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Research ArticleArticle

Application of Target-Mediated Drug Disposition Model to Small Molecule Heat Shock Protein 90 Inhibitors

Shinji Yamazaki, Zhongzhou Shen, Ying Jiang, Bill J. Smith and Paolo Vicini
Drug Metabolism and Disposition June 2013, 41 (6) 1285-1294; DOI: https://doi.org/10.1124/dmd.113.051490
Shinji Yamazaki
Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research and Development, San Diego, California
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Zhongzhou Shen
Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research and Development, San Diego, California
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Ying Jiang
Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research and Development, San Diego, California
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Bill J. Smith
Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research and Development, San Diego, California
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Paolo Vicini
Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research and Development, San Diego, California
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Article Information

vol. 41 no. 6 1285-1294
DOI 
https://doi.org/10.1124/dmd.113.051490
PubMed 
23557746

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received February 15, 2013
  • Accepted April 4, 2013
  • Published online May 13, 2013.

Article Versions

  • Earlier version (April 4, 2013 - 10:02).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Shinji Yamazaki,
  2. Zhongzhou Shen1,
  3. Ying Jiang,
  4. Bill J. Smith, and
  5. Paolo Vicini
  1. Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research and Development, San Diego, California
  1. Address correspondence to:
    Dr. Shinji Yamazaki, Pharmacokinetics, Dynamics, and Metabolism, La Jolla Laboratories, Pfizer Worldwide Research and Development, 10777 Science Center Drive, San Diego, CA 92121. E-mail: shinji.yamazaki{at}pfizer.com
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Drug Metabolism and Disposition: 41 (6)
Drug Metabolism and Disposition
Vol. 41, Issue 6
1 Jun 2013
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Research ArticleArticle

Target-Mediated Drug Disposition of HSP90 Inhibitors

Shinji Yamazaki, Zhongzhou Shen, Ying Jiang, Bill J. Smith and Paolo Vicini
Drug Metabolism and Disposition June 1, 2013, 41 (6) 1285-1294; DOI: https://doi.org/10.1124/dmd.113.051490

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Research ArticleArticle

Target-Mediated Drug Disposition of HSP90 Inhibitors

Shinji Yamazaki, Zhongzhou Shen, Ying Jiang, Bill J. Smith and Paolo Vicini
Drug Metabolism and Disposition June 1, 2013, 41 (6) 1285-1294; DOI: https://doi.org/10.1124/dmd.113.051490
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