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Drug Metabolism & Disposition

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Table of Contents

January 01, 2014; Volume 42,Issue 1

Short Communications

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    Essential Role of the Cytochrome P450 Enzyme CYP2A5 in Olfactory Mucosal Toxicity of Naphthalene
    Jinping Hu, Li Sheng, Lei Li, Xin Zhou, Fang Xie, Jaime D’Agostino, Yan Li and Xinxin Ding
    Drug Metabolism and Disposition January 2014, 42 (1) 23-27; DOI: https://doi.org/10.1124/dmd.113.054429
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    Candidate Gene Polymorphisms in Patients with Acetaminophen-Induced Acute Liver Failure
    Michael H. Court, Inga Peter, Suwagmani Hazarika, Magdalini Vasiadi, David J. Greenblatt, William M. Lee and The Acute Liver Failure Study Group
    Drug Metabolism and Disposition January 2014, 42 (1) 28-32; DOI: https://doi.org/10.1124/dmd.113.053546
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    Selective Inhibition of Cytochrome P450 2D6 by Sarpogrelate and Its Active Metabolite, M-1, in Human Liver Microsomes
    Doo-Yeoun Cho, Soo Hyeon Bae, Joeng Kee Lee, Yang Weon Kim, Bom-Taeck Kim and Soo Kyung Bae
    Drug Metabolism and Disposition January 2014, 42 (1) 33-39; DOI: https://doi.org/10.1124/dmd.113.054296
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    Effects of Single-Nucleotide Polymorphisms of FMO3 and FMO6 Genes on Pharmacokinetic Characteristics of Sulindac Sulfide in Premature Labor
    Sunny Park, Na Ra Lee, Kyung Eun Lee, Jin Young Park, Young Ju Kim and Hye Sun Gwak
    Drug Metabolism and Disposition January 2014, 42 (1) 40-43; DOI: https://doi.org/10.1124/dmd.113.054106

Symposium Report

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    Correlating Structure and Function of Drug-Metabolizing Enzymes: Progress and Ongoing Challenges
    Eric F. Johnson, J. Patrick Connick, James R. Reed, Wayne L. Backes, Manoj C. Desai, Lianhong Xu, D. Fernando Estrada, Jennifer S. Laurence and Emily E. Scott
    Drug Metabolism and Disposition January 2014, 42 (1) 9-22; DOI: https://doi.org/10.1124/dmd.113.054627

