Table of Contents

Articles

• You have access

  Stereoselective Glucuronidation of Ornidazole in Humans: Predominant Contribution of UDP-Glucuronosyltransferases 1A9 and 2B7

  Jiangbo Du, Tiangeng You, Xiaoyan Chen and Dafang Zhong

  Drug Metabolism and Disposition July 2013, 41 (7) 1306-1318; DOI: https://doi.org/10.1124/dmd.113.051235
• You have access

  Mechanistic Pharmacokinetic-Pharmacodynamic Modeling of BACE1 Inhibition in Monkeys: Development of a Predictive Model for Amyloid Precursor Protein Processing

  Xingrong Liu, Harvey Wong, Kimberly Scearce-Levie, Ryan J. Watts, Melis Coraggio, Young G. Shin, Kun Peng, Kristin R. Wildsmith, Jasvinder K. Atwal, Jason Mango, Stephen P. Schauer, Kelly Regal, Kevin W. Hunt, Allen A. Thomas, Michael Siu, Joseph Lyssikatos, Gauri Deshmukh and Cornelis E. C. A. Hop

  Drug Metabolism and Disposition July 2013, 41 (7) 1319-1328; DOI: https://doi.org/10.1124/dmd.112.050864
• You have access

  Optimization of Drug-Drug Interaction Study Design: Comparison of Minimal Physiologically Based Pharmacokinetic Models on Prediction of CYP3A Inhibition by Ketoconazole

  Bing Han, Jialin Mao, Jenny Y. Chien and Stephen D. Hall

  Drug Metabolism and Disposition July 2013, 41 (7) 1329-1338; DOI: https://doi.org/10.1124/dmd.112.050732
• You have access

  In Vitro and In Vivo Human Metabolism of Degarelix, a Gonadotropin-Releasing Hormone Receptor Blocker

  Anders Sonesson and Birgitte Buur Rasmussen

  Drug Metabolism and Disposition July 2013, 41 (7) 1339-1346; DOI: https://doi.org/10.1124/dmd.113.051706
• You have access

  Variability in P-Glycoprotein Inhibitory Potency (IC₅₀) Using Various in Vitro Experimental Systems: Implications for Universal Digoxin Drug-Drug Interaction Risk Assessment Decision Criteria

  Joe Bentz, Michael P. O’Connor, Dallas Bednarczyk, JoAnn Coleman, Caroline Lee, Johan Palm, Y. Anne Pak, Elke S. Perloff, Eric Reyner, Praveen Balimane, Marie Brännström, Xiaoyan Chu, Christoph Funk, Ailan Guo, Imad Hanna, Krisztina Herédi-Szabó, Kate Hillgren, Libin Li, Evelyn Hollnack-Pusch, Masoud Jamei, Xuena Lin, Andrew K. Mason, Sibylle Neuhoff, Aarti Patel, Lalitha Podila, Emile Plise, Ganesh Rajaraman, Laurent Salphati, Eric Sands, Mitchell E. Taub, Jan-Shiang Taur, Dietmar Weitz, Heleen M. Wortelboer, Cindy Q. Xia, Guangqing Xiao, Jocelyn Yabut, Tetsuo Yamagata, Lei Zhang and Harma Ellens

  Drug Metabolism and Disposition July 2013, 41 (7) 1347-1366; DOI: https://doi.org/10.1124/dmd.112.050500
• You have access

  Application of Receiver Operating Characteristic Analysis to Refine the Prediction of Potential Digoxin Drug Interactions

  Harma Ellens, Shibing Deng, JoAnn Coleman, Joe Bentz, Mitchell E. Taub, Isabelle Ragueneau-Majlessi, Sophie P. Chung, Krisztina Herédi-Szabó, Sibylle Neuhoff, Johan Palm, Praveen Balimane, Lei Zhang, Masoud Jamei, Imad Hanna, Michael O’Connor, Dallas Bednarczyk, Malin Forsgard, Xiaoyan Chu, Christoph Funk, Ailan Guo, Kathleen M. Hillgren, LiBin Li, Anne Y. Pak, Elke S. Perloff, Ganesh Rajaraman, Laurent Salphati, Jan-Shiang Taur, Dietmar Weitz, Heleen M. Wortelboer, Cindy Q. Xia, Guangqing Xiao, Tetsuo Yamagata and Caroline A. Lee

  Drug Metabolism and Disposition July 2013, 41 (7) 1367-1374; DOI: https://doi.org/10.1124/dmd.112.050542
• You have access

  Reactive Metabolite Trapping Studies on Imidazo- and 2-Methylimidazo[2,1-b]thiazole-Based Inverse Agonists of the Ghrelin Receptor

  Amit S. Kalgutkar, Tim F. Ryder, Gregory S. Walker, Suvi T. M. Orr, Shawn Cabral, Theunis C. Goosen, Kimberly Lapham and Heather Eng

