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Research ArticleArticle

Human UDP-Glucuronosyltransferase (UGT) 2B10 in Drug N-Glucuronidation: Substrate Screening and Comparison with UGT1A3 and UGT1A4

Yukiko Kato, Takeshi Izukawa, Shingo Oda, Tatsuki Fukami, Moshe Finel, Tsuyoshi Yokoi and Miki Nakajima
Drug Metabolism and Disposition July 2013, 41 (7) 1389-1397; DOI: https://doi.org/10.1124/dmd.113.051565
Yukiko Kato
Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa, Japan (Y.K., T.I., S.O., T.F., T.Y., M.N.); and Center for Drug Research and Division of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland (M.F.)
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Takeshi Izukawa
Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa, Japan (Y.K., T.I., S.O., T.F., T.Y., M.N.); and Center for Drug Research and Division of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland (M.F.)
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Shingo Oda
Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa, Japan (Y.K., T.I., S.O., T.F., T.Y., M.N.); and Center for Drug Research and Division of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland (M.F.)
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Tatsuki Fukami
Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa, Japan (Y.K., T.I., S.O., T.F., T.Y., M.N.); and Center for Drug Research and Division of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland (M.F.)
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Moshe Finel
Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa, Japan (Y.K., T.I., S.O., T.F., T.Y., M.N.); and Center for Drug Research and Division of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland (M.F.)
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Tsuyoshi Yokoi
Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa, Japan (Y.K., T.I., S.O., T.F., T.Y., M.N.); and Center for Drug Research and Division of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland (M.F.)
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Miki Nakajima
Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa, Japan (Y.K., T.I., S.O., T.F., T.Y., M.N.); and Center for Drug Research and Division of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland (M.F.)
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Article Information

vol. 41 no. 7 1389-1397
DOI 
https://doi.org/10.1124/dmd.113.051565
PubMed 
23611809

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received February 13, 2013
  • Accepted April 23, 2013
  • Published online June 13, 2013.

Article Versions

  • Earlier version (April 23, 2013 - 08:55).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Yukiko Kato,
  2. Takeshi Izukawa,
  3. Shingo Oda,
  4. Tatsuki Fukami,
  5. Moshe Finel,
  6. Tsuyoshi Yokoi, and
  7. Miki Nakajima
  1. Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa, Japan (Y.K., T.I., S.O., T.F., T.Y., M.N.); and Center for Drug Research and Division of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland (M.F.)
  1. Address correspondence to:
    Dr. Miki Nakajima, Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan. E-mail: nmiki{at}p.kanazawa-u.ac.jp
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Drug Metabolism and Disposition: 41 (7)
Drug Metabolism and Disposition
Vol. 41, Issue 7
1 Jul 2013
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Research ArticleArticle

Significance of UGT2B10 in N-Glucuronidation of Drugs

Yukiko Kato, Takeshi Izukawa, Shingo Oda, Tatsuki Fukami, Moshe Finel, Tsuyoshi Yokoi and Miki Nakajima
Drug Metabolism and Disposition July 1, 2013, 41 (7) 1389-1397; DOI: https://doi.org/10.1124/dmd.113.051565

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Research ArticleArticle

Significance of UGT2B10 in N-Glucuronidation of Drugs

Yukiko Kato, Takeshi Izukawa, Shingo Oda, Tatsuki Fukami, Moshe Finel, Tsuyoshi Yokoi and Miki Nakajima
Drug Metabolism and Disposition July 1, 2013, 41 (7) 1389-1397; DOI: https://doi.org/10.1124/dmd.113.051565
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