Table of Contents

Articles

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  Evaluation and Mechanistic Analysis of the Cytotoxicity of the Acyl Glucuronide of Nonsteroidal Anti-Inflammatory Drugs

  Taishi Miyashita, Kento Kimura, Tatsuki Fukami, Miki Nakajima and Tsuyoshi Yokoi

  Drug Metabolism and Disposition January 2014, 42 (1) 1-8; DOI: https://doi.org/10.1124/dmd.113.054478
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  MicroRNA-561 Promotes Acetaminophen-Induced Hepatotoxicity in HepG2 Cells and Primary Human Hepatocytes through Downregulation of the Nuclear Receptor Corepressor Dosage-Sensitive Sex-Reversal Adrenal Hypoplasia Congenital Critical Region on the X Chromosome, Gene 1 (DAX-1)

  Minghua Li, Yinxue Yang, Zhi-Xu He, Zhi-Wei Zhou, Tianxin Yang, Peixuan Guo, Xueji Zhang and Shu-Feng Zhou

  Drug Metabolism and Disposition January 2014, 42 (1) 44-61; DOI: https://doi.org/10.1124/dmd.113.052670
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  Oatp1a1 Requires PDZK1 to Traffic to the Plasma Membrane by Selective Recruitment of Microtubule-Based Motor Proteins

  Wen-Jun Wang, John W. Murray and Allan W. Wolkoff

  Drug Metabolism and Disposition January 2014, 42 (1) 62-69; DOI: https://doi.org/10.1124/dmd.113.054536
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  A Role for Cytochrome b₅ in the In Vivo Disposition of Anticancer and Cytochrome P450 Probe Drugs in Mice

  Colin J. Henderson, Lesley A. McLaughlin, Robert D. Finn, Sebastien Ronseaux, Yury Kapelyukh and C. Roland Wolf

  Drug Metabolism and Disposition January 2014, 42 (1) 70-77; DOI: https://doi.org/10.1124/dmd.113.055277
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  Interindividual Variability in Hepatic Organic Anion-Transporting Polypeptides and P-Glycoprotein (ABCB1) Protein Expression: Quantification by Liquid Chromatography Tandem Mass Spectroscopy and Influence of Genotype, Age, and Sex

  Bhagwat Prasad, Raymond Evers, Anshul Gupta, Cornelis E. C. A. Hop, Laurent Salphati, Suneet Shukla, Suresh V. Ambudkar and Jashvant D. Unadkat

  Drug Metabolism and Disposition January 2014, 42 (1) 78-88; DOI: https://doi.org/10.1124/dmd.113.053819
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  Localization of Multidrug Resistance-Associated Proteins along the Blood-Testis Barrier in Rat, Macaque, and Human Testis

  David M. Klein, Stephen H. Wright and Nathan J. Cherrington

  Drug Metabolism and Disposition January 2014, 42 (1) 89-93; DOI: https://doi.org/10.1124/dmd.113.054577
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  Deoxyschizandrin, a Naturally Occurring Lignan, Is a Specific Probe Substrate of Human Cytochrome P450 3A

  Jingjing Wu, Yunfeng Cao, Yanyan Zhang, Yong Liu, James Y. Hong, Liangliang Zhu, Guangbo Ge and Ling Yang

  Drug Metabolism and Disposition January 2014, 42 (1) 94-104; DOI: https://doi.org/10.1124/dmd.113.053884
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  Association of Plasma Concentration of 4β-Hydroxycholesterol with CYP3A5 Polymorphism and Plasma Concentration of Indoxyl Sulfate in Stable Kidney Transplant Recipients

  Yosuke Suzuki, Hiroki Itoh, Takashi Fujioka, Fuminori Sato, Kanako Kawasaki, Yukie Sato, Yuhki Sato, Keiko Ohno, Hiromitsu Mimata and Satoshi Kishino

  Drug Metabolism and Disposition January 2014, 42 (1) 105-110; DOI: https://doi.org/10.1124/dmd.113.054171
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  Tissue-Specific Metabolism of Benzo[a]pyrene in Rainbow Trout (Oncorhynchus mykiss): A Comparison between the Liver and Immune Organs

  Anja-Maria Möller, Corinna Hermsen, Tilman Floehr, Marja H. Lamoree and Helmut Segner

  Drug Metabolism and Disposition January 2014, 42 (1) 111-118; DOI: https://doi.org/10.1124/dmd.113.053777
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  Nonlinear Pharmacokinetics of (±)3,4-Methylenedioxymethamphetamine (MDMA) and Its Pharmacodynamic Consequences in the Rat

