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Index by author

September 01, 2013; Volume 41,Issue 9

B

  1. Barbier, Olivier

    1. The Human UDP-Glucuronosyltransferase UGT2A1 and UGT2A2 Enzymes Are Highly Active in Bile Acid Glucuronidation
      Martin Perreault, Louis Gauthier-Landry, Jocelyn Trottier, Mélanie Verreault, Patrick Caron, Moshe Finel and Olivier Barbier
      Drug Metabolism and Disposition September 2013, 41 (9) 1616-1620; DOI: https://doi.org/10.1124/dmd.113.052613

  2. Barbuch, Robert J.

    1. The Relative Contributions of CYP3A4 and CYP3A5 to the Metabolism of Vinorelbine
      Ariel R. Topletz, Jennifer B. Dennison, Robert J. Barbuch, Chad E. Hadden, Stephen D. Hall and Jamie L. Renbarger
      Drug Metabolism and Disposition September 2013, 41 (9) 1651-1661; DOI: https://doi.org/10.1124/dmd.113.051094

  3. Bergström, Helena

    1. Atorvastatin Treatment Induces Uptake and Efflux Transporters in Human Liver
      Linda Björkhem-Bergman, Helena Bergström, Maria Johansson, Paolo Parini, Mats Eriksson, Anders Rane and Lena Ekström
      Drug Metabolism and Disposition September 2013, 41 (9) 1610-1615; DOI: https://doi.org/10.1124/dmd.113.051698

  4. Bernstein, Hilary J.

    1. An Assessment of Pharmacokinetics and Antioxidant Activity of Free Silymarin Flavonolignans in Healthy Volunteers: A Dose Escalation Study
      Hao-Jie Zhu, Bryan J. Brinda, Kenneth D. Chavin, Hilary J. Bernstein, Kennerly S. Patrick and John S. Markowitz
      Drug Metabolism and Disposition September 2013, 41 (9) 1679-1685; DOI: https://doi.org/10.1124/dmd.113.052423

  5. Björkhem-Bergman, Linda

    1. Atorvastatin Treatment Induces Uptake and Efflux Transporters in Human Liver
      Linda Björkhem-Bergman, Helena Bergström, Maria Johansson, Paolo Parini, Mats Eriksson, Anders Rane and Lena Ekström
      Drug Metabolism and Disposition September 2013, 41 (9) 1610-1615; DOI: https://doi.org/10.1124/dmd.113.051698

  6. Brantley, Scott J.

    1. A Systematic Approach to Evaluate Herb-Drug Interaction Mechanisms: Investigation of Milk Thistle Extracts and Eight Isolated Constituents as CYP3A Inhibitors
      Scott J. Brantley, Tyler N. Graf, Nicholas H. Oberlies and Mary F. Paine
      Drug Metabolism and Disposition September 2013, 41 (9) 1662-1670; DOI: https://doi.org/10.1124/dmd.113.052563

  7. Bridges, Arlene S.

    1. Intestinal First-Pass Metabolism by Cytochrome P450 and Not P-Glycoprotein Is the Major Barrier to Amprenavir Absorption
      Matthew B. Dufek, Arlene S. Bridges and Dhiren R. Thakker
      Drug Metabolism and Disposition September 2013, 41 (9) 1695-1702; DOI: https://doi.org/10.1124/dmd.113.052191

  8. Bridges, Thomas M.

    1. Biotransformation of a Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Contributes to Seizure-Like Adverse Events in Rats Involving a Receptor Agonism-Dependent Mechanism
      Thomas M. Bridges, Jerri M. Rook, Meredith J. Noetzel, Ryan D. Morrison, Ya Zhou, Rocco D. Gogliotti, Paige N. Vinson, Zixiu Xiang, Carrie K. Jones, Colleen M. Niswender, Craig W. Lindsley, Shaun R. Stauffer, P. Jeffrey Conn and J. Scott Daniels
      Drug Metabolism and Disposition September 2013, 41 (9) 1703-1714; DOI: https://doi.org/10.1124/dmd.113.052084

  9. Brinda, Bryan J.

    1. An Assessment of Pharmacokinetics and Antioxidant Activity of Free Silymarin Flavonolignans in Healthy Volunteers: A Dose Escalation Study
      Hao-Jie Zhu, Bryan J. Brinda, Kenneth D. Chavin, Hilary J. Bernstein, Kennerly S. Patrick and John S. Markowitz
      Drug Metabolism and Disposition September 2013, 41 (9) 1679-1685; DOI: https://doi.org/10.1124/dmd.113.052423

C

  1. Carcache, David

    1. Metabolism and Disposition of the Metabotropic Glutamate Receptor 5 Antagonist (mGluR5) Mavoglurant (AFQ056) in Healthy Subjects
      Markus Walles, Thierry Wolf, Yi Jin, Michael Ritzau, Luc Alexis Leuthold, Joel Krauser, Hans-Peter Gschwind, David Carcache, Matthias Kittelmann, Magdalena Ocwieja, Mike Ufer, Ralph Woessner, Abhijit Chakraborty and Piet Swart
      Drug Metabolism and Disposition September 2013, 41 (9) 1626-1641; DOI: https://doi.org/10.1124/dmd.112.050716

  2. Caron, Patrick

    1. The Human UDP-Glucuronosyltransferase UGT2A1 and UGT2A2 Enzymes Are Highly Active in Bile Acid Glucuronidation
      Martin Perreault, Louis Gauthier-Landry, Jocelyn Trottier, Mélanie Verreault, Patrick Caron, Moshe Finel and Olivier Barbier
      Drug Metabolism and Disposition September 2013, 41 (9) 1616-1620; DOI: https://doi.org/10.1124/dmd.113.052613

  3. Chakraborty, Abhijit

    1. Metabolism and Disposition of the Metabotropic Glutamate Receptor 5 Antagonist (mGluR5) Mavoglurant (AFQ056) in Healthy Subjects
      Markus Walles, Thierry Wolf, Yi Jin, Michael Ritzau, Luc Alexis Leuthold, Joel Krauser, Hans-Peter Gschwind, David Carcache, Matthias Kittelmann, Magdalena Ocwieja, Mike Ufer, Ralph Woessner, Abhijit Chakraborty and Piet Swart
      Drug Metabolism and Disposition September 2013, 41 (9) 1626-1641; DOI: https://doi.org/10.1124/dmd.112.050716

  4. Chavin, Kenneth D.

    1. An Assessment of Pharmacokinetics and Antioxidant Activity of Free Silymarin Flavonolignans in Healthy Volunteers: A Dose Escalation Study
      Hao-Jie Zhu, Bryan J. Brinda, Kenneth D. Chavin, Hilary J. Bernstein, Kennerly S. Patrick and John S. Markowitz
      Drug Metabolism and Disposition September 2013, 41 (9) 1679-1685; DOI: https://doi.org/10.1124/dmd.113.052423

