Table of Contents

Articles

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  Toward a Unified Model of Passive Drug Permeation II: The Physiochemical Determinants of Unbound Tissue Distribution with Applications to the Design of Hepatoselective Glucokinase Activators

  Avijit Ghosh, Tristan S. Maurer, John Litchfield, Manthema V. Varma, Charles Rotter, Renato Scialis, Bo Feng, Meihua Tu, Cris R. W. Guimaraes and Dennis O. Scott

  Drug Metabolism and Disposition October 2014, 42 (10) 1599-1610; DOI: https://doi.org/10.1124/dmd.114.058032
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  The Effects of Milk Thistle (Silybum marianum) on Human Cytochrome P450 Activity

  Marina Kawaguchi-Suzuki, Reginald F. Frye, Hao-Jie Zhu, Bryan J. Brinda, Kenneth D. Chavin, Hilary J. Bernstein and John S. Markowitz

  Drug Metabolism and Disposition October 2014, 42 (10) 1611-1616; DOI: https://doi.org/10.1124/dmd.114.057232
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  Differential Effect of Liver Cirrhosis on the Pregnane X Receptor–Mediated Induction of CYP3A1 and 3A2 in the Rat

  Sara De Martin, Daniela Gabbia, Giovanna Albertin, Maria Martina Sfriso, Claudia Mescoli, Laura Albertoni, Giovanna Paliuri, Sergio Bova and Pietro Palatini

  Drug Metabolism and Disposition October 2014, 42 (10) 1617-1626; DOI: https://doi.org/10.1124/dmd.114.058511
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  Biosynthesis of Drug Metabolites and Quantitation Using NMR Spectroscopy for Use in Pharmacologic and Drug Metabolism Studies

  Gregory S. Walker, Jonathan N. Bauman, Tim F. Ryder, Evan B. Smith, Douglas K. Spracklin and R. Scott Obach

  Drug Metabolism and Disposition October 2014, 42 (10) 1627-1639; DOI: https://doi.org/10.1124/dmd.114.059204
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  Assessment of Intestinal Availability (F_G) of Substrate Drugs of Cytochrome P450s by Analyzing Changes in Pharmacokinetic Properties Caused by Drug–Drug Interactions

  Akihiro Hisaka, Mikiko Nakamura, Ayako Tsukihashi, Saori Koh and Hiroshi Suzuki

  Drug Metabolism and Disposition October 2014, 42 (10) 1640-1645; DOI: https://doi.org/10.1124/dmd.114.059147
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  Physiologically Based Pharmacokinetic Prediction of Telmisartan in Human

  Rui Li, Avijit Ghosh, Tristan S. Maurer, Emi Kimoto and Hugh A. Barton

  Drug Metabolism and Disposition October 2014, 42 (10) 1646-1655; DOI: https://doi.org/10.1124/dmd.114.058461
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  The Janus Kinase 2 Inhibitor Fedratinib Inhibits Thiamine Uptake: A Putative Mechanism for the Onset of Wernicke’s Encephalopathy

  Qiang Zhang, Yan Zhang, Sharon Diamond, Jason Boer, Jennifer J. Harris, Yu Li, Mark Rupar, Elham Behshad, Christine Gardiner, Paul Collier, Phillip Liu, Timothy Burn, Richard Wynn, Gregory Hollis and Swamy Yeleswaram

  Drug Metabolism and Disposition October 2014, 42 (10) 1656-1662; DOI: https://doi.org/10.1124/dmd.114.058883
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  Is Nuclear Factor Erythroid 2–Related Factor 2 Responsible for Sex Differences in Susceptibility to Acetaminophen-Induced Hepatotoxicity in Mice?