  Marta Concheiro, Michael H. Baumann, Karl B. Scheidweiler, Richard B. Rothman, Gina F. Marrone and Marilyn A. Huestis

  Drug Metabolism and Disposition January 2014, 42 (1) 119-125; DOI: https://doi.org/10.1124/dmd.113.053678
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  In Vitro Drug Metabolism by Human Carboxylesterase 1: Focus on Angiotensin-Converting Enzyme Inhibitors

  Ragnar Thomsen, Henrik B. Rasmussen, Kristian Linnet and The INDICES Consortium

  Drug Metabolism and Disposition January 2014, 42 (1) 126-133; DOI: https://doi.org/10.1124/dmd.113.053512
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  Hepatic Cytochrome P450s, Phase II Enzymes and Nuclear Receptors Are Downregulated in a Th2 Environment during Schistosoma mansoni Infection

  Sylvie M. Mimche, Beatrice A. Nyagode, Matthew D. Merrell, Choon-Myung Lee, Nina S. Prasanphanich, Richard D. Cummings and Edward T. Morgan

  Drug Metabolism and Disposition January 2014, 42 (1) 134-140; DOI: https://doi.org/10.1124/dmd.113.054957
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  Multiple Cytochrome P450 Isoforms Are Involved in the Generation of a Pharmacologically Active Thiol Metabolite, whereas Paraoxonase 1 and Carboxylesterase 1 Catalyze the Formation of a Thiol Metabolite Isomer from Ticlopidine

  Min-Jung Kim, Eun Sook Jeong, Jung-Soon Park, Su-Jun Lee, Jong Lyul Ghim, Chang-Soo Choi, Jae-Gook Shin and Dong-Hyun Kim

  Drug Metabolism and Disposition January 2014, 42 (1) 141-152; DOI: https://doi.org/10.1124/dmd.113.053017
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  In Vitro Hydrolysis and Transesterification of CDP323, an α4β1/α4β7 Integrin Antagonist Ester Prodrug

  Hugues Chanteux, Maria Rosa, Claude Delatour, Chandra Prakash, Steven Smith and Jean-Marie Nicolas

  Drug Metabolism and Disposition January 2014, 42 (1) 153-161; DOI: https://doi.org/10.1124/dmd.113.054049
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  Studies on the Role of Metabolic Activation in Tyrosine Kinase Inhibitor–Dependent Hepatotoxicity: Induction of CYP3A4 Enhances the Cytotoxicity of Lapatinib in HepaRG Cells

  Klarissa D. Hardy, Michelle D. Wahlin, Ioannis Papageorgiou, Jashvant D. Unadkat, Allan E. Rettie and Sidney D. Nelson

  Drug Metabolism and Disposition January 2014, 42 (1) 162-171; DOI: https://doi.org/10.1124/dmd.113.054817
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  Role of Constitutive Androstane Receptor in Toll-Like Receptor-Mediated Regulation of Gene Expression of Hepatic Drug-Metabolizing Enzymes and Transporters

  Pranav Shah, Tao Guo, David D. Moore and Romi Ghose

  Drug Metabolism and Disposition January 2014, 42 (1) 172-181; DOI: https://doi.org/10.1124/dmd.113.053850
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  Utility of Oatp1a/1b-Knockout and OATP1B1/3-Humanized Mice in the Study of OATP-Mediated Pharmacokinetics and Tissue Distribution: Case Studies with Pravastatin, Atorvastatin, Simvastatin, and Carboxydichlorofluorescein

  J. William Higgins, Jing Q. Bao, Alice B. Ke, Jason R. Manro, John K. Fallon, Philip C. Smith and Maciej J. Zamek-Gliszczynski

  Drug Metabolism and Disposition January 2014, 42 (1) 182-192; DOI: https://doi.org/10.1124/dmd.113.054783
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  In Vivo to In Vitro Effects of Six Bioactive Lignans of Wuzhi Tablet (Schisandra Sphenanthera Extract) on the CYP3A/P-glycoprotein–Mediated Absorption and Metabolism of Tacrolimus

  Xiao Ling Qin, Xiao Chen, Ying Wang, Xin Ping Xue, Ying Wang, Jia Li Li, Xue Ding Wang, Guo Ping Zhong, Chang Xi Wang, Hui Yang, Min Huang and Hui Chang Bi

  Drug Metabolism and Disposition January 2014, 42 (1) 193-199; DOI: https://doi.org/10.1124/dmd.113.053892