  5. Cherrington, Nathan J.

    1. Downregulation of Sulfotransferase Expression and Activity in Diseased Human Livers
      Emine B. Yalcin, Vijay More, Karissa L. Neira, Zhenqiang James Lu, Nathan J. Cherrington, Angela L. Slitt and Roberta S. King
      Drug Metabolism and Disposition September 2013, 41 (9) 1642-1650; DOI: https://doi.org/10.1124/dmd.113.050930

  6. Cohen-Wolkowiez, Michael

    1. The Role of Human Cytochrome P450 Enzymes in the Formation of 2-Hydroxymetronidazole: CYP2A6 is the High Affinity (Low Km) Catalyst
      Robin E. Pearce, Michael Cohen-Wolkowiez, Mario R. Sampson and Gregory L. Kearns
      Drug Metabolism and Disposition September 2013, 41 (9) 1686-1694; DOI: https://doi.org/10.1124/dmd.113.052548

  7. Conn, P. Jeffrey

    1. Biotransformation of a Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Contributes to Seizure-Like Adverse Events in Rats Involving a Receptor Agonism-Dependent Mechanism
      Thomas M. Bridges, Jerri M. Rook, Meredith J. Noetzel, Ryan D. Morrison, Ya Zhou, Rocco D. Gogliotti, Paige N. Vinson, Zixiu Xiang, Carrie K. Jones, Colleen M. Niswender, Craig W. Lindsley, Shaun R. Stauffer, P. Jeffrey Conn and J. Scott Daniels
      Drug Metabolism and Disposition September 2013, 41 (9) 1703-1714; DOI: https://doi.org/10.1124/dmd.113.052084

  8. Cushman, Mark

    1. Inhibition of Cytochrome P450 Enzymes by the E- and Z-Isomers of Norendoxifen
      Jinzhong Liu, Peter J. Flockhart, Deshun Lu, Wei Lv, Wenjie Jessie Lu, Xu Han, Mark Cushman and David A. Flockhart
      Drug Metabolism and Disposition September 2013, 41 (9) 1715-1720; DOI: https://doi.org/10.1124/dmd.113.052506

D

  1. Dallas, Shannon

    1. Critical Review of Preclinical Approaches to Investigate Cytochrome P450–Mediated Therapeutic Protein Drug-Drug Interactions and Recommendations for Best Practices: A White Paper
      Raymond Evers, Shannon Dallas, Leslie J. Dickmann, Odette A. Fahmi, Jane R. Kenny, Eugenia Kraynov, Theresa Nguyen, Aarti H. Patel, J. Greg Slatter and Lei Zhang
      Drug Metabolism and Disposition September 2013, 41 (9) 1598-1609; DOI: https://doi.org/10.1124/dmd.113.052225

  2. Daniels, J. Scott

    1. Biotransformation of a Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Contributes to Seizure-Like Adverse Events in Rats Involving a Receptor Agonism-Dependent Mechanism
      Thomas M. Bridges, Jerri M. Rook, Meredith J. Noetzel, Ryan D. Morrison, Ya Zhou, Rocco D. Gogliotti, Paige N. Vinson, Zixiu Xiang, Carrie K. Jones, Colleen M. Niswender, Craig W. Lindsley, Shaun R. Stauffer, P. Jeffrey Conn and J. Scott Daniels
      Drug Metabolism and Disposition September 2013, 41 (9) 1703-1714; DOI: https://doi.org/10.1124/dmd.113.052084

  3. Dennison, Jennifer B.

    1. The Relative Contributions of CYP3A4 and CYP3A5 to the Metabolism of Vinorelbine
      Ariel R. Topletz, Jennifer B. Dennison, Robert J. Barbuch, Chad E. Hadden, Stephen D. Hall and Jamie L. Renbarger
      Drug Metabolism and Disposition September 2013, 41 (9) 1651-1661; DOI: https://doi.org/10.1124/dmd.113.051094

  4. Dickmann, Leslie J.

    1. Critical Review of Preclinical Approaches to Investigate Cytochrome P450–Mediated Therapeutic Protein Drug-Drug Interactions and Recommendations for Best Practices: A White Paper
      Raymond Evers, Shannon Dallas, Leslie J. Dickmann, Odette A. Fahmi, Jane R. Kenny, Eugenia Kraynov, Theresa Nguyen, Aarti H. Patel, J. Greg Slatter and Lei Zhang
      Drug Metabolism and Disposition September 2013, 41 (9) 1598-1609; DOI: https://doi.org/10.1124/dmd.113.052225

  5. Dufek, Matthew B.

    1. Intestinal First-Pass Metabolism by Cytochrome P450 and Not P-Glycoprotein Is the Major Barrier to Amprenavir Absorption
      Matthew B. Dufek, Arlene S. Bridges and Dhiren R. Thakker
      Drug Metabolism and Disposition September 2013, 41 (9) 1695-1702; DOI: https://doi.org/10.1124/dmd.113.052191

E

  1. Ekström, Lena

    1. Atorvastatin Treatment Induces Uptake and Efflux Transporters in Human Liver
      Linda Björkhem-Bergman, Helena Bergström, Maria Johansson, Paolo Parini, Mats Eriksson, Anders Rane and Lena Ekström
      Drug Metabolism and Disposition September 2013, 41 (9) 1610-1615; DOI: https://doi.org/10.1124/dmd.113.051698

  2. Eriksson, Mats

    1. Atorvastatin Treatment Induces Uptake and Efflux Transporters in Human Liver
      Linda Björkhem-Bergman, Helena Bergström, Maria Johansson, Paolo Parini, Mats Eriksson, Anders Rane and Lena Ekström
      Drug Metabolism and Disposition September 2013, 41 (9) 1610-1615; DOI: https://doi.org/10.1124/dmd.113.051698

  3. Evers, Raymond

    1. Critical Review of Preclinical Approaches to Investigate Cytochrome P450–Mediated Therapeutic Protein Drug-Drug Interactions and Recommendations for Best Practices: A White Paper
      Raymond Evers, Shannon Dallas, Leslie J. Dickmann, Odette A. Fahmi, Jane R. Kenny, Eugenia Kraynov, Theresa Nguyen, Aarti H. Patel, J. Greg Slatter and Lei Zhang
      Drug Metabolism and Disposition September 2013, 41 (9) 1598-1609; DOI: https://doi.org/10.1124/dmd.113.052225

F

  1. Fahmi, Odette A.

    1. Critical Review of Preclinical Approaches to Investigate Cytochrome P450–Mediated Therapeutic Protein Drug-Drug Interactions and Recommendations for Best Practices: A White Paper
      Raymond Evers, Shannon Dallas, Leslie J. Dickmann, Odette A. Fahmi, Jane R. Kenny, Eugenia Kraynov, Theresa Nguyen, Aarti H. Patel, J. Greg Slatter and Lei Zhang
      Drug Metabolism and Disposition September 2013, 41 (9) 1598-1609; DOI: https://doi.org/10.1124/dmd.113.052225

