Selective, Irreversible Inhibitor of Methionine Aminopeptidase-2: Structure Determination and In Vivo Activity
      Christopher C. Arico-Muendel, Bruce Belanger, Dennis Benjamin, Heather S. Blanchette, Teresa M. Caiazzo, Paolo A. Centrella, Jennifer DeLorey, Elisabeth G. Doyle, Ulrike Gradhand, Sarah T. Griffin, Susan Hill, Matthew T. Labenski, Barry A. Morgan, Gary O’Donovan, Kavirayani Prasad, Steven Skinner, Nazbeh Taghizadeh, Charles D. Thompson, James Wakefield, William Westlin and Kerry F. White
      Drug Metabolism and Disposition April 2013, 41 (4) 814-826; DOI: https://doi.org/10.1124/dmd.112.048355

  3. Tamai, Ikumi

    1. Evaluation of Hepatic Disposition of Paroxetine Using Sandwich-Cultured Rat and Human Hepatocytes
      Norikazu Matsunaga, Ken-ichi Nunoya, Masahiro Okada, Mikio Ogawa and Ikumi Tamai
      Drug Metabolism and Disposition April 2013, 41 (4) 735-743; DOI: https://doi.org/10.1124/dmd.112.049817

  4. Thirumaran, Ranjit K.

    1. Drug Transporters on Arachnoid Barrier Cells Contribute to the Blood–Cerebrospinal Fluid Barrier
      Kazuto Yasuda, Cynthia Cline, Peter Vogel, Mihaela Onciu, Soghra Fatima, Brian P. Sorrentino, Ranjit K. Thirumaran, Sean Ekins, Yoshihiro Urade, Ko Fujimori and Erin G. Schuetz
      Drug Metabolism and Disposition April 2013, 41 (4) 923-931; DOI: https://doi.org/10.1124/dmd.112.050344

  5. Thompson, Charles D.

    1. Metabolites of PPI-2458, a Selective, Irreversible Inhibitor of Methionine Aminopeptidase-2: Structure Determination and In Vivo Activity
      Christopher C. Arico-Muendel, Bruce Belanger, Dennis Benjamin, Heather S. Blanchette, Teresa M. Caiazzo, Paolo A. Centrella, Jennifer DeLorey, Elisabeth G. Doyle, Ulrike Gradhand, Sarah T. Griffin, Susan Hill, Matthew T. Labenski, Barry A. Morgan, Gary O’Donovan, Kavirayani Prasad, Steven Skinner, Nazbeh Taghizadeh, Charles D. Thompson, James Wakefield, William Westlin and Kerry F. White
      Drug Metabolism and Disposition April 2013, 41 (4) 814-826; DOI: https://doi.org/10.1124/dmd.112.048355

  6. Tohyama, Kimio

    1. Pharmacokinetic and Pharmacodynamic Modeling of Hedgehog Inhibitor TAK-441 for the Inhibition of Gli1 messenger RNA Expression and Antitumor Efficacy in Xenografted Tumor Model Mice
      Akifumi Kogame, Yoshihiko Tagawa, Sachio Shibata, Hideaki Tojo, Maki Miyamoto, Kimio Tohyama, Takahiro Kondo, Shimoga Prakash, Wen Chyi Shyu and Satoru Asahi
      Drug Metabolism and Disposition April 2013, 41 (4) 727-734; DOI: https://doi.org/10.1124/dmd.112.049650

  7. Tojo, Hideaki

    1. Pharmacokinetic and Pharmacodynamic Modeling of Hedgehog Inhibitor TAK-441 for the Inhibition of Gli1 messenger RNA Expression and Antitumor Efficacy in Xenografted Tumor Model Mice
      Akifumi Kogame, Yoshihiko Tagawa, Sachio Shibata, Hideaki Tojo, Maki Miyamoto, Kimio Tohyama, Takahiro Kondo, Shimoga Prakash, Wen Chyi Shyu and Satoru Asahi
      Drug Metabolism and Disposition April 2013, 41 (4) 727-734; DOI: https://doi.org/10.1124/dmd.112.049650

