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Drug Metabolism & Disposition

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Table of Contents

July 01, 2013; Volume 41,Issue 7

Short Communications

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    Ion Mobility Spectrometry–Mass Spectrometry Analysis for the Site of Aromatic Hydroxylation
    Atsushi Shimizu and Masato Chiba
    Drug Metabolism and Disposition July 2013, 41 (7) 1295-1299; DOI: https://doi.org/10.1124/dmd.113.051953
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    Acrolein, an α,β-Unsaturated Aldehyde, Irreversibly Inhibits the Acetylation of Aromatic Amine Xenobiotics by Human Arylamine N-Acetyltransferase 1
    Linh C. Bui, Amine Manaa, Ximing Xu, Romain Duval, Florent Busi, Jean-Marie Dupret, Fernando Rodrigues-Lima and Julien Dairou
    Drug Metabolism and Disposition July 2013, 41 (7) 1300-1305; DOI: https://doi.org/10.1124/dmd.113.052258

Articles

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    Stereoselective Glucuronidation of Ornidazole in Humans: Predominant Contribution of UDP-Glucuronosyltransferases 1A9 and 2B7
    Jiangbo Du, Tiangeng You, Xiaoyan Chen and Dafang Zhong
    Drug Metabolism and Disposition July 2013, 41 (7) 1306-1318; DOI: https://doi.org/10.1124/dmd.113.051235
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    Mechanistic Pharmacokinetic-Pharmacodynamic Modeling of BACE1 Inhibition in Monkeys: Development of a Predictive Model for Amyloid Precursor Protein Processing
    Xingrong Liu, Harvey Wong, Kimberly Scearce-Levie, Ryan J. Watts, Melis Coraggio, Young G. Shin, Kun Peng, Kristin R. Wildsmith, Jasvinder K. Atwal, Jason Mango, Stephen P. Schauer, Kelly Regal, Kevin W. Hunt, Allen A. Thomas, Michael Siu, Joseph Lyssikatos, Gauri Deshmukh and Cornelis E. C. A. Hop
    Drug Metabolism and Disposition July 2013, 41 (7) 1319-1328; DOI: https://doi.org/10.1124/dmd.112.050864
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    Optimization of Drug-Drug Interaction Study Design: Comparison of Minimal Physiologically Based Pharmacokinetic Models on Prediction of CYP3A Inhibition by Ketoconazole
    Bing Han, Jialin Mao, Jenny Y. Chien and Stephen D. Hall
    Drug Metabolism and Disposition July 2013, 41 (7) 1329-1338; DOI: https://doi.org/10.1124/dmd.112.050732
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    In Vitro and In Vivo Human Metabolism of Degarelix, a Gonadotropin-Releasing Hormone Receptor Blocker
    Anders Sonesson and Birgitte Buur Rasmussen
    Drug Metabolism and Disposition July 2013, 41 (7) 1339-1346; DOI: https://doi.org/10.1124/dmd.113.051706
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    Variability in P-Glycoprotein Inhibitory Potency (IC50) Using Various in Vitro Experimental Systems: Implications for Universal Digoxin Drug-Drug Interaction Risk Assessment Decision Criteria
    Joe Bentz, Michael P. O’Connor, Dallas Bednarczyk, JoAnn Coleman, Caroline Lee, Johan Palm, Y. Anne Pak, Elke S. Perloff, Eric Reyner, Praveen Balimane, Marie Brännström, Xiaoyan Chu, Christoph Funk, Ailan Guo, Imad Hanna, Krisztina Herédi-Szabó, Kate Hillgren, Libin Li, Evelyn Hollnack-Pusch, Masoud Jamei, Xuena Lin, Andrew K. Mason, Sibylle Neuhoff, Aarti Patel, Lalitha Podila, Emile Plise, Ganesh Rajaraman, Laurent Salphati, Eric Sands, Mitchell E. Taub, Jan-Shiang Taur, Dietmar Weitz, Heleen M. Wortelboer, Cindy Q. Xia, Guangqing Xiao, Jocelyn Yabut, Tetsuo Yamagata, Lei Zhang and Harma Ellens
    Drug Metabolism and Disposition July 2013, 41 (7) 1347-1366; DOI: https://doi.org/10.1124/dmd.112.050500
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    Application of Receiver Operating Characteristic Analysis to Refine the Prediction of Potential Digoxin Drug Interactions
    Harma Ellens, Shibing Deng, JoAnn Coleman, Joe Bentz, Mitchell E. Taub, Isabelle Ragueneau-Majlessi, Sophie P. Chung, Krisztina Herédi-Szabó, Sibylle Neuhoff, Johan Palm, Praveen Balimane, Lei Zhang, Masoud Jamei, Imad Hanna, Michael O’Connor, Dallas Bednarczyk, Malin Forsgard, Xiaoyan Chu, Christoph Funk, Ailan Guo, Kathleen M. Hillgren, LiBin Li, Anne Y. Pak, Elke S. Perloff, Ganesh Rajaraman, Laurent Salphati, Jan-Shiang Taur, Dietmar Weitz, Heleen M. Wortelboer, Cindy Q. Xia, Guangqing Xiao, Tetsuo Yamagata and Caroline A. Lee
    Drug Metabolism and Disposition July 2013, 41 (7) 1367-1374; DOI: https://doi.org/10.1124/dmd.112.050542
