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Rapid CommunicationAccelerated Communication

Drug Transporters on Arachnoid Barrier Cells Contribute to the Blood–Cerebrospinal Fluid Barrier

Kazuto Yasuda, Cynthia Cline, Peter Vogel, Mihaela Onciu, Soghra Fatima, Brian P. Sorrentino, Ranjit K. Thirumaran, Sean Ekins, Yoshihiro Urade, Ko Fujimori and Erin G. Schuetz
Drug Metabolism and Disposition April 2013, 41 (4) 923-931; DOI: https://doi.org/10.1124/dmd.112.050344
Kazuto Yasuda
Department of Pharmaceutical Sciences (K.Y., C.C., R.K.T., E.G.S.), Department of Pathology (P.V., M.O.), and Department of Hematology (S.F., B.P.S.), St. Jude Children’s Research Hospital, Memphis, Tennessee; Collaborations in Chemistry, Fuquay-Varina, North Carolina (S.E.); Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka, Japan (Y.U.); and Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, Osaka, Japan (K.F.)
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Cynthia Cline
Department of Pharmaceutical Sciences (K.Y., C.C., R.K.T., E.G.S.), Department of Pathology (P.V., M.O.), and Department of Hematology (S.F., B.P.S.), St. Jude Children’s Research Hospital, Memphis, Tennessee; Collaborations in Chemistry, Fuquay-Varina, North Carolina (S.E.); Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka, Japan (Y.U.); and Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, Osaka, Japan (K.F.)
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Peter Vogel
Department of Pharmaceutical Sciences (K.Y., C.C., R.K.T., E.G.S.), Department of Pathology (P.V., M.O.), and Department of Hematology (S.F., B.P.S.), St. Jude Children’s Research Hospital, Memphis, Tennessee; Collaborations in Chemistry, Fuquay-Varina, North Carolina (S.E.); Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka, Japan (Y.U.); and Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, Osaka, Japan (K.F.)
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Mihaela Onciu
Department of Pharmaceutical Sciences (K.Y., C.C., R.K.T., E.G.S.), Department of Pathology (P.V., M.O.), and Department of Hematology (S.F., B.P.S.), St. Jude Children’s Research Hospital, Memphis, Tennessee; Collaborations in Chemistry, Fuquay-Varina, North Carolina (S.E.); Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka, Japan (Y.U.); and Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, Osaka, Japan (K.F.)
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Soghra Fatima
Department of Pharmaceutical Sciences (K.Y., C.C., R.K.T., E.G.S.), Department of Pathology (P.V., M.O.), and Department of Hematology (S.F., B.P.S.), St. Jude Children’s Research Hospital, Memphis, Tennessee; Collaborations in Chemistry, Fuquay-Varina, North Carolina (S.E.); Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka, Japan (Y.U.); and Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, Osaka, Japan (K.F.)
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Brian P. Sorrentino
Department of Pharmaceutical Sciences (K.Y., C.C., R.K.T., E.G.S.), Department of Pathology (P.V., M.O.), and Department of Hematology (S.F., B.P.S.), St. Jude Children’s Research Hospital, Memphis, Tennessee; Collaborations in Chemistry, Fuquay-Varina, North Carolina (S.E.); Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka, Japan (Y.U.); and Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, Osaka, Japan (K.F.)
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Ranjit K. Thirumaran
Department of Pharmaceutical Sciences (K.Y., C.C., R.K.T., E.G.S.), Department of Pathology (P.V., M.O.), and Department of Hematology (S.F., B.P.S.), St. Jude Children’s Research Hospital, Memphis, Tennessee; Collaborations in Chemistry, Fuquay-Varina, North Carolina (S.E.); Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka, Japan (Y.U.); and Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, Osaka, Japan (K.F.)
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Sean Ekins
Department of Pharmaceutical Sciences (K.Y., C.C., R.K.T., E.G.S.), Department of Pathology (P.V., M.O.), and Department of Hematology (S.F., B.P.S.), St. Jude Children’s Research Hospital, Memphis, Tennessee; Collaborations in Chemistry, Fuquay-Varina, North Carolina (S.E.); Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka, Japan (Y.U.); and Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, Osaka, Japan (K.F.)
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Yoshihiro Urade
Department of Pharmaceutical Sciences (K.Y., C.C., R.K.T., E.G.S.), Department of Pathology (P.V., M.O.), and Department of Hematology (S.F., B.P.S.), St. Jude Children’s Research Hospital, Memphis, Tennessee; Collaborations in Chemistry, Fuquay-Varina, North Carolina (S.E.); Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka, Japan (Y.U.); and Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, Osaka, Japan (K.F.)
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Ko Fujimori
Department of Pharmaceutical Sciences (K.Y., C.C., R.K.T., E.G.S.), Department of Pathology (P.V., M.O.), and Department of Hematology (S.F., B.P.S.), St. Jude Children’s Research Hospital, Memphis, Tennessee; Collaborations in Chemistry, Fuquay-Varina, North Carolina (S.E.); Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka, Japan (Y.U.); and Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, Osaka, Japan (K.F.)
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Erin G. Schuetz
Department of Pharmaceutical Sciences (K.Y., C.C., R.K.T., E.G.S.), Department of Pathology (P.V., M.O.), and Department of Hematology (S.F., B.P.S.), St. Jude Children’s Research Hospital, Memphis, Tennessee; Collaborations in Chemistry, Fuquay-Varina, North Carolina (S.E.); Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka, Japan (Y.U.); and Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, Osaka, Japan (K.F.)
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Article Information