  8. Tomer, Kenneth B.

    1. Characterization of Four New Mouse Cytochrome P450 Enzymes of the CYP2J Subfamily
      Joan P. Graves, Matthew L. Edin, J. Alyce Bradbury, Artiom Gruzdev, Jennifer Cheng, Fred B. Lih, Tiwanda A. Masinde, Wei Qu, Natasha P. Clayton, James P. Morrison, Kenneth B. Tomer and Darryl C. Zeldin
      Drug Metabolism and Disposition April 2013, 41 (4) 763-773; DOI: https://doi.org/10.1124/dmd.112.049429

U

  1. Unadkat, Jashvant D.

    1. A Physiologically Based Pharmacokinetic Model to Predict Disposition of CYP2D6 and CYP1A2 Metabolized Drugs in Pregnant Women
      Alice Ban Ke, Srikanth C. Nallani, Ping Zhao, Amin Rostami-Hodjegan, Nina Isoherranen and Jashvant D. Unadkat
      Drug Metabolism and Disposition April 2013, 41 (4) 801-813; DOI: https://doi.org/10.1124/dmd.112.050161

  2. Urade, Yoshihiro

    1. Drug Transporters on Arachnoid Barrier Cells Contribute to the Blood–Cerebrospinal Fluid Barrier
      Kazuto Yasuda, Cynthia Cline, Peter Vogel, Mihaela Onciu, Soghra Fatima, Brian P. Sorrentino, Ranjit K. Thirumaran, Sean Ekins, Yoshihiro Urade, Ko Fujimori and Erin G. Schuetz
      Drug Metabolism and Disposition April 2013, 41 (4) 923-931; DOI: https://doi.org/10.1124/dmd.112.050344

V

  1. VanWert, Adam L.

    1. Organic Anion Transporter 3 Interacts Selectively with Lipophilic β-Lactam Antibiotics
      Aaron T. Wolman, Michael R. Gionfriddo, Gregory A. Heindel, Paran Mukhija, Sarah Witkowski, Ajay Bommareddy and Adam L. VanWert
      Drug Metabolism and Disposition April 2013, 41 (4) 791-800; DOI: https://doi.org/10.1124/dmd.112.049569

  2. Villeneuve, Lyne

    1. The Relative Protein Abundance of UGT1A Alternative Splice Variants as a Key Determinant of Glucuronidation Activity In Vitro
      Mélanie Rouleau, Joannie Roberge, Sarah-Ann Falardeau, Lyne Villeneuve and Chantal Guillemette
      Drug Metabolism and Disposition April 2013, 41 (4) 694-697; DOI: https://doi.org/10.1124/dmd.112.050468

  3. Vogel, Peter

    1. Drug Transporters on Arachnoid Barrier Cells Contribute to the Blood–Cerebrospinal Fluid Barrier
      Kazuto Yasuda, Cynthia Cline, Peter Vogel, Mihaela Onciu, Soghra Fatima, Brian P. Sorrentino, Ranjit K. Thirumaran, Sean Ekins, Yoshihiro Urade, Ko Fujimori and Erin G. Schuetz
      Drug Metabolism and Disposition April 2013, 41 (4) 923-931; DOI: https://doi.org/10.1124/dmd.112.050344

W

  1. Wakefield, James

    1. Metabolites of PPI-2458, a Selective, Irreversible Inhibitor of Methionine Aminopeptidase-2: Structure Determination and In Vivo Activity
      Christopher C. Arico-Muendel, Bruce Belanger, Dennis Benjamin, Heather S. Blanchette, Teresa M. Caiazzo, Paolo A. Centrella, Jennifer DeLorey, Elisabeth G. Doyle, Ulrike Gradhand, Sarah T. Griffin, Susan Hill, Matthew T. Labenski, Barry A. Morgan, Gary O’Donovan, Kavirayani Prasad, Steven Skinner, Nazbeh Taghizadeh, Charles D. Thompson, James Wakefield, William Westlin and Kerry F. White
      Drug Metabolism and Disposition April 2013, 41 (4) 814-826; DOI: https://doi.org/10.1124/dmd.112.048355

