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Research ArticleArticle

Drug Cocktail Interaction Study on the Effect of the Orally Administered Lavender Oil Preparation Silexan on Cytochrome P450 Enzymes in Healthy Volunteers

Oxana Doroshyenko, Dennis Rokitta, Gregor Zadoyan, Stephan Klement, Sandra Schläfke, Angelika Dienel, Thomas Gramatté, Hendrik Lück and Uwe Fuhr
Drug Metabolism and Disposition May 2013, 41 (5) 987-993; DOI: https://doi.org/10.1124/dmd.112.050203
Oxana Doroshyenko
ITECRA GmbH & Co. KG, Cologne, Germany (O.D., G.Z., H.L., U.F.); Department of Pharmacology, Clinical Pharmacology Unit; University Hospital, University of Cologne, Cologne, Germany (D.R., G.Z., U.F.); Dr. Willmar Schwabe GmbH & Co. KG, Karlsruhe, Germany (S.K., S.S., A.D.); and Drug Development Consulting, Dresden, Germany (T.G.)
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Dennis Rokitta
ITECRA GmbH & Co. KG, Cologne, Germany (O.D., G.Z., H.L., U.F.); Department of Pharmacology, Clinical Pharmacology Unit; University Hospital, University of Cologne, Cologne, Germany (D.R., G.Z., U.F.); Dr. Willmar Schwabe GmbH & Co. KG, Karlsruhe, Germany (S.K., S.S., A.D.); and Drug Development Consulting, Dresden, Germany (T.G.)
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Gregor Zadoyan
ITECRA GmbH & Co. KG, Cologne, Germany (O.D., G.Z., H.L., U.F.); Department of Pharmacology, Clinical Pharmacology Unit; University Hospital, University of Cologne, Cologne, Germany (D.R., G.Z., U.F.); Dr. Willmar Schwabe GmbH & Co. KG, Karlsruhe, Germany (S.K., S.S., A.D.); and Drug Development Consulting, Dresden, Germany (T.G.)
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Stephan Klement
ITECRA GmbH & Co. KG, Cologne, Germany (O.D., G.Z., H.L., U.F.); Department of Pharmacology, Clinical Pharmacology Unit; University Hospital, University of Cologne, Cologne, Germany (D.R., G.Z., U.F.); Dr. Willmar Schwabe GmbH & Co. KG, Karlsruhe, Germany (S.K., S.S., A.D.); and Drug Development Consulting, Dresden, Germany (T.G.)
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Sandra Schläfke
ITECRA GmbH & Co. KG, Cologne, Germany (O.D., G.Z., H.L., U.F.); Department of Pharmacology, Clinical Pharmacology Unit; University Hospital, University of Cologne, Cologne, Germany (D.R., G.Z., U.F.); Dr. Willmar Schwabe GmbH & Co. KG, Karlsruhe, Germany (S.K., S.S., A.D.); and Drug Development Consulting, Dresden, Germany (T.G.)
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Angelika Dienel
ITECRA GmbH & Co. KG, Cologne, Germany (O.D., G.Z., H.L., U.F.); Department of Pharmacology, Clinical Pharmacology Unit; University Hospital, University of Cologne, Cologne, Germany (D.R., G.Z., U.F.); Dr. Willmar Schwabe GmbH & Co. KG, Karlsruhe, Germany (S.K., S.S., A.D.); and Drug Development Consulting, Dresden, Germany (T.G.)
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Thomas Gramatté
ITECRA GmbH & Co. KG, Cologne, Germany (O.D., G.Z., H.L., U.F.); Department of Pharmacology, Clinical Pharmacology Unit; University Hospital, University of Cologne, Cologne, Germany (D.R., G.Z., U.F.); Dr. Willmar Schwabe GmbH & Co. KG, Karlsruhe, Germany (S.K., S.S., A.D.); and Drug Development Consulting, Dresden, Germany (T.G.)
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Hendrik Lück
ITECRA GmbH & Co. KG, Cologne, Germany (O.D., G.Z., H.L., U.F.); Department of Pharmacology, Clinical Pharmacology Unit; University Hospital, University of Cologne, Cologne, Germany (D.R., G.Z., U.F.); Dr. Willmar Schwabe GmbH & Co. KG, Karlsruhe, Germany (S.K., S.S., A.D.); and Drug Development Consulting, Dresden, Germany (T.G.)
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Uwe Fuhr
ITECRA GmbH & Co. KG, Cologne, Germany (O.D., G.Z., H.L., U.F.); Department of Pharmacology, Clinical Pharmacology Unit; University Hospital, University of Cologne, Cologne, Germany (D.R., G.Z., U.F.); Dr. Willmar Schwabe GmbH & Co. KG, Karlsruhe, Germany (S.K., S.S., A.D.); and Drug Development Consulting, Dresden, Germany (T.G.)
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Article Information

vol. 41 no. 5 987-993
DOI 
https://doi.org/10.1124/dmd.112.050203
PubMed 
23401474

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received November 19, 2012
  • Accepted February 7, 2013
  • Published online April 15, 2013.

Article Versions

  • Earlier version (February 11, 2013 - 08:38).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Oxana Doroshyenko,
  2. Dennis Rokitta,
  3. Gregor Zadoyan,
  4. Stephan Klement,
  5. Sandra Schläfke,
  6. Angelika Dienel,
  7. Thomas Gramatté,
  8. Hendrik Lück, and
  9. Uwe Fuhr
  1. ITECRA GmbH & Co. KG, Cologne, Germany (O.D., G.Z., H.L., U.F.); Department of Pharmacology, Clinical Pharmacology Unit; University Hospital, University of Cologne, Cologne, Germany (D.R., G.Z., U.F.); Dr. Willmar Schwabe GmbH & Co. KG, Karlsruhe, Germany (S.K., S.S., A.D.); and Drug Development Consulting, Dresden, Germany (T.G.)
  1. Address correspondence to:
    Dr. Uwe Fuhr, Institut für Pharmakologie, Klinische Pharmakologie, Universität zu Köln, Gleueler Straße 24, 50931 Köln, Germany. E-mail: uwe.fuhr{at}uk-koeln.de
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Drug Metabolism and Disposition: 41 (5)
Drug Metabolism and Disposition
Vol. 41, Issue 5
1 May 2013
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Research ArticleArticle

Cocktail Interaction Study on Silexan in Healthy Subjects

Oxana Doroshyenko, Dennis Rokitta, Gregor Zadoyan, Stephan Klement, Sandra Schläfke, Angelika Dienel, Thomas Gramatté, Hendrik Lück and Uwe Fuhr
Drug Metabolism and Disposition May 1, 2013, 41 (5) 987-993; DOI: https://doi.org/10.1124/dmd.112.050203

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Research ArticleArticle

Cocktail Interaction Study on Silexan in Healthy Subjects

Oxana Doroshyenko, Dennis Rokitta, Gregor Zadoyan, Stephan Klement, Sandra Schläfke, Angelika Dienel, Thomas Gramatté, Hendrik Lück and Uwe Fuhr
Drug Metabolism and Disposition May 1, 2013, 41 (5) 987-993; DOI: https://doi.org/10.1124/dmd.112.050203
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