Research ArticleArticle
Biotransformation of a Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Contributes to Seizure-Like Adverse Events in Rats Involving a Receptor Agonism-Dependent Mechanism
Thomas M. Bridges, Jerri M. Rook, Meredith J. Noetzel, Ryan D. Morrison, Ya Zhou, Rocco D. Gogliotti, Paige N. Vinson, Zixiu Xiang, Carrie K. Jones, Colleen M. Niswender, Craig W. Lindsley, Shaun R. Stauffer, P. Jeffrey Conn and J. Scott Daniels
Drug Metabolism and Disposition September 2013, 41 (9) 1703-1714; DOI: https://doi.org/10.1124/dmd.113.052084
Thomas M. Bridges
Departments of Pharmacology (T.M.B., R.D.M., Y.Z., R.D.G., J.S.D., J.M.R., M.J.N., P.N.V., Z.X., C.M.N., P.J.C., C.K.J., C.W.L., S.R.S.) and Chemistry (C.W.L.),Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, Tennessee
Jerri M. Rook
Departments of Pharmacology (T.M.B., R.D.M., Y.Z., R.D.G., J.S.D., J.M.R., M.J.N., P.N.V., Z.X., C.M.N., P.J.C., C.K.J., C.W.L., S.R.S.) and Chemistry (C.W.L.),Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, Tennessee
Meredith J. Noetzel
Departments of Pharmacology (T.M.B., R.D.M., Y.Z., R.D.G., J.S.D., J.M.R., M.J.N., P.N.V., Z.X., C.M.N., P.J.C., C.K.J., C.W.L., S.R.S.) and Chemistry (C.W.L.),Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, Tennessee
Ryan D. Morrison
Departments of Pharmacology (T.M.B., R.D.M., Y.Z., R.D.G., J.S.D., J.M.R., M.J.N., P.N.V., Z.X., C.M.N., P.J.C., C.K.J., C.W.L., S.R.S.) and Chemistry (C.W.L.),Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, Tennessee
Ya Zhou
Departments of Pharmacology (T.M.B., R.D.M., Y.Z., R.D.G., J.S.D., J.M.R., M.J.N., P.N.V., Z.X., C.M.N., P.J.C., C.K.J., C.W.L., S.R.S.) and Chemistry (C.W.L.),Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, Tennessee
Rocco D. Gogliotti
Departments of Pharmacology (T.M.B., R.D.M., Y.Z., R.D.G., J.S.D., J.M.R., M.J.N., P.N.V., Z.X., C.M.N., P.J.C., C.K.J., C.W.L., S.R.S.) and Chemistry (C.W.L.),Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, Tennessee
Paige N. Vinson
Departments of Pharmacology (T.M.B., R.D.M., Y.Z., R.D.G., J.S.D., J.M.R., M.J.N., P.N.V., Z.X., C.M.N., P.J.C., C.K.J., C.W.L., S.R.S.) and Chemistry (C.W.L.),Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, Tennessee
Zixiu Xiang
Departments of Pharmacology (T.M.B., R.D.M., Y.Z., R.D.G., J.S.D., J.M.R., M.J.N., P.N.V., Z.X., C.M.N., P.J.C., C.K.J., C.W.L., S.R.S.) and Chemistry (C.W.L.),Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, Tennessee
Carrie K. Jones
Departments of Pharmacology (T.M.B., R.D.M., Y.Z., R.D.G., J.S.D., J.M.R., M.J.N., P.N.V., Z.X., C.M.N., P.J.C., C.K.J., C.W.L., S.R.S.) and Chemistry (C.W.L.),Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, Tennessee
Colleen M. Niswender
Departments of Pharmacology (T.M.B., R.D.M., Y.Z., R.D.G., J.S.D., J.M.R., M.J.N., P.N.V., Z.X., C.M.N., P.J.C., C.K.J., C.W.L., S.R.S.) and Chemistry (C.W.L.),Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, Tennessee
Craig W. Lindsley
Departments of Pharmacology (T.M.B., R.D.M., Y.Z., R.D.G., J.S.D., J.M.R., M.J.N., P.N.V., Z.X., C.M.N., P.J.C., C.K.J., C.W.L., S.R.S.) and Chemistry (C.W.L.),Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, Tennessee
Shaun R. Stauffer
Departments of Pharmacology (T.M.B., R.D.M., Y.Z., R.D.G., J.S.D., J.M.R., M.J.N., P.N.V., Z.X., C.M.N., P.J.C., C.K.J., C.W.L., S.R.S.) and Chemistry (C.W.L.),Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, Tennessee
P. Jeffrey Conn
Departments of Pharmacology (T.M.B., R.D.M., Y.Z., R.D.G., J.S.D., J.M.R., M.J.N., P.N.V., Z.X., C.M.N., P.J.C., C.K.J., C.W.L., S.R.S.) and Chemistry (C.W.L.),Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, Tennessee
J. Scott Daniels
Departments of Pharmacology (T.M.B., R.D.M., Y.Z., R.D.G., J.S.D., J.M.R., M.J.N., P.N.V., Z.X., C.M.N., P.J.C., C.K.J., C.W.L., S.R.S.) and Chemistry (C.W.L.),Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, Tennessee
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Biotransformation of mGlu5 PAM to Active Agonist Metabolite
Thomas M. Bridges, Jerri M. Rook, Meredith J. Noetzel, Ryan D. Morrison, Ya Zhou, Rocco D. Gogliotti, Paige N. Vinson, Zixiu Xiang, Carrie K. Jones, Colleen M. Niswender, Craig W. Lindsley, Shaun R. Stauffer, P. Jeffrey Conn and J. Scott Daniels
Drug Metabolism and Disposition September 1, 2013, 41 (9) 1703-1714; DOI: https://doi.org/10.1124/dmd.113.052084
Research ArticleArticle
Biotransformation of mGlu5 PAM to Active Agonist Metabolite
Thomas M. Bridges, Jerri M. Rook, Meredith J. Noetzel, Ryan D. Morrison, Ya Zhou, Rocco D. Gogliotti, Paige N. Vinson, Zixiu Xiang, Carrie K. Jones, Colleen M. Niswender, Craig W. Lindsley, Shaun R. Stauffer, P. Jeffrey Conn and J. Scott Daniels
Drug Metabolism and Disposition September 1, 2013, 41 (9) 1703-1714; DOI: https://doi.org/10.1124/dmd.113.052084
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