  2. Wanek, Thomas

    1. Tariquidar and Elacridar Are Dose-Dependently Transported by P-Glycoprotein and Bcrp at the Blood-Brain Barrier: A Small-Animal Positron Emission Tomography and In Vitro Study
      Jens P. Bankstahl, Marion Bankstahl, Kerstin Römermann, Thomas Wanek, Johann Stanek, Albert D. Windhorst, Maren Fedrowitz, Thomas Erker, Markus Müller, Wolfgang Löscher, Oliver Langer and Claudia Kuntner
      Drug Metabolism and Disposition April 2013, 41 (4) 754-762; DOI: https://doi.org/10.1124/dmd.112.049148

  3. Wang, Lifei

    1. Characterization of Efflux Transporters Involved in Distribution and Disposition of Apixaban
      Donglu Zhang, Kan He, John J. Herbst, Janet Kolb, Wilson Shou, Lifei Wang, Praveen V. Balimane, Yong-Hae Han, Jinping Gan, Charles E. Frost and W. Griffith Humphreys
      Drug Metabolism and Disposition April 2013, 41 (4) 827-835; DOI: https://doi.org/10.1124/dmd.112.050260
    2. Investigating the Enteroenteric Recirculation of Apixaban, a Factor Xa Inhibitor: Administration of Activated Charcoal to Bile Duct-Cannulated Rats and Dogs Receiving an Intravenous Dose and Use of Drug Transporter Knockout Rats
      Donglu Zhang, Charles E. Frost, Kan He, A. David Rodrigues, Xiaoli Wang, Lifei Wang, Theunis C. Goosen and W. Griffith Humphreys
      Drug Metabolism and Disposition April 2013, 41 (4) 906-915; DOI: https://doi.org/10.1124/dmd.112.050575

  4. Wang, Xiaoli

    1. Investigating the Enteroenteric Recirculation of Apixaban, a Factor Xa Inhibitor: Administration of Activated Charcoal to Bile Duct-Cannulated Rats and Dogs Receiving an Intravenous Dose and Use of Drug Transporter Knockout Rats
      Donglu Zhang, Charles E. Frost, Kan He, A. David Rodrigues, Xiaoli Wang, Lifei Wang, Theunis C. Goosen and W. Griffith Humphreys
      Drug Metabolism and Disposition April 2013, 41 (4) 906-915; DOI: https://doi.org/10.1124/dmd.112.050575

  5. Westlin, William

    1. Metabolites of PPI-2458, a Selective, Irreversible Inhibitor of Methionine Aminopeptidase-2: Structure Determination and In Vivo Activity
      Christopher C. Arico-Muendel, Bruce Belanger, Dennis Benjamin, Heather S. Blanchette, Teresa M. Caiazzo, Paolo A. Centrella, Jennifer DeLorey, Elisabeth G. Doyle, Ulrike Gradhand, Sarah T. Griffin, Susan Hill, Matthew T. Labenski, Barry A. Morgan, Gary O’Donovan, Kavirayani Prasad, Steven Skinner, Nazbeh Taghizadeh, Charles D. Thompson, James Wakefield, William Westlin and Kerry F. White
      Drug Metabolism and Disposition April 2013, 41 (4) 814-826; DOI: https://doi.org/10.1124/dmd.112.048355

  6. White, Kerry F.

    1. Metabolites of PPI-2458, a Selective, Irreversible Inhibitor of Methionine Aminopeptidase-2: Structure Determination and In Vivo Activity
      Christopher C. Arico-Muendel, Bruce Belanger, Dennis Benjamin, Heather S. Blanchette, Teresa M. Caiazzo, Paolo A. Centrella, Jennifer DeLorey, Elisabeth G. Doyle, Ulrike Gradhand, Sarah T. Griffin, Susan Hill, Matthew T. Labenski, Barry A. Morgan, Gary O’Donovan, Kavirayani Prasad, Steven Skinner, Nazbeh Taghizadeh, Charles D. Thompson, James Wakefield, William Westlin and Kerry F. White
      Drug Metabolism and Disposition April 2013, 41 (4) 814-826; DOI: https://doi.org/10.1124/dmd.112.048355