  2. Finel, Moshe

    1. The Human UDP-Glucuronosyltransferase UGT2A1 and UGT2A2 Enzymes Are Highly Active in Bile Acid Glucuronidation
      Martin Perreault, Louis Gauthier-Landry, Jocelyn Trottier, Mélanie Verreault, Patrick Caron, Moshe Finel and Olivier Barbier
      Drug Metabolism and Disposition September 2013, 41 (9) 1616-1620; DOI: https://doi.org/10.1124/dmd.113.052613

  3. Flockhart, David A.

    1. Inhibition of Cytochrome P450 Enzymes by the E- and Z-Isomers of Norendoxifen
      Jinzhong Liu, Peter J. Flockhart, Deshun Lu, Wei Lv, Wenjie Jessie Lu, Xu Han, Mark Cushman and David A. Flockhart
      Drug Metabolism and Disposition September 2013, 41 (9) 1715-1720; DOI: https://doi.org/10.1124/dmd.113.052506

  4. Flockhart, Peter J.

    1. Inhibition of Cytochrome P450 Enzymes by the E- and Z-Isomers of Norendoxifen
      Jinzhong Liu, Peter J. Flockhart, Deshun Lu, Wei Lv, Wenjie Jessie Lu, Xu Han, Mark Cushman and David A. Flockhart
      Drug Metabolism and Disposition September 2013, 41 (9) 1715-1720; DOI: https://doi.org/10.1124/dmd.113.052506

G

  1. Gauthier-Landry, Louis

    1. The Human UDP-Glucuronosyltransferase UGT2A1 and UGT2A2 Enzymes Are Highly Active in Bile Acid Glucuronidation
      Martin Perreault, Louis Gauthier-Landry, Jocelyn Trottier, Mélanie Verreault, Patrick Caron, Moshe Finel and Olivier Barbier
      Drug Metabolism and Disposition September 2013, 41 (9) 1616-1620; DOI: https://doi.org/10.1124/dmd.113.052613

  2. Gogliotti, Rocco D.

    1. Biotransformation of a Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Contributes to Seizure-Like Adverse Events in Rats Involving a Receptor Agonism-Dependent Mechanism
      Thomas M. Bridges, Jerri M. Rook, Meredith J. Noetzel, Ryan D. Morrison, Ya Zhou, Rocco D. Gogliotti, Paige N. Vinson, Zixiu Xiang, Carrie K. Jones, Colleen M. Niswender, Craig W. Lindsley, Shaun R. Stauffer, P. Jeffrey Conn and J. Scott Daniels
      Drug Metabolism and Disposition September 2013, 41 (9) 1703-1714; DOI: https://doi.org/10.1124/dmd.113.052084

  3. Graf, Tyler N.

    1. A Systematic Approach to Evaluate Herb-Drug Interaction Mechanisms: Investigation of Milk Thistle Extracts and Eight Isolated Constituents as CYP3A Inhibitors
      Scott J. Brantley, Tyler N. Graf, Nicholas H. Oberlies and Mary F. Paine
      Drug Metabolism and Disposition September 2013, 41 (9) 1662-1670; DOI: https://doi.org/10.1124/dmd.113.052563

  4. Gschwind, Hans-Peter

    1. Metabolism and Disposition of the Metabotropic Glutamate Receptor 5 Antagonist (mGluR5) Mavoglurant (AFQ056) in Healthy Subjects
      Markus Walles, Thierry Wolf, Yi Jin, Michael Ritzau, Luc Alexis Leuthold, Joel Krauser, Hans-Peter Gschwind, David Carcache, Matthias Kittelmann, Magdalena Ocwieja, Mike Ufer, Ralph Woessner, Abhijit Chakraborty and Piet Swart
      Drug Metabolism and Disposition September 2013, 41 (9) 1626-1641; DOI: https://doi.org/10.1124/dmd.112.050716

H

  1. Hadden, Chad E.

    1. The Relative Contributions of CYP3A4 and CYP3A5 to the Metabolism of Vinorelbine
      Ariel R. Topletz, Jennifer B. Dennison, Robert J. Barbuch, Chad E. Hadden, Stephen D. Hall and Jamie L. Renbarger
      Drug Metabolism and Disposition September 2013, 41 (9) 1651-1661; DOI: https://doi.org/10.1124/dmd.113.051094

  2. Hall, Stephen D.

    1. The Relative Contributions of CYP3A4 and CYP3A5 to the Metabolism of Vinorelbine
      Ariel R. Topletz, Jennifer B. Dennison, Robert J. Barbuch, Chad E. Hadden, Stephen D. Hall and Jamie L. Renbarger
      Drug Metabolism and Disposition September 2013, 41 (9) 1651-1661; DOI: https://doi.org/10.1124/dmd.113.051094

  3. Han, Xu

    1. Inhibition of Cytochrome P450 Enzymes by the E- and Z-Isomers of Norendoxifen
      Jinzhong Liu, Peter J. Flockhart, Deshun Lu, Wei Lv, Wenjie Jessie Lu, Xu Han, Mark Cushman and David A. Flockhart
      Drug Metabolism and Disposition September 2013, 41 (9) 1715-1720; DOI: https://doi.org/10.1124/dmd.113.052506

J

  1. Jin, Yi

    1. Metabolism and Disposition of the Metabotropic Glutamate Receptor 5 Antagonist (mGluR5) Mavoglurant (AFQ056) in Healthy Subjects
      Markus Walles, Thierry Wolf, Yi Jin, Michael Ritzau, Luc Alexis Leuthold, Joel Krauser, Hans-Peter Gschwind, David Carcache, Matthias Kittelmann, Magdalena Ocwieja, Mike Ufer, Ralph Woessner, Abhijit Chakraborty and Piet Swart
      Drug Metabolism and Disposition September 2013, 41 (9) 1626-1641; DOI: https://doi.org/10.1124/dmd.112.050716

  2. Johansson, Maria

    1. Atorvastatin Treatment Induces Uptake and Efflux Transporters in Human Liver
      Linda Björkhem-Bergman, Helena Bergström, Maria Johansson, Paolo Parini, Mats Eriksson, Anders Rane and Lena Ekström
      Drug Metabolism and Disposition September 2013, 41 (9) 1610-1615; DOI: https://doi.org/10.1124/dmd.113.051698

  3. Jones, Carrie K.

    1. Biotransformation of a Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Contributes to Seizure-Like Adverse Events in Rats Involving a Receptor Agonism-Dependent Mechanism
      Thomas M. Bridges, Jerri M. Rook, Meredith J. Noetzel, Ryan D. Morrison, Ya Zhou, Rocco D. Gogliotti, Paige N. Vinson, Zixiu Xiang, Carrie K. Jones, Colleen M. Niswender, Craig W. Lindsley, Shaun R. Stauffer, P. Jeffrey Conn and J. Scott Daniels
      Drug Metabolism and Disposition September 2013, 41 (9) 1703-1714; DOI: https://doi.org/10.1124/dmd.113.052084