vol. 41 no. 4 923-931
DOI 
https://doi.org/10.1124/dmd.112.050344
PubMed 
23298861

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received November 26, 2012
  • Accepted January 8, 2013
  • Published online March 13, 2013.

Article Versions

  • Earlier version (January 8, 2013 - 08:31).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Kazuto Yasuda,
  2. Cynthia Cline,
  3. Peter Vogel,
  4. Mihaela Onciu1,
  5. Soghra Fatima,
  6. Brian P. Sorrentino,
  7. Ranjit K. Thirumaran,
  8. Sean Ekins,
  9. Yoshihiro Urade,
  10. Ko Fujimori, and
  11. Erin G. Schuetz
  1. Department of Pharmaceutical Sciences (K.Y., C.C., R.K.T., E.G.S.), Department of Pathology (P.V., M.O.), and Department of Hematology (S.F., B.P.S.), St. Jude Children’s Research Hospital, Memphis, Tennessee; Collaborations in Chemistry, Fuquay-Varina, North Carolina (S.E.); Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka, Japan (Y.U.); and Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, Osaka, Japan (K.F.)
  1. Address correspondence to:
    Erin G. Schuetz, Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105. E-mail: erin.schuetz{at}stjude.org
  1. K.Y. and C.C. contributed equally to this work.

  • ↵1 Current affiliation: OncoMetrix, Memphis, Tennessee.

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Drug Metabolism and Disposition: 41 (4)
Drug Metabolism and Disposition
Vol. 41, Issue 4
1 Apr 2013
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Rapid CommunicationAccelerated Communication

Drug Transporters on Arachnoid Barrier Cells

Kazuto Yasuda, Cynthia Cline, Peter Vogel, Mihaela Onciu, Soghra Fatima, Brian P. Sorrentino, Ranjit K. Thirumaran, Sean Ekins, Yoshihiro Urade, Ko Fujimori and Erin G. Schuetz
Drug Metabolism and Disposition April 1, 2013, 41 (4) 923-931; DOI: https://doi.org/10.1124/dmd.112.050344

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Rapid CommunicationAccelerated Communication

Drug Transporters on Arachnoid Barrier Cells

Kazuto Yasuda, Cynthia Cline, Peter Vogel, Mihaela Onciu, Soghra Fatima, Brian P. Sorrentino, Ranjit K. Thirumaran, Sean Ekins, Yoshihiro Urade, Ko Fujimori and Erin G. Schuetz
Drug Metabolism and Disposition April 1, 2013, 41 (4) 923-931; DOI: https://doi.org/10.1124/dmd.112.050344
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