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Research ArticleArticle

Interindividual Variability of Carboxymethylenebutenolidase Homolog, a Novel Olmesartan Medoxomil Hydrolase, in the Human Liver and Intestine

Tomoko Ishizuka, Veronika Rozehnal, Thomas Fischer, Ayako Kato, Seiko Endo, Yasushi Yoshigae, Atsushi Kurihara and Takashi Izumi
Drug Metabolism and Disposition May 2013, 41 (5) 1156-1162; DOI: https://doi.org/10.1124/dmd.113.051482
Tomoko Ishizuka
Drug Metabolism and Pharmacokinetics Research Laboratories (T.Is., Y.Y., A.Ku., T.Iz.), and Translational Medicine and Clinical Pharmacology Department (S.E.); Daiichi Sankyo Co., Ltd., Tokyo, Japan; Tissue and Cell Research Center Munich, Daiichi Sankyo Europe GmbH, Munich, Germany (V.R., T.F.); and Discovery Science and Technology Department, Daiichi Sankyo RD Novare Co., Ltd. Tokyo, Japan (A.Ka.)
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Veronika Rozehnal
Drug Metabolism and Pharmacokinetics Research Laboratories (T.Is., Y.Y., A.Ku., T.Iz.), and Translational Medicine and Clinical Pharmacology Department (S.E.); Daiichi Sankyo Co., Ltd., Tokyo, Japan; Tissue and Cell Research Center Munich, Daiichi Sankyo Europe GmbH, Munich, Germany (V.R., T.F.); and Discovery Science and Technology Department, Daiichi Sankyo RD Novare Co., Ltd. Tokyo, Japan (A.Ka.)
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Thomas Fischer
Drug Metabolism and Pharmacokinetics Research Laboratories (T.Is., Y.Y., A.Ku., T.Iz.), and Translational Medicine and Clinical Pharmacology Department (S.E.); Daiichi Sankyo Co., Ltd., Tokyo, Japan; Tissue and Cell Research Center Munich, Daiichi Sankyo Europe GmbH, Munich, Germany (V.R., T.F.); and Discovery Science and Technology Department, Daiichi Sankyo RD Novare Co., Ltd. Tokyo, Japan (A.Ka.)
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Ayako Kato
Drug Metabolism and Pharmacokinetics Research Laboratories (T.Is., Y.Y., A.Ku., T.Iz.), and Translational Medicine and Clinical Pharmacology Department (S.E.); Daiichi Sankyo Co., Ltd., Tokyo, Japan; Tissue and Cell Research Center Munich, Daiichi Sankyo Europe GmbH, Munich, Germany (V.R., T.F.); and Discovery Science and Technology Department, Daiichi Sankyo RD Novare Co., Ltd. Tokyo, Japan (A.Ka.)
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Seiko Endo
Drug Metabolism and Pharmacokinetics Research Laboratories (T.Is., Y.Y., A.Ku., T.Iz.), and Translational Medicine and Clinical Pharmacology Department (S.E.); Daiichi Sankyo Co., Ltd., Tokyo, Japan; Tissue and Cell Research Center Munich, Daiichi Sankyo Europe GmbH, Munich, Germany (V.R., T.F.); and Discovery Science and Technology Department, Daiichi Sankyo RD Novare Co., Ltd. Tokyo, Japan (A.Ka.)
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Yasushi Yoshigae
Drug Metabolism and Pharmacokinetics Research Laboratories (T.Is., Y.Y., A.Ku., T.Iz.), and Translational Medicine and Clinical Pharmacology Department (S.E.); Daiichi Sankyo Co., Ltd., Tokyo, Japan; Tissue and Cell Research Center Munich, Daiichi Sankyo Europe GmbH, Munich, Germany (V.R., T.F.); and Discovery Science and Technology Department, Daiichi Sankyo RD Novare Co., Ltd. Tokyo, Japan (A.Ka.)
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Atsushi Kurihara
Drug Metabolism and Pharmacokinetics Research Laboratories (T.Is., Y.Y., A.Ku., T.Iz.), and Translational Medicine and Clinical Pharmacology Department (S.E.); Daiichi Sankyo Co., Ltd., Tokyo, Japan; Tissue and Cell Research Center Munich, Daiichi Sankyo Europe GmbH, Munich, Germany (V.R., T.F.); and Discovery Science and Technology Department, Daiichi Sankyo RD Novare Co., Ltd. Tokyo, Japan (A.Ka.)
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Takashi Izumi
Drug Metabolism and Pharmacokinetics Research Laboratories (T.Is., Y.Y., A.Ku., T.Iz.), and Translational Medicine and Clinical Pharmacology Department (S.E.); Daiichi Sankyo Co., Ltd., Tokyo, Japan; Tissue and Cell Research Center Munich, Daiichi Sankyo Europe GmbH, Munich, Germany (V.R., T.F.); and Discovery Science and Technology Department, Daiichi Sankyo RD Novare Co., Ltd. Tokyo, Japan (A.Ka.)
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Article Information

vol. 41 no. 5 1156-1162
DOI 
https://doi.org/10.1124/dmd.113.051482
PubMed 
23471504

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received February 6, 2013
  • Accepted March 7, 2013
  • Published online April 15, 2013.

Article Versions

  • Earlier version (March 7, 2013 - 07:47).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Tomoko Ishizuka,
  2. Veronika Rozehnal,
  3. Thomas Fischer,
  4. Ayako Kato,
  5. Seiko Endo,
  6. Yasushi Yoshigae,
  7. Atsushi Kurihara, and
  8. Takashi Izumi
  1. Drug Metabolism and Pharmacokinetics Research Laboratories (T.Is., Y.Y., A.Ku., T.Iz.), and Translational Medicine and Clinical Pharmacology Department (S.E.); Daiichi Sankyo Co., Ltd., Tokyo, Japan; Tissue and Cell Research Center Munich, Daiichi Sankyo Europe GmbH, Munich, Germany (V.R., T.F.); and Discovery Science and Technology Department, Daiichi Sankyo RD Novare Co., Ltd. Tokyo, Japan (A.Ka.)
  1. Address correspondence to:
    Tomoko Ishizuka, Drug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan. E-mail: ishizuka.tomoko.xx{at}daiichisankyo.co.jp
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Drug Metabolism and Disposition: 41 (5)
Drug Metabolism and Disposition
Vol. 41, Issue 5
1 May 2013
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Research ArticleArticle

Individual Variation in CMBL in Human Liver and Intestine

Tomoko Ishizuka, Veronika Rozehnal, Thomas Fischer, Ayako Kato, Seiko Endo, Yasushi Yoshigae, Atsushi Kurihara and Takashi Izumi
Drug Metabolism and Disposition May 1, 2013, 41 (5) 1156-1162; DOI: https://doi.org/10.1124/dmd.113.051482

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Research ArticleArticle

Individual Variation in CMBL in Human Liver and Intestine

Tomoko Ishizuka, Veronika Rozehnal, Thomas Fischer, Ayako Kato, Seiko Endo, Yasushi Yoshigae, Atsushi Kurihara and Takashi Izumi
Drug Metabolism and Disposition May 1, 2013, 41 (5) 1156-1162; DOI: https://doi.org/10.1124/dmd.113.051482
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