K

  1. Kearns, Gregory L.

    1. The Role of Human Cytochrome P450 Enzymes in the Formation of 2-Hydroxymetronidazole: CYP2A6 is the High Affinity (Low Km) Catalyst
      Robin E. Pearce, Michael Cohen-Wolkowiez, Mario R. Sampson and Gregory L. Kearns
      Drug Metabolism and Disposition September 2013, 41 (9) 1686-1694; DOI: https://doi.org/10.1124/dmd.113.052548

  2. Kenny, Jane R.

    1. Critical Review of Preclinical Approaches to Investigate Cytochrome P450–Mediated Therapeutic Protein Drug-Drug Interactions and Recommendations for Best Practices: A White Paper
      Raymond Evers, Shannon Dallas, Leslie J. Dickmann, Odette A. Fahmi, Jane R. Kenny, Eugenia Kraynov, Theresa Nguyen, Aarti H. Patel, J. Greg Slatter and Lei Zhang
      Drug Metabolism and Disposition September 2013, 41 (9) 1598-1609; DOI: https://doi.org/10.1124/dmd.113.052225

  3. King, Roberta S.

    1. Downregulation of Sulfotransferase Expression and Activity in Diseased Human Livers
      Emine B. Yalcin, Vijay More, Karissa L. Neira, Zhenqiang James Lu, Nathan J. Cherrington, Angela L. Slitt and Roberta S. King
      Drug Metabolism and Disposition September 2013, 41 (9) 1642-1650; DOI: https://doi.org/10.1124/dmd.113.050930

  4. Kittelmann, Matthias

    1. Metabolism and Disposition of the Metabotropic Glutamate Receptor 5 Antagonist (mGluR5) Mavoglurant (AFQ056) in Healthy Subjects
      Markus Walles, Thierry Wolf, Yi Jin, Michael Ritzau, Luc Alexis Leuthold, Joel Krauser, Hans-Peter Gschwind, David Carcache, Matthias Kittelmann, Magdalena Ocwieja, Mike Ufer, Ralph Woessner, Abhijit Chakraborty and Piet Swart
      Drug Metabolism and Disposition September 2013, 41 (9) 1626-1641; DOI: https://doi.org/10.1124/dmd.112.050716

  5. Krauser, Joel

    1. Metabolism and Disposition of the Metabotropic Glutamate Receptor 5 Antagonist (mGluR5) Mavoglurant (AFQ056) in Healthy Subjects
      Markus Walles, Thierry Wolf, Yi Jin, Michael Ritzau, Luc Alexis Leuthold, Joel Krauser, Hans-Peter Gschwind, David Carcache, Matthias Kittelmann, Magdalena Ocwieja, Mike Ufer, Ralph Woessner, Abhijit Chakraborty and Piet Swart
      Drug Metabolism and Disposition September 2013, 41 (9) 1626-1641; DOI: https://doi.org/10.1124/dmd.112.050716

  6. Kraynov, Eugenia

    1. Critical Review of Preclinical Approaches to Investigate Cytochrome P450–Mediated Therapeutic Protein Drug-Drug Interactions and Recommendations for Best Practices: A White Paper
      Raymond Evers, Shannon Dallas, Leslie J. Dickmann, Odette A. Fahmi, Jane R. Kenny, Eugenia Kraynov, Theresa Nguyen, Aarti H. Patel, J. Greg Slatter and Lei Zhang
      Drug Metabolism and Disposition September 2013, 41 (9) 1598-1609; DOI: https://doi.org/10.1124/dmd.113.052225

  7. Kunori, Mutsuki

    1. Characterization of Microsomal Glutathione S-Transferases MGST1, MGST2, and MGST3 in Cynomolgus Macaque
      Yasuhiro Uno, Norie Murayama, Mutsuki Kunori and Hiroshi Yamazaki
      Drug Metabolism and Disposition September 2013, 41 (9) 1621-1625; DOI: https://doi.org/10.1124/dmd.113.052977

L

  1. Lavery, Gareth G.

    1. Formation of Threohydrobupropion from Bupropion Is Dependent on 11β-Hydroxysteroid Dehydrogenase 1
      Arne Meyer, Anna Vuorinen, Agnieszka E. Zielinska, Petra Strajhar, Gareth G. Lavery, Daniela Schuster and Alex Odermatt
      Drug Metabolism and Disposition September 2013, 41 (9) 1671-1678; DOI: https://doi.org/10.1124/dmd.113.052936

  2. Leuthold, Luc Alexis

    1. Metabolism and Disposition of the Metabotropic Glutamate Receptor 5 Antagonist (mGluR5) Mavoglurant (AFQ056) in Healthy Subjects
      Markus Walles, Thierry Wolf, Yi Jin, Michael Ritzau, Luc Alexis Leuthold, Joel Krauser, Hans-Peter Gschwind, David Carcache, Matthias Kittelmann, Magdalena Ocwieja, Mike Ufer, Ralph Woessner, Abhijit Chakraborty and Piet Swart
      Drug Metabolism and Disposition September 2013, 41 (9) 1626-1641; DOI: https://doi.org/10.1124/dmd.112.050716

  3. Lindsley, Craig W.

    1. Biotransformation of a Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Contributes to Seizure-Like Adverse Events in Rats Involving a Receptor Agonism-Dependent Mechanism
      Thomas M. Bridges, Jerri M. Rook, Meredith J. Noetzel, Ryan D. Morrison, Ya Zhou, Rocco D. Gogliotti, Paige N. Vinson, Zixiu Xiang, Carrie K. Jones, Colleen M. Niswender, Craig W. Lindsley, Shaun R. Stauffer, P. Jeffrey Conn and J. Scott Daniels
      Drug Metabolism and Disposition September 2013, 41 (9) 1703-1714; DOI: https://doi.org/10.1124/dmd.113.052084

  4. Liu, Jinzhong

    1. Inhibition of Cytochrome P450 Enzymes by the E- and Z-Isomers of Norendoxifen
      Jinzhong Liu, Peter J. Flockhart, Deshun Lu, Wei Lv, Wenjie Jessie Lu, Xu Han, Mark Cushman and David A. Flockhart
      Drug Metabolism and Disposition September 2013, 41 (9) 1715-1720; DOI: https://doi.org/10.1124/dmd.113.052506

  5. Lu, Deshun

    1. Inhibition of Cytochrome P450 Enzymes by the E- and Z-Isomers of Norendoxifen
      Jinzhong Liu, Peter J. Flockhart, Deshun Lu, Wei Lv, Wenjie Jessie Lu, Xu Han, Mark Cushman and David A. Flockhart
      Drug Metabolism and Disposition September 2013, 41 (9) 1715-1720; DOI: https://doi.org/10.1124/dmd.113.052506

