Research ArticleArticle
MicroRNA-561 Promotes Acetaminophen-Induced Hepatotoxicity in HepG2 Cells and Primary Human Hepatocytes through Downregulation of the Nuclear Receptor Corepressor Dosage-Sensitive Sex-Reversal Adrenal Hypoplasia Congenital Critical Region on the X Chromosome, Gene 1 (DAX-1)
Minghua Li, Yinxue Yang, Zhi-Xu He, Zhi-Wei Zhou, Tianxin Yang, Peixuan Guo, Xueji Zhang and Shu-Feng Zhou
Drug Metabolism and Disposition January 2014, 42 (1) 44-61; DOI: https://doi.org/10.1124/dmd.113.052670
Minghua Li
Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, Florida (M.L., Z.W.Z., S.F.Z.); Department of Hepatobiliary Surgery, General Hospital of Ningxia Medical University, Yinchuan City, Ningxia Hui Autonomous Region, China (Y.Y.); Guizhou Provincial Key Laboratory for Regenerative Medicine, Stem Cell and Tissue Engineering Research Center, Guiyang Medical University, Guiyang, Guizhou, China (Z.X.H.); Department of Internal Medicine, University of Utah and Salt Lake Veterans Affairs Medical Center, Salt Lake City, Utah (T.Y.); Nanobiotechnology Center and Markey Cancer Center, College of Pharmacy, University of Kentucky, Lexington, Kentucky (P.G.); Research Center for Bioengineering and Sensing Technology, University of Science and Technology Beijing, Beijing, China (X.Z.)
Yinxue Yang
Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, Florida (M.L., Z.W.Z., S.F.Z.); Department of Hepatobiliary Surgery, General Hospital of Ningxia Medical University, Yinchuan City, Ningxia Hui Autonomous Region, China (Y.Y.); Guizhou Provincial Key Laboratory for Regenerative Medicine, Stem Cell and Tissue Engineering Research Center, Guiyang Medical University, Guiyang, Guizhou, China (Z.X.H.); Department of Internal Medicine, University of Utah and Salt Lake Veterans Affairs Medical Center, Salt Lake City, Utah (T.Y.); Nanobiotechnology Center and Markey Cancer Center, College of Pharmacy, University of Kentucky, Lexington, Kentucky (P.G.); Research Center for Bioengineering and Sensing Technology, University of Science and Technology Beijing, Beijing, China (X.Z.)
Zhi-Xu He
Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, Florida (M.L., Z.W.Z., S.F.Z.); Department of Hepatobiliary Surgery, General Hospital of Ningxia Medical University, Yinchuan City, Ningxia Hui Autonomous Region, China (Y.Y.); Guizhou Provincial Key Laboratory for Regenerative Medicine, Stem Cell and Tissue Engineering Research Center, Guiyang Medical University, Guiyang, Guizhou, China (Z.X.H.); Department of Internal Medicine, University of Utah and Salt Lake Veterans Affairs Medical Center, Salt Lake City, Utah (T.Y.); Nanobiotechnology Center and Markey Cancer Center, College of Pharmacy, University of Kentucky, Lexington, Kentucky (P.G.); Research Center for Bioengineering and Sensing Technology, University of Science and Technology Beijing, Beijing, China (X.Z.)
Zhi-Wei Zhou
Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, Florida (M.L., Z.W.Z., S.F.Z.); Department of Hepatobiliary Surgery, General Hospital of Ningxia Medical University, Yinchuan City, Ningxia Hui Autonomous Region, China (Y.Y.); Guizhou Provincial Key Laboratory for Regenerative Medicine, Stem Cell and Tissue Engineering Research Center, Guiyang Medical University, Guiyang, Guizhou, China (Z.X.H.); Department of Internal Medicine, University of Utah and Salt Lake Veterans Affairs Medical Center, Salt Lake City, Utah (T.Y.); Nanobiotechnology Center and Markey Cancer Center, College of Pharmacy, University of Kentucky, Lexington, Kentucky (P.G.); Research Center for Bioengineering and Sensing Technology, University of Science and Technology Beijing, Beijing, China (X.Z.)
