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Drug Metabolism & Disposition

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Table of Contents

May 01, 2013; Volume 41,Issue 5

Minireview

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    Which Metabolites Circulate?
    Cho-Ming Loi, Dennis A. Smith and Deepak Dalvie
    Drug Metabolism and Disposition May 2013, 41 (5) 933-951; DOI: https://doi.org/10.1124/dmd.112.050278

Short Communication

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    Decreased CYP3A Expression and Activity in Guinea Pig Models of Diet-Induced Metabolic Syndrome: Is Fatty Liver Infiltration Involved?
    Dany Patoine, Xavier Levac, Sylvie Pilote, Benoit Drolet and Chantale Simard
    Drug Metabolism and Disposition May 2013, 41 (5) 952-957; DOI: https://doi.org/10.1124/dmd.112.050641

Articles

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    Interaction of Silymarin Flavonolignans with Organic Anion-Transporting Polypeptides
    Kathleen Köck, Ying Xie, Roy L. Hawke, Nicholas H. Oberlies and Kim L. R. Brouwer
    Drug Metabolism and Disposition May 2013, 41 (5) 958-965; DOI: https://doi.org/10.1124/dmd.112.048272
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    Quantitative Prediction of Repaglinide-Rifampicin Complex Drug Interactions Using Dynamic and Static Mechanistic Models: Delineating Differential CYP3A4 Induction and OATP1B1 Inhibition Potential of Rifampicin
    Manthena V. S. Varma, Jian Lin, Yi-An Bi, Charles J. Rotter, Odette A. Fahmi, Justine L. Lam, Ayman F. El-Kattan, Theunis C. Goosen and Yurong Lai
    Drug Metabolism and Disposition May 2013, 41 (5) 966-974; DOI: https://doi.org/10.1124/dmd.112.050583
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    Pharmacokinetic Interactions between Monoamine Oxidase A Inhibitor Harmaline and 5-Methoxy-N,N-Dimethyltryptamine, and the Impact of CYP2D6 Status
    Xi-Ling Jiang, Hong-Wu Shen, Donald E. Mager and Ai-Ming Yu
    Drug Metabolism and Disposition May 2013, 41 (5) 975-986; DOI: https://doi.org/10.1124/dmd.112.050724
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    Drug Cocktail Interaction Study on the Effect of the Orally Administered Lavender Oil Preparation Silexan on Cytochrome P450 Enzymes in Healthy Volunteers
    Oxana Doroshyenko, Dennis Rokitta, Gregor Zadoyan, Stephan Klement, Sandra Schläfke, Angelika Dienel, Thomas Gramatté, Hendrik Lück and Uwe Fuhr
    Drug Metabolism and Disposition May 2013, 41 (5) 987-993; DOI: https://doi.org/10.1124/dmd.112.050203
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    Involvement of Organic Anion-Transporting Polypeptides in the Hepatic Uptake of Dioscin in Rats and Humans
    Aijie Zhang, Changyuan Wang, Qi Liu, Qiang Meng, Jinyong Peng, Huijun Sun, Xiaochi Ma, Xiaokui Huo and Kexin Liu
    Drug Metabolism and Disposition May 2013, 41 (5) 994-1003; DOI: https://doi.org/10.1124/dmd.112.049452
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    Species Difference in the Mechanism of Nonlinear Pharmacokinetics of E2074, a Novel Sodium Channel Inhibitor, in Rats, Dogs, and Monkeys
    Yoko Nagaya, Osamu Takenaka, Kazutomi Kusano and Tsutomu Yoshimura
    Drug Metabolism and Disposition May 2013, 41 (5) 1004-1011; DOI: https://doi.org/10.1124/dmd.112.050062
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    Metabolism-Dependent Inhibition of CYP3A4 by Lapatinib: Evidence for Formation of a Metabolic Intermediate Complex with a Nitroso/Oxime Metabolite Formed via a Nitrone Intermediate
    Joanna E. Barbara, Faraz Kazmi, Andrew Parkinson and David B. Buckley
    Drug Metabolism and Disposition May 2013, 41 (5) 1012-1022; DOI: https://doi.org/10.1124/dmd.113.051151
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    Contribution of Artifacts to N-Methylated Piperazine Cyanide Adduct Formation In Vitro from N-Alkyl Piperazine Analogs
    Minli Zhang, Christina M. Resuello, Jian Guo, Mark E. Powell, Charles S. Elmore, Jun Hu and Karthick Vishwanathan
    Drug Metabolism and Disposition May 2013, 41 (5) 1023-1034; DOI: https://doi.org/10.1124/dmd.112.050450
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    Effect of Ketoconazole on the Pharmacokinetics of the 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor ABT-384 and Its Two Active Metabolites in Healthy Volunteers: Population Analysis of Data from a Drug-Drug Interaction Study
    Guohua An, Wei Liu, David A. Katz, Gerard Marek, Walid Awni and Sandeep Dutta
    Drug Metabolism and Disposition May 2013, 41 (5) 1035-1045; DOI: https://doi.org/10.1124/dmd.112.049742
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    Elucidation of the Metabolic Pathways and the Resulting Multiple Metabolites of Almorexant, a Dual Orexin Receptor Antagonist, in Humans