  6. Lu, Wenjie Jessie

    1. Inhibition of Cytochrome P450 Enzymes by the E- and Z-Isomers of Norendoxifen
      Jinzhong Liu, Peter J. Flockhart, Deshun Lu, Wei Lv, Wenjie Jessie Lu, Xu Han, Mark Cushman and David A. Flockhart
      Drug Metabolism and Disposition September 2013, 41 (9) 1715-1720; DOI: https://doi.org/10.1124/dmd.113.052506

  7. Lu, Zhenqiang James

    1. Downregulation of Sulfotransferase Expression and Activity in Diseased Human Livers
      Emine B. Yalcin, Vijay More, Karissa L. Neira, Zhenqiang James Lu, Nathan J. Cherrington, Angela L. Slitt and Roberta S. King
      Drug Metabolism and Disposition September 2013, 41 (9) 1642-1650; DOI: https://doi.org/10.1124/dmd.113.050930

  8. Lv, Wei

    1. Inhibition of Cytochrome P450 Enzymes by the E- and Z-Isomers of Norendoxifen
      Jinzhong Liu, Peter J. Flockhart, Deshun Lu, Wei Lv, Wenjie Jessie Lu, Xu Han, Mark Cushman and David A. Flockhart
      Drug Metabolism and Disposition September 2013, 41 (9) 1715-1720; DOI: https://doi.org/10.1124/dmd.113.052506

M

  1. Markowitz, John S.

    1. An Assessment of Pharmacokinetics and Antioxidant Activity of Free Silymarin Flavonolignans in Healthy Volunteers: A Dose Escalation Study
      Hao-Jie Zhu, Bryan J. Brinda, Kenneth D. Chavin, Hilary J. Bernstein, Kennerly S. Patrick and John S. Markowitz
      Drug Metabolism and Disposition September 2013, 41 (9) 1679-1685; DOI: https://doi.org/10.1124/dmd.113.052423

  2. Meyer, Arne

    1. Formation of Threohydrobupropion from Bupropion Is Dependent on 11β-Hydroxysteroid Dehydrogenase 1
      Arne Meyer, Anna Vuorinen, Agnieszka E. Zielinska, Petra Strajhar, Gareth G. Lavery, Daniela Schuster and Alex Odermatt
      Drug Metabolism and Disposition September 2013, 41 (9) 1671-1678; DOI: https://doi.org/10.1124/dmd.113.052936

  3. More, Vijay

    1. Downregulation of Sulfotransferase Expression and Activity in Diseased Human Livers
      Emine B. Yalcin, Vijay More, Karissa L. Neira, Zhenqiang James Lu, Nathan J. Cherrington, Angela L. Slitt and Roberta S. King
      Drug Metabolism and Disposition September 2013, 41 (9) 1642-1650; DOI: https://doi.org/10.1124/dmd.113.050930

  4. Morrison, Ryan D.

    1. Biotransformation of a Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Contributes to Seizure-Like Adverse Events in Rats Involving a Receptor Agonism-Dependent Mechanism
      Thomas M. Bridges, Jerri M. Rook, Meredith J. Noetzel, Ryan D. Morrison, Ya Zhou, Rocco D. Gogliotti, Paige N. Vinson, Zixiu Xiang, Carrie K. Jones, Colleen M. Niswender, Craig W. Lindsley, Shaun R. Stauffer, P. Jeffrey Conn and J. Scott Daniels
      Drug Metabolism and Disposition September 2013, 41 (9) 1703-1714; DOI: https://doi.org/10.1124/dmd.113.052084

  5. Murayama, Norie

    1. Characterization of Microsomal Glutathione S-Transferases MGST1, MGST2, and MGST3 in Cynomolgus Macaque
      Yasuhiro Uno, Norie Murayama, Mutsuki Kunori and Hiroshi Yamazaki
      Drug Metabolism and Disposition September 2013, 41 (9) 1621-1625; DOI: https://doi.org/10.1124/dmd.113.052977

N

  1. Neira, Karissa L.

    1. Downregulation of Sulfotransferase Expression and Activity in Diseased Human Livers
      Emine B. Yalcin, Vijay More, Karissa L. Neira, Zhenqiang James Lu, Nathan J. Cherrington, Angela L. Slitt and Roberta S. King
      Drug Metabolism and Disposition September 2013, 41 (9) 1642-1650; DOI: https://doi.org/10.1124/dmd.113.050930

  2. Nguyen, Theresa

    1. Critical Review of Preclinical Approaches to Investigate Cytochrome P450–Mediated Therapeutic Protein Drug-Drug Interactions and Recommendations for Best Practices: A White Paper
      Raymond Evers, Shannon Dallas, Leslie J. Dickmann, Odette A. Fahmi, Jane R. Kenny, Eugenia Kraynov, Theresa Nguyen, Aarti H. Patel, J. Greg Slatter and Lei Zhang
      Drug Metabolism and Disposition September 2013, 41 (9) 1598-1609; DOI: https://doi.org/10.1124/dmd.113.052225

  3. Niswender, Colleen M.

    1. Biotransformation of a Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Contributes to Seizure-Like Adverse Events in Rats Involving a Receptor Agonism-Dependent Mechanism
      Thomas M. Bridges, Jerri M. Rook, Meredith J. Noetzel, Ryan D. Morrison, Ya Zhou, Rocco D. Gogliotti, Paige N. Vinson, Zixiu Xiang, Carrie K. Jones, Colleen M. Niswender, Craig W. Lindsley, Shaun R. Stauffer, P. Jeffrey Conn and J. Scott Daniels
      Drug Metabolism and Disposition September 2013, 41 (9) 1703-1714; DOI: https://doi.org/10.1124/dmd.113.052084

  4. Noetzel, Meredith J.

    1. Biotransformation of a Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Contributes to Seizure-Like Adverse Events in Rats Involving a Receptor Agonism-Dependent Mechanism
      Thomas M. Bridges, Jerri M. Rook, Meredith J. Noetzel, Ryan D. Morrison, Ya Zhou, Rocco D. Gogliotti, Paige N. Vinson, Zixiu Xiang, Carrie K. Jones, Colleen M. Niswender, Craig W. Lindsley, Shaun R. Stauffer, P. Jeffrey Conn and J. Scott Daniels
      Drug Metabolism and Disposition September 2013, 41 (9) 1703-1714; DOI: https://doi.org/10.1124/dmd.113.052084

O

  1. Oberlies, Nicholas H.

    1. A Systematic Approach to Evaluate Herb-Drug Interaction Mechanisms: Investigation of Milk Thistle Extracts and Eight Isolated Constituents as CYP3A Inhibitors
      Scott J. Brantley, Tyler N. Graf, Nicholas H. Oberlies and Mary F. Paine
      Drug Metabolism and Disposition September 2013, 41 (9) 1662-1670; DOI: https://doi.org/10.1124/dmd.113.052563

