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Research ArticleArticle

Utility of Oatp1a/1b-Knockout and OATP1B1/3-Humanized Mice in the Study of OATP-Mediated Pharmacokinetics and Tissue Distribution: Case Studies with Pravastatin, Atorvastatin, Simvastatin, and Carboxydichlorofluorescein

J. William Higgins, Jing Q. Bao, Alice B. Ke, Jason R. Manro, John K. Fallon, Philip C. Smith and Maciej J. Zamek-Gliszczynski
Drug Metabolism and Disposition January 2014, 42 (1) 182-192; DOI: https://doi.org/10.1124/dmd.113.054783
J. William Higgins
Drug Disposition (J.W.H., J.Q.B., A.B.K., M.J.Z.-G.) and Global Statistical Sciences (J.R.M.), Lilly Research Laboratories, Indianapolis, Indiana; and Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina (J.K.F., P.C.S., M.J.Z.-G.)
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Jing Q. Bao
Drug Disposition (J.W.H., J.Q.B., A.B.K., M.J.Z.-G.) and Global Statistical Sciences (J.R.M.), Lilly Research Laboratories, Indianapolis, Indiana; and Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina (J.K.F., P.C.S., M.J.Z.-G.)
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Alice B. Ke
Drug Disposition (J.W.H., J.Q.B., A.B.K., M.J.Z.-G.) and Global Statistical Sciences (J.R.M.), Lilly Research Laboratories, Indianapolis, Indiana; and Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina (J.K.F., P.C.S., M.J.Z.-G.)
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Jason R. Manro
Drug Disposition (J.W.H., J.Q.B., A.B.K., M.J.Z.-G.) and Global Statistical Sciences (J.R.M.), Lilly Research Laboratories, Indianapolis, Indiana; and Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina (J.K.F., P.C.S., M.J.Z.-G.)
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John K. Fallon
Drug Disposition (J.W.H., J.Q.B., A.B.K., M.J.Z.-G.) and Global Statistical Sciences (J.R.M.), Lilly Research Laboratories, Indianapolis, Indiana; and Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina (J.K.F., P.C.S., M.J.Z.-G.)
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Philip C. Smith
Drug Disposition (J.W.H., J.Q.B., A.B.K., M.J.Z.-G.) and Global Statistical Sciences (J.R.M.), Lilly Research Laboratories, Indianapolis, Indiana; and Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina (J.K.F., P.C.S., M.J.Z.-G.)
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Maciej J. Zamek-Gliszczynski
Drug Disposition (J.W.H., J.Q.B., A.B.K., M.J.Z.-G.) and Global Statistical Sciences (J.R.M.), Lilly Research Laboratories, Indianapolis, Indiana; and Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina (J.K.F., P.C.S., M.J.Z.-G.)
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Article Information

vol. 42 no. 1 182-192
DOI 
https://doi.org/10.1124/dmd.113.054783
PubMed 
24194513

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received September 9, 2013
  • Accepted November 5, 2013
  • Published online December 12, 2013.

Article Versions

  • Earlier version (November 5, 2013 - 08:57).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. J. William Higgins,
  2. Jing Q. Bao,
  3. Alice B. Ke,
  4. Jason R. Manro,
  5. John K. Fallon,
  6. Philip C. Smith, and
  7. Maciej J. Zamek-Gliszczynski
  1. Drug Disposition (J.W.H., J.Q.B., A.B.K., M.J.Z.-G.) and Global Statistical Sciences (J.R.M.), Lilly Research Laboratories, Indianapolis, Indiana; and Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina (J.K.F., P.C.S., M.J.Z.-G.)
  1. Address correspondence to:
    Dr. Maciej J. Zamek-Gliszczynski, Lilly Corporate Center, Indianapolis, IN 46285. E-mail: m_zamek-gliszczynski{at}lilly.com
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Drug Metabolism and Disposition: 42 (1)
Drug Metabolism and Disposition
Vol. 42, Issue 1
1 Jan 2014
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Utility of Oatp1a/1b-Knockout and OATP1B1/3-Humanized Mice in the Study of OATP-Mediated Pharmacokinetics and Tissue Distribution: Case Studies with Pravastatin, Atorvastatin, Simvastatin, and Carboxydichlorofluorescein
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Research ArticleArticle

OATP in Drug Pharmacokinetics and Tissue Distribution

J. William Higgins, Jing Q. Bao, Alice B. Ke, Jason R. Manro, John K. Fallon, Philip C. Smith and Maciej J. Zamek-Gliszczynski
Drug Metabolism and Disposition January 1, 2014, 42 (1) 182-192; DOI: https://doi.org/10.1124/dmd.113.054783

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Research ArticleArticle

OATP in Drug Pharmacokinetics and Tissue Distribution

J. William Higgins, Jing Q. Bao, Alice B. Ke, Jason R. Manro, John K. Fallon, Philip C. Smith and Maciej J. Zamek-Gliszczynski
Drug Metabolism and Disposition January 1, 2014, 42 (1) 182-192; DOI: https://doi.org/10.1124/dmd.113.054783
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