  Drug Metabolism and Disposition July 2013, 41 (7) 1375-1388; DOI: https://doi.org/10.1124/dmd.113.051839
• You have access

  Human UDP-Glucuronosyltransferase (UGT) 2B10 in Drug N-Glucuronidation: Substrate Screening and Comparison with UGT1A3 and UGT1A4

  Yukiko Kato, Takeshi Izukawa, Shingo Oda, Tatsuki Fukami, Moshe Finel, Tsuyoshi Yokoi and Miki Nakajima

  Drug Metabolism and Disposition July 2013, 41 (7) 1389-1397; DOI: https://doi.org/10.1124/dmd.113.051565
• You have access

  Effects of Traditional Chinese Medicine Wuzhi Capsule on Pharmacokinetics of Tacrolimus in Rats

  Hua Wei, Xia Tao, Peng Di, Yingbo Yang, Jingxian Li, Xiaofeng Qian, Jin Feng and Wansheng Chen

  Drug Metabolism and Disposition July 2013, 41 (7) 1398-1403; DOI: https://doi.org/10.1124/dmd.112.050302
• You have access

  The Effect of Breast Cancer Resistance Protein, Multidrug Resistant Protein 1, and Organic Anion-Transporting Polypeptide 1B3 on the Antitumor Efficacy of the Lipophilic Camptothecin 7-t-Butyldimethylsilyl-10-Hydroxycamptothecin (AR-67) In Vitro

  Eleftheria Tsakalozou, Eyob D. Adane, Kuei-Ling Kuo, Abigail Daily, Jeffrey A. Moscow and Markos Leggas

  Drug Metabolism and Disposition July 2013, 41 (7) 1404-1413; DOI: https://doi.org/10.1124/dmd.112.050021
• You have access

  Inhibition of CYP2C19 and CYP3A4 by Omeprazole Metabolites and Their Contribution to Drug-Drug Interactions

  Yoshiyuki Shirasaka, Jennifer E. Sager, Justin D. Lutz, Connie Davis and Nina Isoherranen

  Drug Metabolism and Disposition July 2013, 41 (7) 1414-1424; DOI: https://doi.org/10.1124/dmd.113.051722
• You have access

  Characterization of Recombinantly Expressed Rat and Monkey Intestinal Alkaline Phosphatases: In Vitro Studies and In Vivo Correlations

  Murali Subramanian, Sundeep Paruchury, Shashyendra Singh Gautam, Sheelendra Pratap Singh, Rambabu Arla, Sonia Pahwa, Snehasis Jana, Prasannakumar Katnapally, Vadari Yoganand, Basanth Lakshmaiah, Debarati Mazumder Tagore, Kaushik Ghosh, Punit Marathe and Sandhya Mandlekar

  Drug Metabolism and Disposition July 2013, 41 (7) 1425-1432; DOI: https://doi.org/10.1124/dmd.113.051987
• You have access

  Dynamic Modeling of Cytochrome P450 Inhibition In Vitro: Impact of Inhibitor Depletion on IC₅₀ Shift

  Loren M. Berry, Zhiyang Zhao and Min-Hwa Jasmine Lin

  Drug Metabolism and Disposition July 2013, 41 (7) 1433-1441; DOI: https://doi.org/10.1124/dmd.113.051508
• You have access

  Integrated Approach of In Vivo and In Vitro Evaluation of the Involvement of Hepatic Uptake Organic Anion Transporters in the Drug Disposition in Rats Using Rifampicin as an Inhibitor

  Tomoki Imaoka, Tsuyoshi Mikkaichi, Koji Abe, Masakazu Hirouchi, Noriko Okudaira and Takashi Izumi

  Drug Metabolism and Disposition July 2013, 41 (7) 1442-1449; DOI: https://doi.org/10.1124/dmd.113.051052
• You have access

  Aspirin Hydrolysis in Human and Experimental Animal Plasma and the Effect of Metal Cations on Hydrolase Activities

  Fatma Goksin Bahar and Teruko Imai

  Drug Metabolism and Disposition July 2013, 41 (7) 1450-1456; DOI: https://doi.org/10.1124/dmd.113.051805
• You have access

  Combinatorial Metabolism Notably Affects Human Systemic Exposure to Ginsenosides from Orally Administered Extract of Panax notoginseng Roots (Sanqi)

  Zheyi Hu, Junling Yang, Chen Cheng, Yuhong Huang, Feifei Du, Fengqing Wang, Wei Niu, Fang Xu, Rongrong Jiang, Xiumei Gao and Chuan Li

  Drug Metabolism and Disposition July 2013, 41 (7) 1457-1469; DOI: https://doi.org/10.1124/dmd.113.051391