Table of Contents

Articles

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  Interaction of Silymarin Flavonolignans with Organic Anion-Transporting Polypeptides

  Kathleen Köck, Ying Xie, Roy L. Hawke, Nicholas H. Oberlies and Kim L. R. Brouwer

  Drug Metabolism and Disposition May 2013, 41 (5) 958-965; DOI: https://doi.org/10.1124/dmd.112.048272
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  Quantitative Prediction of Repaglinide-Rifampicin Complex Drug Interactions Using Dynamic and Static Mechanistic Models: Delineating Differential CYP3A4 Induction and OATP1B1 Inhibition Potential of Rifampicin

  Manthena V. S. Varma, Jian Lin, Yi-An Bi, Charles J. Rotter, Odette A. Fahmi, Justine L. Lam, Ayman F. El-Kattan, Theunis C. Goosen and Yurong Lai

  Drug Metabolism and Disposition May 2013, 41 (5) 966-974; DOI: https://doi.org/10.1124/dmd.112.050583
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  Pharmacokinetic Interactions between Monoamine Oxidase A Inhibitor Harmaline and 5-Methoxy-N,N-Dimethyltryptamine, and the Impact of CYP2D6 Status

  Xi-Ling Jiang, Hong-Wu Shen, Donald E. Mager and Ai-Ming Yu

  Drug Metabolism and Disposition May 2013, 41 (5) 975-986; DOI: https://doi.org/10.1124/dmd.112.050724
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  Drug Cocktail Interaction Study on the Effect of the Orally Administered Lavender Oil Preparation Silexan on Cytochrome P450 Enzymes in Healthy Volunteers

  Oxana Doroshyenko, Dennis Rokitta, Gregor Zadoyan, Stephan Klement, Sandra Schläfke, Angelika Dienel, Thomas Gramatté, Hendrik Lück and Uwe Fuhr

  Drug Metabolism and Disposition May 2013, 41 (5) 987-993; DOI: https://doi.org/10.1124/dmd.112.050203
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  Involvement of Organic Anion-Transporting Polypeptides in the Hepatic Uptake of Dioscin in Rats and Humans

  Aijie Zhang, Changyuan Wang, Qi Liu, Qiang Meng, Jinyong Peng, Huijun Sun, Xiaochi Ma, Xiaokui Huo and Kexin Liu

  Drug Metabolism and Disposition May 2013, 41 (5) 994-1003; DOI: https://doi.org/10.1124/dmd.112.049452
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  Species Difference in the Mechanism of Nonlinear Pharmacokinetics of E2074, a Novel Sodium Channel Inhibitor, in Rats, Dogs, and Monkeys

  Yoko Nagaya, Osamu Takenaka, Kazutomi Kusano and Tsutomu Yoshimura

  Drug Metabolism and Disposition May 2013, 41 (5) 1004-1011; DOI: https://doi.org/10.1124/dmd.112.050062
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  Metabolism-Dependent Inhibition of CYP3A4 by Lapatinib: Evidence for Formation of a Metabolic Intermediate Complex with a Nitroso/Oxime Metabolite Formed via a Nitrone Intermediate

  Joanna E. Barbara, Faraz Kazmi, Andrew Parkinson and David B. Buckley

  Drug Metabolism and Disposition May 2013, 41 (5) 1012-1022; DOI: https://doi.org/10.1124/dmd.113.051151
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  Contribution of Artifacts to N-Methylated Piperazine Cyanide Adduct Formation In Vitro from N-Alkyl Piperazine Analogs

  Minli Zhang, Christina M. Resuello, Jian Guo, Mark E. Powell, Charles S. Elmore, Jun Hu and Karthick Vishwanathan

  Drug Metabolism and Disposition May 2013, 41 (5) 1023-1034; DOI: https://doi.org/10.1124/dmd.112.050450
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  Effect of Ketoconazole on the Pharmacokinetics of the 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor ABT-384 and Its Two Active Metabolites in Healthy Volunteers: Population Analysis of Data from a Drug-Drug Interaction Study

  Guohua An, Wei Liu, David A. Katz, Gerard Marek, Walid Awni and Sandeep Dutta

  Drug Metabolism and Disposition May 2013, 41 (5) 1035-1045; DOI: https://doi.org/10.1124/dmd.112.049742
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  Elucidation of the Metabolic Pathways and the Resulting Multiple Metabolites of Almorexant, a Dual Orexin Receptor Antagonist, in Humans

  Jasper Dingemanse, Petra Hoever, Matthias Hoch, Alexander Treiber, Winfried Wagner-Redeker, Tommaso Miraval, Gérard Hopfgartner and Kasra Shakeri-Nejad

  Drug Metabolism and Disposition May 2013, 41 (5) 1046-1059; DOI: https://doi.org/10.1124/dmd.112.050120
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  Induction of Xenobiotic Receptors, Transporters, and Drug Metabolizing Enzymes by Oxycodone