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    Reactive Metabolite Trapping Studies on Imidazo- and 2-Methylimidazo[2,1-b]thiazole-Based Inverse Agonists of the Ghrelin Receptor
    Amit S. Kalgutkar, Tim F. Ryder, Gregory S. Walker, Suvi T. M. Orr, Shawn Cabral, Theunis C. Goosen, Kimberly Lapham and Heather Eng
    Drug Metabolism and Disposition July 2013, 41 (7) 1375-1388; DOI: https://doi.org/10.1124/dmd.113.051839
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    Human UDP-Glucuronosyltransferase (UGT) 2B10 in Drug N-Glucuronidation: Substrate Screening and Comparison with UGT1A3 and UGT1A4
    Yukiko Kato, Takeshi Izukawa, Shingo Oda, Tatsuki Fukami, Moshe Finel, Tsuyoshi Yokoi and Miki Nakajima
    Drug Metabolism and Disposition July 2013, 41 (7) 1389-1397; DOI: https://doi.org/10.1124/dmd.113.051565
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    Effects of Traditional Chinese Medicine Wuzhi Capsule on Pharmacokinetics of Tacrolimus in Rats
    Hua Wei, Xia Tao, Peng Di, Yingbo Yang, Jingxian Li, Xiaofeng Qian, Jin Feng and Wansheng Chen
    Drug Metabolism and Disposition July 2013, 41 (7) 1398-1403; DOI: https://doi.org/10.1124/dmd.112.050302
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    The Effect of Breast Cancer Resistance Protein, Multidrug Resistant Protein 1, and Organic Anion-Transporting Polypeptide 1B3 on the Antitumor Efficacy of the Lipophilic Camptothecin 7-t-Butyldimethylsilyl-10-Hydroxycamptothecin (AR-67) In Vitro
    Eleftheria Tsakalozou, Eyob D. Adane, Kuei-Ling Kuo, Abigail Daily, Jeffrey A. Moscow and Markos Leggas
    Drug Metabolism and Disposition July 2013, 41 (7) 1404-1413; DOI: https://doi.org/10.1124/dmd.112.050021
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    Inhibition of CYP2C19 and CYP3A4 by Omeprazole Metabolites and Their Contribution to Drug-Drug Interactions
    Yoshiyuki Shirasaka, Jennifer E. Sager, Justin D. Lutz, Connie Davis and Nina Isoherranen
    Drug Metabolism and Disposition July 2013, 41 (7) 1414-1424; DOI: https://doi.org/10.1124/dmd.113.051722
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    Characterization of Recombinantly Expressed Rat and Monkey Intestinal Alkaline Phosphatases: In Vitro Studies and In Vivo Correlations
    Murali Subramanian, Sundeep Paruchury, Shashyendra Singh Gautam, Sheelendra Pratap Singh, Rambabu Arla, Sonia Pahwa, Snehasis Jana, Prasannakumar Katnapally, Vadari Yoganand, Basanth Lakshmaiah, Debarati Mazumder Tagore, Kaushik Ghosh, Punit Marathe and Sandhya Mandlekar
    Drug Metabolism and Disposition July 2013, 41 (7) 1425-1432; DOI: https://doi.org/10.1124/dmd.113.051987
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    Dynamic Modeling of Cytochrome P450 Inhibition In Vitro: Impact of Inhibitor Depletion on IC50 Shift
    Loren M. Berry, Zhiyang Zhao and Min-Hwa Jasmine Lin
    Drug Metabolism and Disposition July 2013, 41 (7) 1433-1441; DOI: https://doi.org/10.1124/dmd.113.051508
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    Integrated Approach of In Vivo and In Vitro Evaluation of the Involvement of Hepatic Uptake Organic Anion Transporters in the Drug Disposition in Rats Using Rifampicin as an Inhibitor
    Tomoki Imaoka, Tsuyoshi Mikkaichi, Koji Abe, Masakazu Hirouchi, Noriko Okudaira and Takashi Izumi
    Drug Metabolism and Disposition July 2013, 41 (7) 1442-1449; DOI: https://doi.org/10.1124/dmd.113.051052
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    Aspirin Hydrolysis in Human and Experimental Animal Plasma and the Effect of Metal Cations on Hydrolase Activities
    Fatma Goksin Bahar and Teruko Imai
    Drug Metabolism and Disposition July 2013, 41 (7) 1450-1456; DOI: https://doi.org/10.1124/dmd.113.051805
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    Combinatorial Metabolism Notably Affects Human Systemic Exposure to Ginsenosides from Orally Administered Extract of Panax notoginseng Roots (Sanqi)
    Zheyi Hu, Junling Yang, Chen Cheng, Yuhong Huang, Feifei Du, Fengqing Wang, Wei Niu, Fang Xu, Rongrong Jiang, Xiumei Gao and Chuan Li
    Drug Metabolism and Disposition July 2013, 41 (7) 1457-1469; DOI: https://doi.org/10.1124/dmd.113.051391
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Drug Metabolism and Disposition: 41 (7)
Drug Metabolism and Disposition
Vol. 41, Issue 7
1 Jul 2013
  • Table of Contents
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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