  7. Williams, Eric T.

    1. Reversible Inhibition of Human Carboxylesterases by Acyl Glucuronides
      Natalie R. Inoue, Adrian Hall, W. George Lai and Eric T. Williams
      Drug Metabolism and Disposition April 2013, 41 (4) 698-703; DOI: https://doi.org/10.1124/dmd.112.050252

  8. Williams, Suzanne

    1. Potential Role of UGT1A4 Promoter SNPs in Anastrozole Pharmacogenomics
      Vineetha Koroth Edavana, Ishwori B. Dhakal, Suzanne Williams, Rosalind Penney, Gunnar Boysen, Aiwei Yao-Borengasser and Susan Kadlubar
      Drug Metabolism and Disposition April 2013, 41 (4) 870-877; DOI: https://doi.org/10.1124/dmd.112.048157

  9. Wilson, Susan D.

    1. Peginesatide Clearance, Distribution, Metabolism, and Excretion in Monkeys following Intravenous Administration
      Kathryn W. Woodburn, Kei-Lai Fong, Susan D. Wilson, Steven Sloneker, Paul Strzemienski, Eric Solon, Yuu Moriya and Yoshihiko Tagawa
      Drug Metabolism and Disposition April 2013, 41 (4) 774-784; DOI: https://doi.org/10.1124/dmd.112.048033

  10. Windhorst, Albert D.

    1. Tariquidar and Elacridar Are Dose-Dependently Transported by P-Glycoprotein and Bcrp at the Blood-Brain Barrier: A Small-Animal Positron Emission Tomography and In Vitro Study
      Jens P. Bankstahl, Marion Bankstahl, Kerstin Römermann, Thomas Wanek, Johann Stanek, Albert D. Windhorst, Maren Fedrowitz, Thomas Erker, Markus Müller, Wolfgang Löscher, Oliver Langer and Claudia Kuntner
      Drug Metabolism and Disposition April 2013, 41 (4) 754-762; DOI: https://doi.org/10.1124/dmd.112.049148

  11. Witkowski, Sarah

    1. Organic Anion Transporter 3 Interacts Selectively with Lipophilic β-Lactam Antibiotics
      Aaron T. Wolman, Michael R. Gionfriddo, Gregory A. Heindel, Paran Mukhija, Sarah Witkowski, Ajay Bommareddy and Adam L. VanWert
      Drug Metabolism and Disposition April 2013, 41 (4) 791-800; DOI: https://doi.org/10.1124/dmd.112.049569

  12. Wolman, Aaron T.

    1. Organic Anion Transporter 3 Interacts Selectively with Lipophilic β-Lactam Antibiotics
      Aaron T. Wolman, Michael R. Gionfriddo, Gregory A. Heindel, Paran Mukhija, Sarah Witkowski, Ajay Bommareddy and Adam L. VanWert
      Drug Metabolism and Disposition April 2013, 41 (4) 791-800; DOI: https://doi.org/10.1124/dmd.112.049569

  13. Woodburn, Kathryn W.

    1. Peginesatide Clearance, Distribution, Metabolism, and Excretion in Monkeys following Intravenous Administration
      Kathryn W. Woodburn, Kei-Lai Fong, Susan D. Wilson, Steven Sloneker, Paul Strzemienski, Eric Solon, Yuu Moriya and Yoshihiko Tagawa
      Drug Metabolism and Disposition April 2013, 41 (4) 774-784; DOI: https://doi.org/10.1124/dmd.112.048033

X

  1. Xia, Chunhua

    1. Identification of the Active Components in Shenmai Injection that Differentially Affect Cyp3a4-Mediated 1′-Hydroxylation and 4-Hydroxylation of Midazolam
      Caiwen Zeng, Fang He, Chunhua Xia, Hong Zhang and Yuqing Xiong
      Drug Metabolism and Disposition April 2013, 41 (4) 785-790; DOI: https://doi.org/10.1124/dmd.112.048025

  2. Xiong, Yuqing

    1. Identification of the Active Components in Shenmai Injection that Differentially Affect Cyp3a4-Mediated 1′-Hydroxylation and 4-Hydroxylation of Midazolam
      Caiwen Zeng, Fang He, Chunhua Xia, Hong Zhang and Yuqing Xiong
      Drug Metabolism and Disposition April 2013, 41 (4) 785-790; DOI: https://doi.org/10.1124/dmd.112.048025

