Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Drug Metabolism & Disposition
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Drug Metabolism & Disposition

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Visit dmd on Facebook
  • Follow dmd on Twitter
  • Follow ASPET on LinkedIn
Research ArticleArticle

A Systematic Approach to Evaluate Herb-Drug Interaction Mechanisms: Investigation of Milk Thistle Extracts and Eight Isolated Constituents as CYP3A Inhibitors

Scott J. Brantley, Tyler N. Graf, Nicholas H. Oberlies and Mary F. Paine
Drug Metabolism and Disposition September 2013, 41 (9) 1662-1670; DOI: https://doi.org/10.1124/dmd.113.052563
Scott J. Brantley
Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (S.J.B., M.F.P.); and Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina (T.N.G., N.H.O.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tyler N. Graf
Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (S.J.B., M.F.P.); and Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina (T.N.G., N.H.O.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nicholas H. Oberlies
Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (S.J.B., M.F.P.); and Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina (T.N.G., N.H.O.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mary F. Paine
Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (S.J.B., M.F.P.); and Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina (T.N.G., N.H.O.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Article Information

vol. 41 no. 9 1662-1670
DOI 
https://doi.org/10.1124/dmd.113.052563
PubMed 
23801821

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received April 18, 2012
  • Accepted June 25, 2013
  • Published online August 13, 2013.

Article Versions

  • Earlier version (June 25, 2013 - 10:53).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Scott J. Brantley,
  2. Tyler N. Graf,
  3. Nicholas H. Oberlies, and
  4. Mary F. Paine
  1. Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (S.J.B., M.F.P.); and Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina (T.N.G., N.H.O.)
  1. Address correspondence to:
    Dr. Mary F. Paine, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, 2320 Kerr Hall, CB #7569, Chapel Hill, NC 27599-7569. E-mail: mpaine{at}unc.edu
View Full Text

Statistics from Altmetric.com

Article usage

Article usage: June 2013 to February 2021

AbstractFullPdf
Jun 2013192053
Jul 20132812107
Aug 20136362591
Sep 20136041838
Oct 20133842039
Nov 2013254925
Dec 2013131920
Jan 201467418
Feb 2014881321
Mar 20144266
Apr 201438510
May 20143199
Jun 2014391718
Jul 201444410
Aug 20144035
Sep 2014471637
Oct 2014421018
Nov 2014332122
Dec 201433614
Jan 2015361122
Feb 201516711
Mar 2015381114
Apr 201533612
May 201571911
Jun 2015281112
Jul 201522129
Aug 2015241417
Sep 20152585
Oct 2015401021
Nov 2015361613
Dec 20152189
Jan 201635513
Feb 201618611
Mar 2016181216
Apr 2016312112
May 201619415
Jun 201628125
Jul 20161364
Aug 20163174
Sep 20161687
Oct 2016172318
Nov 2016103525
Dec 201633847
Jan 201753221
Feb 201722611
Mar 201761723
Apr 20171255
May 20174228
Jun 20173197
Jul 201711811
Aug 20171237
Sep 20173309
Oct 20171416
Nov 20172417
Dec 20172123
Jan 20184245
Feb 20183228
Mar 20186377
Apr 201843010
May 20181207
Jun 201822910
Jul 20180158
Aug 2018093
Sep 20182185
Oct 201854810
Nov 201826415
Dec 201850235
Jan 201974105
Feb 201967191
Mar 201930189
Apr 20192397
May 20192375
Jun 201917113
Jul 2019921
Aug 20191412
Sep 20191913
Oct 20191646
Nov 20192322
Dec 20192954
Jan 20202341
Feb 20201314
Mar 20203611
Apr 20201322
May 20201612
Jun 20201825
Jul 20203017
Aug 2020534
Sep 20202471
Oct 20203842
Nov 20202220
Dec 20203698
Jan 20212874
Feb 20212651

PreviousNext
Back to top

In this issue

Drug Metabolism and Disposition: 41 (9)
Drug Metabolism and Disposition
Vol. 41, Issue 9
1 Sep 2013
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Drug Metabolism & Disposition article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
A Systematic Approach to Evaluate Herb-Drug Interaction Mechanisms: Investigation of Milk Thistle Extracts and Eight Isolated Constituents as CYP3A Inhibitors
(Your Name) has forwarded a page to you from Drug Metabolism & Disposition
(Your Name) thought you would be interested in this article in Drug Metabolism & Disposition.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleArticle

Milk Thistle Flavonolignans Inhibit CYP3A Activity

Scott J. Brantley, Tyler N. Graf, Nicholas H. Oberlies and Mary F. Paine
Drug Metabolism and Disposition September 1, 2013, 41 (9) 1662-1670; DOI: https://doi.org/10.1124/dmd.113.052563

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Research ArticleArticle

Milk Thistle Flavonolignans Inhibit CYP3A Activity

Scott J. Brantley, Tyler N. Graf, Nicholas H. Oberlies and Mary F. Paine
Drug Metabolism and Disposition September 1, 2013, 41 (9) 1662-1670; DOI: https://doi.org/10.1124/dmd.113.052563
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Acknowledgments
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • In Vivo Functional Effects of CYP2C9 M1L
  • Clearance pathways: fevipiprant with probenecid perpetrator
  • Predicting Volume of Distribution from In Vitro Parameters
Show more Articles

Similar Articles

  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About DMD
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Journal of Pharmacology and Experimental Therapeutics
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-009X (Online)

Copyright © 2021 by the American Society for Pharmacology and Experimental Therapeutics