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Research ArticleArticle

Predicting Metabolic Clearance for Drugs That Are Actively Transported into Hepatocytes: Incubational Binding as a Consequence of in Vitro Hepatocyte Concentration Is a Key Factor

Pär Nordell, Petter Svanberg, James Bird and Ken Grime
Drug Metabolism and Disposition April 2013, 41 (4) 836-843; DOI: https://doi.org/10.1124/dmd.112.050377

Article Information

vol. 41 no. 4 836-843
DOI 
https://doi.org/10.1124/dmd.112.050377
PubMed 
23364509
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received November 28, 2012
  • Accepted January 30, 2013
  • Published online March 13, 2013.

Article Versions

Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Pär Nordell,
  2. Petter Svanberg,
  3. James Bird, and
  4. Ken Grime
  1. Respiratory and Inflammation DMPK, AstraZeneca R&D, Mölndal, Sweden
  1. Address correspondence to:
    Dr. Pär Nordell, AstraZeneca R&D Mölndal, Pepparedsleden, SE-431 83 Mölndal, Sweden. E-mail: par.nordell{at}astrazeneca.com
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A Method to Accurately Assay CLint of Actively Transported Drugs

Pär Nordell, Petter Svanberg, James Bird and Ken Grime
Drug Metabolism and Disposition April 1, 2013, 41 (4) 836-843; DOI: https://doi.org/10.1124/dmd.112.050377
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