  Hazem E. Hassan, Alan L. Myers, Insong J. Lee, Clifford W. Mason, Duan Wang, Michael W. Sinz, Hongbing Wang and Natalie D. Eddington

  Drug Metabolism and Disposition May 2013, 41 (5) 1060-1069; DOI: https://doi.org/10.1124/dmd.112.050401
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  Disposition and Metabolism of GSK2251052 in Humans: A Novel Boron-Containing Antibiotic

  Gary D. Bowers, David Tenero, Parul Patel, Phuong Huynh, James Sigafoos, Kathryn O’Mara, Graeme C. Young, Etienne Dumont, Elizabeth Cunningham, Milena Kurtinecz, Patrick Stump, J. J. Conde, John P. Chism, Melinda J. Reese, Yun Lan Yueh and John F. Tomayko

  Drug Metabolism and Disposition May 2013, 41 (5) 1070-1081; DOI: https://doi.org/10.1124/dmd.112.050153
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  Metabolism of Bis(4-fluorobenzyl)trisulfide and Its Formation of Hemoglobin Adduct in Rat Erythrocytes

  Hao Pan, Liqiang Gu, Siyuan Sun, Zhongjian Chen, Hui Zhou, Su Zeng and Huidi Jiang

  Drug Metabolism and Disposition May 2013, 41 (5) 1082-1093; DOI: https://doi.org/10.1124/dmd.112.048801
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  Modification of the Catalytic Function of Human Hydroxysteroid Sulfotransferase hSULT2A1 by Formation of Disulfide Bonds

  Xiaoyan Qin, Lynn M. Teesch and Michael W. Duffel

  Drug Metabolism and Disposition May 2013, 41 (5) 1094-1103; DOI: https://doi.org/10.1124/dmd.112.050534
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  Significance of Reductive Metabolism in Human Intestine and Quantitative Prediction of Intestinal First-Pass Metabolism by Cytosolic Reductive Enzymes

  Haruka Nishimuta, Tetsuya Nakagawa, Naruaki Nomura and Masashi Yabuki

  Drug Metabolism and Disposition May 2013, 41 (5) 1104-1111; DOI: https://doi.org/10.1124/dmd.113.051177
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  Hydroxylation of CYP11A1-Derived Products of Vitamin D3 Metabolism by Human and Mouse CYP27B1

  Edith K. Y. Tang, Jianjun Chen, Zorica Janjetovic, Elaine W. Tieu, Andrzej T. Slominski, Wei Li and Robert C. Tuckey

  Drug Metabolism and Disposition May 2013, 41 (5) 1112-1124; DOI: https://doi.org/10.1124/dmd.113.050955
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  Tissue Distribution and Identification of Radioactivity Components at Elimination Phase after Oral Administration of [¹⁴C]CS-1036, an α-Amylase Inhibitor, to Rats

  Tomohiro Honda, Hideo Takakusa, Takahiro Murai and Takashi Izumi

  Drug Metabolism and Disposition May 2013, 41 (5) 1125-1133; DOI: https://doi.org/10.1124/dmd.112.050617
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  Biotransformation of Two β-Secretase Inhibitors Including Ring Opening and Contraction of a Pyrimidine Ring

  Anders Lindgren, Göran Eklund, Dominika Turek, Jonas Malmquist, Britt-Marie Swahn, Jörg Holenz, Stefan von Berg, Sofia Karlström and Tjerk Bueters

  Drug Metabolism and Disposition May 2013, 41 (5) 1134-1147; DOI: https://doi.org/10.1124/dmd.112.050351
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  Alcohol Cirrhosis Alters Nuclear Receptor and Drug Transporter Expression in Human Liver

  Vijay R. More, Qiuqiong Cheng, Ajay C. Donepudi, David B. Buckley, Zhenqiang James Lu, Nathan J. Cherrington and Angela L. Slitt

  Drug Metabolism and Disposition May 2013, 41 (5) 1148-1155; DOI: https://doi.org/10.1124/dmd.112.049676
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  Interindividual Variability of Carboxymethylenebutenolidase Homolog, a Novel Olmesartan Medoxomil Hydrolase, in the Human Liver and Intestine

  Tomoko Ishizuka, Veronika Rozehnal, Thomas Fischer, Ayako Kato, Seiko Endo, Yasushi Yoshigae, Atsushi Kurihara and Takashi Izumi

  Drug Metabolism and Disposition May 2013, 41 (5) 1156-1162; DOI: https://doi.org/10.1124/dmd.113.051482
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  Pulmonary Metabolism of Resveratrol: In Vitro and In Vivo Evidence

  Satish Sharan and Swati Nagar

  Drug Metabolism and Disposition May 2013, 41 (5) 1163-1169; DOI: https://doi.org/10.1124/dmd.113.051326