  2. Ocwieja, Magdalena

    1. Metabolism and Disposition of the Metabotropic Glutamate Receptor 5 Antagonist (mGluR5) Mavoglurant (AFQ056) in Healthy Subjects
      Markus Walles, Thierry Wolf, Yi Jin, Michael Ritzau, Luc Alexis Leuthold, Joel Krauser, Hans-Peter Gschwind, David Carcache, Matthias Kittelmann, Magdalena Ocwieja, Mike Ufer, Ralph Woessner, Abhijit Chakraborty and Piet Swart
      Drug Metabolism and Disposition September 2013, 41 (9) 1626-1641; DOI: https://doi.org/10.1124/dmd.112.050716

  3. Odermatt, Alex

    1. Formation of Threohydrobupropion from Bupropion Is Dependent on 11β-Hydroxysteroid Dehydrogenase 1
      Arne Meyer, Anna Vuorinen, Agnieszka E. Zielinska, Petra Strajhar, Gareth G. Lavery, Daniela Schuster and Alex Odermatt
      Drug Metabolism and Disposition September 2013, 41 (9) 1671-1678; DOI: https://doi.org/10.1124/dmd.113.052936

P

  1. Paine, Mary F.

    1. A Systematic Approach to Evaluate Herb-Drug Interaction Mechanisms: Investigation of Milk Thistle Extracts and Eight Isolated Constituents as CYP3A Inhibitors
      Scott J. Brantley, Tyler N. Graf, Nicholas H. Oberlies and Mary F. Paine
      Drug Metabolism and Disposition September 2013, 41 (9) 1662-1670; DOI: https://doi.org/10.1124/dmd.113.052563

  2. Parini, Paolo

    1. Atorvastatin Treatment Induces Uptake and Efflux Transporters in Human Liver
      Linda Björkhem-Bergman, Helena Bergström, Maria Johansson, Paolo Parini, Mats Eriksson, Anders Rane and Lena Ekström
      Drug Metabolism and Disposition September 2013, 41 (9) 1610-1615; DOI: https://doi.org/10.1124/dmd.113.051698

  3. Patel, Aarti H.

    1. Critical Review of Preclinical Approaches to Investigate Cytochrome P450–Mediated Therapeutic Protein Drug-Drug Interactions and Recommendations for Best Practices: A White Paper
      Raymond Evers, Shannon Dallas, Leslie J. Dickmann, Odette A. Fahmi, Jane R. Kenny, Eugenia Kraynov, Theresa Nguyen, Aarti H. Patel, J. Greg Slatter and Lei Zhang
      Drug Metabolism and Disposition September 2013, 41 (9) 1598-1609; DOI: https://doi.org/10.1124/dmd.113.052225

  4. Patrick, Kennerly S.

    1. An Assessment of Pharmacokinetics and Antioxidant Activity of Free Silymarin Flavonolignans in Healthy Volunteers: A Dose Escalation Study
      Hao-Jie Zhu, Bryan J. Brinda, Kenneth D. Chavin, Hilary J. Bernstein, Kennerly S. Patrick and John S. Markowitz
      Drug Metabolism and Disposition September 2013, 41 (9) 1679-1685; DOI: https://doi.org/10.1124/dmd.113.052423

  5. Pearce, Robin E.

    1. The Role of Human Cytochrome P450 Enzymes in the Formation of 2-Hydroxymetronidazole: CYP2A6 is the High Affinity (Low Km) Catalyst
      Robin E. Pearce, Michael Cohen-Wolkowiez, Mario R. Sampson and Gregory L. Kearns
      Drug Metabolism and Disposition September 2013, 41 (9) 1686-1694; DOI: https://doi.org/10.1124/dmd.113.052548

  6. Perreault, Martin

    1. The Human UDP-Glucuronosyltransferase UGT2A1 and UGT2A2 Enzymes Are Highly Active in Bile Acid Glucuronidation
      Martin Perreault, Louis Gauthier-Landry, Jocelyn Trottier, Mélanie Verreault, Patrick Caron, Moshe Finel and Olivier Barbier
      Drug Metabolism and Disposition September 2013, 41 (9) 1616-1620; DOI: https://doi.org/10.1124/dmd.113.052613

R

  1. Rane, Anders

    1. Atorvastatin Treatment Induces Uptake and Efflux Transporters in Human Liver
      Linda Björkhem-Bergman, Helena Bergström, Maria Johansson, Paolo Parini, Mats Eriksson, Anders Rane and Lena Ekström
      Drug Metabolism and Disposition September 2013, 41 (9) 1610-1615; DOI: https://doi.org/10.1124/dmd.113.051698

  2. Renbarger, Jamie L.

    1. The Relative Contributions of CYP3A4 and CYP3A5 to the Metabolism of Vinorelbine
      Ariel R. Topletz, Jennifer B. Dennison, Robert J. Barbuch, Chad E. Hadden, Stephen D. Hall and Jamie L. Renbarger
      Drug Metabolism and Disposition September 2013, 41 (9) 1651-1661; DOI: https://doi.org/10.1124/dmd.113.051094

  3. Ritzau, Michael

    1. Metabolism and Disposition of the Metabotropic Glutamate Receptor 5 Antagonist (mGluR5) Mavoglurant (AFQ056) in Healthy Subjects
      Markus Walles, Thierry Wolf, Yi Jin, Michael Ritzau, Luc Alexis Leuthold, Joel Krauser, Hans-Peter Gschwind, David Carcache, Matthias Kittelmann, Magdalena Ocwieja, Mike Ufer, Ralph Woessner, Abhijit Chakraborty and Piet Swart
      Drug Metabolism and Disposition September 2013, 41 (9) 1626-1641; DOI: https://doi.org/10.1124/dmd.112.050716

  4. Rook, Jerri M.

    1. Biotransformation of a Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Contributes to Seizure-Like Adverse Events in Rats Involving a Receptor Agonism-Dependent Mechanism
      Thomas M. Bridges, Jerri M. Rook, Meredith J. Noetzel, Ryan D. Morrison, Ya Zhou, Rocco D. Gogliotti, Paige N. Vinson, Zixiu Xiang, Carrie K. Jones, Colleen M. Niswender, Craig W. Lindsley, Shaun R. Stauffer, P. Jeffrey Conn and J. Scott Daniels
      Drug Metabolism and Disposition September 2013, 41 (9) 1703-1714; DOI: https://doi.org/10.1124/dmd.113.052084

S

  1. Sampson, Mario R.

    1. The Role of Human Cytochrome P450 Enzymes in the Formation of 2-Hydroxymetronidazole: CYP2A6 is the High Affinity (Low Km) Catalyst
      Robin E. Pearce, Michael Cohen-Wolkowiez, Mario R. Sampson and Gregory L. Kearns
      Drug Metabolism and Disposition September 2013, 41 (9) 1686-1694; DOI: https://doi.org/10.1124/dmd.113.052548

