Research ArticleArticle
A Physiologically Based Pharmacokinetic Model to Predict Disposition of CYP2D6 and CYP1A2 Metabolized Drugs in Pregnant Women
Alice Ban Ke, Srikanth C. Nallani, Ping Zhao, Amin Rostami-Hodjegan, Nina Isoherranen and Jashvant D. Unadkat
Drug Metabolism and Disposition April 2013, 41 (4) 801-813; DOI: https://doi.org/10.1124/dmd.112.050161
Alice Ban Ke
Department of Pharmaceutics, University of Washington, Seattle, Washington (A.B.K., N.I., J.D.U.); Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland (A.B.K., S.C.N., P.Z.); School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom(A.R.-H.); and Simcyp Limited, now part of Certara, Sheffield, United Kingdom (A.R-.H.)
Srikanth C. Nallani
Department of Pharmaceutics, University of Washington, Seattle, Washington (A.B.K., N.I., J.D.U.); Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland (A.B.K., S.C.N., P.Z.); School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom(A.R.-H.); and Simcyp Limited, now part of Certara, Sheffield, United Kingdom (A.R-.H.)
Ping Zhao
Department of Pharmaceutics, University of Washington, Seattle, Washington (A.B.K., N.I., J.D.U.); Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland (A.B.K., S.C.N., P.Z.); School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom(A.R.-H.); and Simcyp Limited, now part of Certara, Sheffield, United Kingdom (A.R-.H.)
Amin Rostami-Hodjegan
Department of Pharmaceutics, University of Washington, Seattle, Washington (A.B.K., N.I., J.D.U.); Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland (A.B.K., S.C.N., P.Z.); School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom(A.R.-H.); and Simcyp Limited, now part of Certara, Sheffield, United Kingdom (A.R-.H.)
Nina Isoherranen
Department of Pharmaceutics, University of Washington, Seattle, Washington (A.B.K., N.I., J.D.U.); Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland (A.B.K., S.C.N., P.Z.); School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom(A.R.-H.); and Simcyp Limited, now part of Certara, Sheffield, United Kingdom (A.R-.H.)
Jashvant D. Unadkat
Department of Pharmaceutics, University of Washington, Seattle, Washington (A.B.K., N.I., J.D.U.); Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland (A.B.K., S.C.N., P.Z.); School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom(A.R.-H.); and Simcyp Limited, now part of Certara, Sheffield, United Kingdom (A.R-.H.)
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Research ArticleArticle
PBPK Prediction of PK Changes During Pregnancy
Alice Ban Ke, Srikanth C. Nallani, Ping Zhao, Amin Rostami-Hodjegan, Nina Isoherranen and Jashvant D. Unadkat
Drug Metabolism and Disposition April 1, 2013, 41 (4) 801-813; DOI: https://doi.org/10.1124/dmd.112.050161
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