Tianxin Yang
Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, Florida (M.L., Z.W.Z., S.F.Z.); Department of Hepatobiliary Surgery, General Hospital of Ningxia Medical University, Yinchuan City, Ningxia Hui Autonomous Region, China (Y.Y.); Guizhou Provincial Key Laboratory for Regenerative Medicine, Stem Cell and Tissue Engineering Research Center, Guiyang Medical University, Guiyang, Guizhou, China (Z.X.H.); Department of Internal Medicine, University of Utah and Salt Lake Veterans Affairs Medical Center, Salt Lake City, Utah (T.Y.); Nanobiotechnology Center and Markey Cancer Center, College of Pharmacy, University of Kentucky, Lexington, Kentucky (P.G.); Research Center for Bioengineering and Sensing Technology, University of Science and Technology Beijing, Beijing, China (X.Z.)
Peixuan Guo
Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, Florida (M.L., Z.W.Z., S.F.Z.); Department of Hepatobiliary Surgery, General Hospital of Ningxia Medical University, Yinchuan City, Ningxia Hui Autonomous Region, China (Y.Y.); Guizhou Provincial Key Laboratory for Regenerative Medicine, Stem Cell and Tissue Engineering Research Center, Guiyang Medical University, Guiyang, Guizhou, China (Z.X.H.); Department of Internal Medicine, University of Utah and Salt Lake Veterans Affairs Medical Center, Salt Lake City, Utah (T.Y.); Nanobiotechnology Center and Markey Cancer Center, College of Pharmacy, University of Kentucky, Lexington, Kentucky (P.G.); Research Center for Bioengineering and Sensing Technology, University of Science and Technology Beijing, Beijing, China (X.Z.)
Xueji Zhang
Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, Florida (M.L., Z.W.Z., S.F.Z.); Department of Hepatobiliary Surgery, General Hospital of Ningxia Medical University, Yinchuan City, Ningxia Hui Autonomous Region, China (Y.Y.); Guizhou Provincial Key Laboratory for Regenerative Medicine, Stem Cell and Tissue Engineering Research Center, Guiyang Medical University, Guiyang, Guizhou, China (Z.X.H.); Department of Internal Medicine, University of Utah and Salt Lake Veterans Affairs Medical Center, Salt Lake City, Utah (T.Y.); Nanobiotechnology Center and Markey Cancer Center, College of Pharmacy, University of Kentucky, Lexington, Kentucky (P.G.); Research Center for Bioengineering and Sensing Technology, University of Science and Technology Beijing, Beijing, China (X.Z.)
Shu-Feng Zhou
Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, Florida (M.L., Z.W.Z., S.F.Z.); Department of Hepatobiliary Surgery, General Hospital of Ningxia Medical University, Yinchuan City, Ningxia Hui Autonomous Region, China (Y.Y.); Guizhou Provincial Key Laboratory for Regenerative Medicine, Stem Cell and Tissue Engineering Research Center, Guiyang Medical University, Guiyang, Guizhou, China (Z.X.H.); Department of Internal Medicine, University of Utah and Salt Lake Veterans Affairs Medical Center, Salt Lake City, Utah (T.Y.); Nanobiotechnology Center and Markey Cancer Center, College of Pharmacy, University of Kentucky, Lexington, Kentucky (P.G.); Research Center for Bioengineering and Sensing Technology, University of Science and Technology Beijing, Beijing, China (X.Z.)
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Research ArticleArticle
miR-561 Exacerbates Acetaminophen-Induced Hepatotoxicity
Minghua Li, Yinxue Yang, Zhi-Xu He, Zhi-Wei Zhou, Tianxin Yang, Peixuan Guo, Xueji Zhang and Shu-Feng Zhou
Drug Metabolism and Disposition January 1, 2014, 42 (1) 44-61; DOI: https://doi.org/10.1124/dmd.113.052670
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