  2. Schuster, Daniela

    1. Formation of Threohydrobupropion from Bupropion Is Dependent on 11β-Hydroxysteroid Dehydrogenase 1
      Arne Meyer, Anna Vuorinen, Agnieszka E. Zielinska, Petra Strajhar, Gareth G. Lavery, Daniela Schuster and Alex Odermatt
      Drug Metabolism and Disposition September 2013, 41 (9) 1671-1678; DOI: https://doi.org/10.1124/dmd.113.052936

  3. Slatter, J. Greg

    1. Critical Review of Preclinical Approaches to Investigate Cytochrome P450–Mediated Therapeutic Protein Drug-Drug Interactions and Recommendations for Best Practices: A White Paper
      Raymond Evers, Shannon Dallas, Leslie J. Dickmann, Odette A. Fahmi, Jane R. Kenny, Eugenia Kraynov, Theresa Nguyen, Aarti H. Patel, J. Greg Slatter and Lei Zhang
      Drug Metabolism and Disposition September 2013, 41 (9) 1598-1609; DOI: https://doi.org/10.1124/dmd.113.052225

  4. Slitt, Angela L.

    1. Downregulation of Sulfotransferase Expression and Activity in Diseased Human Livers
      Emine B. Yalcin, Vijay More, Karissa L. Neira, Zhenqiang James Lu, Nathan J. Cherrington, Angela L. Slitt and Roberta S. King
      Drug Metabolism and Disposition September 2013, 41 (9) 1642-1650; DOI: https://doi.org/10.1124/dmd.113.050930

  5. Stauffer, Shaun R.

    1. Biotransformation of a Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Contributes to Seizure-Like Adverse Events in Rats Involving a Receptor Agonism-Dependent Mechanism
      Thomas M. Bridges, Jerri M. Rook, Meredith J. Noetzel, Ryan D. Morrison, Ya Zhou, Rocco D. Gogliotti, Paige N. Vinson, Zixiu Xiang, Carrie K. Jones, Colleen M. Niswender, Craig W. Lindsley, Shaun R. Stauffer, P. Jeffrey Conn and J. Scott Daniels
      Drug Metabolism and Disposition September 2013, 41 (9) 1703-1714; DOI: https://doi.org/10.1124/dmd.113.052084

  6. Strajhar, Petra

    1. Formation of Threohydrobupropion from Bupropion Is Dependent on 11β-Hydroxysteroid Dehydrogenase 1
      Arne Meyer, Anna Vuorinen, Agnieszka E. Zielinska, Petra Strajhar, Gareth G. Lavery, Daniela Schuster and Alex Odermatt
      Drug Metabolism and Disposition September 2013, 41 (9) 1671-1678; DOI: https://doi.org/10.1124/dmd.113.052936

  7. Swart, Piet

    1. Metabolism and Disposition of the Metabotropic Glutamate Receptor 5 Antagonist (mGluR5) Mavoglurant (AFQ056) in Healthy Subjects
      Markus Walles, Thierry Wolf, Yi Jin, Michael Ritzau, Luc Alexis Leuthold, Joel Krauser, Hans-Peter Gschwind, David Carcache, Matthias Kittelmann, Magdalena Ocwieja, Mike Ufer, Ralph Woessner, Abhijit Chakraborty and Piet Swart
      Drug Metabolism and Disposition September 2013, 41 (9) 1626-1641; DOI: https://doi.org/10.1124/dmd.112.050716

T

  1. Thakker, Dhiren R.

    1. Intestinal First-Pass Metabolism by Cytochrome P450 and Not P-Glycoprotein Is the Major Barrier to Amprenavir Absorption
      Matthew B. Dufek, Arlene S. Bridges and Dhiren R. Thakker
      Drug Metabolism and Disposition September 2013, 41 (9) 1695-1702; DOI: https://doi.org/10.1124/dmd.113.052191

  2. Topletz, Ariel R.

    1. The Relative Contributions of CYP3A4 and CYP3A5 to the Metabolism of Vinorelbine
      Ariel R. Topletz, Jennifer B. Dennison, Robert J. Barbuch, Chad E. Hadden, Stephen D. Hall and Jamie L. Renbarger
      Drug Metabolism and Disposition September 2013, 41 (9) 1651-1661; DOI: https://doi.org/10.1124/dmd.113.051094

  3. Trottier, Jocelyn

    1. The Human UDP-Glucuronosyltransferase UGT2A1 and UGT2A2 Enzymes Are Highly Active in Bile Acid Glucuronidation
      Martin Perreault, Louis Gauthier-Landry, Jocelyn Trottier, Mélanie Verreault, Patrick Caron, Moshe Finel and Olivier Barbier
      Drug Metabolism and Disposition September 2013, 41 (9) 1616-1620; DOI: https://doi.org/10.1124/dmd.113.052613

U

  1. Ufer, Mike

    1. Metabolism and Disposition of the Metabotropic Glutamate Receptor 5 Antagonist (mGluR5) Mavoglurant (AFQ056) in Healthy Subjects
      Markus Walles, Thierry Wolf, Yi Jin, Michael Ritzau, Luc Alexis Leuthold, Joel Krauser, Hans-Peter Gschwind, David Carcache, Matthias Kittelmann, Magdalena Ocwieja, Mike Ufer, Ralph Woessner, Abhijit Chakraborty and Piet Swart
      Drug Metabolism and Disposition September 2013, 41 (9) 1626-1641; DOI: https://doi.org/10.1124/dmd.112.050716

  2. Uno, Yasuhiro

    1. Characterization of Microsomal Glutathione S-Transferases MGST1, MGST2, and MGST3 in Cynomolgus Macaque
      Yasuhiro Uno, Norie Murayama, Mutsuki Kunori and Hiroshi Yamazaki
      Drug Metabolism and Disposition September 2013, 41 (9) 1621-1625; DOI: https://doi.org/10.1124/dmd.113.052977

V

  1. Verreault, Mélanie

    1. The Human UDP-Glucuronosyltransferase UGT2A1 and UGT2A2 Enzymes Are Highly Active in Bile Acid Glucuronidation
      Martin Perreault, Louis Gauthier-Landry, Jocelyn Trottier, Mélanie Verreault, Patrick Caron, Moshe Finel and Olivier Barbier
      Drug Metabolism and Disposition September 2013, 41 (9) 1616-1620; DOI: https://doi.org/10.1124/dmd.113.052613