    Jasper Dingemanse, Petra Hoever, Matthias Hoch, Alexander Treiber, Winfried Wagner-Redeker, Tommaso Miraval, Gérard Hopfgartner and Kasra Shakeri-Nejad
    Drug Metabolism and Disposition May 2013, 41 (5) 1046-1059; DOI: https://doi.org/10.1124/dmd.112.050120
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    Induction of Xenobiotic Receptors, Transporters, and Drug Metabolizing Enzymes by Oxycodone
    Hazem E. Hassan, Alan L. Myers, Insong J. Lee, Clifford W. Mason, Duan Wang, Michael W. Sinz, Hongbing Wang and Natalie D. Eddington
    Drug Metabolism and Disposition May 2013, 41 (5) 1060-1069; DOI: https://doi.org/10.1124/dmd.112.050401
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    Disposition and Metabolism of GSK2251052 in Humans: A Novel Boron-Containing Antibiotic
    Gary D. Bowers, David Tenero, Parul Patel, Phuong Huynh, James Sigafoos, Kathryn O’Mara, Graeme C. Young, Etienne Dumont, Elizabeth Cunningham, Milena Kurtinecz, Patrick Stump, J. J. Conde, John P. Chism, Melinda J. Reese, Yun Lan Yueh and John F. Tomayko
    Drug Metabolism and Disposition May 2013, 41 (5) 1070-1081; DOI: https://doi.org/10.1124/dmd.112.050153
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    Metabolism of Bis(4-fluorobenzyl)trisulfide and Its Formation of Hemoglobin Adduct in Rat Erythrocytes
    Hao Pan, Liqiang Gu, Siyuan Sun, Zhongjian Chen, Hui Zhou, Su Zeng and Huidi Jiang
    Drug Metabolism and Disposition May 2013, 41 (5) 1082-1093; DOI: https://doi.org/10.1124/dmd.112.048801
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    Modification of the Catalytic Function of Human Hydroxysteroid Sulfotransferase hSULT2A1 by Formation of Disulfide Bonds
    Xiaoyan Qin, Lynn M. Teesch and Michael W. Duffel
    Drug Metabolism and Disposition May 2013, 41 (5) 1094-1103; DOI: https://doi.org/10.1124/dmd.112.050534
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    Significance of Reductive Metabolism in Human Intestine and Quantitative Prediction of Intestinal First-Pass Metabolism by Cytosolic Reductive Enzymes
    Haruka Nishimuta, Tetsuya Nakagawa, Naruaki Nomura and Masashi Yabuki
    Drug Metabolism and Disposition May 2013, 41 (5) 1104-1111; DOI: https://doi.org/10.1124/dmd.113.051177
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    Hydroxylation of CYP11A1-Derived Products of Vitamin D3 Metabolism by Human and Mouse CYP27B1
    Edith K. Y. Tang, Jianjun Chen, Zorica Janjetovic, Elaine W. Tieu, Andrzej T. Slominski, Wei Li and Robert C. Tuckey
    Drug Metabolism and Disposition May 2013, 41 (5) 1112-1124; DOI: https://doi.org/10.1124/dmd.113.050955
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    Tissue Distribution and Identification of Radioactivity Components at Elimination Phase after Oral Administration of [14C]CS-1036, an α-Amylase Inhibitor, to Rats
    Tomohiro Honda, Hideo Takakusa, Takahiro Murai and Takashi Izumi
    Drug Metabolism and Disposition May 2013, 41 (5) 1125-1133; DOI: https://doi.org/10.1124/dmd.112.050617
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    Biotransformation of Two β-Secretase Inhibitors Including Ring Opening and Contraction of a Pyrimidine Ring
    Anders Lindgren, Göran Eklund, Dominika Turek, Jonas Malmquist, Britt-Marie Swahn, Jörg Holenz, Stefan von Berg, Sofia Karlström and Tjerk Bueters
    Drug Metabolism and Disposition May 2013, 41 (5) 1134-1147; DOI: https://doi.org/10.1124/dmd.112.050351
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    Alcohol Cirrhosis Alters Nuclear Receptor and Drug Transporter Expression in Human Liver
    Vijay R. More, Qiuqiong Cheng, Ajay C. Donepudi, David B. Buckley, Zhenqiang James Lu, Nathan J. Cherrington and Angela L. Slitt
    Drug Metabolism and Disposition May 2013, 41 (5) 1148-1155; DOI: https://doi.org/10.1124/dmd.112.049676
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    Interindividual Variability of Carboxymethylenebutenolidase Homolog, a Novel Olmesartan Medoxomil Hydrolase, in the Human Liver and Intestine
    Tomoko Ishizuka, Veronika Rozehnal, Thomas Fischer, Ayako Kato, Seiko Endo, Yasushi Yoshigae, Atsushi Kurihara and Takashi Izumi
    Drug Metabolism and Disposition May 2013, 41 (5) 1156-1162; DOI: https://doi.org/10.1124/dmd.113.051482
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    Pulmonary Metabolism of Resveratrol: In Vitro and In Vivo Evidence
    Satish Sharan and Swati Nagar
    Drug Metabolism and Disposition May 2013, 41 (5) 1163-1169; DOI: https://doi.org/10.1124/dmd.113.051326
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Drug Metabolism and Disposition: 41 (5)
Drug Metabolism and Disposition
Vol. 41, Issue 5
1 May 2013
  • Table of Contents
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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