  Philip R. Rohrer, Swetha Rudraiah, Michael J. Goedken and José E. Manautou

  Drug Metabolism and Disposition October 2014, 42 (10) 1663-1674; DOI: https://doi.org/10.1124/dmd.114.059006
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  Identification of Diet-Derived Constituents as Potent Inhibitors of Intestinal Glucuronidation

  Brandon T. Gufford, Gang Chen, Philip Lazarus, Tyler N. Graf, Nicholas H. Oberlies and Mary F. Paine

  Drug Metabolism and Disposition October 2014, 42 (10) 1675-1683; DOI: https://doi.org/10.1124/dmd.114.059451
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  Transcriptional Regulation of Human Hydroxysteroid Sulfotransferase SULT2A1 by LXRα

  Zhimin Ou, Mengxi Jiang, Bingfang Hu, Yixian Huang, Meishu Xu, Songrong Ren, Song Li, Suhuan Liu, Wen Xie and Min Huang

  Drug Metabolism and Disposition October 2014, 42 (10) 1684-1689; DOI: https://doi.org/10.1124/dmd.114.058479
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  Microbial Metabolites of Omeprazole Activate Murine Aryl Hydrocarbon Receptor In Vitro and In Vivo

  Kazuhiro Shiizaki, Masanobu Kawanishi and Takashi Yagi

  Drug Metabolism and Disposition October 2014, 42 (10) 1690-1697; DOI: https://doi.org/10.1124/dmd.114.058966
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  Characterization of the Active Site Properties of CYP4F12

  John Eksterowicz, Dan A. Rock, Brooke M. Rock, Larry C. Wienkers and Robert S. Foti

  Drug Metabolism and Disposition October 2014, 42 (10) 1698-1707; DOI: https://doi.org/10.1124/dmd.114.059626
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  Threonine-290 Regulates Nuclear Translocation of the Human Pregnane X Receptor through Its Phosphorylation/Dephosphorylation by Ca²⁺/Calmodulin-Dependent Protein Kinase II and Protein Phosphatase 1

  Junko Sugatani, Yoshiki Hattori, Yuji Noguchi, Masahiko Yamaguchi, Yasuhiro Yamazaki and Akira Ikari

  Drug Metabolism and Disposition October 2014, 42 (10) 1708-1718; DOI: https://doi.org/10.1124/dmd.114.059139
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  Pharmacoproteomics-Based Reconstruction of In Vivo P-Glycoprotein Function at Blood-Brain Barrier and Brain Distribution of Substrate Verapamil in Pentylenetetrazole-Kindled Epilepsy, Spontaneous Epilepsy, and Phenytoin Treatment Models

  Yasuo Uchida, Sumio Ohtsuki and Tetsuya Terasaki

  Drug Metabolism and Disposition October 2014, 42 (10) 1719-1726; DOI: https://doi.org/10.1124/dmd.114.059055
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  Cytochrome P450–Mediated Metabolic Activation of Diosbulbin B

  Dongju Lin, Chunyan Li, Ying Peng, Huiyuan Gao and Jiang Zheng

  Drug Metabolism and Disposition October 2014, 42 (10) 1727-1736; DOI: https://doi.org/10.1124/dmd.114.059261
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  Metabolism of Diosbulbin B In Vitro and In Vivo in Rats: Formation of Reactive Metabolites and Human Enzymes Involved

  Baohua Yang, Wei Liu, Kaixian Chen, Zhengtao Wang and Changhong Wang

  Drug Metabolism and Disposition October 2014, 42 (10) 1737-1750; DOI: https://doi.org/10.1124/dmd.114.058222
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  Cynomolgus Monkey as a Surrogate for Human Aldehyde Oxidase Metabolism of the EGFR Inhibitor BIBX1382

  J. Matthew Hutzler, Matthew A. Cerny, Young-Sun Yang, Constance Asher, Diane Wong, Kosea Frederick and Kyle Gilpin

  Drug Metabolism and Disposition October 2014, 42 (10) 1751-1760; DOI: https://doi.org/10.1124/dmd.114.059030
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  Metabolism and Disposition of Bupropion in Pregnant Baboons (Papio cynocephalus)

  Erik Rytting, Xiaoming Wang, Daria I. Vernikovskaya, Ying Zhan, Cassondra Bauer, Susan M. Abdel-Rahman, Mahmoud S. Ahmed and Tatiana N. Nanovskaya

  Drug Metabolism and Disposition October 2014, 42 (10) 1773-1779; DOI: https://doi.org/10.1124/dmd.114.058255