  2. Vinson, Paige N.

    1. Biotransformation of a Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Contributes to Seizure-Like Adverse Events in Rats Involving a Receptor Agonism-Dependent Mechanism
      Thomas M. Bridges, Jerri M. Rook, Meredith J. Noetzel, Ryan D. Morrison, Ya Zhou, Rocco D. Gogliotti, Paige N. Vinson, Zixiu Xiang, Carrie K. Jones, Colleen M. Niswender, Craig W. Lindsley, Shaun R. Stauffer, P. Jeffrey Conn and J. Scott Daniels
      Drug Metabolism and Disposition September 2013, 41 (9) 1703-1714; DOI: https://doi.org/10.1124/dmd.113.052084

  3. Vuorinen, Anna

    1. Formation of Threohydrobupropion from Bupropion Is Dependent on 11β-Hydroxysteroid Dehydrogenase 1
      Arne Meyer, Anna Vuorinen, Agnieszka E. Zielinska, Petra Strajhar, Gareth G. Lavery, Daniela Schuster and Alex Odermatt
      Drug Metabolism and Disposition September 2013, 41 (9) 1671-1678; DOI: https://doi.org/10.1124/dmd.113.052936

W

  1. Walles, Markus

    1. Metabolism and Disposition of the Metabotropic Glutamate Receptor 5 Antagonist (mGluR5) Mavoglurant (AFQ056) in Healthy Subjects
      Markus Walles, Thierry Wolf, Yi Jin, Michael Ritzau, Luc Alexis Leuthold, Joel Krauser, Hans-Peter Gschwind, David Carcache, Matthias Kittelmann, Magdalena Ocwieja, Mike Ufer, Ralph Woessner, Abhijit Chakraborty and Piet Swart
      Drug Metabolism and Disposition September 2013, 41 (9) 1626-1641; DOI: https://doi.org/10.1124/dmd.112.050716

  2. Woessner, Ralph

    1. Metabolism and Disposition of the Metabotropic Glutamate Receptor 5 Antagonist (mGluR5) Mavoglurant (AFQ056) in Healthy Subjects
      Markus Walles, Thierry Wolf, Yi Jin, Michael Ritzau, Luc Alexis Leuthold, Joel Krauser, Hans-Peter Gschwind, David Carcache, Matthias Kittelmann, Magdalena Ocwieja, Mike Ufer, Ralph Woessner, Abhijit Chakraborty and Piet Swart
      Drug Metabolism and Disposition September 2013, 41 (9) 1626-1641; DOI: https://doi.org/10.1124/dmd.112.050716

  3. Wolf, Thierry

    1. Metabolism and Disposition of the Metabotropic Glutamate Receptor 5 Antagonist (mGluR5) Mavoglurant (AFQ056) in Healthy Subjects
      Markus Walles, Thierry Wolf, Yi Jin, Michael Ritzau, Luc Alexis Leuthold, Joel Krauser, Hans-Peter Gschwind, David Carcache, Matthias Kittelmann, Magdalena Ocwieja, Mike Ufer, Ralph Woessner, Abhijit Chakraborty and Piet Swart
      Drug Metabolism and Disposition September 2013, 41 (9) 1626-1641; DOI: https://doi.org/10.1124/dmd.112.050716

X

  1. Xiang, Zixiu

    1. Biotransformation of a Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Contributes to Seizure-Like Adverse Events in Rats Involving a Receptor Agonism-Dependent Mechanism
      Thomas M. Bridges, Jerri M. Rook, Meredith J. Noetzel, Ryan D. Morrison, Ya Zhou, Rocco D. Gogliotti, Paige N. Vinson, Zixiu Xiang, Carrie K. Jones, Colleen M. Niswender, Craig W. Lindsley, Shaun R. Stauffer, P. Jeffrey Conn and J. Scott Daniels
      Drug Metabolism and Disposition September 2013, 41 (9) 1703-1714; DOI: https://doi.org/10.1124/dmd.113.052084

Y

  1. Yalcin, Emine B.

    1. Downregulation of Sulfotransferase Expression and Activity in Diseased Human Livers
      Emine B. Yalcin, Vijay More, Karissa L. Neira, Zhenqiang James Lu, Nathan J. Cherrington, Angela L. Slitt and Roberta S. King
      Drug Metabolism and Disposition September 2013, 41 (9) 1642-1650; DOI: https://doi.org/10.1124/dmd.113.050930

  2. Yamazaki, Hiroshi

    1. Characterization of Microsomal Glutathione S-Transferases MGST1, MGST2, and MGST3 in Cynomolgus Macaque
      Yasuhiro Uno, Norie Murayama, Mutsuki Kunori and Hiroshi Yamazaki
      Drug Metabolism and Disposition September 2013, 41 (9) 1621-1625; DOI: https://doi.org/10.1124/dmd.113.052977

Z

  1. Zhang, Lei

    1. Critical Review of Preclinical Approaches to Investigate Cytochrome P450–Mediated Therapeutic Protein Drug-Drug Interactions and Recommendations for Best Practices: A White Paper
      Raymond Evers, Shannon Dallas, Leslie J. Dickmann, Odette A. Fahmi, Jane R. Kenny, Eugenia Kraynov, Theresa Nguyen, Aarti H. Patel, J. Greg Slatter and Lei Zhang
      Drug Metabolism and Disposition September 2013, 41 (9) 1598-1609; DOI: https://doi.org/10.1124/dmd.113.052225

  2. Zhou, Ya

    1. Biotransformation of a Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Contributes to Seizure-Like Adverse Events in Rats Involving a Receptor Agonism-Dependent Mechanism
      Thomas M. Bridges, Jerri M. Rook, Meredith J. Noetzel, Ryan D. Morrison, Ya Zhou, Rocco D. Gogliotti, Paige N. Vinson, Zixiu Xiang, Carrie K. Jones, Colleen M. Niswender, Craig W. Lindsley, Shaun R. Stauffer, P. Jeffrey Conn and J. Scott Daniels
      Drug Metabolism and Disposition September 2013, 41 (9) 1703-1714; DOI: https://doi.org/10.1124/dmd.113.052084

  3. Zhu, Hao-Jie

    1. An Assessment of Pharmacokinetics and Antioxidant Activity of Free Silymarin Flavonolignans in Healthy Volunteers: A Dose Escalation Study
      Hao-Jie Zhu, Bryan J. Brinda, Kenneth D. Chavin, Hilary J. Bernstein, Kennerly S. Patrick and John S. Markowitz
      Drug Metabolism and Disposition September 2013, 41 (9) 1679-1685; DOI: https://doi.org/10.1124/dmd.113.052423

  4. Zielinska, Agnieszka E.

    1. Formation of Threohydrobupropion from Bupropion Is Dependent on 11β-Hydroxysteroid Dehydrogenase 1
      Arne Meyer, Anna Vuorinen, Agnieszka E. Zielinska, Petra Strajhar, Gareth G. Lavery, Daniela Schuster and Alex Odermatt
      Drug Metabolism and Disposition September 2013, 41 (9) 1671-1678; DOI: https://doi.org/10.1124/dmd.113.052936
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