Y

  1. Yao, Sylvia Y.M.

    1. Transport of A1 Adenosine Receptor Agonist Tecadenoson by Human and Mouse Nucleoside Transporters: Evidence for Blood-Brain Barrier Transport by Murine Equilibrative Nucleoside Transporter 1 mENT1
      Eve-Irene Lepist, Vijaya L. Damaraju, Jing Zhang, Wendy P. Gati, Sylvia Y.M. Yao, Kyla M. Smith, Edward Karpinski, James D. Young, Kwan H. Leung and Carol E. Cass
      Drug Metabolism and Disposition April 2013, 41 (4) 916-922; DOI: https://doi.org/10.1124/dmd.112.049858

  2. Yao-Borengasser, Aiwei

    1. Potential Role of UGT1A4 Promoter SNPs in Anastrozole Pharmacogenomics
      Vineetha Koroth Edavana, Ishwori B. Dhakal, Suzanne Williams, Rosalind Penney, Gunnar Boysen, Aiwei Yao-Borengasser and Susan Kadlubar
      Drug Metabolism and Disposition April 2013, 41 (4) 870-877; DOI: https://doi.org/10.1124/dmd.112.048157

  3. Yasuda, Kazuto

    1. Drug Transporters on Arachnoid Barrier Cells Contribute to the Blood–Cerebrospinal Fluid Barrier
      Kazuto Yasuda, Cynthia Cline, Peter Vogel, Mihaela Onciu, Soghra Fatima, Brian P. Sorrentino, Ranjit K. Thirumaran, Sean Ekins, Yoshihiro Urade, Ko Fujimori and Erin G. Schuetz
      Drug Metabolism and Disposition April 2013, 41 (4) 923-931; DOI: https://doi.org/10.1124/dmd.112.050344

  4. Yoo, Byunggil

    1. RNA-Sequencing Quantification of Hepatic Ontogeny and Tissue Distribution of mRNAs of Phase II Enzymes in Mice
      Hong Lu, Sumedha Gunewardena, Julia Y. Cui, Byunggil Yoo, Xiao-bo Zhong and Curtis D. Klaassen
      Drug Metabolism and Disposition April 2013, 41 (4) 844-857; DOI: https://doi.org/10.1124/dmd.112.050211

  5. Yoshigae, Yasushi

    1. The Inactivation of Human CYP2E1 by Phenethyl Isothiocyanate, a Naturally Occurring Chemopreventive Agent, and Its Oxidative Bioactivation
      Yasushi Yoshigae, Chitra Sridar, Ute M. Kent and Paul F. Hollenberg
      Drug Metabolism and Disposition April 2013, 41 (4) 858-869; DOI: https://doi.org/10.1124/dmd.112.050609

  6. Young, James D.

    1. Transport of A1 Adenosine Receptor Agonist Tecadenoson by Human and Mouse Nucleoside Transporters: Evidence for Blood-Brain Barrier Transport by Murine Equilibrative Nucleoside Transporter 1 mENT1
      Eve-Irene Lepist, Vijaya L. Damaraju, Jing Zhang, Wendy P. Gati, Sylvia Y.M. Yao, Kyla M. Smith, Edward Karpinski, James D. Young, Kwan H. Leung and Carol E. Cass
      Drug Metabolism and Disposition April 2013, 41 (4) 916-922; DOI: https://doi.org/10.1124/dmd.112.049858

Z

  1. Zamek-Gliszczynski, Maciej J.

    1. Pharmacokinetics, Metabolism, and Excretion of the Glycogen Synthase Kinase-3 Inhibitor LY2090314 in Rats, Dogs, and Humans: A Case Study in Rapid Clearance by Extensive Metabolism with Low Circulating Metabolite Exposure
      Maciej J. Zamek-Gliszczynski, Trent L. Abraham, Jeffrey J. Alberts, Palaniappan Kulanthaivel, Kimberley A. Jackson, Kay H. Chow, Denis J. McCann, Haitao Hu, Shelby Anderson, Nathan A. Furr, Robert J. Barbuch and Kenneth C. Cassidy
      Drug Metabolism and Disposition April 2013, 41 (4) 714-726; DOI: https://doi.org/10.1124/dmd.112.048488