Articles

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    Evaluation and Mechanistic Analysis of the Cytotoxicity of the Acyl Glucuronide of Nonsteroidal Anti-Inflammatory Drugs
    Taishi Miyashita, Kento Kimura, Tatsuki Fukami, Miki Nakajima and Tsuyoshi Yokoi
    Drug Metabolism and Disposition January 2014, 42 (1) 1-8; DOI: https://doi.org/10.1124/dmd.113.054478
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    MicroRNA-561 Promotes Acetaminophen-Induced Hepatotoxicity in HepG2 Cells and Primary Human Hepatocytes through Downregulation of the Nuclear Receptor Corepressor Dosage-Sensitive Sex-Reversal Adrenal Hypoplasia Congenital Critical Region on the X Chromosome, Gene 1 (DAX-1)
    Minghua Li, Yinxue Yang, Zhi-Xu He, Zhi-Wei Zhou, Tianxin Yang, Peixuan Guo, Xueji Zhang and Shu-Feng Zhou
    Drug Metabolism and Disposition January 2014, 42 (1) 44-61; DOI: https://doi.org/10.1124/dmd.113.052670
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    Oatp1a1 Requires PDZK1 to Traffic to the Plasma Membrane by Selective Recruitment of Microtubule-Based Motor Proteins
    Wen-Jun Wang, John W. Murray and Allan W. Wolkoff
    Drug Metabolism and Disposition January 2014, 42 (1) 62-69; DOI: https://doi.org/10.1124/dmd.113.054536
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    A Role for Cytochrome b5 in the In Vivo Disposition of Anticancer and Cytochrome P450 Probe Drugs in Mice
    Colin J. Henderson, Lesley A. McLaughlin, Robert D. Finn, Sebastien Ronseaux, Yury Kapelyukh and C. Roland Wolf
    Drug Metabolism and Disposition January 2014, 42 (1) 70-77; DOI: https://doi.org/10.1124/dmd.113.055277
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    Interindividual Variability in Hepatic Organic Anion-Transporting Polypeptides and P-Glycoprotein (ABCB1) Protein Expression: Quantification by Liquid Chromatography Tandem Mass Spectroscopy and Influence of Genotype, Age, and Sex
    Bhagwat Prasad, Raymond Evers, Anshul Gupta, Cornelis E. C. A. Hop, Laurent Salphati, Suneet Shukla, Suresh V. Ambudkar and Jashvant D. Unadkat
    Drug Metabolism and Disposition January 2014, 42 (1) 78-88; DOI: https://doi.org/10.1124/dmd.113.053819
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    Localization of Multidrug Resistance-Associated Proteins along the Blood-Testis Barrier in Rat, Macaque, and Human Testis
    David M. Klein, Stephen H. Wright and Nathan J. Cherrington
    Drug Metabolism and Disposition January 2014, 42 (1) 89-93; DOI: https://doi.org/10.1124/dmd.113.054577
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    Deoxyschizandrin, a Naturally Occurring Lignan, Is a Specific Probe Substrate of Human Cytochrome P450 3A
    Jingjing Wu, Yunfeng Cao, Yanyan Zhang, Yong Liu, James Y. Hong, Liangliang Zhu, Guangbo Ge and Ling Yang
    Drug Metabolism and Disposition January 2014, 42 (1) 94-104; DOI: https://doi.org/10.1124/dmd.113.053884
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    Association of Plasma Concentration of 4β-Hydroxycholesterol with CYP3A5 Polymorphism and Plasma Concentration of Indoxyl Sulfate in Stable Kidney Transplant Recipients
    Yosuke Suzuki, Hiroki Itoh, Takashi Fujioka, Fuminori Sato, Kanako Kawasaki, Yukie Sato, Yuhki Sato, Keiko Ohno, Hiromitsu Mimata and Satoshi Kishino
    Drug Metabolism and Disposition January 2014, 42 (1) 105-110; DOI: https://doi.org/10.1124/dmd.113.054171
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    Tissue-Specific Metabolism of Benzo[a]pyrene in Rainbow Trout (Oncorhynchus mykiss): A Comparison between the Liver and Immune Organs
    Anja-Maria Möller, Corinna Hermsen, Tilman Floehr, Marja H. Lamoree and Helmut Segner
    Drug Metabolism and Disposition January 2014, 42 (1) 111-118; DOI: https://doi.org/10.1124/dmd.113.053777
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    Nonlinear Pharmacokinetics of (±)3,4-Methylenedioxymethamphetamine (MDMA) and Its Pharmacodynamic Consequences in the Rat
    Marta Concheiro, Michael H. Baumann, Karl B. Scheidweiler, Richard B. Rothman, Gina F. Marrone and Marilyn A. Huestis
