Table of Contents

Articles

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  Sorafenib Hepatobiliary Disposition: Mechanisms of Hepatic Uptake and Disposition of Generated Metabolites

  Brandon Swift, Noelia Nebot, Jin Kyung Lee, Tianxiang Han, William R. Proctor, Dhiren R. Thakker, Dieter Lang, Martin Radtke, Mark J. Gnoth and Kim L. R. Brouwer

  Drug Metabolism and Disposition June 2013, 41 (6) 1179-1186; DOI: https://doi.org/10.1124/dmd.112.048181
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  Differential Expression of Human Cytochrome P450 Enzymes from the CYP3A Subfamily in the Brains of Alcoholic Subjects and Drug-Free Controls

  Iris M. Booth Depaz, Francesca Toselli, Peter A. Wilce and Elizabeth M. J. Gillam

  Drug Metabolism and Disposition June 2013, 41 (6) 1187-1194; DOI: https://doi.org/10.1124/dmd.113.051359
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  Metabolism and Pharmacokinetics of Novel Selective Vascular Endothelial Growth Factor Receptor-2 Inhibitor Apatinib in Humans

  Juefang Ding, Xiaoyan Chen, Zhiwei Gao, Xiaojian Dai, Liang Li, Cen Xie, Haoyuan Jiang, Lijia Zhang and Dafang Zhong

  Drug Metabolism and Disposition June 2013, 41 (6) 1195-1210; DOI: https://doi.org/10.1124/dmd.112.050310
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  Metabolism Studies of Unformulated Internally [³H]-Labeled Short Interfering RNAs in Mice

  Jesper Christensen, Karine Litherland, Thomas Faller, Esther van de Kerkhof, François Natt, Jürg Hunziker, Joel Krauser and Piet Swart

  Drug Metabolism and Disposition June 2013, 41 (6) 1211-1219; DOI: https://doi.org/10.1124/dmd.112.050666
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  Prilocaine- and Lidocaine-Induced Methemoglobinemia Is Caused by Human Carboxylesterase-, CYP2E1-, and CYP3A4-Mediated Metabolic Activation

  Ryota Higuchi, Tatsuki Fukami, Miki Nakajima and Tsuyoshi Yokoi

  Drug Metabolism and Disposition June 2013, 41 (6) 1220-1230; DOI: https://doi.org/10.1124/dmd.113.051714
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  Chalcogenopyrylium Dyes as Differential Modulators of Organic Anion Transport by Multidrug Resistance Protein 1 (MRP1), MRP2, and MRP4

  Robert L. Myette, Gwenaëlle Conseil, Sean P. Ebert, Bryan Wetzel, Michael R. Detty and Susan P. C. Cole

  Drug Metabolism and Disposition June 2013, 41 (6) 1231-1239; DOI: https://doi.org/10.1124/dmd.112.050831
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  Nicotine Kinetics in Zebra Finches In Vivo and In Vitro

  Sharon Miksys, Susanne L.T. Cappendijk, William M. Perry, Bin Zhao and Rachel F. Tyndale

  Drug Metabolism and Disposition June 2013, 41 (6) 1240-1246; DOI: https://doi.org/10.1124/dmd.112.050765
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  In Vitro Metabolism and Pharmacokinetic Studies on Methylone

  Anders Just Pedersen, Trine Hedebrink Petersen and Kristian Linnet

  Drug Metabolism and Disposition June 2013, 41 (6) 1247-1255; DOI: https://doi.org/10.1124/dmd.112.050880
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  Population Pharmacokinetic Analysis of Daikenchuto, a Traditional Japanese Medicine (Kampo) in Japanese and US Health Volunteers

  Masaya Munekage, Kengo Ichikawa, Hiroyuki Kitagawa, Kazuhisa Ishihara, Hideaki Uehara, Junko Watanabe, Toru Kono and Kazuhiro Hanazaki

  Drug Metabolism and Disposition June 2013, 41 (6) 1256-1263; DOI: https://doi.org/10.1124/dmd.112.050112
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  The CYP2B6*6 Allele Significantly Alters the N-Demethylation of Ketamine Enantiomers In Vitro

  Yibai Li, Janet K. Coller, Mark R. Hutchinson, Kathrin Klein, Ulrich M. Zanger, Nathan J. Stanley, Andrew D. Abell and Andrew A. Somogyi

  Drug Metabolism and Disposition June 2013, 41 (6) 1264-1272; DOI: https://doi.org/10.1124/dmd.113.051631
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  The Glucuronidation of R- and S-Lorazepam: Human Liver Microsomal Kinetics, UDP-Glucuronosyltransferase Enzyme Selectivity, and Inhibition by Drugs

  Verawan Uchaipichat, Chuthamanee Suthisisang and John O. Miners

  Drug Metabolism and Disposition June 2013, 41 (6) 1273-1284; DOI: https://doi.org/10.1124/dmd.113.051656
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  Application of Target-Mediated Drug Disposition Model to Small Molecule Heat Shock Protein 90 Inhibitors

  Shinji Yamazaki, Zhongzhou Shen, Ying Jiang, Bill J. Smith and Paolo Vicini

  Drug Metabolism and Disposition June 2013, 41 (6) 1285-1294; DOI: https://doi.org/10.1124/dmd.113.051490