  2. Zeldin, Darryl C.

    1. Characterization of Four New Mouse Cytochrome P450 Enzymes of the CYP2J Subfamily
      Joan P. Graves, Matthew L. Edin, J. Alyce Bradbury, Artiom Gruzdev, Jennifer Cheng, Fred B. Lih, Tiwanda A. Masinde, Wei Qu, Natasha P. Clayton, James P. Morrison, Kenneth B. Tomer and Darryl C. Zeldin
      Drug Metabolism and Disposition April 2013, 41 (4) 763-773; DOI: https://doi.org/10.1124/dmd.112.049429

  3. Zeng, Caiwen

    1. Identification of the Active Components in Shenmai Injection that Differentially Affect Cyp3a4-Mediated 1′-Hydroxylation and 4-Hydroxylation of Midazolam
      Caiwen Zeng, Fang He, Chunhua Xia, Hong Zhang and Yuqing Xiong
      Drug Metabolism and Disposition April 2013, 41 (4) 785-790; DOI: https://doi.org/10.1124/dmd.112.048025

  4. Zhang, Donglu

    1. Characterization of Efflux Transporters Involved in Distribution and Disposition of Apixaban
      Donglu Zhang, Kan He, John J. Herbst, Janet Kolb, Wilson Shou, Lifei Wang, Praveen V. Balimane, Yong-Hae Han, Jinping Gan, Charles E. Frost and W. Griffith Humphreys
      Drug Metabolism and Disposition April 2013, 41 (4) 827-835; DOI: https://doi.org/10.1124/dmd.112.050260
    2. Investigating the Enteroenteric Recirculation of Apixaban, a Factor Xa Inhibitor: Administration of Activated Charcoal to Bile Duct-Cannulated Rats and Dogs Receiving an Intravenous Dose and Use of Drug Transporter Knockout Rats
      Donglu Zhang, Charles E. Frost, Kan He, A. David Rodrigues, Xiaoli Wang, Lifei Wang, Theunis C. Goosen and W. Griffith Humphreys
      Drug Metabolism and Disposition April 2013, 41 (4) 906-915; DOI: https://doi.org/10.1124/dmd.112.050575

  5. Zhang, Hong

    1. Identification of the Active Components in Shenmai Injection that Differentially Affect Cyp3a4-Mediated 1′-Hydroxylation and 4-Hydroxylation of Midazolam
      Caiwen Zeng, Fang He, Chunhua Xia, Hong Zhang and Yuqing Xiong
      Drug Metabolism and Disposition April 2013, 41 (4) 785-790; DOI: https://doi.org/10.1124/dmd.112.048025

  6. Zhang, Jing

    1. Transport of A1 Adenosine Receptor Agonist Tecadenoson by Human and Mouse Nucleoside Transporters: Evidence for Blood-Brain Barrier Transport by Murine Equilibrative Nucleoside Transporter 1 mENT1
      Eve-Irene Lepist, Vijaya L. Damaraju, Jing Zhang, Wendy P. Gati, Sylvia Y.M. Yao, Kyla M. Smith, Edward Karpinski, James D. Young, Kwan H. Leung and Carol E. Cass
      Drug Metabolism and Disposition April 2013, 41 (4) 916-922; DOI: https://doi.org/10.1124/dmd.112.049858

  7. Zhao, Ping

    1. A Physiologically Based Pharmacokinetic Model to Predict Disposition of CYP2D6 and CYP1A2 Metabolized Drugs in Pregnant Women
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      Drug Metabolism and Disposition April 2013, 41 (4) 801-813; DOI: https://doi.org/10.1124/dmd.112.050161

  8. Zhong, Xiao-bo

    1. RNA-Sequencing Quantification of Hepatic Ontogeny and Tissue Distribution of mRNAs of Phase II Enzymes in Mice
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      Drug Metabolism and Disposition April 2013, 41 (4) 844-857; DOI: https://doi.org/10.1124/dmd.112.050211
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