    Drug Metabolism and Disposition January 2014, 42 (1) 119-125; DOI: https://doi.org/10.1124/dmd.113.053678
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    In Vitro Drug Metabolism by Human Carboxylesterase 1: Focus on Angiotensin-Converting Enzyme Inhibitors
    Ragnar Thomsen, Henrik B. Rasmussen, Kristian Linnet and The INDICES Consortium
    Drug Metabolism and Disposition January 2014, 42 (1) 126-133; DOI: https://doi.org/10.1124/dmd.113.053512
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    Hepatic Cytochrome P450s, Phase II Enzymes and Nuclear Receptors Are Downregulated in a Th2 Environment during Schistosoma mansoni Infection
    Sylvie M. Mimche, Beatrice A. Nyagode, Matthew D. Merrell, Choon-Myung Lee, Nina S. Prasanphanich, Richard D. Cummings and Edward T. Morgan
    Drug Metabolism and Disposition January 2014, 42 (1) 134-140; DOI: https://doi.org/10.1124/dmd.113.054957
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    Multiple Cytochrome P450 Isoforms Are Involved in the Generation of a Pharmacologically Active Thiol Metabolite, whereas Paraoxonase 1 and Carboxylesterase 1 Catalyze the Formation of a Thiol Metabolite Isomer from Ticlopidine
    Min-Jung Kim, Eun Sook Jeong, Jung-Soon Park, Su-Jun Lee, Jong Lyul Ghim, Chang-Soo Choi, Jae-Gook Shin and Dong-Hyun Kim
    Drug Metabolism and Disposition January 2014, 42 (1) 141-152; DOI: https://doi.org/10.1124/dmd.113.053017
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    In Vitro Hydrolysis and Transesterification of CDP323, an α4β1/α4β7 Integrin Antagonist Ester Prodrug
    Hugues Chanteux, Maria Rosa, Claude Delatour, Chandra Prakash, Steven Smith and Jean-Marie Nicolas
    Drug Metabolism and Disposition January 2014, 42 (1) 153-161; DOI: https://doi.org/10.1124/dmd.113.054049
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    Studies on the Role of Metabolic Activation in Tyrosine Kinase Inhibitor–Dependent Hepatotoxicity: Induction of CYP3A4 Enhances the Cytotoxicity of Lapatinib in HepaRG Cells
    Klarissa D. Hardy, Michelle D. Wahlin, Ioannis Papageorgiou, Jashvant D. Unadkat, Allan E. Rettie and Sidney D. Nelson
    Drug Metabolism and Disposition January 2014, 42 (1) 162-171; DOI: https://doi.org/10.1124/dmd.113.054817
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    Role of Constitutive Androstane Receptor in Toll-Like Receptor-Mediated Regulation of Gene Expression of Hepatic Drug-Metabolizing Enzymes and Transporters
    Pranav Shah, Tao Guo, David D. Moore and Romi Ghose
    Drug Metabolism and Disposition January 2014, 42 (1) 172-181; DOI: https://doi.org/10.1124/dmd.113.053850
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    Utility of Oatp1a/1b-Knockout and OATP1B1/3-Humanized Mice in the Study of OATP-Mediated Pharmacokinetics and Tissue Distribution: Case Studies with Pravastatin, Atorvastatin, Simvastatin, and Carboxydichlorofluorescein
    J. William Higgins, Jing Q. Bao, Alice B. Ke, Jason R. Manro, John K. Fallon, Philip C. Smith and Maciej J. Zamek-Gliszczynski
    Drug Metabolism and Disposition January 2014, 42 (1) 182-192; DOI: https://doi.org/10.1124/dmd.113.054783
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    In Vivo to In Vitro Effects of Six Bioactive Lignans of Wuzhi Tablet (Schisandra Sphenanthera Extract) on the CYP3A/P-glycoprotein–Mediated Absorption and Metabolism of Tacrolimus
    Xiao Ling Qin, Xiao Chen, Ying Wang, Xin Ping Xue, Ying Wang, Jia Li Li, Xue Ding Wang, Guo Ping Zhong, Chang Xi Wang, Hui Yang, Min Huang and Hui Chang Bi
    Drug Metabolism and Disposition January 2014, 42 (1) 193-199; DOI: https://doi.org/10.1124/dmd.113.053892

Erratum

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    Correction to “Meeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPac”
    Drug Metabolism and Disposition January 2014, 42 (1) 200; DOI: https://doi.org/10.1124/dmd.113.01er14
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Drug Metabolism and Disposition: 42 (1)
Drug Metabolism and Disposition
Vol. 42, Issue 1
1 Jan 2014
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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